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Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70

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Journal of Traditional Chinese Medicine 2000年第4期20卷 297-301页

作者：吴卫平匡培根姜树军张小澍杨炯炯隋南 albert chen 匡培梓 Neurotransmitter Research Laboratory Department of NeurologyChinese PLA General HospitalPostgraduate Military Medical SchoolBeijing 100853 Neurotransmitter Research Laboratory Department of NeurologyChinese PLA General HospitalPostgraduate Military Medical School Beijing 100853 Neurotransmitter Research Laboratory Department of NeurologyChinese PLA General Hospital Postgraduate Military Medical SchoolBeijing 100853 PLA 261 Hospital Beijing 100094 Institute of Psychology Chinese Academy of SciencesBeijing 100101

　　The effect of Batroxobin on spatial memory disorder of left temporal ischemic rats and the expression of HSP32 and HSP70 were investigated with Morri`s water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats in searching a goal were significantly longer than those of the sham-operated rats and at the same time HSP32 and HSP70 expression of left temporal ischemic region in rats was significantly increased as compared with the sham-operated rats. However, the mean reaction time and distance of the Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of HSP32 and HSP70 immune reactive cells of Batroxobin-treated rats was also less than that of the ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats; and the down-regulation of the expression of HSP32 and HSP70 is probably related to the attenuation of ischemic injury.

关键词： Oxygenases Animals Batroxobin Brain Ischemia Down-Regulation HSP70 Heat-Shock Proteins Heat-Shock Proteins Heme Oxygenase (Decyclizing) Learning Disorders Male Maze Learning Memory Disorders Random Allocation Rats Rats, Wistar Snake Venoms Spatial Behavior Temporal Lobe

Data for critical infrastructure network modelling of natural hazard impacts:Needs and influence on model characteristics

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Resilient Cities and Structures 2024年第1期3卷 55-65页

作者： Roman Schotten Evelyn Mühlhofer Georgios-Alexandros Chatzistefanou Daniel Bachmann albert S.chen Elco E.Koks Work Group Flood Risk Management University of Applied Science MagdeburgGermany Weather and Climate Risks Group Institute for Environmental DecisionsETH ZürichSwitzerland KWR Water Research Institute NieuwegeinNetherlands Center for Water Systems University of ExeterExeterUnited Kingdom Water and Climate Risk Group Institute for Environmental StudiesVrije Universiteit AmsterdamNetherlands

Natural hazards impact interdependent infrastructure networks that keep modern society *** a va-riety of modelling approaches are available to represent critical infrastructure networks(CINs)on different scales and analyse the impacts of natural hazards,a recurring challenge for all modelling approaches is the availability and accessibility of sufficiently high-quality input and validation *** resulting data gaps often require mod-ellers to assume specific technical parameters,functional relationships,and system *** other cases,expert knowledge from one sector is extrapolated to other sectoral structures or even cross-sectorally applied to fill data *** uncertainties introduced by these assumptions and extrapolations and their influence on the quality of modelling outcomes are often poorly understood and difficult to capture,thereby eroding the reliability of these models to guide resilience ***,ways of overcoming the data avail-ability challenges in CIN modelling,with respect to each modelling purpose,remain an open *** address these challenges,a generic modelling workflow is derived from existing modelling approaches to examine model definition and validations,as well as the six CIN modelling stages,including mapping of infrastructure assets,quantification of dependencies,assessment of natural hazard impacts,response&recovery,quantification of CI services,and adaptation *** data requirements of each stage were systematically defined,and the literature on potential sources was reviewed to enhance data collection and raise awareness of potential *** application of the derived workflow funnels into a framework to assess data availability *** is shown through three case studies,taking into account their different modelling purposes:hazard hotspot assess-ments,hazard risk management,and sectoral *** on the three model purpose types provided,a framework is suggested

关键词： Critical infrastructure networks Impact modelling Data availability Natural hazards

Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer Database

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Cancer Communications 2019年第1期39卷 548-556页

作者： Gary D.Lewis Yan Xing Waqar Haque Tejal Patel Mary Schwartz albert chen Andrew Farach Sandra S.Hatch E.Brian Butler Jenny Chang Bin S.Teh Department of Radiation Oncology University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Houston Methodist HospitalHoustonTX 77030USA Department of Pathology and Genomic Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical BranchGalvestonTX 77555USA

Background:Invasive micropapillary carcinoma(IMPC)is an uncommon subtype of breast *** studies of this subtype demonstrated a higher propensity for lymph node metastases as compared with invasive ductal carci-noma(IDC).The purpose of the present study was to determine the clinical characteristics,outcomes,and propensity for lymph node metastasis of patients with IMPC of the breast recorded in the National Cancer Database(NCDB).Methods:Records of patients with IMPC diagnosed between 2004 and 2014 were retrieved from the ***-rank test was performed to evaluate associations of clinical characteristics with overall survival(OS).Cox proportional hazards model was used to determine variables associated with ***:Overall,2660 patients with IMPC met the selection criteria;the 5-year OS rate was 87.5%and 24.9%of patients had nodal involvement at *** with≥4 positive lymph nodes had shorter OS than node-negative patients,whereas patients with 1-3 positive nodes had similar OS to node-negative ***<65 years,receipt of radiotherapy,and estrogen receptor positivity were also associated with prolonged *** benefit of radiotherapy was limited to IMPC patients undergoing lumpectomy;there was no benefit for the patients undergoing mastectomy(regardless of nodal positivity/negativity).Conclusions:Favorable prognostic factors of IMPC patients included age<65 years,<4 positive lymph nodes,receipt of radiotherapy,and estrogen receptor *** results presented herein suggest a survival benefit asso-ciated with radiotherapy in IMPC treatment,though this may be limited to the patients treated with lumpectomy.

关键词： Breast cancer Invasive micropapillary carcinoma Radiotherapy Surgery Survival Hormone receptor

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美杜莎的倒影—《想象之城》书评

景观设计学（中英文） 2021年第5期9卷 104-117页

作者：陈峥能 Stoss景观都市主义工作室

瓦莱里奥·莫拉比托最近出版的《想象之城》一书质疑了景观解读的图像性概念,并探索了通过讲故事来阅读和呈现景观的可能性,这种景观强调景观设计学的文学性和交流性倾向。本文包括4个部分,分别从历史、认识论、方法,以及相关文学渊源(... 详细信息

瓦莱里奥·莫拉比托最近出版的《想象之城》一书质疑了景观解读的图像性概念,并探索了通过讲故事来阅读和呈现景观的可能性,这种景观强调景观设计学的文学性和交流性倾向。本文包括4个部分,分别从历史、认识论、方法,以及相关文学渊源(尤其是书中受到伊塔洛·卡尔维诺启发的部分)等方面对《想象之城》进行评述。作者认为,《想象之城》描绘了在图像与语言传统之间进行景观表现的历史范例;体现了旅行见闻的真实性,以及莫拉比托处理旅行记忆的方法;讲述了莫拉比托如何将故事叙述中认知的不完美性应用到他的经验主义方法中,以平衡对景观的实证主义解读;凸显了莫拉比托视觉语言中形式自治与诗歌传统之间的张力。本文探讨并进一步开启了可感知存在与虚构景观之间的本质对话,对人类栖居深层意义的解读与消费,以及实证主义与人文主义立场在这一学科中的认知矛盾与调和。

关键词：伊塔洛·旅行见闻景观表达阅读会说话的绘画故事讲述伊塔洛·卡尔维诺

CHINA-ASEAN INTEGRATION THRIVES ON SHARED CULTURAL TIES AND MUTUAL BENEFITS

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China Report ASEAN 2023年第11期8卷 62-62页

作者： albert chen Yongquan Asia Pacific Economic Review

China’s Belt and Road Initiative is now in its tenth *** experience has shown that the countries that comprise the Association of Southeast Asian Nations(ASEAN)make up a favorable region for Chinese entrepreneurs to ... 详细信息

关键词： evolve ASEAN Southeast

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巴曲酶对大鼠颞叶梗塞后学习障碍的改善作用

临床神经病学杂志 1999年第4期12卷 195-198页

作者：杨炯炯隋南匡培梓吴卫平姜树军匡培根 albert chen 中国科学院心理研究所中国人民解放军总医院神经介质实验室 DEPARTMENT OF PSYCHOLOGY UNIVERSITY OF MICHIGAN

目的研究巴曲酶对大鼠左侧颞叶梗塞后空间学习障碍的改善作用。方法采用立体定向光化学诱导脑梗塞技术选择性地导致大鼠左侧颞叶皮层梗塞，术前３０分钟及术后第３天分别给巴曲酶组大鼠腹腔注射巴曲酶８ＢＵ／ｋｇ，行为实验装置由Ｍｏ... 详细信息

目的研究巴曲酶对大鼠左侧颞叶梗塞后空间学习障碍的改善作用。方法采用立体定向光化学诱导脑梗塞技术选择性地导致大鼠左侧颞叶皮层梗塞，术前３０分钟及术后第３天分别给巴曲酶组大鼠腹腔注射巴曲酶８ＢＵ／ｋｇ，行为实验装置由Ｍｏｒｒｉｓ水迷宫及图像自动监视系统组成。结果（１）巴曲酶可以显著地缩短梗塞大鼠在Ｍｏｒｒｉｓ迷宫中搜索目标的平均反应时和行程；（２）巴曲酶组大鼠较多、较早地使用了正常的认知策略。结论巴曲酶对左侧颞叶梗塞大鼠空间认知功能障碍具有明显的改善作用。它除了溶栓作用外，还参与了神经损伤的修复过程。

关键词：巴曲酶脑梗塞空间认知 Morris迷宫

采用美国国家癌症数据库数据分析淋巴浸润性微乳头状乳腺癌的预后

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癌症 2020年第2期39卷 77-86页

作者： Gary DLewis Yan Xing Waqar Haque Tejal Patel Mary Schwartz albert chen Andrew Farach Sandra SHatch EBrian Butler Jenny Chang Bin S.Teh Department of Radiation Oncology University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Houston Methodist HospitalHoustonTX 77030USA Department of Pathology and Genomic Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical BranchGalvestonTX 77555USA.

背景与目的浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)是乳腺癌中一种罕见的亚型。已有研究表明,与浸润性导管癌(invasive ductal carcinoma,IDC)相比,该亚型更易发生淋巴结转移。本研究旨在明确美国国家癌症数据库(Nat... 详细信息

背景与目的浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)是乳腺癌中一种罕见的亚型。已有研究表明,与浸润性导管癌(invasive ductal carcinoma,IDC)相比,该亚型更易发生淋巴结转移。本研究旨在明确美国国家癌症数据库(National Cancer Database,NCDB)中记录的乳腺IMPC患者的临床特征、结局和淋巴结转移倾向性。方法从NCDB中检索2004–2014年之间诊断为IMPC患者的病历,并对其进行log-rank检验以评估临床特征与总生存期(overall survival,OS)的相关性。采用Cox比例风险模型确定OS相关因素。结果本研究共纳入2660例IMPC患者。5年OS率为87.5%,24.9%患者出现淋巴结转移。阳性淋巴结数≥4的患者的OS短于阴性淋巴结的患者,而阳性淋巴结数为1–3的患者的OS与阴性淋巴结患者相似。年龄<65岁、接受放疗和雌激素受体阳性也与OS延长有关。放疗仅对接受肿块切除术的IMPC患者有效,对进行乳房切除术的患者无效(无论淋巴结阳性/阴性)。结论IMPC患者的有利预后因素包括年龄<65岁、阳性淋巴结数<4、接受放疗和雌激素受体阳性。本研究结果表明,IMPC患者的生存获益与放疗相关,但可能仅限于经肿块切除术治疗的患者。

关键词：乳腺癌浸润性微乳头状癌放疗手术生存激素受体

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“现场实验室”:设计驱动的研究

景观设计学（中英文） 2022年第1期10卷 88-93页

作者：艾米·怀特塞德斯陈峥能美国Stoss景观都市主义工作室波士顿02127 美国哈佛大学设计研究生院剑桥02138

在景观设计领域,设计研究经常在生态、社会和政治体系中依照各体系中相应的语言、要求和限制条件构建本学科的学术话语体系。本文通过对Stoss景观都市主义工作室进行的多项设计项目进行简要说明,阐释了Stoss如何在不断变化的环境中,利... 详细信息

在景观设计领域,设计研究经常在生态、社会和政治体系中依照各体系中相应的语言、要求和限制条件构建本学科的学术话语体系。本文通过对Stoss景观都市主义工作室进行的多项设计项目进行简要说明,阐释了Stoss如何在不断变化的环境中,利用材料和场地作为设计实践的实验室,以此解决景观设计项目中的实际问题。通过建造小尺度装置和花园,Stoss在场地上测试设计想法,以此为后续项目提供适用的经验。与此同时,根据场地条件和变量的特点,Stoss模拟了生态动态和社会中使用者活动情景,为解决不同尺度的设计项目提供公众交流和调查方法。本文将Stoss的日常景观实践中的设计研究的项目特点总结为三个小节:(1)通过小尺度装置和花园试验设计项目思路;(2)将会随时间推移而变化的环境和社会动态融入到设计研究方向中,甚至将其作为工具,解决城市环境中的问题;(3)利用数字化制造的技术将生物材料打造为可触碰的介质,探索新颖、创新的设计。本文以几个Stoss早期设计或落地的项目为案例,突出项目的设计过程。例如在“装置”一节中,加拿大魁北克盛大梅蒂斯国际花园节的“安全区”、美国马萨诸塞州的哈佛大学拉德克利夫院子的“原料堆”和西丹尼斯的巴斯河公园项目,这三个实践在解决了技术难题的同时,收集材料并测试其效果,还通过项目建立起社会或生态互动。这些项目可为未来进行的项目提供动力,甚至这些简单的设计想法可以发展为更大尺度的设计项目。在“动态”一节中,美国剑桥市的三角公园和哈佛广场、安阿伯市的杰斯塔克树林和波士顿的莫克利公园均利用了动画和编程,进行设计与交流。这些技术可不断模拟该场地随时间演变的状态。“好奇心”一节重点介绍了菌丝体,一种可以形成蘑菇根部的生物材料在设计中的应用。上述思路和工具的使用为设计研究传统的目的和方法提供了一个新的视角,并进一步讨论了设计师应如何在这种新的研究形式中发挥主导作用,以及相关研究结果如何解决未来可能出现的问题。

关键词：设计实验景观设计过程动态动画城市森林花园

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超极化磁共振波谱的原理和应用

磁共振成像 2015年第12期6卷 881-887页

作者：齐海云张晓璐徐雅芳文建国许予明程敬亮 albert P.chen Lotte Bonde Bertelsen Steffen Ringgaard Christoffer Laustsen Hans Stodkilde-Jorgensen MR研究中心临床医学系奥胡斯大学郑州大学第一附属医院郑州450052 GE Healthcare

通过动态核极化(dynamic nuclear polarization,DNP)的方法使原子核自旋极化达到热平衡之上来增强分子磁共振10,000倍以上的信号,这一过程称为超极化(hyperpolarization,HP)。溶解性DNP允许超极化分子以液体形式转移至生物体内,可实时... 详细信息

通过动态核极化(dynamic nuclear polarization,DNP)的方法使原子核自旋极化达到热平衡之上来增强分子磁共振10,000倍以上的信号,这一过程称为超极化(hyperpolarization,HP)。溶解性DNP允许超极化分子以液体形式转移至生物体内,可实时观测体内的生物灌注、代谢产物的运输和代谢反应。该技术的发明克服了传统磁共振信号低,不能实时监测体内代谢过程的缺点。本文旨在介绍动态核极化的定义和技术、常用的超极化生物探针、超极化磁共振波谱图像的结果分析以及初步的动物实验和临床试验结果。

关键词：超极化动态核极化生物探针生物反应器磁共振波谱磁共振成像