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Building a global schistosomiasis alliance:an opportunity to join forces to fight inequality and rural poverty

Infectious Diseases of Poverty 2017年第1期6卷 558-563页

作者： Lorenzo Savioli Marco Albonico Daniel G.Colley Rodrigo Correa-Oliveira alan Fenwick Will Green Narcis Kabatereine Achille Kabore Naftale Katz Katharina Klohe Philip TLoVerde david Rollinson JRussell Stothard Louis-Albert Tchuem Tchuente Johannes Waltz Xiao-Nong Zhou Global Schistosomiasis Alliance GenevaSwitzerland Center for Tropical Diseases Sacro Cuore Hospital-WHO Collaborating Centre on strongyloidiasis and other intestinal parasitic infectionsNegrarVeronaItaly Schistosomiasis Consortium for Operational Research and Evaluation The University of GeorgiaAthensGeorgiaUSA Centro de Pesquisas ReneRachou-Fiocruz Belo HorizonteBrazil and Universidade Federal de Ouro PretoOuro PretoBrazil Department of Infectious Disease Epidemiology SCIImperial CollegeLondonUK Trinity College Cambridge CambridgeUK Imperial College London LondonUK RTI International WashingtonDCUSA Research Center Rene Rachou-Oswaldo Cruz Foundation Belo HorizonteBrazil Global Schistosomiasis Alliance MunichGermany University of Texas Health Science Center San AntonioTXUSA Life Sciences Department The Natural History MuseumLondonUK Department of Parasitology Liverpool School of Tropical MedicineLiverpool L35QAUK Centre for Schistosomiasis&Parasitology YaoundeCameroon Global Schistosomiasis Alliance LondonUK National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention ShanghaiChina

Schistosomiasis,one of the 17 neglected tropical diseases listed by the World Health Organization,presents a substantial public health and economic *** the 261 million people requiring preventive chemotherapy for schistosomiasis in 2013,92%of them lived in sub-Saharan Africa and only 12.7%received preventive ***,in 2010,the WHO reported that schistosomiasis mortality could be as high as 280000 per year in Africa *** May 2012 delegates to the sixty-fifth World Health Assembly adopted resolution WHA65.21 that called for the elimination of schistosomiasis,and foresees the regular treatment of at least 75%of school age children in at-risk *** resolution urged member states to intensify schistosomiasis control programmes and to initiate elimination campaigns where *** this,in June 2015,schistosomiasis was indicated to have the lowest level of preventive chemotherapy implementation in the spectrum of neglected tropical *** was also highlighted as the disease most lacking in *** is perhaps unsurprising,given that it was also the only NTD with access to drug donations but without a coalition of stakeholders that collaborates to boost commitment and *** a consequence,and to ensure that the WHO NTDs Roadmap Targets of 2012 and World Health Assembly Resolution WHA65.21 are met,the Global Schistosomiasis Alliance(GSA)has been set *** and representative,the GSA aims to be a partnership of endemic countries,academic and research institutions,international development agencies and foundations,international organizations,non-governmental development organizations,private sector companies and advocacy and resource mobilisation ***,the GSA calls for a partnership to work for the benefit of endemic countries by addressing health inequity and rural poverty.

关键词： Neglected tropical diseases Schistosomiasis Global Schistosomiasis Alliance Elimination

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Localizing Effects of Leptin on Upper Airway and Respiratory Control during Sleep

Localizing Effects of Leptin on Upper Airway and Respiratory...

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第二届中国西部睡眠医学大会

作者： Qiaoling Yao Huy Pho Jason Kirkness Ellen E.Ladenheim Sheng Bi Timothy H.Moran david D.Fuller Paul J.Reiter david C.Bloom alan R.Schwartz Vsevolod Y.Polotsky

Objectives Obesity hypoventilation syndrome and obstructive sleep apnea are common complications of obesity linked to defects in respiratory pump and upper airway neural *** deficient ob/ob mice have impaired hypercapnic ventilatory response and inspiratory flow limitation during sleep,which are both reversed with *** study is to localize CNS site（s） of leptin action on respiratory and upper airway neuro-ventilatory *** We localized the effect of leptin to medulla *** by administering intracerbroventricular leptin（10μg/2ul）vs vehicle to the lateral（n=14）vs fourth ventricle（n=11）of ob/ob mice followed by a 6 h polysomnographic *** were stratified for effects on respiratory（non-flow limited breaths） and upper airway（inspiratory flow limitation） *** loci were identified by（a） leptin-induced STAT3 phosphorylation and（b）projections of respiratory and upper airway motoneurons with a retrograde tracer pseudorabies *** Both routes of leptin administration increased minute ventilation during non-flow limited breathing in *** motoneurons projected to the nucleus of the solitary tract,which showed STAT3 phosphorylation,but not to the *** flow limitation and obstructive hypopneas were attenuated by leptin administration to the lateral,but not to the fourth cerebral *** airway motoneurons projected to the dorsomedial hypothalamus,which exhibited STAT3 *** Leptin relieves upper airway obstruction in sleep apnea by activating the forebrain,possibly in the dorsomedial *** contrast,leptin up-regulates ventilatory control through hindbrain sites of action,possibly in the nucleus of the solitary tract.

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Localization of urea transporter B in the developing bovine rumen

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Animal Nutrition 2022年第3期10卷 216-222页

作者： Chongliang Zhong Tamsin Lyons Orla Heussaff Evelyn Doyle Eoin O'Hara Sinead M.Waters david Kenny Gavin S.Stewart School of Biology and Environmental Science University College DublinBelfieldDublin 4Ireland Animal and Bioscience Research Department Animal and Grassland Research and Innovation CentreTeagascGrangeCounty MeathIreland Department of Agriculture Foodand Nutritional SciencesUniversity of AlbertaEdmontonAlbertaCanada

Urea nitrogen secreted from blood to rumen is a crucial factor shaping the symbiotic relationship between host ruminants and their microbial *** of urea across rumen epithelia is facilitated by urea transporter B(UT-B),but the long-term regulation of these proteins remains *** ruminal function develops over a period of months,the developing rumen is an excellent model with which to investigate this *** rumen epithelium samples of calves from birth to 96 d of age,this study performed immunolocalization studies to localize and semi-quantify UT-B protein *** expected,preliminary experiments confirmed that ruminal monocarboxylate transporter 1(MCT1)short chain fatty acid transporter protein abundance increased with age(P<0.01,n=4).Further investigation revealed that ruminal UT-B was present in the first few weeks of life and initially detected in the basolateral membrane of stratum basale *** the next 2 months,UT-B staining spread to other epithelial layers and semi-quantification indicated that UT-B abundance significantly increased with age(P<0.01,n=4 or 6).These changes were in line with the development of rumen function after the advent of solid feed intake and weaning,exhibiting a similar pattern to both MCT1 transporters and papillae *** study therefore confirmed age-dependent changes of in situ ruminal UT-B protein,adding to our understanding of the long-term regulation of ruminal urea transporters.

关键词： UT-B Immunolocalization Rumen Bovine Development

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高技术指标:2007年度33国(地区)技术竞争力报告

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科学观察 2008年第3期3卷 1-18页

作者： alan L. Porter Nils C. Newman Xiao-Yin Jin david M. Johnson J. david Roessner 朱海峰(翻译) Technology Policy and Assessment Center Georgia Institute of Technology Atlanta GA USA 30332-0345 不详

文中的高技术指标(High Tech Indicators,HTI)为佐治亚理工大学发布的沿用多年的指标。数据对比的时间段分别为1993年、1996年、1999年、2002/3年和2007年。论文给出了33个国家(地区)当前的竞争力指标——技术排名(Technological Standi... 详细信息

文中的高技术指标(High Tech Indicators,HTI)为佐治亚理工大学发布的沿用多年的指标。数据对比的时间段分别为1993年、1996年、1999年、2002/3年和2007年。论文给出了33个国家(地区)当前的竞争力指标——技术排名(Technological Standing,TS),同时提供了四个表征未来竞争力前景的主要指标——国家发展取向指标(National Orientation,NO)、社会经济基础指标(Socio-Economic Infrastructure,SE)、技术基础指标(Technological Infrastructure,TI)与生产能力指标(Productive Capacity,PC)。论文无意在高技术指标的结果上多加笔墨,但是也的确注意到,中国已经取代美国占据了技术排名的首位。这一结果反映了高技术指标的特点,更重要的是,它反映了中国过去15年的惊人发展速度。

关键词：高技术指标竞争力比较

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Comprehensive literature review on the radiographic findings, imaging modalities, and the role of radiology in the COVID-19 pandemic

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World Journal of Radiology 2021年第9期13卷 258-282页

作者： Aman Pal Abulhassan Ali Timothy R Young Juan Oostenbrink Akul Prabhakar Amogh Prabhakar Nina Deacon Amar Arnold Ahmed Eltayeb Charles Yap david M Young alan Tang Subramanian Lakshmanan Ying Yi Lim Martha Pokarowski Pramath Kakodkar School of Medicine National University of Ireland GalwayGalway H91 TK33GalwayIreland Department of Computer Science Yale UniversityNew HavenCO 06520United States Department of Health Science Duke UniversityDurhamNC 27708United States The Hospital for Sick Kids University of TorontoToronto M5SOntarioCanada

Since the outbreak of the coronavirus disease 2019(COVID-19)pandemic,over 103214008 cases have been reported,with more than 2231158 deaths as of January 31,*** the gold standard for diagnosis of this disease remains the reverse-transcription polymerase chain reaction of nasopharyngeal and oropharyngeal swabs,its false-negative rates have ignited the use of medical imaging as an important adjunct or *** imaging assists in identifying the pathogenesis,the degree of pulmonary damage,and the characteristic features in each imaging *** literature review collates the characteristic radiographic findings of COVID-19 in various imaging modalities while keeping the preliminary focus on chest radiography,computed tomography(CT),and ultrasound *** the higher sensitivity and greater proficiency in detecting characteristic findings during the early stages,CT scans are more reliable in diagnosis and serve as a practical method in following up the disease time *** research rapidly expands,we have emphasized the CO-RADS classification system as a tool to aid in communicating the likelihood of COVID-19 suspicion among healthcare ***,the utilization of other scoring systems such as MuLBSTA,Radiological Assessment of Lung Edema,and Brixia in this pandemic are reviewed as they integrate the radiographic findings into an objective scoring system to risk stratify the patients and predict the severity of ***,current progress in the utilization of artificial intelligence via radiomics is ***,the lesson from the first wave and preparation for the second wave from the point of view of radiology are summarized.

关键词： Coronavirus COVID-19 Computed tomography Ultrasound MuLBSTA Scoring system Radiological Assessment of Lung Edema classification Brixia score

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第十七届悉尼双年展

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艺术界 2010年第4期 184-187页

作者： alan Cruickshank

在这个全球竞争的大市场里，有关“双年展”价值何在的讨论，无论是从奇观、全球动荡、制造世界，还是从文化旅游、消费文化或者“新事物”切入，所有问题都在今年的悉尼双年展“距离之美：动荡时期的生存赞歌”中浮现出来。

关键词：双年展悉尼伊斯坦布尔全球竞争文化旅游消费文化艺术总监美术馆

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Concurrent multi-peak Bragg coherent x-ray diffraction imaging of 3D nanocrystal lattice displacement via global optimization

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npj Computational Materials 2023年第1期9卷 1579-1590页

作者： Siddharth Maddali Travis D.Frazer Nazar Delegan Katherine J.Harmon Sean E.Sullivan Marc Allain Wonsuk Cha alan Dibos Ishwor Poudyal Saugat Kandel Youssef S.G.Nashed F.Joseph Heremans Hoydoo You Yue Cao Stephan O.Hruszkewycz Materials Science Division Argonne National LaboratoryLemontIL 60439USA Center for Molecular Engineering Argonne National LaboratoryLemontIL 60439USA Aix-Marseille Univ CNRSCentrale MarseilleInstitut FresnelMarseilleFrance X-ray Science Division Argonne National LaboratoryLemontIL 60439USA Center for Nanoscale Materials Argonne National LaboratoryLemontIL 60439USA Mathematics&Computer Science Division Argonne National LaboratoryLemontIL 60439USA Pritzker School of Molecular Engineering University of Chicago5640 South Ellis AvenueChicagoIL 60637USA SLAC National Accelerator Laboratory Menlo ParkCAUSA

In this paper we demonstrated a method to reconstruct vector-valued lattice distortion fields within nanoscale crystals by optimization of a forward model of multi-reflection Bragg coherent diffraction imaging(MR-BCDI)*** method flexibly accounts for geometric factors that arise when making BCDI measurements,is amenable to efficient inversion with modern optimization toolkits,and allows for globally constraining a single image reconstruction to multiple Bragg peak *** is enabled by a forward model that emulates the multiple Bragg peaks of a MR-BCDI experiment from a single estimate of the 3D crystal *** present this forward model,we implement it within the stochastic gradient descent optimization framework,and we demonstrate it with simulated and experimental data of nanocrystals with inhomogeneous internal lattice *** find that utilizing a global optimization approach to MR-BCDI affords a reliable path to convergence of data which is otherwise challenging to reconstruct.

关键词： optimization coherent lattice

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Hawaii地区钠激光雷达与流星雷达和中频雷达同时观测水平风场的对比分析

Hawaii地区钠激光雷达与流星雷达和中频雷达同时观测水平风场的对...

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第二届中国激光雷达学术会议

作者：谷升阳李陶 alan Liu Gary Swenson Chester Gardner Dennis Riggin david Fritts 中国科学技术大学地球物理与行星科学系 Department of Physical Sciences Embry-Riddle Aeronautical University Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign

钠激光雷达、流星雷达和中频雷达是测量中间层顶水平风场的三个重要手段。Hawaii地区在2002005年间同时存在这三种仪器,多次进行了对中间层大气水平风场的同时观测。通过对2002年7月9日晚和2003年10月23日晚这三种设备连续8h同时探测的... 详细信息

钠激光雷达、流星雷达和中频雷达是测量中间层顶水平风场的三个重要手段。Hawaii地区在2002005年间同时存在这三种仪器,多次进行了对中间层大气水平风场的同时观测。通过对2002年7月9日晚和2003年10月23日晚这三种设备连续8h同时探测的风场数据进行对比分析,发现钠激光雷达与流星雷达观测的径向风和纬向风结果比较吻合,并且都远大于(约两倍)中频雷达观测的结果。风场的夜平均垂直廓线表明,在速度较小并且风速变化比较平稳时,中频雷达能够表现出与钠激光雷达和流星雷达相对较好的一致性;反之,差异较大。

关键词：大气光学中间层顶水平风场钠激光雷达流星雷达中频雷达

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Truculent View on Target-2:Greenspan Points to 'Destabilising' Euro

Truculent View on Target-2:Greenspan Points to 'Destabilisin...

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作者： david MARSH OMFIF

Rising creditor-debtor central bank balances in the euro area under the Target-2 overdraft system underline the'destabilising potential'of the European single currency,according to alan Greenspan,former chairman of the Federal Reserve ***,a sprightly yet wistful 92,used a New York dinner organised by the World Gold Council and NYU Stern Business School to repeat long-held truculence on economic and

关键词： Target Destabilising Truculent View on Target-2:Greenspan Points to

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中国-澳大利亚20世纪建筑遗产沙龙

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当代建筑 2020年第4期 6-10页

作者：金磊 Sheridan Burke Jane Lawrence Christine Garnaut 顾宁 david Wixted Ken Taylor 陈雳 alan Croker Jyoti Somerville 苗淼(整理) 朱有恒(整理) 中国文物学会20世纪建筑遗产委员会中国建筑学会建筑评论学术委员会 ICOMOS20世纪科学委员会南澳大学西校区艺术建筑和设计学院南澳大学国际规划历史学会南澳大学艺术、建筑、设计学院澳大利亚遗产联盟澳大利亚国立大学北京建筑大学 Design 5建筑师事务所 GML Heritage

地点:澳大利亚GML Heritage主办:澳大利亚ICOMOS,澳大利亚DOCOMOMO,中国文物学会20世纪建筑遗产委员会支持媒体:《当代建筑》编辑部"2019年5月中上旬,中国文物学会20世纪建筑遗产委员会、《中国建筑文化遗产》编辑部应联合国教科文组织I... 详细信息

地点:澳大利亚GML Heritage主办:澳大利亚ICOMOS,澳大利亚DOCOMOMO,中国文物学会20世纪建筑遗产委员会支持媒体:《当代建筑》编辑部"2019年5月中上旬,中国文物学会20世纪建筑遗产委员会、《中国建筑文化遗产》编辑部应联合国教科文组织ICOMOS 20世纪科学委员会前主席、现任秘书长谢尔丹·波克(Sheridan Burke)女士及南澳大学西校区艺术建筑和设计学院院长简·劳伦斯(Jane Lawrence)女士等专家邀请,对澳大利亚诸城市的20世纪建筑遗产进行了考察。本文汇总了在南澳大学、悉尼GML Heritage办公大楼举办的"中国—澳大利亚20世纪建筑遗产沙龙"中双方专家交流研讨的主要发言内容。"

关键词：建筑遗产中国文物学会建筑文化遗产南澳大学发言内容交流研讨澳大利亚西校区

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