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苜蓿豆血红蛋白cDNA的分子克隆

生物工程学报 1988年第3期 222-225页

作者：荆玉祥 Moo Je Cho 鲍绍琦温杰布里尔中国科学院植物研究所 Gyeongsang大学农学院农化系美国威斯康辛大学细菌学系

豆血红蛋白是一种与动物肌红蛋白相似的蛋白,是共生固氮根瘤的蛋白。豆血红蛋白结合氧,并对固氮类菌体进行氧分压的调节。我们对苜蓿根瘤豆血红蛋白的组分、性质及其 mRNA 和合成的转译水平调节等进行了研究。本文在合成苜蓿豆血红蛋白 ... 详细信息

豆血红蛋白是一种与动物肌红蛋白相似的蛋白,是共生固氮根瘤的蛋白。豆血红蛋白结合氧,并对固氮类菌体进行氧分压的调节。我们对苜蓿根瘤豆血红蛋白的组分、性质及其 mRNA 和合成的转译水平调节等进行了研究。本文在合成苜蓿豆血红蛋白 cDNA 的基础上报道其分子克隆的初步结果。

关键词： cDNA clone leghemoglobin root nodule alfalfa

加利福尼亚大学圣迭戈分校在中国的生物技术合作与商业化机遇

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加利福尼亚大学圣迭戈分校在中国的生物技术合作与商业化机遇

Late Neoproterozoic adakitic magmatism of the eastern Arabian Nubian shield

首届国际生物经济高层论坛

作者： alan paau 加利福尼亚大学圣迭戈分校加利福尼亚大学圣迭戈分校技术转让和知识产权中心

＜正＞加利福尼亚大学圣迭戈分校透过科技转换与知识产权服务办公室（TechTips）将UCsD的研究成果授权与全世界使用。近几年在全球已有二百多家企业或创业人利用该校专利技术成立新公司并获得快速发展。UCsD意欲在中国扩大影响,寻求建...

＜正＞加利福尼亚大学圣迭戈分校透过科技转换与知识产权服务办公室（TechTips）将UCsD的研究成果授权与全世界使用。近几年在全球已有二百多家企业或创业人利用该校专利技术成立新公司并获得快速发展。UCsD意欲在中国扩大影响,寻求建立长期合作关系。我们将介绍生物技术相关的专利技术,并希望能与中国的科技界、产业界建立广泛的联系。

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Geoscience Frontiers 2019年第6期10卷 1981-1992页

作者： Grant M.Cox John Foden alan s.Collins Centre for Tectonics Resources and Exploration(TRaX) Dept of Earth SciencesThe University of Adelaide

Late Neoproterozoic adakitic magmatism within the Eastern Arabian Nubian shield has been dated at633.2±9.0 Ma(2σ).These magnas intrude the forearc Ad Dawadimi Basin,which is composed of metapelitic schists and greywacke along with ophiolitic melanges of boninitic affinity which underwent inversion and deformation by^620 *** adakitic magmatism,while intruding parts of the Ad Dawadimi Basin,predates this deformation,but is possibly coincident with basin *** adakitic magmatism requires melting of an amphibolite or eclogitic source,empirical and experimental constraints require anomalously hot supra-subduction zone *** that this magmatism immediately predates basin inversion,these magmas possibly pinpoint the timing of the slab breaking,marking the terminal stages of arc magmatism,terrane accretion and the influx of hot oceanic asthenospheric *** influx of hot asthenospheric mantle may also be responsible for postcolltsional A-type magmatism.

关键词： Arabian Nubian shield Adakites A-type magmatism

Development and course of heart failure after a myocardial infarction in younger and older people

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Journal of Geriatric Cardiology 2014年第1期11卷 1-12页

作者： Azam Torabi John GF Cleland alan s Rigby Nasser sherwi Department of Cardiology Castle Hill Hospital Hull York Medical School University of Hull Kingston upon Hull HU16 5JQ United Kingdom

Background Acute myocardial infarction （AMI） is a common cause of heart failure （HF）, which can develop soon after AMI and may persist or resolve or develop late. HF after an MI is a major source of mortality. The cumulative incidence, prevalence and resolution of HF after MI in different age groups are poorly described. This study describes the natural history of HF after AMI according to age. Methods Patients with AMI during 1998 were identified from hospital records. HF was defined as treatment of symptoms and signs of HF with loop diuretics and was considered to have resolved if loop diuretic therapy could be stopped without recurrence of symptoms. Patients were cate- gorised into those aged 〈 65 years, 65-75 years, and 〉 75 years. Results Of 896 patients, 311,297 and 288 were aged 〈 65, 65-75 and 〉75 years and of whom 24%, 57% and 82% had died respectively by December 2005. Of these deaths, 24 （8%）, 68 （23%） and 107 （37%） oc- curred during the index admission, many associated with acute HF. A further 37 （12%）, 63 （21%） and 82 （29%） developed HF that persisted until discharge, of whom 15, 44 and 62 subsequently died. After discharge, 53 （24%）, 55 （40%） and 37 （47%） patients developed I-IF for the first time, of whom 26%, 62% and 76% subsequently died. Death was preceded by the development of HF in 35 （70%）, 93 （91%） and 107 （85%） in aged 〈 65 years, 65-75 years and 〉75 years, respectively. Conclusions The risk of developing HF and of dying after an MI in- creases progressively with age. Regardless of age, most deaths after a MI are preceded by the development of HF.

关键词： Myocardial infarction Heart failure Age

Combinatorial genetics methods for discovering high-order regulatory combinations and engineering genetic drivers for neural differentiation

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Neural Regeneration Research 2021年第12期16卷 2403-2404页

作者： Dawn G.L.Thean alan s.L.Wong Laboratory of Combinatorial Genetics and synthetic Biology School of Biomedical SciencesThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong Kong Special Administrative RegionChina

Diving into the search for effective cell differentiation factors:Researchers are still striving to find better therapeutics to revert or slow down the progression of neurological disorders such as Parkinson’s disease,Alzheimer’s disease,and Huntington’s *** disorders are the result of neuronal cell death in different parts of the *** or treatments used to relieve the symptoms in patients have not been well *** do not recover the damaged neural tissues and can result in unwanted side effects.

关键词： Huntington neural Alzheimer

Mineralogical Evidence for Regional Metamorphism Overprinted by Contact Metamorphism

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Acta Geologica sinica(English Edition) 2012年第1期86卷 48-64页

作者： Mahboobeh JAMsHIDI BADR Fariborz MAsOUDI alan s.COLLINs Ali sORBI Department of Geology Payam Noor University Department of Geology Shahid Beheshi University Tectonics Resources and Exportation(TRaX)School of Earth and Environmental SciencesUniversity of Adelaide Department of sciences Karaj BranchIslamic Azad University

The soursat metamorphic complex （sMC） in northwestern Iran is part of the sanandaj- sirjan metamorphic belt. The complex is composed of different metamorphic and plutonic rocks, but is dominated by metapelites composed of garnet, staurolite, kyanite, fibrolite, cordierite, and andalusite. Porphyroblasts in schists have the same fabric, and three stages of schistosity are present. The internal schistosity （sn） inclusion trails are also offset by conjugate sets of extensional schistosity （sn＋l） and a second （sn＋2） that crenulates （sn＋l）. Polyphase metamorphisms are present in the complex. Garnet, staurolite, kyanite, and fibrolite assemblage preserves conditions during the M1 metamorphic event. This assemblage yields a P-t estimate of 645±11℃ and 6.5±0.5 kbar. Other samples of the central part of sMC contain cordierite and andalusite （M2） overgrowth that yields a P- t estimate of 532±33℃ and 2.1±1.1 kbar.

关键词： metamorphism north-west Iran sanandaj-sirjan zone soursat metamorphic complex.

A study of fire propagation in coal seam with numerical simulation of heat transfer and chemical reaction rate in mining field

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International Journal of Mining science and Technology 2019年第6期29卷 873-879页

作者： Moisés Oswaldo Bustamante Rúa alan José Daza Aragón Pablo Bustamante Baena National University of Colombia Cr 65 # 63 20 CIMEX Minerals Institute

spontaneous combustion of coal is a problem that affects the mining operation and generates environ-mental,economic,social and geotechnical *** phenomenon has been divided into two pro-cesses:ignition and *** propagation develops in coal seams because of a set of factors such as direction and wind speed,fracturing and *** this work,heat transfer and chemical kinetics are studied from conservation equations of energy and species,respectively,using the software COMsOL Multiphysics to simulate the propagation of fires in coal *** possible scenarios were analyzed that usually occur in the walls of the coal seams,such as fire focus and fire complete *** was found that the propagation kinetics of the fire changes depending on the temperature,the fractur-ing of rock mass and the area of fire *** temperature values lower than 300℃,there is con-sumption around 250 cm^3/h,values around 700℃,the consumption is 1500 cm^3/h,and for fires of 1200℃ have values of 3000 cm^3/*** on the speed of propagation can vary from 4 to 17cm/day,considering on the level and fracturing of the final wall of the open pit.

关键词： spontaneous combustion of coal Open pit mines simulation Heat transfer Chemical reaction COMsOL

NORMAL MODEs OF FLUID-sTRUCTURE INTERACTION IN INTERNAL FLOWs

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Journal of Hydrodynamics 1998年第4期10卷 71-89页

作者： Zhang, Lixiang Huang, Wenhu Tijsseling, Arris s. Vardy, alan E. Yunnan Polytechnic Univ Kunming China

The Information in frequency domain was deducted by a discrete Fourier transforms. The modal information of the fluid-structure interaction in internal flows was analyzed. The dispersive and dissipative term in a fully coupled manner can be treated. The method has been validated by comparison with an exact analytical solution, with the results obtained by discrete Fourier transform and an analysis using the method of characteristics as well as with measured data from a laboratory apparatus.

关键词： Dispersions Fourier transforms Frequency response Mathematical models Pipe flow Vibrators

Controlling human platelet activation with calcium-binding nanoparticles

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Nano Research 2020年第10期13卷 2697-2705页

作者： David Cabrera Karen Walker sandhya Moise Neil D.Telling alan G.s.Harper school of Pharmacy and Bioengineering Keele UniversityGuy Hilton Research CenireThormburrow DriveHartshill Stoke-on Trent ST47QBUK ?Central Electron Microscope Unit School of Life SciencesKeele UniversityNewcastle-under LIymeStaffordshireST55BGUK Department of Chemical Engineering University of BathBath BA27AYUK school of Medicine Keele UniversityNewcastle-under-LymeStaffordshireST55BGUK

Human platelets aggregate at sites of blood vessel damage in response to a rise in their cytosolic calcium *** these cytosolic calcium rises would provide a method to inhibit platelet activation and prevent the unwanted blood clots that causes heart attack and *** we have predicted that calcium accumulation within the lumen of an infolded portion of the platelet plasma membrane called the open canalicular system(OCs)is essential for maintaining this cytosolic calcium *** to its nanometer dimensions of the OCs,it has been difficult to measure or interfere with the predicted luminal calcium *** we utilise iron oxide magnetic nanoparticles coated with the known calcium chelator,citrate,to create calcium-binding *** were used to assess whether an OCs calcium store plays a role in controlling the dynamics of human platelet activation and *** demonstrate that citrate-coated nanoparticles are rapidly and selectively uptaken into the OCs of activated human platelets,where they act to buffer the accumulation of calcium *** with these calcium-binding nanoparticles reduced thrombin-evoked cytosolic calcium rises,and slowed platelet aggregation and clot retraction in human *** contrast,nanoparticles that cannot bind calcium have no *** study demonstrates that the OCs acts as a key source of calcium for maintaining cytosolic calcium rises and accelerating platelet aggregation,and that calcium-binding nanoparticles targeted to the OCs could provide an anti-platelet therapy to treat patients at risk of suffering heart attacks or strokes.

关键词： nanochelators human platelets open canalicular system calcium signaling nanoparticles