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Can CT Perfusion Guide Patient Selection for Treatment of Delayed Cerebral Ischemia?

Advances in Computed Tomography 2013年第1期2卷 4-12页

作者： Pina C. Sanelli Rachel Gold Nikesh Anumula Austin Ferrone Carl E. Johnson Joseph P. Comunale Apostolos J. Tsiouris Howard Riina Halinder Mangat Axel Rosengart alan z. segal Department of Neurological Surgery Weill Cornell Medical College New York USA Department of Neurology Weill Cornell Medical College New York USA Department of Radiology Weill Cornell Medical College New York USA

Purpose: To evaluate qualitative and quantitative CT perfusion (CTP) for different treatment options of delayed cerebral ischemia (DCI) in aneurysmal SAH. Methods: Retrospective study of consecutive SAH patients enrolled in a prospective IRB-approved clinical trial. Qualitative analysis of CTP deficits were determined by two blinded neuroradiologists. Quantitative CTP was performed using standardiz.d protocol with region-of-interest placement sampling the cortex. DCI was assessed by clinical and imaging criteria. Patients were classified into treatment groups: 1) hypertension-hemodilution-hypervolemia (HHH);2) intra-arterial (IA) vasodilators and/or angioplasty;3) no treatment. Mean quantitative CTP values were compared using ANOVA pairwise comparisons. Receiver operating characteristic (ROC) curves, standard error (SE) and optimal threshold values were calculated. Results: Ninety-six patients were classified into three treatment groups;21% (19/96) HHH, 34% (33/96) IA-therapy and 46% (44/96) no treatment. DCI was diagnosed in 42% (40/96);of which 18% (7/40) received HHH, 80% (32/40) IA-therapy, and 2% (1/40) no treatment. CTP deficits were seen in 50% (48/96);occurring in 63% (12/19) HHH, 94% (31/33) IA-therapy, and 11% (5/44) no treatment. Presence of CTP deficits had 83% sensitivity, 89% specificity, 90% positive predictive and 81% negative predictive values for treatment. Mean quantitative CTP values revealed significant differences in CBF (p mL/100 gm/min (89% specificity, 71% sensitivity) for determining treatment. Conclusion: These initial findings of significant differences in CTP deficits for different treatment groups suggest that CTP may have a potential role in guiding patient selection for treatment of DCI.

关键词： CT Perfusion Aneurysmal Subarachnoid Hemorrhage Delayed Cerebral Ischemia Treatment

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太平洋十年涛动对全球地表气温变化的影响足迹

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Science Bulletin 2024年第4期69卷 445-448页

作者：梁莉莉 alan D.z.egler 陈德亮 Philippe Ciais 李肇新梁时婧王大山徐荣嵘曾振中 School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China SUSTech Energy Institute for Carbon Neutrality Southern University of Science and TechnologyShenzhen 518055China Faculty of Fisheries Technology and Aquatic Resources Mae Jo UniversityChiang Mai 50000Thailand Regional Climate Group Department of Earth SciencesUniversity of GothenburgGothenburg 40530Sweden Laboratoire des Sciences du Climat et de l’Environnement UniversitéParis-SaclayGif-sur-Yvette 91191France Laboratoire de Météorologie Dynamique Centre national de la recherche scientifiqueSorbonne UniversitéÉcole Normale SupérieureÉcole PolytechniqueParis 75000France Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Sea surface temperature modes have been found to modulate anthropogenic global warming rates on annual and decadal timescales,sometimes leading to periods of“slowdown”despite increasing greenhouse gas emissions^([1]).

关键词：太平洋十年涛动地表气温 greenhouse

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Manipulation of photosensory and circadian signaling restricts phenotypic plasticity in response to changing environmental conditions in Arabidopsis

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Molecular Plant 2024年第9期17卷 1458-1471页

作者： Martin William Battle Scott Fraser Ewing Cathryn Dickson Joseph Obaje Kristen N.Edgeworth Rebecca Bindbeutel Rea LAntoniou-Kourounioti Dmitri A.Nusinow Matthew alan Jones Plant Science Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Danforth Plant Science Center St.LouisMO 63132USA Department of Biological and Biomedical Sciences Washington University in St.LouisSt.LouisMO 63130USA Present address:School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpool L22QPUK

Plants exploit phenotypic plasticity to adapt their growth and development to prevailing environmental *** of light and temperature signals is aided by the circadian system,which provides a temporal *** plasticity provides a selective and competitive advantage in nature but is obstructive during large-scale,intensive agricultural practices since economically important traits(including vegetative growth and flowering time)can vary widely depending on local environmental *** prevents accurate prediction of harvesting times and produces a variable *** this study,we sought to restrict phenotypic plasticity and circadian regulation by manipulating signaling systems that govern plants'responses to environmental *** modeling of plant growth and develop-ment predicted reduced plant responses to changing environments when circadian and light signaling pathways were *** tested this prediction by utiliz.ng a constitutively active allele of the plant photoreceptor phytochrome B,along with disruption of the circadian systemvia mutation of *** found that these manipulations produced plants that are less responsive to light and temper-ature cues and thus fail to anticipate *** engineered plants have uniform vegetative growth and flowering time,demonstrating how phenotypic plasticity can be limited while maintaining plant *** has significant implications for future agriculture in both open fields and controlled environments.

关键词： circadian developmental plasticity phenotypic plasticity external coincidence light temperature

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Carbon pool trends and dynamics within a subtropical peatland during long-term restoration

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Ecological Processes 2017年第1期6卷 449-462页

作者： Paul Julian II Stefan Gerber alan L.Wright Binhe Gu Todd z.Osborne University of Florida Soil and Water Sciences DepartmentFt.PierceFL 34945USA. University of Florida Soil and Water Sciences DepartmentGainesvilleFL 32611USA. South Florida Water Management District Water Quality BureauWest Palm BeachFL 33406USA. University of Florida Whitney Laboratory for Marine BioscienceSt AugustineFL 32080USA.

Introduction:The Florida Everglades has undergone significant ecological change spanning the continuum of disturbance to *** the restoration effort is not complete and the ecosystem continues to experience short duration perturbations,a better understanding of long-term C dynamics of the Everglades is needed to facilitate new restoration *** study evaluated temporal trends of different aquatic carbon(C)pools of the northern Everglades Protection Area over a 20-year period to gauge historic C cycling *** inorganic C(DIC),dissolved organic C(DOC),particulate organic C(POC),and surface water carbon dioxide(pCO2(aq))were investigated between May 1,1994 and April 30,***:Annual mean concentrations of DIC,DOC,POC,and pCO2(aq)significantly decreased through time or remained constant across the Water Conservation Areas(WCAs).Overall,the magnitude of the different C pools in the water column significantly differed between *** of CO2 was dynamic across the Everglades ranging from 420 to 2001 kg CO2 year−***,the historic trend in CO2 flux from the marsh declined across our study area while pCO2(aq)largely remained somewhat constant with the exception of Water Conservation Area 2 which experienced significant declines in pCO2(aq).Particulate OC concentrations were consistent between WCAs,but a significantly decreasing trend in annual POC concentrations was ***:Hydrologic condition and nutrient inputs significantly influenced the balance,speciation,and flux of C pools across WCAs suggesting a subsidy-stress response in C dynamics relative to landscape scale responses in nutrient *** interplay between nutrient inputs and hydrologic condition exert a driving force on the balance between DIC and DOC production via the metabolism of organic matter which forms the base of the aquatic food *** the restoration trajectory as water quality and hydrology continues to improve,it is expect

关键词： Inorganic carbon Organic carbon Carbon dioxide Particulate carbon Hydrology Nutrients

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Handbook of Neurocritical Care 1

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丛书名： Current Clinical Neurology

2004年

作者： Bhardwaj Anish. Mirski Marek Alexander z. Ulatowski John alan.

ISBN: (纸本)1588292738

Leading neurocritical care and intensive care specialists from the Neurosciences Critical Care Unit of the Johns Hopkins Hospital have joined forces to spell out concisely for first line health care providers the diverse standards and therapeutic regimens required for the care of critically ill neurological and neurosurgical patients. Their authoritative reference guide takes an algorithmic approach to immediate patient care, incorporating both ancillary investigation to confirm clinical diagnosis and appropriate management guidelines. The book offers comprehensive summaries of the best diagnostic and management practices for a wide range of neurocritical problems, including encephalopathy, intercerebral and subarachnoid hemorrhage, traumatic brain injury postoperative care, ischemic stroke, brain tumors, spinal cord injury, and more. A compact disk accompanies the book for downloading an ebook version to the reader's PC or PDA. Authoritative and highly practical, the Handbook of Neurocritical Care offers first-line hospital physicians and EMS personnel a comprehensive quick-reference guide to the rapid diagnosis and management of critically ill neurological and neurosurgical patients

关键词： Nervous System Diseases

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Amplitude-mode spectroscopy of chemically injected and photogenerated charge carriers in semiconducting single-walled carbon nanotubes

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Nano Research 2023年第4期16卷 5619-5625页

作者： Shai R。Vardeny alan Phillips Kira A。Thurman z.aly Vardeny Jeffrey L.Blackburn Division of Electrical Electronicand Infocommunications EngineeringOsaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan Materials Chemistryand Computation Science DirectorateNational Renewable Energy LaboratoryGoldenCO 80401USA Department of Physics Colorado School of MinesGoldenCO 80401USA Department of Physics&Astronomy University of UtahSalt Lake CityUT 84112USA

In one-dimensional semiconductors such as conjugated polymers and semiconducting single-walled carbon nanotubes(s-SWCNTs),injected charge carriers(electrons or holes)can have profound impacts on both electronic conductivity and optical spectra,even at low carrier *** charge-related spectral features is a key fundamental challenge with important technological ***,we employ a systematic suite of experimental and theoretical tools to understand the mid-infrared charge signatures of heavily p-type doped polymer-wrapped *** a broad range of nanotube diameters,we find that hole charge carriers induce strong Fano anti-resonances in mid-infrared transmission spectra that correspond to defect-related(D-band)and in-plane tangential(G-band)Raman-active vibrational modes,along with antiresonances arising from infrared(IR)-active polymer and SWCNT *** employ^(13)C isotope-labeled s-SWCNTs and a removable wrapping polymer to clarify the relative intensities,energies,and sources of all observed *** performed with the“amplitude mode model”are used to quantitatively reproduce Raman spectra and also help to explain the outsiz.d intensity of the D-band anti-resonance,relative to the G-band,observed for both moderately and degenerately doped *** results provide a framework for future studies of ground-and excited-state charge carriers in s-SWCNTs and a variety of low-dimensional materials.

关键词： carbon nanotubes doping charge carriers phonons electron-phonon coupling

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生态文明视野下杭州市水文化遗产资源的保护与利用

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浙江水利水电学院学报 2024年第4期36卷 8-11页

作者：房利苏阿兰浙江机电职业技术学院浙江杭州310053

杭州市水文化遗产具有历史文化底蕴深厚、文化类型丰富、水乡地域特色鲜明的特点,凝聚成杭州山水之城的灵魂。杭州市水文化遗产在保护和利用方面存在新发展理念贯彻不到位、资源整合困难、遗产活化不足、开发利用同质化严重等问题。因此... 详细信息

杭州市水文化遗产具有历史文化底蕴深厚、文化类型丰富、水乡地域特色鲜明的特点,凝聚成杭州山水之城的灵魂。杭州市水文化遗产在保护和利用方面存在新发展理念贯彻不到位、资源整合困难、遗产活化不足、开发利用同质化严重等问题。因此,在建设生态文明和美丽城市的背景下,杭州市水文化遗产要在坚持生态文明观的前提下,从贯彻生态文明理念,强化遗产活化传承,推进文旅融合发展等方面进行保护与利用,不仅要充分发挥水文化遗产的历史文化价值,还要实现生态、文化、经济效益三者的统一。

关键词：生态文明水文化遗产保护与利用

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Evaluation of nutrient stoichiometric relationships among ecosystem compartments of a subtropical treatment wetland. Do we have “Redfield wetlands”?

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Ecological Processes 2019年第1期8卷 267-287页

作者： Paul Julian II Stefan Gerber Rupesh K.Bhomia Jill King Todd z.Osborne alan L.Wright Matthew Powers Jacob Dombrowski Soil and Water Sciences Department University of FloridaFt.PierceFL34945USA Soil and Water Sciences Department University of FloridaGainesvilleFL 32611USA South Florida Water Management District Water Quality Treatment TechnologiesWest Palm BeachFL 33406USA Whitney Laboratory for Marine Bioscience University of FloridaSt AugustineFL 32080USA.

Background:Evaluation of carbon(C),nitrogen(N),and phosphorus(P)ratios in aquatic and terrestrial ecosystems can advance our understanding of biological processes,nutrient cycling,and the fate of organic matter(OM)in these *** of aquatic ecosystems can change the accumulation and decomposition of OM which can alter biogeochemical cycling and alter the base of the aquatic food *** study investigated nutrient stoichiometry within and among wetland ecosystem compartments(i.e.,water column,flocculent,soil,and aboveground vegetation biomass)of two subtropical treatment wetlands with distinct vegetation *** flow-ways(FWs)within the network of Everglades Stormwater Treatment Areas in south Florida(USA)were selected for this *** evaluated nutrient stoichiometry of these to understand biogeochemical cycling and controls of nutrient removal in a treatment wetland within an ecological stoichiometry ***:This study demonstrates that C,N,and P stoichiometry can be highly variable among ecosystem compartments and between *** law slopes of C,N,and P within surface water floc,soil,and vegetation were significantly different between and along ***:Assessment of wetland nutrient stoichiometry between and within ecosystem compartments suggests unconstrained stoichiometry related to P that conforms with the notion of P limitation in the *** in N:P ratios between floc and soil suggest different pathways of organic nutrient accumulation and retention between *** nutrient stoichiometry was highly variable and decoupled(or close to decoupled as indicated byz. that decoupling may be the imprint of variability in inflow nutrient ***,despite active biogeochemical cycles that could act to restore nutrient stoichiometry along the FW,there was little evidence that such balancing occurred,as the

关键词： Decomposition Mineraliz.tion Everglades Treatment wetlands

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应用碘伏、氧氟沙星及洗必泰减少门诊患者环境中的结膜菌群

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 18-19页

作者： Barkana Y. Almer z. segal O. 韩静 Department of Ophthalmology Assaf Harofe Medical Centre Beer Yaacov Zerifin 70300 Israel Dr.

Purpose: To compare the reduction of conjunctival bacterial flora by povidone -iodine 4%,ofloxacin 0.3%, and chlorhexidine 0.05%for endophthalmitis prophy laxis before corneal suture removal in an outpatient setting. Methods: In each g roup of 25 consecutive subjects who presented for outpatient ophthalmic evaluati on, one eye was treated with either povidone-iodine4%(PI), ofloxacin 0.3%(Ofl ox) or chlorhexidine 0.05%(Chex). The other eye served as a control. Three minu tes after treatment, cultures were taken from the inferior conjunctival sac in b oth eyes. Following incubation at 35°for 48 hours, the numbers of colonies were counted and compared. The difference in the numbers of colonies in each pair of treated and control eyeswas assessed for each drug and compared. Results: The r eduction in colony-formingunits was highly significant for each of the three dr ugs tested (Wilcoxon signed-ranks test; p < 0.0001). There was no significant d ifference between percent reduction by the three drugs (Kruskal-Wallis test; p= 0.68). Sterile cultures following preparation by PI, Oflox and Chex were obtaine d in 52%, 68%and 52%, respectively. Conclusions: The regimens tested were sim ilarly effective in reducing conjunctival commensals. They may all be considered as options for a quick prophylaxis against infection following suture removal i n an outpatient setting.

关键词：洗必泰氧氟沙星眼科检查眼内炎秩和检验 allis 无菌培养

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胺碘酮引发的严重共济失调

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中国处方药 2006年第6期5卷 64-65页

作者： Daniel G.Krauser alan z.segal Paul Kligfield 林宝琴

服用胺碘酮后引发震颤、周围感觉运动神经病变、近端肌无力和共济失调的神经毒性的案例报道极少,且没有引起人们的注意。一位调研者报道:一名患有肥厚型梗阻性心肌病伴阵发房颤的老年妇女停止服用小剂量的胺碘酮后,其4个月来日益加重的... 详细信息

服用胺碘酮后引发震颤、周围感觉运动神经病变、近端肌无力和共济失调的神经毒性的案例报道极少,且没有引起人们的注意。一位调研者报道:一名患有肥厚型梗阻性心肌病伴阵发房颤的老年妇女停止服用小剂量的胺碘酮后,其4个月来日益加重的共济失调症状快速并彻底消失了。虽然胺碘酮半衰期长,但停药几天后她的症状就开始减轻,1周内就可以正常行走。广泛了解服用胺碘酮引发神经毒性的临床症状,就可以缩短明确诊断所需要的时间,并将有助于其神经毒性的早日消除。

关键词：共济失调胺碘酮肥厚型梗阻性心肌病运动神经病变神经毒性临床症状近端肌无力老年妇女阵发房颤服用

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