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Insect Science 2018年第2期25卷 199-210页

作者： alan yen Conrad Bilney Michael Shackleton Susan Lawler Biosciences Research Branch Department of Economic Development Jobs Transport ＆ Resources Bundoora Victoria Australia School of Applied Systems Biology La Trobe University Bundoora Victoria Australia Department of Environment Ecology ＆ Evolution La Trobe University Victoria Australia The Murray-Darling Freshwater Research Centre School of Life Sciences La Trobe University Victoria Australi

The so called witchetty grub is a publicized food source for Australian Aborig- ines. Despite heavy use, the identities and number of species consumed is still not known because of the lack of identified voucher specimens. Taxonomy based on adults makes identification of larval forms difficult. Dwelling in the root, trunks, and stems of woody plants, grubs are a reliable and highly valued food source that may be in decline. Much information on edible insects may already be lost in parts of Australia heavily settled by Europeans. However, there are many parts of Australia where information on edible insects is still strong and needs to be recorded accurately for long-term use. Recent iden- tification of＂witchetty grubs＂ from the witchetty bush at Barrow Creek has revealed that those there, based on their DNA, are not Endoxyla leucomochla. As grubs are collected and eaten before they mature and scientific taxonomy is based on adults, there are many unanswered questions on the grub identification and biology, host plants, and plant and grub distributions.

关键词： Australian Aborigines edible insects witchetty grubs

Apoptotic and cytostatic actions of maslinic acid in colorectal cancer cells through possible IKK-β inhibition

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Asian Pacific Journal of Tropical Biomedicine 2021年第3期11卷 122-131页

作者： Kai Xin Ooi Menaga Subramaniam Lai yen Fong Hoe Han Goh Soo Beng alan Khoo Yang Mooi Lim Centre for Cancer Research Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanLOT PT 21144.Jalan Sungai LongBandar Sungai LongCheras 43000 KajangSelangorMalaysia Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanLOT PT 21144.Jalan Sungai LongBandar Sungai LongCheras 43000 KajangSelangorMalaysia Institute of Systems Biology Universiti Kebangsaan Malaysia43600 BangiSelangor Darul EhsanMalaysia Molecular Pathology Unit Cancer Research CentreInstitute for Medical ResearchKuala LumpurMalaysia

Objective:To explore the anti-cancer activity of maslinic acid against colorectal cancer(CRC)cell lines and its possible ***:The inhibitory effect of maslinic acid was screened against five CRC cell lines(HT-29,HCT 116,SW480,SW48,and LS 174 T)via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** and cell cycle analyses were carried out using annexinⅤ-FITC/propidium iodide staining and propidium iodide staining,respectively and subjected to fluorescence-activated cell sorting *** expression studies of inhibitor ofκB kinase-β(IKK-β),checkpoint kinase 1(Chk1)and cyclin D1 were conducted using the JESS ***:Maslinic acid exhibited growth inhibitory effect in a doseand time-dependent manner in HT-29 and HCT 116 cell lines.A more prominent apoptosis induced by maslinic acid was observed in HCT 116 cell ***,in HT-29 cell line,maslinic acid induced cell cycle arrest by inhibiting the G1-S transition,which was accompanied by the downregulation of cyclin *** expression of unphosphorylated IKK-βprotein was increased in both(HT-29 and HCT 116)cell lines after maslinic acid ***:Maslinic acid inhibits the growth of HT-29 and HCT 116 cells in a different manner,induces cell cycle arrest in HT-29 cells and causes apoptosis in HCT 116 cells partially via NF-κB pathway inhibition.

关键词： Maslinic acid Colorectal cancer Apoptosis Cell cycle arrest NF-κB pathway IKK-β

Identification of Pathogens in Clinical Specimens by Selective Proteotypic-peptide Analysis （SPA）

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Identification of Pathogens in Clinical Specimens by Selecti...

第四届海峡两岸分析化学学术会议

作者： yen-Peng Ho alan A．-L．Lo Anren Hu Cheng-Tung Chen Pei-Jen Tsai Department of Chemistry National Dong Hwa UniversityHualienTaiwan Department of Chemistry National Dong Hwa UniversityHualienTaiwan Department of Chemistry National Dong Hwa UniversityHualienTaiwan Department of Laboratory Medicine ＆ Biotechnology Tzu Chi UniversityHualienTaiwan Department of Chemistry National Dong Hwa UniversityHualienTaiwan Department of Laboratory Medicine ＆ Biotechnology Tzu Chi UniversityHualienTaiwan

＜正＞This paper describes a method-using a combination of MS/MS of selected bacteria-specific peptides and protein database searching-for determining the species of common pathogens present in clinical specimens. We searched the MS/MS spectra acquired from the proteolytic digests of pure bacterial cell extracts against protein databases. The identified proteotypic peptides that matched a protein associated with a particular pathogen were selected as marker ions to identify that bacterium in

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墨尔本郊外的袋鼠

自然与科技 2009年第6期 50-51页

作者：艾伦·路易·耶思（alan Louey yen）[澳]

谈起澳大利亚。人们自然会联想到蹦蹦跳跳的袋鼠。这种哺乳动物在澳大利亚十分常见，它们的幼崽平时待在母袋鼠的幼儿袋里。袋鼠是澳大利亚的“名片”。眼下，这些“名片”正广泛散落在当地居民中间，这种“人鼠混居”的现象。常令初到... 详细信息

谈起澳大利亚。人们自然会联想到蹦蹦跳跳的袋鼠。这种哺乳动物在澳大利亚十分常见，它们的幼崽平时待在母袋鼠的幼儿袋里。袋鼠是澳大利亚的“名片”。眼下，这些“名片”正广泛散落在当地居民中间，这种“人鼠混居”的现象。常令初到澳洲的旅游者感到新鲜。

关键词：袋鼠墨尔本澳大利亚哺乳动物旅游者名片

Predictive Value of Resting Pd/Pa for Fractional Flow Reserve Assessed with Monorail Pressure Microcatheter in Real-World Practice

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Cardiovascular Innovations and Applications 2019年第B7期4卷 113-120页

作者： Keng Tat Koh Asri Said Khaw Chee Sin Oon yen Yee Erwin Mulia Tan Chen Ting Francis Shu Eng Pbeng Ho Kian Hui Voon Chi yen Cham Yee Ling Khiew Ning Zan Nor Hanim Mohd Amin alan Fong Yean Yip Ong Tiong Kiam Department of Cardiology Sarawak Heart Centre3rd RoundaboutSamarahan Expressway94300 Kota SamarahanSarawakMalaysia Faculty of Medicine and Health Sciences University Malaysia Sarawak94300 Kota SamarahanSarawakMalaysia Clinical Research Centre Sarawak General HospitalJalan Hospital 93586 KuchingSarawakMalaysia

Background and Objectives:The aims of this study were(1)to examine the diagnostic accuracy of resting timeaveraged distal coronary pressure(Pd)to mean aortic pressure(Pa)ratio to predict hyperemic fractional flow reserve(FFR)and(2)to identify a resting Pd/Pa value that can preclude the need for hyperemic FFR assessed with use of a monorail pressure ***:A total of 191 stenoses were *** exclusions,157 FFR data sets from 103 patients were ***:Resting Pd/Pa showed poor agreement with hyperemic FFR(r=0.619,P<0.001).The receiver operating characteristic curve for resting Pd/Pa with reference to hyperemic FFR of 0.80 or less showed an area under the curve of 0.800(95%confi dence interval 0.732– 0.868,P<0.001),with the greatest diagnostic accuracy of 74.5%for resting Pd/Pa of less than *** Pd/Pa of 0.96 or greater had a sensitivity of 100%and a negative predictive value of 100%,and resting Pd/Pa of 0.82 or less had a specifi city of 98.9%and a positive predictive value of 94.1%to predict abnormal FFR of 0.80 or *** results were consistent regardless of the vessels studied,the location of lesions,and the severity of ***:Resting Pd/Pa showed poor agreement with hyperemic FFR assessed with use of a monorail pressure ***,resting Pd/Pa of 0.96 or greater had excellent sensitivity and negative predictive value to predict normal hyperemic FFR,and resting Pd/Pa of 0.82 or less had excellent specifi city and positive predictive value to predict abnormal hyperemic FFR.

关键词： fractional fl ow reserve monorail pressure catheter resting time-averaged distal coronary pressure to mean aortic pressure ratio

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电活性导电聚合物组织工程支架材料研究进展

中国医学科学院学报 2006年第6期28卷 845-848页

作者：李梦燕 Paul Bidez Elizabeth Guterman-Tretter 郭毅 alan G.MacDiarmid Peter I.Lelkes 原续波袁晓燕盛京李华宋存先危岩 School of Biomedical Engineering Science &Health SystemsDrexel University PhiladelphiaPA19104 School of Biomedical Engineering Science &Health Systems Drexel University PhiladelphiaPA19104 Departmentof Chemistry University of PennsylvaniaPhiladelphia PA19104 USA Departmentof Poly-mer Materials Science &Engineering School of Materials Science &EngineeringTianjin University Tianjin 300072 Tianjin Biomedical Materials KeyLaboratory Institute of Biomedical EngineeringCAMS and PUMCTianjin 300192

由于具有电活性,导电聚合物在神经和心肌等电刺激响应性细胞的培养及相关电活性组织工程支架的研究中具有潜在的应用前景,而通过键合氨基酸基团或与天然蛋白共混可以提高其生物相容性。本文主要综述两种典型的导电聚合物-聚吡咯和聚苯胺... 详细信息

由于具有电活性,导电聚合物在神经和心肌等电刺激响应性细胞的培养及相关电活性组织工程支架的研究中具有潜在的应用前景,而通过键合氨基酸基团或与天然蛋白共混可以提高其生物相容性。本文主要综述两种典型的导电聚合物-聚吡咯和聚苯胺(PANi)在组织工程支架方面的研究进展,并特别阐述短肽与PANi的共价键合和电纺PA-Ni/明胶共混纳米纤维的研究。

关键词：导电聚合物聚吡咯聚苯胺生物相容性组织工程

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陷入困境

中国远洋海运 2015年第1期 46-46页

作者： alan M.Field

欧洲和亚洲主要市场需求疲软使美国集装箱出口在2016年前都很难获得反弹的动力。去年春天,世界贸易组织预测2014年全球贸易量将增长4.7%,但将2015年的全球贸易量增长预期从5.3%下调到4.0%。更可悲的是,美国集装箱货物出口商也将继续面... 详细信息

欧洲和亚洲主要市场需求疲软使美国集装箱出口在2016年前都很难获得反弹的动力。去年春天,世界贸易组织预测2014年全球贸易量将增长4.7%,但将2015年的全球贸易量增长预期从5.3%下调到4.0%。更可悲的是,美国集装箱货物出口商也将继续面临困境,且2015年美国集装箱出口量将继续下滑。在经历了2008年到2009年的全球经济萧条后,市场于2010年和2011年发生

关键词：集装箱欧洲包装箱出口量需求疲软美利坚合众国北美洲美国经济增长预期亚洲经济萧条印度次大陆全球贸易量