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Posterior Stabilization for Management of Neglected Odontoid Fractures

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Open Journal of Modern Neurosurgery 2021年第2期11卷 73-89页

作者： Mohammed Attia alaa rashad Neurosurgery Department Faculty of Medicine Al-Azhar University Cairo Egypt

Background: Odontoid fractures are specific types of cervical fractures that show many challenges in their management. There are several types of Odontoid fractures with different modes of stability. There is no definite widely accepted way of management of Type II fractures among spine surgeons. There is a high rate of delayed or non-union of Odontoid fracture cases that are managed conservatively which may lead to dangerous complications. If non-union occurs, the patient should undergo surgical intervention as early as possible to avoid neurological deterioration. Objective: To demonstrate the value of intra-operative reduction and posterior stabilization of atlanto-axial junction in cases of non-union old Odontoid fractures and their outcome. The study was also to check for criteria associated with a favorable outcome and if posterior decompression will be associated with a better outcome. Patients and Methods: 12 patients of old neglected Odontoid fractures following conservative management and complicated by non-union were operated through intra-operative reduction with posterior stabilization and fixation of atlanto-axial junction at Al-Azhar University Hospitals during the period starting from June 2016 till the end of December 2019 using Screws and Rods. Intra-operative reduction under C-Arm X-ray and firm stabilization were aimed in all cases. Posterior cord decompression was an option in selected 4 patients with severe cord compression. Both intra-operative, post-operative radiological and clinical outcomes were assessed. Results: Good intra-operative reduction and alignment of fractured Odontoid process were obtained in all cases with use of 4 screws and 2 rods (2 screws and 1 rod on each side) in 11 cases and with using 2 screws and 1 rod (unilateral fixation) in one case. Good clinical outcome was obtained in all patients with improvement of pre-operative condition except in 3 patients

关键词： Spine Odontoid Fractures Non-Union Posterior Stabilization

Microscopic Anterior Callosotomy for Management of Intractable Epilepsy (Al-Azhar Experience)

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Open Journal of Modern Neurosurgery 2021年第3期11卷 180-193页

作者： alaa rashad Ibrahim Mohammed Attia Neurosurgery Department Faculty of Medicine Al-Azhar University Cairo Egypt

Background: Anterior Corpus Callosotomy is a palliative treatment for drug-resistant generalized or multifocal epilepsy patients where focus excision is not an option for management. Callosotomy prevents propagation of epileptic discharge from one cerebral hemisphere to the other. Objective: To describe Al-Azhar University Hospitals experience and clinical outcome of Anterior Corpus Callosotomy for management of drug-resistant generalized epilepsy patients as an inexpensive palliative method. Patients and Methods: In this study, there are 15 patients admitted to Neurosurgery Department in Al-Azhar University Hospitals with drug-resistant generalized epilepsy. These patients were not candidates for lesionectomy. They were managed by anterior two thirds Corpus Callosotomy between February 2017 and December 2019. They were followed at outpatient clinic for at least 14 months. Clinical outcome regarding seizure control was assessed using Engel classification. Results: All 15 patients in this study underwent anterior two thirds corpus callosotomy and followed for at least 14 months. The post-operative improvement of seizure frequency has been evaluated using Engel outcome scale with 12 patients (80%) of the patients becoming Engel class II and 3 patients (20%) becoming Engel class III. Only 3 patients (20%) had minor transient postoperative complications;one patient (6.67%) had contra-lateral lower limb heaviness Grade 4 which was transient, one patient (6.67%) had contra-lateral lower limb Jacksonian focal fits and one patient (6.67%) had behavioral changes for one month. Conclusion: Corpus callosotomy is a palliative procedure and inexpensive method for management of patients with intractable focal with generalization and generalized drug-resistant epilepsy who are not suitable for resective surgery and with good outcome.

关键词： Drug-Resistant Epilepsy Palliative Treatment Corpus Callosotomy Engel Surgery Outcome Scale

Multivariate form of Hermite sampling series

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 253-265页

作者： rashad M.Asharabi Department of Mathematics College of Arts and SciencesNajran UniversityNajranSaudi Arabia

In this paper,we establish a new multivariate Hermite sampling series involving samples from the function itself and its mixed and non-mixed partial derivatives of arbitrary *** multivariate form of Hermite sampling will be valid for some classes of multivariate entire functions,satisfying certain growth *** will show that many known results included in Commun Korean Math Soc,2002,17:731-740,Turk J Math,2017,41:387-403 and Filomat,2020,34:3339-3347 are special cases of our ***,we estimate the truncation error of this sampling based on localized sampling without decay *** examples are also presented.

关键词： multidimensional sampling series sampling with partial derivatives contour integral truncation error

Revealing the Void Formation Mechanism during Superplastic Deformation of a Fine-Grained Ni-Co-Base Superalloy

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 915-920页

作者： rashad AAl-Hammadi Rui Zhang Chuanyong Cui Zijian Zhou Yizhou Zhou Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

The mechanism behind void formation during superplasticity remains a subject of *** study presented a novel insight into the void formation in a fine-grained Ni-Co-based superalloy during *** was observed that the dissolution ofγ′-particles resulted in the creation of vacancies due to differences in atomic size between the matrix and the *** vacancies acted as inclusions,leading to the formation of ***,excessive void formation correlated with higher particle dissolution was experimentally observed,highlighting a direct relationship between void formation and particle dissolution.

关键词： Superplasticity Void formation Ni-Co-based superalloy Microstructure

CD62L Percentage in Peripheral T Cells of Kidney Transplant Recipients Children

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Open Journal of Nephrology 2021年第3期11卷 422-436页

作者： alaa rashad Fatina I. Fadel Doaa M. Salah Eman A. Elghoroury Neemat M. A. Kassem Eman Mahmoud Mervat Ismail Manal F. Elshamaa Department of Pediatrics National Research Centre Cairo Egypt Department of Pediatrics Faculty of Medicine Cairo University Cairo Egypt Departments of Clinical Pathology National Research Centre Cairo Egypt Oncology Department Faculty of Medicine Cairo University Cairo Egypt

Backgrounds: Recent advances in post Kidney Transplantation (KT) care, have led to a dramatic improvement in short-term outcomes in order to achieve transplantation tolerance;including the ideal tool for clinical monitoring & new therapeutic line. This study was undertaken to analyze the CD62L in Kidney Transplant Recipients (KTRs) and to investigate its efficacy as a marker of good graft survival. Methods: Fifty pediatric KTRs and 12 healthy controls were included in the study, the frequency of T cell activation markers;CD62L was measured with flow cytometry after renal transplantation. Clinical, laboratory, immunosuppressive therapy data and graft function of transplant recipients were collected and correlated with their CD62L peripheral blood percentage. Results: The circulating CD62L% was significantly more in transplant recipients than controls (44.74% ± 17.45% vs. 33.36% ± 11.54%, p = 0.02). CD 62L% was more frequent in recipients of living related donors (p = 0.05), positively correlated with donor age (p = 0.04, r = -0.29*) and CD 4% (p = 0.000, r = 0.615). CD26L% did not show significant association with acute rejection or chronic rejection (p = 0.432, p = 0.91 respectively) or with graft function (serum creatinine or eGFR, p = 0.086, p = 0.988 respectively) or immunosuppressive medications. Conclusion: Peripheral CD62L% is increased after KT than healthy controls, however, it cannot reflect either clinical (serum creatinine and eGFR) or pathological renal graft injury. CD62L surface marker needs more analysis for its potential diagnostic and therapeutic implications as a Treg cell activation marker.

关键词： CD62L Regulatory T Cells Transplantation Graft Survival Children

Complex Decision Modeling Framework with Fairly Operators and Quaternion Numbers under Intuitionistic Fuzzy Rough Context

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1893-1932页

作者： Nadeem Salamat Muhammad Kamran Shahzaib Ashraf Manal Elzain Mohammed Abdulla rashad Ismail Mohammed M.Al-Shamiri Institute of Mathematics Khwaja Fareed University of Engineering&Information TechnologyRahim Yar Khan64200Pakistan Department of Mathematics Thal University BhakkarPunjab30000Pakistan Department of Mathematics Faculty of Science and ArtsKing Khalid UniversityMuhayl Assir61913Saudi Arabia

The main goal of informal computing is to overcome the limitations of hypersensitivity to defects and uncertainty while maintaining a balance between high accuracy,accessibility,and *** paper investigates the potential applications of intuitionistic fuzzy sets(IFS)with rough sets in the context of sparse *** it comes to capture uncertain information emanating fromboth upper and lower approximations,these intuitionistic fuzzy rough numbers(IFRNs)are superior to intuitionistic fuzzy sets and pythagorean fuzzy sets,*** use rough sets in conjunction with IFSs to develop several fairly aggregation operators and analyze their underlying *** present numerous impartial laws that incorporate the idea of proportionate dispersion in order to ensure that the membership and non-membership activities of IFRNs are treated equally within these *** operations lead to the development of the intuitionistic fuzzy rough weighted fairly aggregation operator(IFRWFA)and intuitionistic fuzzy rough ordered weighted fairly aggregation operator(IFRFOWA).These operators successfully adjust to membership and non-membership categories with fairness and *** highlight the unique qualities of these suggested aggregation operators and investigate their use in the multiattribute decision-making *** use the intuitionistic fuzzy rough environment’s architecture to create a novel strategy in situation involving several decision-makers and non-weighted ***,we developed a novel technique by combining the IFSs with quaternion *** establish a unique connection between alternatives and qualities by using intuitionistic fuzzy quaternion numbers(IFQNs).With the help of this framework,we can simulate uncertainty in real-world situations and address a number of decision-making *** the examples we have released,we offer a sophisticated and systematically constructed illustrative scenario that is intricately wo

关键词： Intuitionistic fuzzy set quaternion numbers fuzzy logic decision-making rough set

Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats:oxidative/inflammatory/apoptotic pathways

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Asian Journal of Andrology 2024年第4期26卷 396-401页

作者： Ramadan S Hussein Moustafa M Eyada rashad M Mostafa Samah M Elaidy Shereen H Elsayed Hany M Saad Department of Dermatology College of Medicine Prince Sattam Bin Abdulaziz UniversityAl-Kharj 16242Saudi Arabia Department of Dermatology Andrology and STDsAssiut Police HospitalAssiut 71525Egypt Department of Dermatology Venereology and AndrologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Andrology and Sexology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Clinical Pharmacology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Rehabilitation Sciences Faculty of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh 12271Saudi Arabia.

Thyroid hormones play essential roles in spermatogenesis,but their effects on infertile males remain poorly *** study aimed to evaluate the impact of combining carbimazole(CBZ)with vitamin E(VE)on testicular injury induced by experimental hyperthyroidism in adult albino rats,focusing on oxidative,inflammatory,and apoptotic *** this experimental study,64 adult male albino Wistar rats were divided into eight groups:Group I(control-untreated),Group II(CBZ-control),Group III(VE-control),Group IV(CBZ+VE-control),Group V(levothyroxine-induced testicular injury),Group VI(levothyroxine+CBZ-treated),Group VII(levothyroxine+VE-treated),and Group VIII(levothyroxine+CBZ+VE-treated).The study was conducted in the Faculty of Medicine,Suez Canal University(Ismailia,Egypt).After cervical decapitation,both testes and epididymis were examined histopathologically and *** differences were observed among groups concerning malondialdehyde(MDA),glutathione(GSH),superoxide dismutase(SOD),and catalase(CAT;all P<0.001).Polymerase chain reaction analysis showed significant differences in tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),Bcl-2-associated X protein(BAX),B-cell lymphoma 2 protein(Bcl2),p53,Caspase-3,Caspase-8,Caspase-9,and nuclear factor-kappa B(NF-κB)mRNA levels(all P<0.001).Hyperthyroid group treated with CBZ alone(Group VI)exhibited testicular side effects,affecting seminiferous tubules and ***,the Group VIII showed improved spermatogenesis and a decrease in testicular side *** addition of VE to the treatment of hyperthyroid rats with CBZ reduced testicular side effects and seminiferous tubular affection when potentially improving *** research is needed to elucidate the underlying mechanisms fully.

关键词： antithyroid drugs testicular injury thyroid gland vitamin E

Understanding the low temperature electrochemistry of magnesium-lithium hybrid ion battery in all-phenyl-complex solutions

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Journal of Energy Chemistry 2021年第5期30卷 383-390页

作者： Muhammad rashad Muhammad Asif School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003JiangsuChina Bernal Institute Department of Chemical SciencesUniversity of LimerickLimerick V94 T9PXIreland

Magnesium-lithium hybrid ion batteries have emerged as a new class of energy storage systems owing to dendrite free cycling of magnesium anode and possibility of practice of numerous conventional lithium *** present work,we used hybrid ion strategy to analyze the performance of lithium titanate based lithium cathode,magnesium metal anode,and all-phenyl complex(APC)electrolytes at different temperatures(25℃,10℃,0℃,-10℃,and-20℃).The hybrid ion battery exhibited excellent rate performance(228 m Ah g^(-1)/20 m A g^(-1) and 163 mAh g^(-1)/1000 mA g^(-1))with stable voltage plateaus at 0.90 and 0.75 V,which corresponds to specific energy of 178 Wh kg^(-1) at room temperature(25℃).Experimental results revealed that APC-THF solutions have strong potential to suppress the freezing of electrolyte solutions owing to low boiling point of *** low temperature electrochemical testing revealed the reversible capacities of 213.4,165.5,143.8,133.2 and 78.56 mAh g^(-1) at 25,10,0,-10,and-20℃,***,ex-situ XRD,SEM,and EIS tests were carried out to understand the reaction kinetics of both Mg2+and Li+ions inside the lithium titanate *** hope this work will shed light on low temperature prospective of electrochemical devices for use in cold environments.

关键词： Mg ion battery Mg-Li hybrid ion batteries Electrochemical properties Low temperature Energy storage

tRNA cleavage: a new insight

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Neural Regeneration Research 2020年第1期15卷 47-52页

作者： Sherif rashad Kuniyasu Niizuma Teiji Tominaga Department of Neurosurgery Tohoku University Graduate School of MedicineSendaiJapan Department of Neurosurgical Engineering and Translational Neuroscience Tohoku University Graduate School of MedicineSendaiJapan Department of Neurosurgical Engineering and Translational Neuroscience Graduate School of Biomedical EngineeringTohoku UniversitySendaiJapan

Over the past decades,tRNA was found to be a rich hub of RNA modifications such as 1-methyladenosine and 5-methycytosine modifications and others,holding more than half of all modifications occurring in RNA ***,tRNA was discovered to be a source of various small noncoding RNA species,such as the stress induced angiogenin cleaved tRNA halves(tiRNA)or the miRNA like tRNA derived *** cleavage under stress was fist discovered in bacteria and later was found to be conserved across different species,including *** cellular stress conditions,tRNA undergoes conformational changes and angiogenin cleaves it into 3′and 5′halves.5′tiRNA halves were shown to repress protein *** cleavage is thought of to be a cytoprotective mechanism by which cells evade apoptosis,however some data hints to the opposite;that tiRNA are cytotoxic or at least related to apoptosis *** cleavage also was shown to be affected by tRNA modifications via different enzymes in the cytosol and *** this review,we will highlight the biology of tRNA cleavage,show the evidence of it being cytoprotective or a marker of cell death and shed a light on its role in disease models and human diseases as well as possible future directions in this field of RNA research.

关键词： angiogenin apoptosis cell stress RNA modification stress granules stroke tiRNA translation repression tRNA tRNA cleavage