检索结果-南通市图书馆

Pharmacokinetics and Bioequivalence of Dienogest in Healthy Bangladeshi Female Volunteers: An Open-Label, Single-Dose, Randomized, Two-Way Crossover Study

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2024年第5期14卷 779-789页

作者： Nusrat Mahmud Nafisa Ahamed Uttom Kumar Bhowmik Sabrina Akter Tushi Nayan Ghosh Nithon Chandra Sahana Arifa akram Md. Alimur Reza BIRDEM General Hospital Dhaka Bangladesh Medical College for Women & Hospital Dhaka Bangladesh Novus Clinical Research Services Ltd. Dhaka Bangladesh National Institute of Laboratory Medicine & Referral Centre (NILMRC) Dhaka Bangladesh

Background: Dienogest is a potential treatment for pelvic pain associated with endometriosis, a condition of significant concern in gynaecology. The current study was conducted as a crossover-randomized bioequivalence assessment of two oral Dienogest 2 mg formulations, aiming to provide valuable insights for healthcare professionals and researchers in this field. Objective: The primary aim of this research was to evaluate and compare the pharmacokinetic characteristics of Dienogest 2 mg tablets. Dinogest (Dienogest 2 mg) tablets, manufactured by Nuvista Pharma Limited in Bangladesh, and Visanne (Dienogest 2 mg) tablets, manufactured by Bayer Pharma in Germany, were the test and reference formulations, respectively. Materials and Method: The study was an open-label, balanced, randomized, two treatments, two sequences, two periods, two-way crossover, laboratory blind, single oral dose bioequivalence study conducted in healthy adult females under fasting conditions. The study was carried out on 13 healthy, non-pregnant female subjects, and all the subjects completed both study periods with a 15-day washout in between. Randomization was used to assign the test and reference formulations to the subjects. Following each oral administration, a series of blood samples were obtained at different time intervals from pre-dose to 72 hours post-dose and analyzed for Dienogest concentrations using a validated bio-analytical method. A standard non-compartmental model was used to analyze the pharmacokinetic parameters. The primary pharmacokinetic parameters were peak plasma drug concentration (Cmax), the area under the plasma concentration-time curve from time zero to time t (AUC0–t), and AUC from t = 0 to infinity (AUC0–∞). The other PK parameters included time to reach Cmax (Tmax), terminal elimination rate constant (Kel), and half-life (t1/2). Result: The ratios and 90% CI for the geometric mean test/re

关键词： Dienogest Bioequivalence Study Endometriosis Novus CRSL

Pharmacokinetic Comparison and Bioequivalence Evaluation of Two 20-mg Vonoprazan Fumarate Tablets in Bangladeshi Healthy Male Subjects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2024年第8期12卷 230-243页

作者： Md. Alimur Reza Uttom Kumar Bhowmik Sabrina Akter Tushi Nayan Ghosh Nithon Chandra Sahana Md. Ashraful Islam Nafisa Ahamed Arifa akram Novus Clinical Research Services Ltd. Dhaka Bangladesh Medical College for Women & Hospital Dhaka Bangladesh National Institute of Laboratory Medicine & Referral Centre (NILMRC) Dhaka Bangladesh

Background: Vonoprazan fumarate, a novel potassium-competitive acid blocker, outperforms traditional proton pump inhibitors in acid suppression and can be effectively combined with antibiotics to eradicate Helicobacter pylori. Objective: The study aimed to determine if two Vonoprazan formulations—Vonoprazan Fumarate 20 mg Tablet of Beximco Pharmaceuticals Limited, Bangladesh (test product) and Takecab 20 mg Tablet of Takeda Pharmaceutical Company Limited, Japan (reference product)—met FDA’s bioequivalence requirements by comparing their pharmacokinetic characteristics in healthy Bangladeshi adults. Methods: This was a single-center, randomized, open-label, two-period, two-sequence, laboratory-blind, double-crossover experiment. After 10 hours of fasting, 18 subjects were randomly assigned to receive a single oral dose of either formulation. During each treatment period, blood samples were collected at specific times (pre-dose and up to 48 hours post-dose) to measure plasma Vonoprazan levels using liquid chromatography-tandem mass spectrometry. A non-compartmental model was used to calculate pharmacokinetic parameters using the plasma drug concentration-time profile. A statistical comparison of the pharmacokinetic parameters of the two formulations of the test and reference product was conducted using SAS® statistical software to assess the bioequivalence. Primary pharmacokinetic parameters (Cmax, AUC0-t, and AUC0-∞) and secondary parameters (Tmax, T1/2, Kel, and AUC extrapolation) were calculated for both drug formulations. If the confidence intervals for the natural log-transformed Cmax, AUC0-t, and AUC0-∞ values fell between 80% and 125%, the drug products would be considered bioequivalent. Result: The geometric mean ratio of Vonoprazan between the test and reference groups was found to be 109.04% (99.47% - 119.53%), 101.37% (95.58% - 107.50%), and 101.24% (95.43% - 107.41%), with 90% confidence intervals (CIs) for the Cmax, AUC0–t, and AUC0–∞, and these outcomes

关键词： Bioequivalence Vonoprazan Pharmacokinetics

Kinetics of Soil Potassium Release Under Long-Term Imbalanced Fertilization in Calcareous Soils

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2017年第6期27卷 1105-1115页

作者： akram FATEMI Soil Science Department Razi UniversityKermanshah ***(Iran)

Knowledge on potassium ion(K^+) release from soils makes K fertilizer recommendation more efficient and *** of K^+release under continuous fertilization of no fertilizer(CK), urea(N), triple superphosphate(P), and urea + triple superphosphate(NP) without K fertilizer was investigated in calcareous(chloritic and kaolinitic) soils on the Miandarband Plain in Kermanshah Province of *** results showed that the kinetics of K^+release included an initial reaction and a slow *** phosphateand NH_4^+-induced K^+release followed the same rate process during the rapid(2–192 h) and slow release periods(192–1 090 h).There were no significant differences in the cumulative K^+released from the chloritic and kaolinitic soils among all the *** cumulative K^+released was positively correlated with P adsorption capacity for the chloritic(r = 0.461, P N = CK for the chloritic soils, and N =P > NP > CK for the kaolinitic *** study showed that K fixation potential and P adsorption capacities controlled K^+release from *** information will be helpful for precise fertilizer recommendations for the studied soils.

关键词： clay mineralogy initial release rate index K fixation potential P adsorption capacity triple superphosphate urea

Magnetohydrodynamic peristaltic flow of a hyperbolic tangent fluid in a vertical asymmetric channel with heat transfer

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2011年第2期27卷 237-250页

作者： Sohail Nadeem Safia akram Department of Mathematics Quaid-i-Azam University 45320 Islamabad 44000 Pakistan Department of Electrical (Telecom) Engineering Military College of Signals National University of Sciences and Technology Rawalpindi 46000 Pakistan

In the present paper we discuss the magnetohydrodynamic （MHD） peristaltic flow of a hyperbolic tangent fluid model in a vertical asymmetric channel under a zero Reynolds number and long wavelength approximation. Exact solution of the temperature equation in the absence of dissipation term has been computed and the analytical ex- pression for stream function and axial pressure gradient are established. The flow is analyzed in a wave frame of reference moving with the velocity of wave. The expression for pressure rise has been computed numerically. The physical features of pertinent parameters are analyzed by plotting graphs and discussed in detail.

关键词： MHD flow Hyperbolic tangent fluid Vertical asymmetric channel Heat transfer

SYNTHESIS AND CHARACTERIZATION OF OPTICALLY ACTIVE POLY(AMIDE-IMIDE)S BASED ON[N,N'-(4,4'-CARBONYLDIPHTALOYL)-BIS-LAMINO DIACID]S AND l,5-BIS(4-AMINOPHENYL)PENTA-l,4-DIEN-3-ONE

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2012年第6期30卷 777-785页

作者： Khalil Faghihi akram Feyzi Organic Polymer Chemistry Research Laboratory Department of ChemistryFaculty of ScienceArak UniversityArak38156Iran

Six dicarboxylic acids 3a-3f were synthesized dianhydride 1 with L-aminoacids 2a-2f in a solution of glacial new poly（amide-imide）s PAIs were synthesized from by the reaction of 3,3＇,4,4＇-benzophenonetetracarboxylic acetic acid/pyridine （Py） at refluxing temperature. Then six the direct polycondensation reaction of [N,N＇-（4,4＇- carbonyldiphtaloyl）-bis-L-amino diacid]s with 1,5-bis（4-aminophenyl）penta-l,4-dien-3-one （APPD）. The polymerization reactions produced a series of new optically active PAls with high yield and good inherent viscosity. Also these PAls are optically active and soluble in various organic solvents chromatography for the separation of enantiomeric mixtures. FTIR and 1H-NMR spectroscopy, elemental analyses, thermogravimetric analysis （TGA）. These resulting new polymers can be used in column The resulted polymers were fully characterized by means of inherent viscosity measurements, solubility tests and

关键词： Organosoluble polymers Thermal properties Glass transition.

Wedge-Shaped Pop-Up Structure in the Eslami Peninsula, Lake Urmia, Northwestern Iran

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2017年第4期91卷 1264-1269页

作者： akram ALIZADEH Fayezeh JANGJOO Department of Geology Faculty of Science Urmia University Urmia 57153-165 Iran

Ancient subduction zones are characterized by metamorphic and orogenic belts. The Zagros Orogenic Belt comprises almost all sections of an ancient subduction zone along which Neo-Tethyan oceanic crust was subducted beneath central Iran. The Eslami Peninsula, as a part of the Zagros Orogenic Belt in Azerbaijan province, northwestern Iran, is situated between the Lake Urmia fore-arc basin and the Sahand Magmatic Arc. This region contains Eocene leucite dikes, trachyte, tephrite, phenolite, basanite and syenite. Volcanic features related to the Sahand are located in the eastern part of the Eslami Peninsula. In view of its relative age and composition, the Eslami Peninsula proposed as an outer arc of the Sahand Magmatic Arc that formed within the post-collisional setting of the central Iranian and Arabian plates. After subduction and contact of the two plates, a symmetric pop-up structure has been created by thrusting in the Zagros belt as a result of the collision processes. The injesction of dikes in the Eslami Peninsula is also a result of the continent continent collision.

关键词： Eslami Peninsula Lake Urmia Sahand post-collision Zagros

Hybrid Effects of Thermal and Concentration Convection on Peristaltic Flow of Fourth Grade Nanofluids in an Inclined Tapered Channel: Applications of Double-Diffusivity

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2021年第6期127卷 901-922页

作者： Safia akram Alia Razia MCS National University of Sciences and TechnologyIslamabadPakistan

This article brings into focus the hybrid effects of thermal and concentration convection on peristaltic pumping of fourth grade nanofluids in an inclined tapered ***,the brief mathematical modelling of the fourth grade nanofluids is provided along with thermal and concentration *** Lubrication method is used to simplify the partial differential equations which are tremendously ***,analytical technique is applied to solve the differential equations that are strongly nonlinear in nature,and exact solutions of temperature,volume fraction of nanoparticles,and concentration are *** and graphical findings manifest the influence of various physical flow-quantity *** is observed that the nanoparticle fraction decreases because of the increasing values of Brownian motion parameter and Dufour parameter,whereas the behaviour of nanoparticle fraction is quite opposite for thermophoresis *** is also noted that the temperature profile decreases with increasing Brownian motion parameter values and rises with Dufour parameter ***,the concentration profile ascends with increasing thermophoresis parameter and Soret parameter values.

关键词： Nanofluids thermal and concentration convection peristaltic flow inclined tapered channel fourth grade fluid

Endoscopic ultrasound-guided gastroenterostomy for gastric outlet obstruction in Mexico

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Surgical Procedures 2024年第3期14卷 15-20页

作者： Massiel Madelin Rosario-Morel Rodrigo Soto-Solis Katia Picazo-Ferrera Miriam Idalia Torres-Ruiz JoséAlberto Estradas-Trujillo Mario Alberto Gallardo-Ramírez Gerardo akram Darwich-del Moral Luis Ariel Waller-González Department of Endoscopy Centro Médico Nacional“20 de Noviembre”ISSSTEMexico City 03229Mexico Department of Gastroenterology HospitalÁngeles PedregalMexico City 10700Mexico Department of Endoscopy Centro Médico ABCMexico City 01120Mexico Department of Endoscopy Hospital General de México“Dr.Eduardo Liceaga”Mexico City 06720Mexico

BACKGROUND Endoscopic ultrasound-guided gastroenterostomy(EUS-GE)has recently emerged as an alternative treatment for gastric outlet obstruction(GOO)in selected *** To report the initial experience of EUS-GE in patients with *** This study was a retrospective,observational,multicenter study in which the data from 10 patients who underwent EUS-GE due to GOO between September 2021 and May 2023 were *** analyzed technical success,clinical success,adverse events,and *** success was defined as adequate positioning and deployment of the *** success was defined as the patient’s ability to tolerate oral intake without vomiting 7 d after the *** adverse events were *** Eleven procedures in 10 patients with GOO were *** mean age of the patients was 67.5 years(range:56-77 years).Malignant GOO was present in 9 *** success was achieved in 9/11 procedures(82%).Among them,clinical success was achieved in 9 patients(100%).Adverse events occurred in 1 patient(9%).The median survival was 3 months(n=7;range:1-8 months).CONCLUSION EUS-GE is a feasible therapeutic option in the treatment of GOO.

关键词： Endoscopic ultrasound-guided gastroenterostomy Gastric outlet obstruction Lumen apposing metal stent Interventional endoscopic ultrasound Gastrojejunostomy Duodenal stenting

Effects of medicinal plants on Alzheimer＇s disease and memory deficits

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第4期12卷 660-670页

作者： Muhammad akram Allah Nawaz Department of Eastern Medicine and Surgery Faculty of Medical and Health Sciences The University of Poonch Rawalakot Azad Jammu and Kashmir Pakistan First Department of Internal Medicine Faculty of Medicine University of Toyama Toyama Japan

Alzheimer＇s disease is an age-related neurodegenerative disorder characterized by memory deficits. Various studies have been carried out to find therapeutic approaches for Alzheimer＇s disease. However, the proper treatment option is still not available. There is no cure for Alzheimer＇s disease, but symptomatic treatment may improve the memory and other dementia related problems. Traditional medicine is practiced world- wide as memory enhancer since ancient times. Natural therapy including herbs and medicinal plants has been used in the treatment of memory deficits such as dementia, amnesia, as well as Alzheimer＇s disease since a long time. Medicinal plants have been used in different systems of medicine, particularly Unani system of medicines and exhibited their powerful roles in the management and cure of memory disorders. Most of herbs and plants have been chemically evaluated and their efficacy has also been proven in clinical trials. However, the underlying mechanisms of actions are still on the way. In this paper, we have reviewed the role of different medicinal plants that play an important role in the treatment of Alzheimer＇s disease and memory deficits using conventional herbal therapy.

关键词： nerve regeneration memory Alzheimer's disease medicinal plants efficacy literature review neural regeneration