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rapid turnover proteins as prognostic nutritional indices in cancer patients

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中华临床营养杂志 1994年第4期12卷 50-,32页

作者： akira okada Yoshifumi Inoue Department of Pediatric Surgery and Surgery OsakaUniversity Medical SchooL SuitaOsakaJapan 565Department of Pediatric Surgery and SurgeryOsakaUniversity Medical SchooL SuitaOsakaJapan 565

Cancer patients in advanced stages are frequentlyaccompanied by protein-malnutrition from variouscauses as disease advances and such an emaciated con-dition is generally termed“cancer cachexia”.The re-cent progress in total parenteral nutrition(TPN)hasmade it possible to maintain nutritional status of criti-cally ill patients and has thereby led to a great im-provement in cancer therapy. Unfortunately, ad-vanced cancer patients fail not infrequently to be ade-quately benefited even from TPN and this had report-edly been ascribed to metabolic derangements peculiarto cancer-bearing organisms. These

关键词： nutritional parenteral malnutrition turnover prognostic maintain indices advances thereby accord

rapid turnover proteins as prognostic nutritional indices in cancer patients

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中华临床营养杂志 1994年第4期 50+32-50+32页

作者： akira okada,Yoshifumi Inoue Department of Pediatric Surgery and Surgery Osaka University Medical SchooL Suita Osaka Japan 565 Department of Pediatric Surgery and Surgery Osaka University Medical SchooL Suita Osaka Japan 565

关键词： TPN Th rapid turnover proteins as prognostic nutritional indices in cancer patients

High-quality micro-shape fabrication of monocrystalline diamond by nanosecond pulsed laser and acid cleaning

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International Journal of Extreme Manufacturing 2022年第2期4卷 173-183页

作者： Yasuhiro Okamoto Tubasa Okubo Atsuya Kajitani akira okada Graduate School of Natural Science and Technology Okayama UniversityOkayamaJapan

The flat plane of small surface roughness below 0.1μm average roughness was obtained for monocrystalline diamond by nanosecond pulsed laser irradiation of 1060 nm and post-process acid cleaning,at a laser fluence around the material removal threshold *** glossy and flat plane at the bottom of the micro-groove was parallel to the top surface of the specimen,although the round beam of Gaussian mode was irradiated in the direction perpendicular to the top surface of *** square beam of top-hat mode produced a shallower micro-groove with a wider,flatter bottom compared with the round beam in Gaussian *** creation method of the flat plane with small surface roughness was discussed in the arrangement strategy of linear micro-grooving by the square beam of top-hat *** side-by-side repetition of linear micro-grooving did not create a flat plane with constant ***,a two-step scanning method was proposed in order to overcome the problem in the normal side-by-side repetition of liner ***-removal areas were partly retained between the processing lines in the first step,and the laser scanning was conducted on the retained area in the second *** newly proposed two-step scanning method was practical and useful to create a widely flat plane with small surface roughness,and the two-step scanning method provided superior control over the micro-groove *** proposed method can reduce the surface roughness in addition to the shape creation of monocrystalline diamond,and it can be used as a high-quality micro-shape fabrication method of monocrystalline diamond.

关键词： monocrystalline diamond nanosecond pulsed laser flat surface smooth surface micro-grooving

High Resolution X-Ray Diffraction Analyses of (La,Sr)MnO<sub>3</sub>/ZnO/Sapphire(0001) Double Heteroepitaxial Films

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Advances in Materials Physics and Chemistry 2013年第1期3卷 72-89页

作者： Katsuhiko Inaba Shintaro Kobayashi Kenichi Uehara akira okada Sanapa Lakshmi Reddy Tamio Endo Department of Physics Sri Venkateswara Degree College Kadapa India Graduate School of Engineering Mie University Tsu Japan X-Ray Research Laboratory Rigaku Corporation Tokyo Japan

The epitaxial relationships of lattices and crystalline qualities of LSMO/ZnO/sapphire double-hetero systems were thoroughly analyzed using X-ray diffraction techniques with a modern high resolution XRD system. It was revealed that the epitaxial growth of the LSMO (110) phase was promoted under higher temperature accompanying the suppression of other competitive growth of the LSMO (001) and (111) phases. Supplying the plasma oxygen accelerated the suppression of the LSMO (111) phase. The complex epitaxial orientational relationships in these three growth modes were revealed from the precise analyses with the high resolution out-of-plane XRD and the in-plane XRD measurements, pole figure measurements, and reciprocal space mappings measurements, as [112ˉ](111)LSMO//[11ˉ00](0001)ZnO//[112ˉ0](0001)Sap, [110ˉ](111LSMO)//[11ˉ00](0001)Zno//[112ˉ0](0001)Sap, and [110](001)LSMO//[11ˉ00](0001)Zno//[112ˉ0](0001)Sap. The validity of this model for the epitaxial orientational relationships in LSMO/ZnO/sapphire double heteroepitaxial layers was confirmed identically with the data ana- lyses of the out-of-plane wide-range Reciprocal Space Mapping using the 2-dimensional X-ray detector.

关键词： X-Ray Diffraction Heteroepitaxy LSMO Orientational Relations

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营养评估的现状

中国临床营养杂志 2000年第1期8卷 38-39页

作者： akira okada MD 刘卫日本大阪医学院

随着肠外和肠内营养支持的进展，住院和门诊病人营养支持治疗的管理也有调整，相应地，营养状况的评估也成为临床营养支持的关键问题。以往常用一些简单的指标模糊地评价病人的营养状况，特别是蛋白质营养情况，如体重和血清总蛋白。现... 详细信息

随着肠外和肠内营养支持的进展，住院和门诊病人营养支持治疗的管理也有调整，相应地，营养状况的评估也成为临床营养支持的关键问题。以往常用一些简单的指标模糊地评价病人的营养状况，特别是蛋白质营养情况，如体重和血清总蛋白。现在，我们都认识到使用简单、灵敏和准确的方法客观评价病人营养状况是非常必要的。已经有临床和基础的研究检验了以往使用的各种方法的实用性和局限性。这些测定指标可分为人类学、生化学、免疫学、生理学、放射核医学等。人类学测定指标简单易行，花费少，适合作为大群体的筛选，但缺乏精确度和灵敏度。生化指标中，血清白蛋白准确且稳定，但灵敏度差。血清中快速更新的蛋白或3．甲基组氨酸较白蛋白灵敏，但会受饮食和应激的影响而不稳定。免疫学指标有时很灵敏准确，但不总是能反应机体的营养状况。生理学指标，如伤口愈合情况、呼吸肌力量等，与上面情况类似。因此，目前看来还没有一个能准确反应营养状况的指标。最近，一些仪器提供了测定瘦体组织（leanbodymass）的新方法，可以更准确地测定人体组成。在一些研究机构已经在临床使用了生物电阻抗分析（BIA、电传导性测定（TOBEC）、双能量X钱吸收测定（DEXA）、体内中子活化分析（IVNA）。

关键词：营养评估肠内营养支持营养支持治疗临床营养支持营养状况蛋白质营养血清总蛋白门诊病人关键问题客观评价实用性

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本刊国际编委的信

中华临床营养杂志 1993年第1期11卷 10-13页

作者： Dougles W. Wilmore M.D. 杨少卫 Erik Vinnars M.D Ph.D. akira okada M.D. F.A.C.S. 美国哈佛医学院Brgham and Women’s Hospital 瑞典Karolinska大学St. Goran医院加强医疗单位和麻醉科日本Osaka University医学院儿外科

My warmest congratulations to the Chinese physicians and their associates who are interested in the nutritional and metabolic care of hospitalized patients for their founding of a new journal dealing with the science ... 详细信息

关键词： enteral nutrition 国际编委肠内营养支持 dealing founding nutrients 支持治疗脂肪乳剂病人营养状况

Fabrication of initial trabecular bone-inspired three-dimensional structure with cell membrane nano fragments

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Regenerative Biomaterials 2023年第1期10卷 73-80页

作者： Koichi Kadoya Emilio Satoshi Hara Masahiro okada Yu Yang Jiao Takayoshi Nakano akira Sasaki Takuya Matsumoto Department of Biomaterials Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Department of Maxillofacial Surgery Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Division of Materials&Manufacturing Science Osaka UniversityOsaka 565-0871Japan

The extracellular matrix of trabecular bone has a large surface exposed to the bone marrow and plays important roles such as hematopoietic stem cell niche formation and *** vitro reproduction of trabecular bone microenvironment would be valuable not only for developing a functional scaffold for bone marrow tissue engineering but also for understanding its biological ***,we analyzed and reproduced the initial stages of trabecular bone formation in mouse femur *** identified that the trabecular bone formation progressed through the following steps:(i)partial rupture of hypertrophic chondrocytes;(ii)calcospherite formation on cell membrane nano fragments(CNFs)derived from the ruptured cells;and(iii)calcospherite growth and fusion to form the initial three-dimensional(3D)structure of trabecular *** reproducing the initial trabecular bone formation in vitro,we collected CNFs from cultured cells and used as nucleation sites for biomimetic calcospherite ***,almost the same 3D structure of the initial trabecular bone could be obtained in vitro by using additional CNFs as a binder to fuse biomimetic calcospherites.

关键词： trabecular bone calcospherites cell membrane nano fragments three dimensionalization bone tissue synthesis

Current status of sperm banking for young cancer patients in Japanese nationwide survey

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Asian Journal of Andrology 2018年第4期20卷 336-341页

作者： Yasushi Yumura akira Tsujimura Hiroshi okada Kuniaki Ota Masahumi Kitazawa Tatsuya Suzuki Tosiyuki Kakinuma Seido Takae Nao Suzuki Teruaki Iwamoto Reproduction Center Yokohama City University Medical Center Yokohama 232-0024 Japan Department of Urology Juntendo University Urayasu Hospital Chiba 279-0021 Japan Department of Urology Dokkyo Medical University Koshigaya Hospital Saitama 343-8555 Japan Department of Obstetrics and Gynecology Nasu Red Cross Hospital Tochigi 324-8686 Japan Department of Obstetrics and Gynecology Dokkyo Medical University Tochigi 321-0293 Japan Department of Obstetrics and Gynecology Jichi Medical University Tochigi 329-0498 Japan Department of Obstetrics and Gynecology International University of Health and Welfare Tochigi 329-2763 Japan Department of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki 216-8511 Japan Division Male Infertility Center for Human Reproduction International University of Health and Welfare Sanno Hospital Tokyo 107-0052 Japan

This study aimed to ascertain the current status of Japanese sperm banking for young cancer patients. During 2015, we mailed the directors of 695 institutes where sperm cryopreservation might be performed with questionnaires requesting information on the number of patients, age, precryopreservation chemotherapy, semen analyses results and diagnoses, cryopreservation success rate, and causes of unsuccessful cryopreservation. Of these 695 institutes, 92 had cryopreserved sperm before chemotherapy within the study period. In all, 820 cancer patients （237 testicular, 383 hematological, 46 bone and soft tissue, 20 brain, and 134 other malignancy） consulted the responding institutes for sperm cryopreservation. Except for testicular tumor, the number of patients whose sperm was preserved before cancer treatment was low compared to that of young cancer patients. Approximately 20% of patients with malignancies other than testicular tumor underwent chemotherapy before cryopreservation. The success rate of cryopreservation in hematological malignancy was 82.5%, significantly lower than that of both the testicular cancer （93.6%） and other malignancy groups （95.6%）（P 〈 0.05）. The primary reasons for preservation failure were azoospermia and poor semen quality. Patients with hematological malignancies had a higher rate of unsuccessful cryopreservation compared to those in other groups, possibly due to the large number of patients requesting sperm cryopreservation after chemotherapy induction. In Japan, information regarding sperm banking prior to cancer treatment appears to be lacking. Information regarding sperm preservation before chemotherapy should be provided to all Japanese oncologists.

关键词： cancer chemotherapy fertility preservation sperm preservation survey

Clinical and histopathological study of preoperative radiochemotherapy with concomitant docetaxel in patients with squamous cell carcinoma of the oral cavity

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中国口腔颌面外科杂志 2008年第B5期6卷 167-168页

作者： Takahiro Oneyama akira Tanaka Syuji Toya akira Yamoguchi Kazuhiko Hiroyasu zumi Mataga Yasuo okada Oral and Maxillofacial Surgery The Nippon Dental University Niigata Hospital Department of Oral and Maxillofacial Surgery H The Nippon Dental University School of Life Dentistry at Niigata Department of Pathology The Nippon Dental University School of Life Dentistry at Niigatajapan

Purpose: A comparative study on therapeutic effects was performed on 29 patients with squamous cell carcinoma of the oral cavity in whom clinical and histopathological effects could be evaluated among patients with primary squamous cell carcinoma of the oral cavity treated in the Oral and Maxillofacial Surgery, Nippon Dental University Niigata Hospital. Methods: The 11 patients in the concomitant docetaxel group consisted of six men and five women with a mean age of 53.8 years. The primary sites were the tongue in four patients, the upper gum in four and lower gum in one patient. The T classification was T2 in two cases, T3 in eight and T4a in one. The 18 patients in the non-concomitant group were mainly given cisplatin and 5-Fu and consisted of ten men and eight women with a mean age of 63.1 years. The primary site was the tongue in six patients, floor of the mouth in one, buccal mucosa in eight, upper gum in two and lower gum in three patients. The T classification was T2 in 11 cases, T3 in five and T4a in two. The basic treatment method was docetaxel at 50 mg/m2 and cisplatin at 50 mg/m2 on day 1 and 5-Fu at 250 mg/m2 on days 2 to 6. The therapeutic effects were evaluated clinically by macroscopic inspections, palpations, CT and MRI. The histopathological effects according to the Oboshi-Shimosato classification was judged from surgical excisioned speciemens. Results: In the clinical evaluation of therapeutic effects, one patient was NC, nine were PR and one CR. In the histological evaluation of therapeutic effects, four patients were IIa, two were lib, four were III and one was IVb. In the non-concomitant group, these figures were NC in three, PR in 13, PD in two patients clinically and I in one, IIa in nine,

关键词：口腔鳞状细胞癌组织病理学放射线疗法