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Clinical and histopathological study of preoperative radiochemotherapy with concomitant docetaxel in patients with squamous cell carcinoma of the oral cavity

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中国口腔颌面外科杂志 2008年第B5期6卷 167-168页

作者： Takahiro Oneyama akira Tanaka Syuji Toya akira yamoguchi Kazuhiko Hiroyasu zumi Mataga Yasuo Okada Oral and Maxillofacial Surgery The Nippon Dental University Niigata Hospital Department of Oral and Maxillofacial Surgery H The Nippon Dental University School of Life Dentistry at Niigata Department of Pathology The Nippon Dental University School of Life Dentistry at Niigatajapan

Purpose: A comparative study on therapeutic effects was performed on 29 patients with squamous cell carcinoma of the oral cavity in whom clinical and histopathological effects could be evaluated among patients with primary squamous cell carcinoma of the oral cavity treated in the Oral and Maxillofacial Surgery, Nippon Dental University Niigata Hospital. Methods: The 11 patients in the concomitant docetaxel group consisted of six men and five women with a mean age of 53.8 years. The primary sites were the tongue in four patients, the upper gum in four and lower gum in one patient. The T classification was T2 in two cases, T3 in eight and T4a in one. The 18 patients in the non-concomitant group were mainly given cisplatin and 5-Fu and consisted of ten men and eight women with a mean age of 63.1 years. The primary site was the tongue in six patients, floor of the mouth in one, buccal mucosa in eight, upper gum in two and lower gum in three patients. The T classification was T2 in 11 cases, T3 in five and T4a in two. The basic treatment method was docetaxel at 50 mg/m2 and cisplatin at 50 mg/m2 on day 1 and 5-Fu at 250 mg/m2 on days 2 to 6. The therapeutic effects were evaluated clinically by macroscopic inspections, palpations, CT and MRI. The histopathological effects according to the Oboshi-Shimosato classification was judged from surgical excisioned speciemens. Results: In the clinical evaluation of therapeutic effects, one patient was NC, nine were PR and one CR. In the histological evaluation of therapeutic effects, four patients were IIa, two were lib, four were III and one was IVb. In the non-concomitant group, these figures were NC in three, PR in 13, PD in two patients clinically and I in one, IIa in nine,

关键词：口腔鳞状细胞癌组织病理学放射线疗法

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