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The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura akira yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

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Photocatalytic dry reforming of methane by rhodium supported monoclinic TiO_(2)-B nanobelts

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Journal of Energy Chemistry 2022年第8期31卷 562-571,I0015页

作者： Masaru Kushida akira yamaguchi Masahiro Miyauchi School of Materials and Chemical Technology Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8552Japan

The conversion of methane and carbon dioxide into syngas(dry reforming of methane;DRM)has attracted attention owing to the potential to reuse greenhouse gases.Titanium dioxide(TiO_(2))-based photocatalysts,which have been widely commercialized owing to their high efficiency,non-toxicity,and low cost,are strongly desired in DRM.Here,we report a monoclinic-phase TiO_(2)-B nanobelts-supported rhodium(Rh/TiO_(2)-B nanobelts)catalyst that efficiently promotes DRM under ultraviolet light irradiation at low temperatures.Photogenerated holes in the TiO_(2)-B nanobelts were used to oxidize methane,while the electrons were trapped in rhodium to reduce carbon dioxide.Rh/TiO_(2)-B nanobelts exhibited considerably higher durability and activity than Rh-loaded conventional TiO_(2)(anatase and rutile),owing to the lattice and/or surface oxygen reactivity in TiO_(2)-B nanobelts,which was suggested by X-ray photoelectron spectroscopy measurements and photocatalytic performance tests under an atmosphere of methane alone.This study paves the path for the effective utilization of methane by constructing active TiO_(2)-based nanometal photocatalysts.

关键词： Photocatalysis Dry reforming of methane Greenhouse gas conversion Gas-phase reaction Titanium dioxide TiO_(2)-B

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Recent update on electrochemical CO_(2)reduction catalyzed by metal sulfide materials

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Materials Reports(Energy) 2023年第2期3卷 103-123,I0003页

作者： An Niza El Aisnada Masahiro Miyauchi Min Liu akira yamaguchi Department of Materials Science and Engineering School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo152=8552Japan Biofunctional Catalyst Research Team RIKEN Center for Sustainable Resource Science2=1 HirosawaWakoSaitama351-0198Japan Hunan Joint International Research Center for Carbon Dioxide Resource Utilization State Key Laboratory of Powder MetallurgySchool of Physical and ElectronicsCentral South UniversityChangsha410083China

Seeking and developing efficient CO_(2)reduction reaction(CO_(2)RR)electrocatalysts is a hot topic in this era of global warming.Among material candidates for sustainable and cost-effective applications,metal sulfides have attracted attention as promising nature-inspired materials due to multiple adsorption sites which are enhanced by the covalent character of sulfur.This article summarizes the current status regarding the utilization and development of metal sulfide materials as CO_(2)RR electrocatalysts.First,the research background and basic principles of electrochemical CO_(2)RR are introduced.Next,an overview of the main obstacles to developing efficient CO_(2)RR electrocatalysts is presented.The section is followed by a summary of the empirical evidence supporting the application of metal sulfides as CO_(2)RR electrocatalysts beside nature-inspired motivation.The summary of synthesis methods of various metal sulfides is also presented.Furthermore,the paper also highlights the recent works on metal sulfide as efficient CO_(2)RR including the undertaking strategy on the activity enhancement,and finally,discusses the challenges and prospect of metal sulfides-based CO_(2)RR electrocatalysts.Despite recent efforts,metal sulfides remain relatively unexplored as materials for CO_(2)RR electrocatalytic applications.Therefore,this review aims to stimulate novel ideas and research for improved catalyst designs and functionality.

关键词： Metal sulfides Electrocatalyst Electrochemical CO_(2)reduction Bi-metal sulfides Active site Defect engineering Selectivity Faradaic efficiency

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Recent advances in the utilization of copper sulfide compounds for electrochemical CO2 reduction

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纳米材料科学：英文版 2020年第3期2卷 235-247页

作者： Yingkang Chen Kejun Chen Junwei Fu akira yamaguchi Hongmei Li Hao Pan Junhua Hu Masahiro Miyauchi Min Liu State Key Laboratory of Powder Metallurgy Shenzhen Research InstituteSchool of Physics and ElectronicsCentral South UniversityPR China Department of Periodontics&Oral Mucosal Section Xiangya Stomatological HospitalCentral South University72 Xiangya RoadChangsha410008HunanPR China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002PR China Department of Materials Science and Engineering School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo152-8552Japan

Converting carbon dioxide(CO2)into value-added chemicals by CO2 reduction has been considered as a potential way to solve the current energy crisis and environmental problem.Among the methods of CO2 reduction,the electrochemical method has been widely used due to its mild reaction condition and high reaction efficiency.In the electrochemical reduction system,the CO2 electrocatalyst is the most important part.Although many CO2 electrocatalysts have been developed,efficient catalysts with high activity,selectivity and stability are still lacking.Copper sulfide compound,as a low-toxicity and emerging material,has broad prospects in the field of CO2 reduction due to its unique structural and electrochemical properties.Much progress has been achieved with copper sulfide nanocrystalline and the field is rapidly developing.This paper summarizes the preparation,recent progress in development,and factors affecting the electrocatalytic CO2 reduction performance with copper sulfide compound as a catalyst.Prospects for future development are also outlined,with the aim of using copper sulfide compound as a highly active and stable electrocatalyst for CO2 reduction.

关键词： CO2 reduction Copper sulfide compound Electrocatalyst Product selectivity

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Characteristics and Problem of Chrome-containing Refractory

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China's Refractories 2007年第3期16卷 3-7页

作者： akira yamaguchi Okayama Ceramics Research Foundation Nishikatakami 1406-18 Bizen Okayama 705-0021 Japan

One of characteristics of Cr2O3-containing refractory is excellent corrosion resistance. However, there is a problem of hexavalent chromium, which is noxious to the human body, and easily formed by the reactions among the refractory and CaO, Na2O and/or K2O in slag. In this article, the reason why the Cr2O3-containing refractory has excellent corrosion resistance, the forming conditions of hexavalent compounds, and the methods for suppressing generation of the compound, are described as a base of further development of excellent refractories.

关键词： Chrome-containing refractory Cr2O3 CaCr2O4 CaCrO4 Corrosion resistance Hexavalent chromium compound

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Criteria for versatile GaN MOVPE tool:high growth rate GaN by atmospheric pressure growth

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Journal of Semiconductors 2011年第1期32卷 21-23页

作者： Koh Matsumoto Kazutada Ikenaga Jun Yamamoto Kazuki Naito Yoshiki Yano Akinori Ubukata Hiroki Tokunaga Tadanobu Arimura Katsuaki Cho Toshiya Tabuchi akira yamaguchi Yasuhiro Harada Yuzaburo Ban Kousuke Uchiyama TN-EMC Ltd 2008-2 Wada TamaTokyo 206-0001Japan Business Strategy Planning div.Electronics Group TAIYO NIPPON SANSO Corporation 10 OkuboTsukuba 300-2611Japan Compound-semiconductor Division TAIYO NIPPON SANSO Corp. 6-2 KojimachoKawasaki-shi210-0861Japan

Growth rate has a direct impact on the productivity of nitride LED production. Atmospheric pressure growth of GaN with a growth rate as high as 10/zm/h and also Alo.lGao.gN growth of 1μm/h by using 4 inch by 11 production scale MOVPE are described. XRD of （002） and （102） direction was 200 arcsec and 250 arcsec, respectively. Impact of the growth rate on productivity is discussed.

关键词： MOVPE GaN： AlGaN atmospheric pressure growth high growth rate

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Treatment and care for elderly patients with oral and maxillofacial malignant tumors

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中国口腔颌面外科杂志 2008年第B5期6卷 169-170页

作者： Mie Tsujiuchi Takahiro Oneyama akira Tanaka akira yamaguchi Minako Suzuki Izumi Mataga Oral and Maxillofacial Surgery The Nippon Dental University Niigata Hospital Department of Oral and Maxillofacial Surgery 2 The Nippon Dental University School of Life Dentistry at Niigata Niigata Japan

Purpose: Oral care for elderly patients has recently required to prevent systemic complication such as pneumonia or infections and to control their nutrition in Japan。In general, they need support in daily because of low level of activities。When treatment of the radical cure by the surgery may cause a fall of ADL (activity of daily living index) or QOL(quality of life) by postoperative after effects, therefore the choice of treatments is important。Methods: Subjectes are 15 elderly patients older than 65 years of age requiring support care treated in our hospital with oral and maxillofacial malignant tumors during the 6 years between 2001 and 2006。They were ten women and five men, with an age ranged from 66 to 93 years (median, 84.6 years)。A retrospective study was performed with the review of available medical records including primary site, stage, pathology, general status, complication, daily independence degree, ADL, thought for the treatment,treatment content and prognosis。Results: Primary tumors were five tongue carcinomas, four gum of maxilla, three gum of mandible,two buccal carcinomas and one carcinoma of floor of the mouth。Progress of each tumors, two T1, three T2, six T3 and four T4 in T category, and more than half was occupied by T3 in this series。All squamous cell carcinoma histopathologically。The most frequent systemic complication was cerebrovascular disorder, second was dementia followed by cardiac disease, fracture of femur。For ADL of their patients varied, and in other words there was the patient of complete bedridden state, the care-giver are always necessary whenever they eat, move and take a bath even during treatment tumors。In the therapy for malignant tumors, palliative treatment is often selected because of these systemic complications and also easy shifted to the treatment for a termination phase。Conclusion: For the elderly patients with oral and maxillofacial malignant tumors, daily support during treatment and oral care is important situation to complete the treatment and it is consider

关键词：口腔上颌面恶性肿瘤老年病人

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Numerical Simulation of Countercurrent Flow in a PWR Hot Leg by Using Two-Fluid Model

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Journal of Energy and Power Engineering 2013年第7期7卷 1215-1222页

作者： Michio Murase Yoichi Utanohara Chihiro Yanagi Takashi Takata akira yamaguchi Akio Tomiyama Institute of Nuclear Technology Institute of Nuclear Safety System Fukui 919-1205 Japan Department of Sustainable Energy and Environmental Engineering Osaka University Osaka 565-0871 Japan Department of Mechanical Engineering Kobe University Hyogo 657-8501 Japan

In order to evaluate CCFL (countercurrent flow limitation) characteristics in a PWR (pressurized water reactor) hot leg under reflux condensation, numerical simulations have been conducted using a 2F (two-fluid) model and a VOF (volume of fluid) method implemented in the CFD (computational fluid dynamics) software, FLUENT6.3.26. The 2F model gave good agreement with CCFL data in low pressure conditions but did not give good results for high pressure steam-water conditions. In the previous study, the computational grid and schemes were improved in the VOF method to improve calculations in circular tubes, and the calculated CCFL characteristics agreed well with the UPTF (Upper Plenum Test Facility) data at 1.5 MPa. In this study, therefore, using the 2F model and the computational grid previously improved for the VOF calculations, numerical simulations were conducted for steam-water flows at 1.5 MPa under PWR full-scale conditions. In the range of medium gas volumetric fluxes, the calculated CCFL characteristics agreed well with the values calculated by the VOF method and the UPTF data at 1.5 MPa. This indicated that the reference set of the interfacial drag correlations employed in this study could be applied not only to low pressures but also to high pressures.

关键词：双流体模型数值模拟计算流体动力学逆流压水堆 VOF方法 CCFL 流体体积

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CuPd催化剂调节中间反应能垒提高电催化CO_(2)生成二碳产物的选择性

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Chinese Journal of Catalysis 2021年第9期42卷 1500-1508页

作者：朱莉林翌阳刘康 Emiliano Cortés 李红梅胡俊华 akira yamaguchi 刘小良 Masahiro Miyauchi 傅俊伟刘敏中南大学物理与电子学院湖南长沙410083 慕尼黑大学物理学院慕尼黑德国郑州大学材料科学与工程学院河南郑州450052 东京工业大学材料与化工技术学院材料与科学工程系东京日本

过度的碳排放已造成了严重的全球环境问题,电催化CO_(2)还原是一种利用间歇性过剩电能将CO_(2)转化为有价值的化学物质的有效策略.在多种CO_(2)还原产物中,二碳(C2)产物(如乙烯、乙醇)因其比一碳产物(如甲酸、甲烷、甲醇)具有更高的能... 详细信息

过度的碳排放已造成了严重的全球环境问题,电催化CO_(2)还原是一种利用间歇性过剩电能将CO_(2)转化为有价值的化学物质的有效策略.在多种CO_(2)还原产物中,二碳(C2)产物(如乙烯、乙醇)因其比一碳产物(如甲酸、甲烷、甲醇)具有更高的能量密度而备受关注.Cu是唯一能用电化学方法将CO_(2)转化为多碳产物的单金属催化剂.如何提高Cu基催化剂上CO_(2)还原为C2产物的效率已引起了极大关注.电催化还原CO_(2)生成C2产物有两个重要步骤:一是参与碳碳偶联反应的CO*中间体的量(*代表中间体吸附在基底表面),二是碳碳偶联步骤的能垒.对于Cu单金属催化剂,虽然其表面碳碳偶联步骤的能垒相对较低,但是Cu对CO_(2)的吸附能力和CO_(2)*加氢能力并不高,导致在Cu表面不能生成足量的CO*中间体参与碳碳偶联反应,因而对C2产物的选择性和活性并不理想.与Cu单金属催化剂相反,在Pd单金属催化剂表面,CO*中间体的形成具有超快的反应动力学,但是CO*易在Pd表面中毒且后续碳碳偶联步骤的能垒极高,使其表面不能生成C2产物.为了充分发挥Cu(碳碳偶联步骤能垒较低)和Pd(CO*形成具有超快反应动力学)的双重优势,本文构建了一种紧密的CuPd(100)界面,以调节中间反应能垒,从而提高C2产率.密度泛函理论(DFT)计算表明,CuPd(100)界面增强了CO_(2)的吸附,且降低了CO_(2)*加氢步骤的能垒,从而能够催化生成更多的CO*中间体参与碳碳偶联反应.且CuPd(100)界面上CO_(2)还原为C2产物的电位决定步骤能垒为0.61 eV,低于Cu(100)表面的(0.72 eV).本文采用了一种简便的湿化学法制备了CuPd(100)界面催化剂.X射线衍射和X射线光电子能谱测试以及扩展X射线吸收精细结构光谱结果表明,合成的是相分离的CuPd双金属催化剂,而非CuPd合金催化剂.同时高分辨透射电镜可以观察到清晰的CuPd(100)界面.由此可见,本文成功合成了CuPd(100)界面催化剂.程序升温脱附实验结果表明,CuPd(100)界面对CO_(2)和CO*的吸附比Cu强,结果与理论预测一致.气体传感实验结果表明,CuPd(100)界面CO_(2)*加氢能力比Cu强.为评估CuPd(100)界面催化剂的催化活性,进行了CO_(2)电化学还原实验.结果表明,在0.1 mol/L的KHCO3电解液中,CuPd(100)界面催化剂在‒1.4 VRHE下,C2产物的法拉第效率为50.3%±1.2%,是同电位下Cu催化剂的(23.6%±1.5%)的2.1倍,C2产物的选择性是Cu催化剂的2.4倍,且具有更高的电流密度和更大的电化学活性面积.本文通过调控中间反应能垒以合理设计铜基CO_(2)还原电催化剂提供了参考.

关键词：二氧化碳电催化还原二碳产物铜钯界面催化剂中间反应能垒

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Evaluation of Linux Bonding Features

Evaluation of Linux Bonding Features

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2006 10th International Conference on Communication Technology（ICCT 2006）

作者： Stefan Aust Jong-Ok Kim Peter Davis akira yamaguchi Sadao Obana ATR Adaptive Communications Research Laboratories 2-2-2 Hikaridai Keihanna Science City Kyoto 619-0288 Japan

The paper contains an evaluation of the current Linux bonding implementation for wired interfaces. The Linux bonding provides methods to aggregate multiple wired interfaces to support load balancing, fault-tolerance and throughput improvement. The intention is to identify the performance of the current Linux bonding implementation and to use the results and assumptions for future discussions about bonding of wireless interfaces. The paper presents details about interface bonding in a RedHat Linux system and discusses measurement results of two bonded LAN interfaces using the round-robin bonding mode.

关键词： Linux Bonding Switches Throughput Fault tolerance Communication switching Out of order Local area networks Ethernet networks Personal communication networks

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