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Infectious Diseases of Poverty 2022年第5期11卷 87-89页

作者： akinola stephen oluwole Uwem Friday Ekpo Obiageli Josephine Nebe Nse Michael Akpan Solomon Monday Jacob Uche Veronica Amazigo John Russell Stothard Department of Pure and Applied Zoology Federal University of AgricultureAbeokutaOgun StateNigeria Neglected Tropical Disease Control Division Department of Public HealthFederal Ministry of HealthAbujaNigeria Pan-African Community Initiative on Education and Health(PACIEH) EnuguNigeria Department of Tropical Disease Biology Liverpool School of Tropical MedicineLiverpool L35QAUK.

Background With some 134,073,166 people living in endemic communities at risk of infection[1],Nigeria is the most endemic country in Africa and requires preventive chemotherapy(PC)for a total of 26.3 million persons[2].The National Schistosomiasis Elimination Programme(NSCHEP),with the support of international partners,has been implementing PC in Nigeria since 2009 and most recently will need to revise its current strategy(Additional file 1).For example,the new World Health Organization(WHO)guideline has six key recommendations that will dramatically change the implementation of schistosomiasis elimination in endemic countries[3].However,its impact and programmatic implications will vary from country to country,hence the need for a country-specific analysis.

关键词： schistosomiasis Schistosomiasis Nigeria

Water Resource, Hygienic Practice, and Soil Transmitted Helminthiasis in Some Rural Communities of Osun State, Nigeria

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Journal of Water Resource and Protection 2017年第2期9卷 99-110页

作者： Tolulope Sunday Fafunwa Hammed Oladeji Mogaji akinola stephen oluwole Abdulhakeem Adebiyi Adeniran Mariam Tobi Fagbenro Sammy Olufemi Sam-Wobo Babatunde Saheed Bada Uwem Friday Ekpo Department of Pure and Applied Zoology Federal University of Agriculture Abeokuta Nigeria Department of Animal and Environmental Biology Federal University Oye-Ekiti Oye-Ekiti Nigeria Department of Environmental Management and Toxicology Federal University of Agriculture Abeokuta Nigeria

Provision of water, sanitation and hygiene (WASH) resources has been advocated as necessary add-on strategy for sustainable control of soil-transmitted helminthiasis (STH) alongside annual mass drug administration (MDA) of albendazole to endemic communities. This study investigated the burden of STH and status of WASH resources in eight rural communities in Aiyedaade LGA, Osun State, Nigeria. Four of the communities were supported with improved water and hygiene resources (Category A), and another four supported only with improved water resources (Category B). Two hundred and sixteen (216) fresh stool samples were collected from consenting community members and screened for Ascaris lumbricoides, Hookworm and Trichuris trichiura infections using ether concentration method. The status and condition of WASH resources were determined using questionnaire and physical observation. An overall prevalence of 35.2% was observed for any STH infection. Species’ prevalence of Ascaris lumbricoides, Hookworm and Trichuris trichiura prevalence was 33.8%, 22.7%, and 0.5% respectively. Intensity of STH infection was significantly higher in Category A communities than in Category B communities. The prevalence of STH in Category A communities was higher (42.0%) than that in Category B communities (30.1%). There were significant differences (p = 0.000) in STH infections between the two categories. The status of improved water supply was not significantly different (p = 0.3153) in the two categories. Knowledge, attitude, and practices about STH, its transmission and control were low in both categories of communities. These results imply that current implementation of WASH which tends to focus on resource distribution, equity, and coverage, is unlikely to impact on STH transmission and control. Therefore, it is necessary for WASH providers to consider STH transmission control in their planning and implementation of WASH intervention for STH endemic communities.

关键词： Water Sanitation Hygiene Soil Transmitted Helminthiasis Osun State Nigeria

Neuropeptide cholecystokinin:a key neuromodulator for hippocampal functions

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Neural Regeneration Research 2025年第7期20卷 1991-1992页

作者： Fengwen Huang stephen Temitayo Bello Department of Neuroscience City University of Hong KongKowloon TongHong Kong Special Administrative RegionChina Center for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong Special Administrative RegionChina

Spatial memory is crucial for survival within external surroundings and wild *** hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and *** neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal ***(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target *** instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety ***,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.

关键词： abundant functions modulator

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

是否应该在非洲医学院校中教授补充替代医学?(英文)

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中西医结合学报 2011年第11期9卷 1165-1169页

作者： oluwole Busayo akinola Department of Anatomy Faculty of Basic Medical SciencesCollege of Health SciencesUniversity of IlorinIlorinNigeria

在非洲社会,补充替代医学疗法是家庭常用的疗法。大多数非洲人使用补充替代医学疗法替代主流医学疗法。出现这一现象的原因一是因为传统,二是因为很多人从经济上无法负担常规的治疗手段。在发达国家,补充替代医学的使用不断增长,因此,... 详细信息

在非洲社会,补充替代医学疗法是家庭常用的疗法。大多数非洲人使用补充替代医学疗法替代主流医学疗法。出现这一现象的原因一是因为传统,二是因为很多人从经济上无法负担常规的治疗手段。在发达国家,补充替代医学的使用不断增长,因此,这些国家的很多医学院校将补充替代医学的课程纳入了医学本科生的课程体系。而在非洲,大部分医学院校并没有向学生教授补充替代医学。基于越来越多的非洲人开始使用补充替代医学疗法,以及潜在的补充替代医学疗法与常规疗法的相互作用,医生们有必要熟知那些常用的补充替代医学疗法。要达到这一目标,建议将补充替代医学的课程纳入非洲医学院校医学本科生的授课体系。这将有助于未来的非洲医生掌握整体治疗的手段,并与国际的发展趋势接轨。

关键词：教育医学补充疗法非洲

Effects of Navier slip on unsteady flow of a reactive variable viscosity non-Newtonian fluid through a porous saturated medium with asymmetric convective boundary conditions

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Journal of Hydrodynamics 2015年第6期27卷 934-944页

作者： RUNDORA Lazarus MAKINDE oluwole Daniel Department of Mathematics and Applied Mathematics University of LimpopoTurfloop Campus Faculty of Military Science Stellenbosch University

A study on the effects of Navier slip, in conjunction with other flow parameters, on unsteady flow of reactive variable viscosity third-grade fluid through a porous saturated medium with asymmetric convective boundary conditions is presented. The channel walls are assumed to be subjected to asymmetric convective heat exchange with the ambient, and exothermic chemical reactions take place within the flow system. The heat exchange with the ambient obeys Newton＇s law of cooling. The coupled equations, arising from the law of conservation of momentum and the first law of thermodynamics, then the derived system are non- dimensionalised and solved using a semi-implicit finite difference scheme. The lower wall slip parameter is observed to increase the fluid velocity profiles, whereas the upper wall slip parameter retards them because of backflow at the upper channel wall. Heat pro- duction in the fluid is seen to increase with the slip parameters. The wall shear stress increases with the slip parameters while the wall heat transfer rate is largely unaltered by the lower wall slip parameter but marginally increased by the upper wall slip parameter.

关键词： Navier slip saturated porous medium third-grade fluid temperature dependent viscosity convective boundary condi-tions

A Unified Spatio-Temporal Framework of the Cuerno-Barabasi Stochastic Continuum Model of Surface Sputtering

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Communications in Theoretical Physics 2012年第7期58卷 165-170页

作者： oluwole Emmanuel Oyewande Department of Physics University of Ibadan

The nonlinear continuum model proposed by Cuerno and Barabasi is the most successful and widely acceptable theoretical description of oblique incidence ion sputtered surfaces to date and is quite robust in its predictions of the time evolution and scaling of interfaces driven by ion bombardment. However, this theory has thus far predicted only ripple topographies and rough surfaces for short and large scales, respectively. As a result, its application to the interpretation and study of nanodots, predicted by Monte Carlo simulations for, and observed in experiments of, oblique incidence sputtering is still unclear and, hence, an open problem. In this paper, we provide a new insight to the theory, within the same length scale, that explains nanodot formation on off-normal incidence sputtered surfaces, among others, and propose ways of observing the predicted topographies of the MC simulations, as well as possible control of the size of the nanodots, in the framework of the Cuerno-Barabasi continuum theory.

关键词： topographic phase diagrams surface nanostructures surface nanodots Cuerno-Barabasi model

Nutritional quality, functional property and acceptability of maize (Zea mays) based complementary foods enriched with defatted groundnut (Arachis hypogea L.) and ginger (Zinger officinale Roscoe) powder in Wistar rats

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Food Production, Processing and Nutrition 2022年第1期4卷 144-161页

作者： oluwole Steve Ijarotimi Department of Food Science and Technology Federal University of TechnologyAkureNigeria

Traditional complementary foods in Africa are cereal-based, low in nutrient-density;hence, causing severe-acute-malnutrition. This study was aimed to formulate and evaluate nutritional quality of complementary foods (CF) using locally available food materials. Yellow maize (raw, germinated & fermented), defatted groundnut (DGF) and ginger flour (GGF) were blended to obtain RDG (76.7% raw yellow maize, 20.8% DGF and 2.5% GGF), GDG (74.4% germinated yellow maize, 23.1% DGF, 2.5% GGF), and FDG (72.6% fermented yellow maize, 24.9% DGF, 2.5% GGF). Food samples were evaluated for nutritional qualities and sensory attributes using standard methods. Protein (g/100 g), energy value (kCal/100 g), total amino acids and essential amino acids (g/100 g protein) of formulated CF ranged from 19.38 to 28.58, 373.49 to 394.53, 87.33 to 91.89 and 36.17 to 37.63, respectively, and were comparable to control (17.07, 401.22, 94.47 & 35.35). Minerals were present in appreciable amount in the foods, while phytate/mineral (Ca, Fe, Zn) and oxalate/calcium molar ratios were lower than critical levels. Bulk density (1.4 - 1.6 g/mL), least gelation (4 - 6%), water absorption capacity (10.5 - 15.8%) and swelling capacity (0.5 - 1.2%) were significantly (p < 0.05) lower in formulated CF than in control, except for bulk density. Biological value (78.44%) of FDG was significantly (P < 0.05) higher than GDG (78.4%) and RDG (75.87%), respectively, but lower than control (93.48%). Pack cell volume (22.50%), haemoglobin concentration (7.5 g/dL), red blood cell (3 × 103 mm− 3), albumin (3.72 g/dL), total blood protein (5.62 g/dL) and globulin (1.9 g/dL) of rats fed on FDG were significantly (p < 0.05) higher than other diets, but comparable to that of control. Kidney (urea, 10.16 mg/dL;creatinine, 4.8 mg/dL) and liver function index (AST/ALT ratio, 0.38) of rats fed on FDG were lower than in those rats fed on RDG, GDG and control. For sensorial attributes, RDG was ranked best next by FDG in appearance,

关键词： Infant diets Protein-energy-density complementary foods Indigenous food materials Home-based processing methods

Doctoral research on architecture in Niseria： Exploring domains, extending boundaries

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Frontiers of Architectural Research 2016年第1期5卷 134-142页

作者： Adetokunbo oluwole Ilesanmi Department of Architecture Obafemi Awolowo University lie lfe Osun Nigeria

This paper explored through a literature review, the domains of research in Architecture and the nature of doctoral research, with a view to contributing to the evolving research agenda in the Nigerian context. The research method involved a descriptive and thematic analysis of the titles and abstracts of completed doctoral theses in Architecture in Nigeria, in the last 26 years （1990-2015）, complemented by semi-structured interviews with six key informants. The study revealed an emphasis on Housing-related topics （34%） relative to other research modules, such as＇ History and Theory＇（20%） and ＇Design and Production＇（18%）. It also reflected the limited coverage and scope of current research, relative to the global terrain, as evidenced in the article titles and contents of 45 Architecture-related Journals. The results of the interviews indicated the strong influence of supervisors＇ areas of interest in the choices of thesis titles. It highlighted reasons for the perceived focus on Housing, which reflect its unique place and multi-disciplinary nature. It concluded that extending the boundaries of architectural research at the doctoral level could be beneficial to the discipline and profession in Nigeria in order to align with global trends, while keeping cognizance of the local contexts.

关键词： Architectural research Doctoral Domain Housing Nigeria Research agenda

Thermal criticality for a reactive gravity driven thin film flow of a third-grade fluid with adiabatic free surface down an inclined plane

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Applied Mathematics and Mechanics(English Edition) 2009年第3期30卷 373-380页

作者： oluwole Daniel Makinde Zhe-wei ZHOU Faculty of Engineering Cape Peninsula University of Technology P. O. Box 1906 Bellville 7535 South Africa 不详

This study is devoted to the investigation of thermal criticality for a reactive gravity driven thin film flow of a third-grade fluid with adiabatic free surface down an inclined isothermal plane. It is assumed that the reaction is exothermic under Arrhenius kinetics, neglecting the consumption of the material. The governing non-linear equations for conservation of momentum and energy are obtained and solved by using a new computational approach based on a special type of Hermite-Padé approximation technique implemented in MAPLE. This semi-numerical scheme offers some advantages over solutions obtained with traditional methods such as finite differences, spectral method, and shooting method. It reveals the analytical structure of the solution function. Important properties of overall flow structure including velocity field, temperature field, thermal criticality, and bifurcations are discussed.

关键词： isothermal inclined plate third-grade fluid Hermite-Padé approximation thermal criticality