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Russell body gastritis with Dutcher bodies evaluated using magnification endoscopy

World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 417-424页

作者： Kenji Yorita Takehiro Iwasaki Kunihisa Uchita Naoto Kuroda Koji Kojima Shinichi Iwamura Yutaka Tsutsumi akinobu ohno Hiroaki Kataoka Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital Department of Internal Medicine Japanese Red Cross Kochi Hospital Department of Pathology Fujita Health University School of Medicine Pathology Section University of Miyazaki Hospital Section of Oncopathology and Regenerative Biology Department of PathologyFaculty of MedicineUniversity of Miyazaki

Russell body gastritis(RBG) is an unusual type of chronic gastritis characterized by marked infiltration of Mott cells,which are plasma cells filled with spherical eosinophilic bodies referred to as Russell *** was initially thought that Helicobacter pylori(***) infection was a major cause of RBG and that the infiltrating Mott cells were polyphenotypic;however,a number of cases of RBG without *** infection or with monoclonal Mott cells have been ***,diagnostic difficulty exists in distinguishing RBG with monoclonal Mott cells from malignant ***,we report an unusual case of an 86-year-old-Japanese man with ***-positive *** the examination of melena,endoscopic evaluation confirmed a 13-mm whitish,flat lesion in the gastric *** endoscopy with narrowband imaging suggested that the lesion was most likely a poorly differentiated *** findings were consistent with chronic gastritis with many Mott cells with intranuclear inclusions referred to as Dutcher *** submucosal dissection confirmed the diagnosis of RBG with kappa-restricted monoclonal Mott *** lymphoma was unlikely given the paucity of cytological atypia and Ki-67 immunoreactivity of monoclonal Mott *** is the first reported case of RBG with endoscopic diagnosis of malignant tumor and the presence of Dutcher bodies.

关键词： Russell body gastritis Mott cell Dutcher body Mucosa-associated lymphoid tissue lymphoma Plasmacytoma Magnification endoscopy with narrow-band imaging

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