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Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

World Journal of Gastroenterology 2015年第7期21卷 2108-2115页

作者： Yasuharu Maeda Kazuo Ohtsuka Shin-ei Kudo Kunihiko Wakamura Yuichi Mori Noriyuki Ogata Yoshiki Wada Masashi Misawa akihiro yamauchi Seiko Hayashi Toyoki Kudo Takemasa Hayashi Hideyuki Miyachi Fuyuhiko Yamamura Fumio Ishida Haruhiro Inoue Shigeharu Hamatani Digestive Disease Center Showa University Northern Yokohama Hospital Department of Gastroenterology and Hepatology Tokyo Medical and Dental University Hospital Endoscopy Center Showa Hospital Department of Pathology Showa University Northern Yokohama Hospital

AIM:To assess the efficacy of endocytoscopic narrowband imaging(EC-NBI)for evaluating the severity of inflammation in ulcerative colitis(UC).METHODS:This retrospective study was conducted at a single tertiary care referral *** included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December *** was performed,and the images were evaluated by assessing visibility,increased vascularization,and the increased calibers of capillaries and were classified as Obscure,Visible or *** was indicative of inactive disease,while Visible and Dilated were indicative of acute *** study received Institutional Review Board *** primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological *** conventional endoscopic images were classified according to the Mayo endoscopic score.A score of 0 or 1 indicated inactive disease,whereas a score of 2 indicated active ***:Fifty-two patients were *** was a strong correlation between the EC-NBI findings and the histological assessment(r=0.871,P<0.01).The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%,100%,87.1%,100%,and 92.3%,respectively,while those for the Mayo endoscopic score were 100%,40.7%,100%,61.0%,and 69.2%,*** with conventional endoscopy,EC-NBI was superior in diagnostic specificity,negative predictive value,and accuracy(P<0.001,P=0.001 and P=0.047,respectively).CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC.

关键词： Endosytoscopy Narrow-band imaging Magnified endosc

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Superconducting joints using reacted multifilament MgB_(2)wires:A technology toward cryogen-free MRI magnets

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Journal of Magnesium and Alloys 2024年第1期12卷 159-170页

作者： Dipak Patel Akiyoshi Matsumoto Hiroaki Kumakura Yuka Hara Toru Hara Minoru Maeda Hao Liang Yusuke yamauchi Seyong Choi Jung Ho Kim Md Shahriar A.Hossain School of Mechanical and Mining Engineering The University of QueenslandSt LuciaQueensland 4072Australia National Institute for Materials Science(NIMS) 1-2-1 SengenTsukubaIbaraki 305-0047Japan Department of Electrical Engineering and Kangwon High Magnetic Field Center Institute of Quantum Convergence TechnologyKangwon National UniversityGangwon 24341Republic of Korea Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandSt LuciaQueensland 4072Australia Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityNagoyaAichi 464-8603Japan Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongNorth WollongongNew South Wales 2500Australia

The development of superconducting joining technology for reacted magnesium diboride(MgB_(2))conductors remains a critical challenge for the advancement of cryogen-free MgB_(2)-based magnets for magnetic resonance imaging(MRI).Herein,the fabrication of superconducting joints using reacted carbon-doped multifilament MgB_(2)wires for MRI magnets is *** achieve successful superconducting joints,the powder-in-mold method was employed,which involved tuning the filament protection mechanism,the powder compaction pressure,and the heat treatment *** fabricated joints demonstrated clear superconducting-to-normal transitions in self-field,with effective magnetic field screening up to 0.5 T at 20 *** evaluate the interface between one of the MgB_(2)filaments and the MgB_(2)bulk within the joint,serial sectioning was conducted for the first time in this type of superconducting *** serial sectioning revealed space formation at the interface,potentially caused by the volume shrinkage associated with the MgB_(2)formation or the combined effect of the volume shrinkage and the different thermal expansion coefficients of the MgB_(2)bulk,the filament,the mold,and the sealing *** findings are expected to be pivotal in developing MgB_(2)superconducting joining technology for MRI magnet applications through interface engineering.

关键词： Mg B2 superconducting joint MgB_(2)conductor MRI applications Cryogen-free magnet Persistent-mode operation

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Ageing Society and Assistive Products

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稀有金属材料与工程 2006年第A3期35卷 67-70页

作者： Shigeru yamauchi Department of Health Science and Social Welfare Faculty of Human Sciences Waseda UniversityMikajima 2-579-15TokorozawaSaitama 359-1192Japan

North East Asian countries are facing to rapid increase in aged population *** most recent values of aged population ratios are 19.5%,8.7%,and 6.9%,for Japan,Korea and China,*** of the welfare services in the aged society is provision of assistive *** control systems are commonly adopted in modern assistive products and sensors are indispensable for control *** systems,such as fire alarm,smoke detectors,and gas leak detectors,have been regarded as indispensable to safety of elderly persons and persons with *** application of chemical sensors in home care of elderly persons is in the field of personal care and personal medical *** for personal medical treatment include that for medical treatment in home care and that to keep elderly persons *** market is expected in the latter one.

关键词： population ageing assistive products long term care personal mental treatment

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Species-dependent effects of the phenolic herbicide ioxynil with potential thyroid hormone disrupting activity: modulation of its cellular uptake and activity by interaction with serum thyroid hormone-binding proteins

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Journal of Environmental Sciences 2012年第5期24卷 949-955页

作者： Sakura Akiyoshi Gobun Sai Kiyoshi yamauchi Department of Biological Science Faculty of Science Shizuoka University

Ioxynil, a phenolic herbicide, is known to exert thyroid hormone （TH） disrupting activity by interfering with TH-binding to plasma proteins and a step of the cellular TH-signaling pathway in restricted animal species. However, comparative studies are still lacking on the TH disruption. We investigated the interaction of [125I] ioxynil with serum proteins from rainbow trout, bullfrog, chicken, pig, rat, and mouse, using native polyacrylamide gel electrophoresis. Candidate ioxynil-binding proteins, which included lipoproteins, albumin and transthyretin （TTR）, differed among the vertebrates tested. Rainbow trout and bullfrog tadpole serum had the lowest binding activity for ioxynil, whereas the eutherian serum had the highest binding activity. The cellular uptake of, and response to, ioxynil were suppressed by rat serum greater than by tadpole serum. The cellular uptake of [125I]ioxynil competed strongly with phenols with a single ring, but not with THs. Our results suggested that ioxynil interferes with TH homeostasis in plasma and with a step of cellular TH-signaling pathway other than TH-uptake system, in a species-specific manner.

关键词： endocrine disruption ioxynil thyroid hormone serum transthyretin uptake

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Bin-scanning:Segmentation of X-ray CT volume of binned parts using Morse skeleton graph of distance transform

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Computational Visual Media 2023年第2期9卷 319-333页

作者： Yuta yamauchi Tatsuya Yatagawa Yutaka Ohtake Hiromasa Suzuki School of Engineering The University of Tokyo7–3–1HongoBunkyo-kuTokyoJapan

X-ray CT scanners,due to the transmissive nature of X-rays,have enabled the non-destructive evaluation of industrial products,even inside their *** light of its effectiveness,this study introduces a new approach to accelerate the inspection of many mechanical parts with the same shape in a *** input to this problem is a volumetric image(i.e.,CT volume)of many parts obtained by a single CT *** need to segment the parts in the volume to inspect each of them;however,random postures and dense contacts of the parts prohibit part segmentation using traditional template *** address this problem,we convert both the scanned volumetric images of the template and the binned parts to simpler graph structures and solve a subgraph matching problem to segment the *** perform a distance transform to convert the CT volume into a distance ***,we construct a graph based on Morse theory,in which graph nodes are located at the extremum points of the distance *** experimental evaluation demonstrates that our fully automatic approach can detect target parts appropriately,even for a heap of 50 ***,the overall computation can be performed in approximately 30 min for a large CT volume of approximately 2000×2000×1000 voxels.

关键词： X-ray computed tomography(CT) volume segmentation graph matching non-destructive inspection

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Gas6-Tyro3 signaling is required for Schwann cell myelination and possible remyelination

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Neural Regeneration Research 2016年第2期11卷 215-216页

作者： Tomohiro Torii Junji yamauchi apan Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Bunkyo Tokyo lapan

Myelin plays important roles in vertebrates,ensuring the rapid propagation of action potentials and the long-term integrity of axons,but the molecular mechanisms of myelin formation remain poorly *** studies have demo... 详细信息

关键词： cell Gas6-Tyro3 signaling is required for Schwann cell myelination and possible remyelination LINGO

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Changes in serum thyroid hormone levels and thyroid gland activity of artificially maturing female Japanese eel (Anguilla japonica)

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Acta Oceanologica Sinica 2003年第1期22卷 111-122页

作者：曲宪成 Massaki Nagae Sinji Adachi Kohei yamauchi Fisheries College Shanghai Fisheries University334 Jungong RoadShanghai 200090China Faculty of Environmental Studies Course of Environmental Conservation and PlanningNagasaki University1-14 Bunkyo-machiNagasaki 852-8521Japan Department of Biology Faculty of FisheriesHokkaido University3-1-1 Minato-choHakodate 041-0821Japan

In order to evaluate the involvement of the thyroid gland in reproduction, thyroid functioning was described in female cultivated Japanese eel (Anguilla japonica) in progressive stages of sexual maturation induced by chum salmon pituitary homogenate (SPH) treatment. Serum thyroid hormones, thyroxine (T4) and triiodothyronine (T3) were also measured in each stage. Thyroid gland activity (epithelial cell height) was high before SPH injection (previtellogenic stage), further increasing at the early vitellogenic stage, thereafter decreasing to late vitellogenic and migratory nucleus stages. The profiles of both T3 and T4 changed during vitellogenesis, being high during previtellogenic and early vitellogenic stages, and subsequently declining, thus mimicking thyroid gland activity. These results suggest that the thyroid has relation with eel ovarian development during artificial maturation.

关键词： Thyroid activity thyroxine (T4) triiodothyronine (T3) Japanese eel artificial maturation

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Study of Optical Fibers Strain-Temperature Sensitivities Using Hybrid Brillouin-Rayleigh System

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Photonic Sensors 2014年第1期4卷 1-11页

作者： Kinzo Kishida Yoshiaki yamauchi Artur Guzik Neubrex Co.Ltd. Sakaemachi-dori 1-1-24Chuo-kuKobeHyogo650-0023Japan

In this paper, the most recent progress as well as challenges of distributed optical fiber sensing （DOFS） in industrial applications is discussed. Compared to the vast market of sensors used to measure strain or temperature, the success of distributed optical fiber sensing （DOFS） at the industrial level is very limited, at best. One of the reasons for this lack of the wider acceptance is the mismatch between the commercially available systems and actual industrial requirements, especially for the spatial resolution and precision. These requirements are organized and clarified in the paper. It also describes the hybrid Brillouin-Rayleigh system, which exhibits capabilities surpassing those of strain gauges. The principles of the system are illustrated considering the fiber calibration methodology. Formulas required for determining strain, temperature, and hydro-pressure are derived and discussed. Finally, the examples of applications are presented.

关键词： Hybrid Brillouin/Rayleigh system cross-sensitivity material dependence

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Non-genetic contributions of the sperm nucleus to embryonic development

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Asian Journal of Andrology 2011年第1期13卷 31-35页

作者： Yasuhiro yamauchi Jeffrey A Shaman W Steven Ward Department Anatomy and Reproductive Biology Institute for Biogenesis Research John A. Burns School of Medicine University of Hawaii at Manoa Honolulu HI USA GLP Services GENEWlZ Inc. 115 Corporate Blvd. South Plainfield NJ 07080 USA

Recent data from several laboratories have provided evidence that the newly fertilized oocyte inherits epigenetic signals from the sperm chromatin that are required for proper embryonic development. For the purposes of this review, the term epigenetic is used to describe all types of molecular information that are transmitted from the sperm cell to the embryo. There are at least six different forms of epigenetic information that have already been established as being required for proper embryogenesis in mammals or for which there is evidence that it may do so. These are （i） DNA methylation; （ii） sperm-specific histones, （iii） other chromatin-associated proteins; （iv） the perinuclear theca proteins; （v） sperm-born RNAs and, the focus of this review; and （vi） the DNA loop domain organization by the sperm nuclear matrix. These epigenetic signals should he considered when designing protocols for the manipulation and cryopreservation of spermatozoa for assisted reproductive technology as necessary components for effective fertilization and subsequent embryo development.

关键词： embryogenesis epigenetics sperm DNA sperm nuclear matrix DNA loop domain organization

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Machine learning adaptation of intraocular lens power calculation for a patient group

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Eye and Vision 2021年第5期8卷 422-430页

作者： Yosai Mori Tomofusa yamauchi Shota Tokuda Keiichiro Minami Hitoshi Tabuchi Kazunori Miyata Miyata Eye Hospital 6‑3 Kurahara‑choMiyakonojoMiyazaki 885‑0051Japan Department of Ophthalmology Tsukazaki Hospital68‑1 WakuAboshi‑kuHimejiHyogo 671‑1227Japan Department of Technology and Design Thinking for Medicine Hiroshima University1‑2‑3 KasumiMinami‑kuHiroshima 734‑8553Japan

Background:To examine the effectiveness of the use of machine learning for adapting an intraocular lens(IOL)power calculation for a patient ***:In this retrospective study,the clinical records of 1,611 eyes of 1,169 Japanese patients who received a single model of monofocal IOL(SN60WF,Alcon)at Miyata Eye Hospital were reviewed and *** biometric metrics and postoperative refractions of 1211 eyes of 769 patients,constants of the SRK/T and Haigis formulas were *** SRK/T formula was adapted using a support vector *** errors in the use of adapted formulas as well as the SRK/T,Haigis,Hill-RBF and Barrett Universal II formulas were evaluated with data from 395 eyes of 395 distinct *** prediction errors,median absolute errors,and percentages of eyes within±0.25 D,±0.50 D,and±1.00 D,and over+0.50 D of errors were compared among ***:The mean prediction errors in the use of the SRT/K and adapted formulas were smaller than the use of other formulas(P<0.001).In the absolute errors,the Hill-RBF and adapted methods were better than *** performance of the Barrett Universal II was not better than the others for the patient *** were the least eyes with hyperopic refractive errors(16.5%)in the use of the adapted ***:Adapting IOL power calculations using machine learning technology with data from a particular patient group was effective and promising.

关键词： Machine learning Adaptation Intraocular lens power calculation Patient ethnicity Patient race Region of patient SRK/T formula

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