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Levels of evidence and grades of recommendation supporting European society for medical oncology clinical practice guidelines

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Oncology Research 2024年第5期32卷 807-815页

作者： MARKO SKELIN BRUNA PERKOV-STIPIČIN SANJA VUŠKOVIĆ MARINAŠANDRK PLEHAČEK ANE BAŠIĆ DAVIDŠARČEVIĆ MAJA ILIĆ IVAN KREČak Pharmacy Department General Hospital ofŠibenik-Knin CountyŠibenikCroatia Faculty of Medicine University of RijekaRijekaCroatia Undergraduate Study in Nursing University of Applied SciencesŠibenikCroatia Department of Oncology University Hospital Center ZagrebZagrebCroatia Pharmacies Joukhadar Sveta NedeljaCroatia Pharmacies Prima Pharme ZagrebCroatia Pharmacy Department General Hospital ZadarZadarCroatia Pharmacy Department General Hospital PulaPulaCroatia Department of Internal Medicine General Hospital ofŠibenik-Knin CountyŠibenikCroatia

Background:The European Society for Medical Oncology(ESMO)guidelines are among the most comprehensive and widely used clinical practice guidelines(CPGs)***,the level of scientific evidence supporting ESMO CPG recommendations has not been systematically *** study assessed ESMO CPG levels of evidence(LOE)and grades of recommendations(GOR),as well as their trends over time across various cancer ***:We manually extracted every recommendation with the Infectious Diseases Society of America(IDSA)classification from each *** examined the distribution of LOE and GOR in all available ESMO CPG guidelines across different topics and cancer ***:Among the 1,823 recommendations in the current CPG,30%were classified as LOEⅠ,and 43%were classified as GOR ***,there was a slight decrease in LOEⅠ(−2%)and an increase in the proportion of GOR A(+1%)in the current CPG compared to previous *** proportion of GOR A recommendations based on higher levels of evidence such as randomized trials(LOEⅠ–Ⅱ)shows a decrease(71%vs.63%,p=0.009)while recommendations based on lower levels of evidence(LOEⅢ–Ⅴ)show an increase(29%vs.37%,p=0.01)between previous and current *** the current versions,the highest proportion of LOEⅠ(42%)was found in recommendations related to pharmacotherapy,while the highest proportion of GOR A recommendations was found in the areas of pathology(50%)and diagnostic(50%)*** variability in LOEⅠand GOR A recommendations and their changes over time was observed across different cancer ***:One-third of the current ESMO CPG recommendations are supported by the highest level of *** well-designed randomized clinical trials are needed to increase the proportion of LOEⅠand GOR A recommendations,ultimately leading to improved outcomes for cancer patients.

关键词： ESMO guidelines Clinical practice guidelines Level of evidence Grade of recommendation

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对目前葡萄球菌分类的补充意见

国外医学(微生物学分册) 1990年第2期 82-83页

作者： akaTob ak 桂海泉

本文介绍了到目前为止已被发现的葡萄球菌至少有23种,这些种均经DNA同源性测定和DNA杂交证明其成立。

关键词：葡萄球菌亚种血浆凝固酶微球菌

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H_1受体拮抗剂对荨麻疹瘙痒的治疗作用

国外医学（皮肤性病学分册） 1993年第2期19卷 107-109页

作者： Black ak 钱恒林

复习了 H_1抗组胺药对慢性特发性荨麻疹和物理性荨麻疹瘙痒及风团的治疗效果。为致不多的研究表明,在应用 H_1抗组胺药治疗时,尽管存在着个体差异,但瘙痒及风团同时平均减轻2/3。在某些物理性荨麻疹患者,瘙痒和风团以及红斑的改善不成... 详细信息

复习了 H_1抗组胺药对慢性特发性荨麻疹和物理性荨麻疹瘙痒及风团的治疗效果。为致不多的研究表明,在应用 H_1抗组胺药治疗时,尽管存在着个体差异,但瘙痒及风团同时平均减轻2/3。在某些物理性荨麻疹患者,瘙痒和风团以及红斑的改善不成比例。镇静作用轻微的 H_1抗组胺药疗效等同于或较强于经典的抗组胺药。抗组胺药完全消除组胺风团的剂量仅部分减轻荨麻疹风团,由此推理对瘙痒作用亦相同。因此,有必要寻求针对组胺以外的致痒介质的疗法,以改善荨麻疹的瘙痒情况。

关键词：荨麻疹瘙痒 H1受体拮抗剂

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苯妥英的皮肤反应及免疫反应

国外医学（皮肤性病学分册） 1989年第3期15卷 155-158页

作者： Silverman ak 钱恒林

苯妥英又名二苯乙内酰脲或大仑丁,它是临床上应用广泛的抗惊厥及抗心律失常药物。最近几年皮肤病学家又利用它治疗隐性遗传性营养不良型大疱性表皮松解症、带状硬皮病和先天性厚甲症等。相对来说,其并发症是很少的,但对其所引起的多种... 详细信息

苯妥英又名二苯乙内酰脲或大仑丁,它是临床上应用广泛的抗惊厥及抗心律失常药物。最近几年皮肤病学家又利用它治疗隐性遗传性营养不良型大疱性表皮松解症、带状硬皮病和先天性厚甲症等。相对来说,其并发症是很少的,但对其所引起的多种皮肤及免疫反应已有报道,现综述如下。苯妥英的药理学在成年人苯妥英经胃肠道吸收很快,肌注则吸收较慢,其半衰期为22小时,而且容易保持稳定的治疗水平(10～20μg/ml)。在婴儿及儿童,由于解毒系统发育不成熟,苯妥英的半衰期及血浆水平变化很大,因此在治疗时。

关键词：苯妥英皮肤免疫

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An Overview of Turkish Pistachio Sector

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Journal of Agricultural Science and Technology(B) 2011年第2期1卷 168-176页

作者： T. Isgin B. E. ak Department of Agricuhural Economics University of Harran Osmanbey Campus Block D-52 Sanliurfa 63100 Turkey Department of Horticulture University of Harran Osmanbey Campus Block C. Sanliurfa 63100 Turkey

Originating from the genus Pistacia, the only edible species, Pistacia vera, covers at least 10 different sub-species and has a commercial value in the nut industry as a snack food. Pistachio kernels arc very popular ingredients used in meat products and in the confectionary industry as a part of various pastry products. Historically, Iran has the advantage in supply side and leads the world in pistachio trade. Turkey comes in the third place in terms of production and provides over 70 thousand metric tons of pistachios in 2007, capturing 14 percent production share world wide. As being one of the major habitats of pistachios, Turkey has potential to develop new variaties and increase the productivity, thereby to take advantage of higher profits that may arise from foreign trade in pistachios. Even though pistachio production in Turkey has increased in the last 20 years, this opportunity is yet to be discovered since yield and quality factors are still at low levels, resulting in dramatic losses in foreign market shares. Possible remedies for this problem include irrigation made available to pistachio orchards, adopting new caltivars more tolerant to diseases, preventing the illegal entrance of Iranian pistachios, facilitating the unification of pistachio producers, provoking the consumption of fresh pistachios, and expanding the business into new international markets.

关键词： Pistachio foreign trade production Turkey.

Global trends in research related to sleeve gastrectomy:A bibliometric and visualized study

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World Journal of Gastrointestinal Surgery 2021年第11期13卷 1509-1522页

作者： Abdulkarim Barqawi Faris ak Abushamma Maha akkawi Samah W Al-Jabi Moyad Jamal Shahwan Ammar Abdulrahman Jairoun Sa'ed H Zyoud Department of Medicine College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of General Surgery An-Najah National University HospitalNablus 44839Palestine Department of Urology An-Najah National University HospitalNablus 44839Palestine Department of Pathology An-Najah National University HospitalNablus 44839Palestine Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Clinical Sciences College of Pharmacy and Health SciencesAjman UniversityAjman 346United Arab Emirates Department of Health and Safety Dubai MunicipalityDubai 67United Arab Emirates Poison Control and Drug Information Center College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research Centre An-Najah National University HospitalNablus 44839Palestine

BACKGROUND One of the most popular bariatric procedures is sleeve gastrectomy,and it has become significantly more common in recent *** To evaluate the research activity in sleeve gastrectomy over the last two decades,and to visualize the hot spots and emerging trends in this type of bariatric surgeryusing bibliometric *** The Scopus database was used to search for publications related to sleeve *** retrieved publications were reviewed in terms of year of publication,type of study,country of origin,institutions,journals,and citation patterns by using descriptive *** network and term cooccurrence analysis were visualized by using VOSviewer *** The search strategy yielded a total of 6508 publications on sleeve gastrectomy from 2001 to *** regards the document type,the majority were articles(n=5230;80.36%),followed by reviews(n=544;8.36%).The top three countries are the United States,with 1983 publications(30.47%),followed by France(600;9.22%)and Italy(417;6.71%).The most cited publication was published in 2012 by Schauer et al in the New England Journal of Medicine(n=1435 citations).This publication found that weight loss was greater in the sleeve gastrectomy group than in the medical therapy ***,this study demonstrated that 12 mo of medical therapy plus bariatric surgery greatly improved glycemic regulation in obese patients with uncontrolled type 2 diabetes compared with medical therapy *** focus of the current literature on sleeve gastrectomy was directed toward several themes such as morbidity and potential complications,the complexity of the procedure and different surgical approaches,and diabetes and body mass index in correlation to sleeve *** The number of sleeve gastrectomy publications has gradually grown over the last 20 *** bibliometric analysis could help researchers better understand the knowledge base and research frontiers surrounding sleeve

关键词： Sleeve gastrectomy Bibliometric Scopus VOSviewer Bariatric surgery

关于人氟齿中葡萄糖葡聚糖的硫酸异状体的研究

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国外医学（医学地理分册） 1989年第2期10卷 83-83,F003页

作者： Sush.,ak 都玲玲

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环孢菌素在皮肤病领域中的应用

国外医药（抗生素分册） 1990年第5期11卷 377-381页

作者： Cupta ak 徐积恩

环孢菌素(Cyclocporine)是一种天然的亲脂性环状肽,由11个氨基酸组成。1972年瑞士山道士公司实验室首先由Tolypocladium inflatum gams分离的抗真菌产物,以后发现本品有很强的免疫抑制性质,1978年首先用于人体器官移植,后来用于防止器... 详细信息

环孢菌素(Cyclocporine)是一种天然的亲脂性环状肽,由11个氨基酸组成。1972年瑞士山道士公司实验室首先由Tolypocladium inflatum gams分离的抗真菌产物,以后发现本品有很强的免疫抑制性质,1978年首先用于人体器官移植,后来用于防止器官排斥反应,用于其它方面的报道也越来越多。一、药理学环孢菌素可以口服和静注给药,而肌注给药由于吸收不规则未被推荐。口服后胃肠道内食物可影响本品的吸收,在2-4小时内可达到血峰浓度,生物利用度约为30%。本品在肝内代谢,通过肝内单氧化酶系统。

关键词：环孢霉素皮肤病临床应用

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Helicobacter Pylori Infection: Epidemiological, Clinical and Pathological Aspects in a Digestive Endoscopy Unit and the Pathological Anatomy Service of Parakou in Benin Republic

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Open Journal of Gastroenterology 2023年第7期13卷 225-236页

作者： Khadidjatou Saké Marie Claire Ballè Luc Valère Codjo Brun Nonvignon Murielle Somitondji Cossi Angelo Attinsounon Serge Adè Cossi Adébayo Alassani Lionel David Togbenon Comlan Albert Dovonou Marie Thérèse akélé akpo Department of Medicine Departmental University Hospital Center of Borgou Parakou Benin Pathological Anatomy and Cytology Service Departmental University Hospital Center of Borgou Parakou Benin Pathological Anatomy and Cytology Service Faculty of Health Sciences National Hospital and University Center Cotonou Benin

Introduction: Helicobacter pylori (Hp) infection is the most common bacterial infection in the world. World Health Organization has classified this bacterium as a Class I carcinogen. The objective of this work is to study the epidemiological, clinical and pathological aspects of Helicobacter pylori infection among adults in a digestive endoscopy unit and the pathological anatomy service of Parakou. Patients and Methods: This was a descriptive and analytical cross-sectional study conducted from January 2020 to September 2020 in the digestive endoscopy unit and pathological anatomy service at the Departmental University Hospital Center of Borgou. Patients aged 18 years and older, who had undergone a gastroscopy with biopsies and who gave their oral consent were included. Three antral biopsies and two fundic biopsies were performed. The search for Hp was done under an optical microscope after staining with hematoxylin eosin. Results: A total of 151 patients were included and 51.66% were infected with Hp. Their average age was 40.63 ± 15.32 years and the sex ratio was 0.9. Epigastric pain was the most reported symptom (71.01%). Endoscopically, the prevalence of erythematous gastropathy was 98.72%. The study of chronic Hp gastritis according to Sydney system had shown signs of activity in 100% of patients with Hp and glandular atrophy in 83.33% of them. Intestinal metaplasia and dysplasia accounted for 24.35% and 29.48% of cases, respectively. Factors associated with Hp infection were: absence of proton pump inhibitor intake prior to examination, absence of handwashing with soap and water before eating, erythematous aspect of gastritis on gastroscopy, absence of intestinal metaplasia of the fundus, active and chronic aspects of gastritis on histology. Conclusion: The frequency of Hp infection in hospitals among adults admitted to the Digestive Endoscopy Unit of Parakou is high. To reduce this prevalence, it will be necessary to act on the factors identified.

关键词： Helicobacter pylori Gastroscopy Pathological Anatomy Parakou Benin Republic