检索结果-南通市图书馆

Neovascular Glaucoma: An Update on Etiopathogenesis, Diagnostics and Management

Open Journal of Ophthalmology 2022年第3期12卷 242-258页

作者： Sunil kumar Sujata kumari ajay kumar Sinha Patna Medical College Patna India

Neovascular glaucoma (NVG) is a severe secondary and refractory *severe secondary conditio, that accounts for a varying prevalence between 0.01% to 5.1% of all glaucoma those studied in different regions of the world. **This is a pathological condition, which is caused by the new vessels over iris surface and followed by fibrovascular membrane formation over the trabecular meshwork, secondary to a local angiogenic stimulus. The fibrovascular membrane over trabecular meshwork obstructs the aqueous outflow at an angle of the anterior chamber. ***The obstruction in outflow of the aqueous results increase of intraocular pressure (IOP), within the eyeball. NVG results from a number of ocular and systemic conditions with retinal ischemia leading to anoxia as a mediator in over 95% of cases. Most of them are affected with proliferative diabetic retinopathy (PDR) followed by central retinal venous occlusion (CRVO), and ocular ischemic syndrome (OIS) along with other uncommon causes or all those causes that causes retinal anoxia which led to angiogenic activity in retina and iris of eye. Although NVG overall prevalence is low, but it is a dreadful condition led to blindness. The objective of this review is to provide detailed information on its basic and clinical aspects, to enable us to manage it logically. Here its etiopathogenesis, methods of early diagnosis and management are discussed. It was concluded that if NVG is detected earlier and managed systematically (both medical and surgical) along with an eye on alleviation of different aggravating factors of the retinal hypoxia, it could be a sight-saving measure to the affected person.

关键词： Neovascular Glaucoma Rubeosis Iridis Retinal Hypoxia Diabetic Retinopa-thy Central Retinal Venous Occlusion Ocular Ischemic Syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of cystatin A in breast cancer and its functional link with ERa

引用

Journal of Genetics and Genomics 2017年第12期44卷 593-597页

作者： Dixcy Jaba Sheeba John Mary Mohan C.Manjegowda ajay kumar Sarbajeet Dutta Anil M.Limaye Department of Biosciences and Bioengineering Indian Institute of Technology GuwahatiGuwahati 781039India

Aberrant expression of lysosomal cysteine proteinases（cathepsins）leads to abnormal proteolytic processing of extracellular matrix *** in turn promotes invasion,migration and metastasis of tumor cells（Nomura and Katunuma,2005）.Cystatins are natural inhibitors of ***,dysregulated expression of cystatins and the consequent alteration in the cathepsin：cystatin ratio are likely to play an important role in malignant progression of tumors.

关键词： breast cancer link with ERa

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enabling intercalation-type TiNb_(24)O_(62)anode for sodiumand potassium-ion batteries via a synergetic strategy of oxygen vacancy and carbon incorporation

引用

SusMat 2023年第2期3卷 222-234页

作者： ajay Piriya Vijaya kumar Saroja Zhipeng Wang Henry R.Tinker Feng RyanWang Paul R.Shearing Yang Xu Department of Chemistry University College LondonLondonUK Materials and Catalysis Laboratory Department of Chemical EngineeringUniversity College LondonLondonUK Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College LondonLondonUK

The key to develop earth-abundant energy storage technologies sodium-and potassium-ion batteries(SIBs and PIBs)is to identify low-cost electrode materials that allow fast and reversible Na^(+)/K^(+)***,we report an intercalation-type material TiNb_(24)O_(62)as a versatile anode for SIBs and PIBs,via a synergistic strategy of oxygen vacancy and carbon incorporation to enhance ion and electron *** TiNb_(24)O_(62-x)/reduced graphene oxide(rGO)composite anode delivers high reversible capacities(130 mA h g^(-1)for SIBs and 178 mA h g^(-1)for PIBs),great rate performance(54 mA h g^(-1)for SIBs and 37 mA h g^(-1)for PIBs at 1 A g^(-1)),and superior cycle stability(73.7%after 500 cycles for SIBs and 84%after 300 cycles for PIBs).The performance is among the best results of intercalation-typemetal oxide anodes for SIBs and *** better performance of TiNb_(24)O_(62-x)/rGO in SIBs than PIBs is due to the better reaction kinetics of the ***,mechanistic study confirms that the redox activity of Nb4+/5+is responsible for the reversible intercalation of Na^(+)/K^(+).Our results suggest that TiNb_(24)O_(62-x)/rGO is a promising anode for SIBs and PIBs and may stimulate further research on intercalation-type compounds as candidate anodes for large ion batteries.

关键词： anode defects intercalation potassium-ion battery sodium-ion battery sustainability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comprehensive studies on dielectric properties of p-methoxy benzylidene p-decyl aniline with function of temperature and frequency in planar geometry: A potential nematic liquid crystal for display devices

引用

Chinese Physics B 2021年第6期30卷 329-333页

作者： Pankaj kumar Tripathi Kunwar Vikram Mithlesh Tiwari ajay Shriram Department of Physics Lovely Professional UniversityPhagwara-144411PunjabIndia Department of Allied Science Graphic Era(Deemed to be university)Dehradun-248002 India Department of Physics and Electronics Dr.Ram Manohar Lohia Avadh UniversityAyodhya-224001U.P.India School of Computer Science&Information Technology Jain(Deemed-to-be-University)Bengaluru-560069KarnatakaIndia

The dielectric properties of the nematic mesophase, p-methoxy benzylidene p-decyl aniline(MBDA), measured in planar geometry with a function of frequency and temperature are investigated in detail. The complex dielectric permittivity(ε' and ε'') is also studied at a bias voltage of 10 V for planar aligned sample cell of nematic mesophase. The dielectric permittivity with bias voltage attains a higher(> 2 times) value than that without bias voltage at a temperature of 56℃,which is due to the fact that the linking group of nematic molecules is internally interacted with an applied bias *** is supported by observing an enhanced dielectric permittivity of nematic liquid crystal(LC) in the presence of bias voltage, which can be fully explained as the increasing of the corresponding dipole moment. The dielectric relaxation behaviors of nematic LC are also demonstrated for planar aligned sample cell. The remarkable results are observed that the relaxation frequency shifts into low frequency region with the increase of the bias voltage applied to the planar aligned sample cells. The dielectric relaxation spectra are fitted by Cole–Cole nonlinear curve fitting for nematic mesophase in order to determine the dielectric strength.

关键词： dielectric permittivity dielectric loss relaxation frequency nematic mesogen

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mass spectra and Regge trajectories of Λ_c^+,∑_c^0,Ξ_c^0 and Ω_c^0 baryons

引用

Chinese Physics C 2016年第12期40卷 10-21页

作者： Zalak Shah Kaushal Thakkar ajay kumar Rai P. C. Vinodkumar Department of Applied Physics Sardar Vallabhbhai National Institute of Technology Surat Gujarat 395007 India Department of Applied Sciences &: Humanities GIDC Degree Engineering college Abrama Navsari 396406 India Department of physics Sardar Patel University V.V. Nagar Anand 388120 India

We calculate the mass spectra of the singly charmed baryons （∧＋ c, ∑0 c,[I]0c and Ω0 c） using the hypercentral constituent quark model （hCQM）. The hyper color Coulomb plus linear potential is used to calculate the masses ofpositive （up to JP = 7＋/2 ）9 and negative （up to JP = 9-/2）parity excited states. The spin-spin, spin-orbital and tensorinteraction terms are-also incorporated for mass spectra. We have compared our results with other theoretical and lattice QCD predictions for each baryon. Moreover, the known experimental results are also reasonably close to our predicted masses. By using the radial and orbital excitation, we construct Regge trajectories for the baryons in the （n,M2） plane and find their slopes and intercepts. Other properties of these baryons, like magnetic moments, radiative transitions and radiative decay widths, are also calculated successfully.

关键词： baryons potential model Regge trajectories

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cosmic Ray Associated with Coronal Index and Solar Flare Index during Solar Cycle 22 - 23

引用

International Journal of Astronomy and Astrophysics 2017年第3期7卷 162-173页

作者： Prithvi Raj Singh Shabir Ahmad A. C. Pandey ajay kumar Saxena Chandra Mani Tiwari A. P. mishra Department of Physics A.P.S. University Rewa M.P. India

We study the relation between monthly average counting rates of the cosmic ray intensity (CRI) observed at Moscow Neutron Monitoring Station, solar flare index (SFI) and coronal index during the solar cycles 22 and 23, for the period 1986-2008. The long-term behaviour of various solar activity parameters: sunspot numbers (SSN), solar flare index (Hα flare index), coronal index (CI) in relation to the duration of solar cycles 22 and 23 is examined. We find that the correlation coefficient of CRI with the coronal index as well as Hα flare index is relatively large anti-correlation during solar cycle 22. However, the monthly mean values of sunspot number, Hα flare index, and coronal index are well positively correlated with each other. We have analyzed the statistical analysis of the above parameters using of linear model and second order polynomial fits model.

关键词： Solar Activity Sunspot Number Coronal Index Solar Flare Index Cosmic Ray Intensity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent Advances in the Quest for Treatment and Management of Alzheimer and Other Dementia

引用

Open Journal of Medicinal Chemistry 2019年第1期9卷 1-35页

作者： Sameena E. Tanwir ajay kumar School of Science Technology and Environment Universidad Ana G. Mendez San Juan PR USA

Alzheimer’s disease (AD) is a neurodegenerative disease distinguished by progressive cognitive deterioration along with declining activities of daily living and behavioral changes. It is the commonest type of pre-senile and senile dementia. Many new therapeutic strategies have been developed in the last few years. We aimed at reviewing the evidence supporting these new therapeutic targets, including anti-amyloid and anti-Tau strategies. This review is focused on important future direction in investigation of potential therapeutic targets for AD drug discovery. Medical advances have improved treatment of many diseases but still there is a need to establish new tools for early diagnosis of AD. A thorough comprehensive understanding of the unexplored mechanism can ameliorate the diagnostic and therapeutic management of AD. There have been several disease-modifying therapeutic strategies for AD in the last few years and are presently at various phases of investigation. Few of them have shown promising results, but their safety and efficacy need to be further explored.

关键词： Alzheimer β Amyloid Tau Acetylcholinesterase Amyloid Precursor Protein Plaques Tangles Neurodegeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Classification and management of community forests in Indian Eastern Himalayas:implications on ecosystem services,conservation and livelihoods

引用

Ecological Processes 2018年第1期7卷 297-311页

作者： Ranjay K.Singh Shah M.Hussain T.Riba Anshuman Singh Egul Padung Orik Rallen Y.J.Lego ajay kumar Bhardwaj College of Horticulture and Forestry Central Agricultural UniversityPasighatArunachal Pradesh 791102India ICAR-Central Soil Salinity Research Institute KarnalHaryana 132001India Doying Gumin College East SiangPasighatArunachal PradeshIndia Pasighat India

Introduction:Evidence is mounting that traditional knowledge can play a critical role in shaping the biodiversity conservation strategies and maintaining ecosystem *** study was conducted with Adi community of Arunachal Pradesh(Ar P)state in the Eastern Indian Himalayas to understand as how local systems of forest classification governs conservation tradition and influences subsistence *** Adi villages were sampled from East Siang district of Ar P.A total of 197 men and 204 women(total of 401)Adi respondents were selected for this study.A combination of methodologies including in-depth interview,transect walks,focus group discussion,participant observation and informal interactions were combined for data ***:Local forests are classified into 10 different categories based on indicators such as topography,cultural significance,use typology,ownership rights and plant diversity *** people assign different values(economic,cultural and ecological)to different forest ***,morang followed by regpi and homegardens are perceived to be more valuable to the local needs than other forests with relative ranking of a particular forest reflecting its *** access several diverse services from these community-managed *** to men(3–35%),the role of women was assessed to be much higher(65 to 100%)in conserving forest ***-led practices,instrumental in sustainable forest management,included deliberate manipulations of micro-habitats,sustainable harvesting strategies and species *** were mostly involved in ownership and decision-making roles and in devising social norms to ensure *** celebrate a number of cultural events to sustain ***-based livelihoods are intrinsically connected to forest resource conservation and are governed by community *** of the community members gather plants,hunt wild animals and access other ecosystem se

关键词： Adi tribe Forest classification Traditional ecological knowledge Indigenous institutions Ecosystem services Conservation Livelihoods

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation

引用

Cellular & Molecular Immunology 2019年第2期16卷 138-153页

作者： Prabhakaran kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein ajay V Maker Bellur S Prabhakar Department of Microbiology and Immunology University of Illinois-College of MedicineChicagoILUSA Department of Pathology University of Southern California Keck School of MedicineLos AngelesCAUSA Department of Surgery Division of Surgical OncologyUniversity of Illinois-College of MedicineChicagoILUSA

Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of *** Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)***,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose ***,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)*** of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by ***,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg ***40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell *** to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature *** ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR *** novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity.

关键词： Thymic Tregs OX40L IL-2 Treg proliferation maturation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biological Activity of N-Hydroxyethyl-4-aza-2,3-didehydropodophyllotoxin Derivatives upon Colorectal Adenocarcinoma Cells

引用

Open Journal of Medicinal Chemistry 2014年第1期4卷 1-11页

作者： Christian Vélez Beatriz Zayas ajay kumar Universidad Metropolitana School of Environmental Affairs San Juan Puerto Rico USA

Etoposide is a chemotherapy drug derived from the natural lignin podophyllotoxin. Our novel generated Aza-podophyllotoxin compounds (AZP 8a & AZP 9a) are analogues of podophyllotoxin and were previously screened for anti-cancer activity through the NCI 60 cell line screening panel showing activity on various cell types including colon cancer. This study expands the toxicological screening by studying apoptosis and various hallmark events as part of the mechanism of action of these compounds on colon cancer cells. The COLO 205 cell line was selected and exposed to AZP to determine the IC50 doses at 24 hours treatment. Apoptosis hallmark events such as migration of phosphatidylserine (PS) to the cell membrane, DNA fragmentation, cell cycle effects, mitochondrial membrane permeabilization and caspase activation were included. Experiments were performed in triplicates for all tested compounds including AZP 8a, AZP 9a, camptothecin as positive control and vehicle as negative control. Our results present contrasting apoptotic activity between the experimental compounds. Compound 8a presented migration of PS (annexin V assay), DNA fragmentation and cell cycle arrest at S phase. Compound 9a presented PS migration with fragmented DNA, cell cycle arrest at S phase, mitochondrial membrane permeabilization and activation of caspase 3, 8 and 9. Compound 8a without the oxygen atoms in ring A appears to cause effects similarly to autophagy as induced by etoposide, a cancer drug analogue of our heterocyclic compounds. Compound 9a with the oxygen atoms in expanded ring A presented induction of cell death following activation of a classical apoptosis pathway. Our results suggest that minor structural differences among these AZP can account for the difference in biological response and cancer cell toxicity.

关键词： Etoposide Podophyllotoxin Aza-Podophyllotoxin Colon Cancer COLO 205

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：