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Multi-omics:Powerful accelerator for uncovering plant specialized metabolic pathways:The case of leonurine

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Molecular Plant 2024年第1期17卷 13-15页

作者： Priyanka Gupta Anuj sharma Dinesh A.Nagegowda Molecular Plant Biology and Biotechnology Lab CSIR-Central Institute of Medicinal and Aromatic PlantsResearch CentreBengaluru 560065India Academy of Scientific and Innovative Research Ghaziabad 201002India

As sessile organisms,plants employ a unique adaptive strategy to survive harsh terrestrial environments and defend against or interact with coevolving animals and *** strategy involves expanding their metabolic systems,resulting in the production of plant specialized metabolites(PSMs)or natural ***,PSMs constitute a highly diverse group of compounds based on their common core structure,comprising terpenoids,phenylpropanoids,benzenoids,alkaloids and nitrogen-containing compounds,glucosinolates,indoles and sulfur-containing indole compounds,phenolics,and fatty acid derivatives(Garagounis et al.,2021).

关键词： expanding alkaloids sulfur

Design and evaluation of Swift routing for payment channel network

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BLOCKCHAIN-RESEARCH AND APPLICATIONS 2024年第2期5卷 62-72页

作者： sharma, Neeraj Kapoor, Kalpesh Anirudh, V. Indian Inst Technol Guwahati Dept Comp Sci & Engn Gauhati 781039 Assam India Indian Inst Technol Guwahati Dept Math Gauhati 781039 Assam India

Payment Channel Networks (PCNs) are a promising alternative to improve the scalability of a blockchain network. A PCN employs off-chain micropayment channels that do not need a global block confirmation procedure, thereby sacrificing the ability to confirm transactions instantaneously. PCN uses a routing algorithm to identify a path between two users who do not have a direct channel between them to settle a transaction. The performance of most of the existing centralized path-finding algorithms does not scale with network size. The rapid growth of Bitcoin PCN necessitates considering distributed algorithms. However, the existing decentralized algorithms suffer from resource underutilization. We present a decentralized routing algorithm, Swift, focusing on fee optimization. The concept of a secret path is used to reduce the path length between a sender and a receiver to optimize the fees. Furthermore, we reduce a network structure into combinations of cycles to theoretically study fee optimization with changes in cloud size. The secret path also helps in edge load sharing, which results in an improvement of throughput. Swift routing achieves up to 21% and 63% in fee and throughput optimization, respectively. The results from the simulations follow the trends identified in the theoretical analysis.

关键词： Blockchain Payment channel networks Bitcoin Lightning network Routing protocols Layer 2 protocols

Experimental investigation on effective aerosol scavenging using different spray configurations with pre-injection of water mist for Fukushima Daiichi decommissioning

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Nuclear Science and Techniques 2024年第5期35卷 154-172页

作者： Rui-Cong Xu Avadhesh Kumar sharma Erdal Ozdemir Shuichiro Miwa Shunichi Suzuki Department of Nuclear Engineering and Management The University of Tokyo7‑3‑1 HongoBunkyo‑KuTokyo 113‑8656Japan Nuclear Professional School The University of Tokyo2‑2

During the decommissioning of the Fukushima Daiichi nuclear power plant,it is important to consider the retrieval of resolidified debris both in air and underwater *** the subsequent retrieval of debris from the reactor building,the resolidified debris must be cut into smaller pieces using various cutting *** the cutting process,aerosol particles are expected to be generated at the submicron *** has been noted that such aerosols sizing within the Greenfield gap(0.1-1μm)are difficult to remove effectively using traditional spraying ***,to improve the aerosol removal efficiency of the spray system,a new aerosol agglomeration method was recently proposed,which involves injecting water mist to enlarge the sizes of the aerosol particles before removing them using water *** this study,a series of experiments were performed to clarify the proper spray configurations for effective aerosol scavenging and to improve the performance of the water *** experimental results showed that the spray flow rate and droplet characteristics are important factors for the aerosol-scavenging efficiency and performance of the water *** results obtained from this study will be helpful for the optimization of the spray system design for effective aerosol scavenging during the decommissioning of the Fukushima Daiichi plant.

关键词： Fukushima Daiichi decommissioning Aerosol scavenging Multiphase flow Spray system Aerosol-mist agglomeration

MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

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Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender sharma Melissa MTorres Sheryl Rodriguez Laxman Gangwani Subodh Kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life Sciences Center and Department of Veterinary Pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate School of Biomedical Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related *** previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease *** study investigated a new molecular relationship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and *** silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase ***,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the molecular mechanism of regulation of GABAergic synapses by *** propose that micro-RNA,in particular miR-502-3p,could be a potential the

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-clamp

Dengue causing relapse of minimal change disease: A double-edged sword

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Asian Pacific Journal of Tropical Medicine 2024年第5期17卷 237-238页

作者： Sourabh sharma Himanshu Verma Sanjay Kalra Department of Nephrology VMMC&Safdarjung HospitalNew DelhiIndia Department of Endocrinology Bharti HospitalKarnalIndia

Dengue virus infection is endemic in India with seasonal *** can lead to lethal consequences with plasma leakage and/or bleeding[1,2].Dengue shock syndrome has high mortality in developing countries like *** can cause functional proteinuria and even heavy proteinuria[3-6].Though dengue has been implicated to cause glomerulonephritis[7],to the best of our knowledge,dengue as a cause of relapse of minimal change disease(MCD)has not been reported.

关键词： relapse mortality bleeding

Techno-economic and environmental impact analysis of electric two-wheeler batteries in India

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CLEAN ENERGY 2024年第3期8卷 147-156页

作者： Gupta, Aman Bose, Ditipriya Tiwari, Sandeep sharma, Vikrant Prakash, Jai Aligarh Muslim Univ Zakir Husain Coll Engn & Technol Dept Green Energy & Sustainable Dev Aligarh 202002 Uttar Pradesh India Natl Inst Solar Energy Battery Testing Facil Gurugram Faridabad Rd Gurugram 122003 Haryana India

This paper presents a comprehensive techno-economic and environmental impact analysis of electric two-wheeler batteries in India. The technical comparison reveals that sodium-ion (Na-ion) and lithium-ion (Li-ion) batteries outperform lead-acid batteries in various parameters, with Na-ion and Li-ion batteries exhibiting higher energy densities, higher power densities, longer cycle lives, faster charge rates, better compactness, lighter weight and lower self-discharge rates. In economic comparison, Na-ion batteries were found to be similar to 12-14% more expensive than Li-ion batteries. However, the longer lifespans and higher energy densities of Na-ion and Li-ion batteries can offset their higher costs through improved performance and long-term savings. Lead-acid batteries have the highest environmental impact, while Li-ion batteries demonstrate better environmental performance and potential for recycling. Na-ion batteries offer promising environmental advantages with their abundance, lower cost and lower toxic and hazardous material content. Efficient recycling processes can further enhance the environmental benefits of Na-ion batteries. Overall, this research examines the potential of Na-ion batteries as a cheaper alternative to Li-ion batteries, considering India's abundant sodium resources in regions such as Rajasthan, Chhattisgarh, Jharkhand and others.

关键词： electric two-wheelers environmental impact assessment lead-acid batteries lithium-ion batteries sodium-ion batteries techno-economic analysis VEHICLES TECHNOLOGIES HYBRID

Colorimetric Sensor for Detection of Tabun Mimic Diethyl Cyanophosphonate

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Journal of Analysis and Testing 2024年第3期8卷 374-384页

作者： Madhu Bala Dheeraj Pandey Nikita Patel Sheetal Yadav Abha sharma Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research RaebareliTransit Campus

Herein,a colorimetric chemosensor （probe 7） was designed and synthesized for sensing diethyl cyanophosphonate （DCNP）,a Tabun nerve agent *** sensitive,selective,fast response and photostable probe 7 in dimethylsulfoxide （DMSO）responded to DCNP at low concentrations with visual naked eye color change from pink to pale yellow and displayed unresponsive behaviour against various interferences except for copper ions,which can be di?erentiated by adding ethylene diamine where the yellow color persisted in the case of DCNP but turned to pink in the case of copper ***,the yellow aqueous solution of probe 7 at pH 10 and 12 turned colorless against the response of *** limit of detection（LOD） of probe 7 was found to be 50 nmol/L in an aqueous basic solution at pH 10 for the detection of *** formation of the cyclized product was elucidated by1H and31P NMR nuclear magnetic resonance (1H NMR,31P NMR),Fourier transform infrared spectroscopy （FTIR）,and high-resolution mass spectrometry （HRMS） ***?lter paper and silica plate loaded with probe 7 were fabricated for real-time and on-site detection of DCNP.

关键词： Chemosensor Colorimetric Fluorescence Tabun mimic

A Survey and Experimental Review on Data Distribution Strategies for Parallel Spatial Clustering Algorithms

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Journal of Computer Science & Technology 2024年第3期39卷 610-636页

作者： Jagat Sesh Challa Navneet Goyal Amogh sharma Nikhil Sreekumar Sundar Balasubramaniam Poonam Goyal Advanced Data Analytics and Parallel Technologies Laboratory Birla Institute of Technology and Science Pilani 333031India Uber New York 11101U.S.A. Computer Science and Engineering Department University of MinnesotaMinneapolis 55455U.S.A.

The advent of Big Data has led to the rapid growth in the usage of parallel clustering algorithms that work over distributed computing frameworks such as MPI,MapReduce,and *** important step for any parallel clustering algorithm is the distribution of data amongst the cluster *** step governs the methodology and performance of the entire *** typically use random,or a spatial/geometric distribution strategy like kd-tree based partitioning and grid-based partitioning,as per the requirements of the ***,these strategies are generic and are not tailor-made for any specific parallel clustering *** this paper,we give a very comprehensive literature survey of MPI-based parallel clustering algorithms with special reference to the specific data distribution strategies they *** also propose three new data distribution strategies namely Parameterized Dimensional Split for parallel density-based clustering algorithms like DBSCAN and OPTICS,Cell-Based Dimensional Split for dGridSLINK,which is a grid-based hierarchical clustering algorithm that exhibits efficiency for disjoint spatial distribution,and Projection-Based Split,which is a generic distribution *** of these preserve spatial locality,achieve disjoint partitioning,and ensure good data load *** experimental analysis shows the benefits of using the proposed data distribution strategies for algorithms they are designed for,based on which we give appropriate recommendations for their usage.

关键词： parallel data mining data distribution parallel clustering spatial locality preservation

Effect of process parameter on the flowability of nanocrystalline CoNiCrAlY powder synthesized by mechanical milling

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Particuology 2024年第9期92卷 210-223页

作者： Annadaa Shankara Dash Indranil Manna Deepa Devapal Sharad Chandra sharma Jyotsna Dutta Majumdar School of Nanoscience and Technology IIT KharagpurWest BengalIndia BIT Mesra RanchiJharkhandIndia Department of Metallurgical and Materials Engineering IIT KharagpurWest BengalIndia Vikram Sarabhai Space Centre ThiruvanthapuramKeralaIndia

The present study concerns understanding the effect of process parameters on the characteristics and flowability of nanocrystalline CoNiCrAlY powder synthesized by mechanical *** milling has been conducted in a planetary ball mill with tungsten carbide(WC)ball,with ball to powder ratio of 10:1 at 300 rpm speed,using 1%stearic acid and toluene as process control agent(PCA)with time varying from 10 h to 36 *** synthesized nanocrystalline powder were characterized by Scanning Electron Microscopy,X-ray Diffraction technique,X-ray Photoelectron Spectroscopy,and Differential Scanning ***,flowability in terms of Hausner ratio was assessed by Tap Density *** particle size of the powder was found to decrease from 33μm to 22μm after 10 h of milling and further increases to 43μm and 38μm after 25 and 36 h of milling,respectively,in stearic acid ***,in toluene medium particle size continuously decreases from 33μm to 9.7μm with increasing milling *** particle morphology changes from spherical to platelet shape at low milling hours in both of the *** 25 h of milling,the shape of the particles is nearly spherical for stearic acid and irregular for toluene used as a *** size was found to decrease with increasing milling time from 147 nm to 7.7 nm and to 6.4 nm in stearic acid and toluene media,*** was presence ofγ,γʹ,β,hcp-Co,Al_(2)O_(3)and AlOOH phases on the powder particles milled in both the *** measured Hausner ratio of the powders was found to vary from 1.18 to 1.32 in stearic acid medium,and was found to increase with increasing milling *** the other hand,in toluene media flowability decreases(Hausner ratio increases from 1.33 to 1.44)with increasing milling time.

关键词： Mechanical milling Microstructure Process control agent(PCA) CoNiCrAIY Toluene Stearic acid Flowability