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Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment

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Signal Transduction and Targeted Therapy 2023年第1期8卷 288-301页

作者： Haiying Que Weiqi Hong Tianxia Lan Hao Zeng Li Chen Dandan Wan Zhenfei Bi Wenyan Ren Min luo Jingyun Yang Cai He ailing Zhong Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuanPeople’s Republic of China

For coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),15–30%of patients are likely to develop COVID-19-related acute respiratory distress syndrome(ARDS).There are still few effective and well-understood therapies *** variants and short-lasting immunity are posing challenges to vaccine efficacy,so finding antiviral and antiinflammatory treatments remains ***,tripterin(TP),a traditional Chinese medicine,was encapsulated into liposome(TP lipo)to investigate its antiviral and antiinflammatory effects in severe *** using two severe COVID-19 models in human ACE2-transgenic(hACE2)mice,an analysis of TP lipo’s effects on pulmonary immune responses was *** pathological alterations and viral burden were reduced by TP lipo *** lipo inhibits SARS-CoV-2 replication and hyperinflammation in infected cells and mice,two crucial events in severe COVID-19 pathophysiology,it is a promising drug candidate to treat SARS-CoV-2-induced ARDS.

关键词： immunity alterations distress

侵及多组脑神经和马尾神经的神经淋巴瘤病1例

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中华放射学杂志 2022年第11期56卷 1257-1258页

作者：罗勇胡艾苓刘含秋泸州市人民医院医学影像科泸州646000 复旦大学附属华山医院放射科上海200040

本文报道了1例侵及多组脑神经和马尾神经的神经淋巴瘤病患者。该患者为32岁男性, 主要临床表现为马尾综合征。脑神经和腰椎MRI表现为多组脑神经及马尾神经明显增粗呈均匀明显强化, 扩散加权成像表现为扩散受限明显, 符合典型神经淋巴瘤... 详细信息

本文报道了1例侵及多组脑神经和马尾神经的神经淋巴瘤病患者。该患者为32岁男性, 主要临床表现为马尾综合征。脑神经和腰椎MRI表现为多组脑神经及马尾神经明显增粗呈均匀明显强化, 扩散加权成像表现为扩散受限明显, 符合典型神经淋巴瘤病的影像学表现。由于神经淋巴瘤病在临床罕见, 早期诊断困难, 故当怀疑是此病时, 应尽早进行MRI、活体组织检查。该患者经过骨髓穿刺和全面脑脊液检查后最终确诊为神经淋巴瘤病。

关键词：磁共振成像神经淋巴瘤病脑神经

Adipose-derived mesenchymal stem cells(MSCs)are a superior cell source for bone tissue engineering

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Bioactive Materials 2024年第4期34卷 51-63页

作者： Yannian Gou Yanran Huang Wenping luo Yanan Li Piao Zhao Jiamin Zhong Xiangyu Dong Meichun Guo Aohua Li ailing Hao Guozhi Zhao Yonghui Wang Yi Zhu Hui Zhang Yunhan Shi William Wagstaff Hue H.Luu Lewis L.Shi Russell R.Reid Tong-Chuan He Jiaming Fan Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistrySchool of Laboratory MedicineChongqing Medical UniversityChongqing400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL60637USA Departments of Orthopedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Laboratory Animal Center Southwest UniversityChongqing400715China Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences The Stomatological Hospital of Chongqing Medical UniversityChongqing401147China Department of Geriatrics Xinhua HospitalShanghai Jiao-Tong University School of MedicineShanghai200000China Department of Orthopaedic Surgery Beijing HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China The Breast Cancer Center Chongqing University Cancer HospitalChongqing4000430China Department of Psychology School of Arts and SciencesUniversity of RochesterRochesterNY14627USA Department of Surgery The University of Chicago Medical CenterChicagoIL60637USA Laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL60637USA

Effective bone regeneration through tissue engineering requires a combination of osteogenic progenitors,osteoinductive biofactors and biocompatible scaffold *** stem cells(MSCs)represent the most promising seed cells for bone tissue *** multipotent stem cells that can self-renew and differentiate into multiple lineages including bone and fat,MSCs can be isolated from numerous tissues and exhibit varied differentiation *** identify an optimal progenitor cell source for bone tissue engineering,we analyzed the proliferative activity and osteogenic potential of four commonly-used mouse MSC sources,including immortalized mouse embryonic fibroblasts(iMEF),immortalized mouse bone marrow stromal stem cells(imBMSC),immortalized mouse calvarial mesenchymal progenitors(iCAL),and immortalized mouse adipose-derived mesenchymal stem cells(iMAD).We found that iMAD exhibited highest osteogenic and adipogenic capabilities upon BMP9 stimulation in vitro,whereas iMAD and iCAL exhibited highest osteogenic capability in BMP9-induced ectopic osteogenesis and critical-sized calvarial defect *** analysis revealed that,while each MSC line regulated a distinct set of target genes upon BMP9 stimulation,all MSC lines underwent osteogenic differentiation by regulating osteogenesis-related signaling including Wnt,TGF-β,PI3K/AKT,MAPK,Hippo and JAK-STAT ***,our results demonstrate that adipose-derived MSCs represent optimal progenitor sources for cell-based bone tissue engineering.

关键词： Mesenchymal stem cell(MSC) Bone tissue engineering Multipotent progenitor cells Adipose-derived mesenchymal stem cells Osteogenic differentiation Adipogenesis

Warming and grazing enhance litter decomposition and nutrient release independent of litter quality in an alpine meadow

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Journal of Plant Ecology 2022年第5期15卷 977-990页

作者： Bowen Li Wangwang Lv Jianping Sun Lirong Zhang Lili Jiang Yang Zhou Peipei Liu Huan Hong Qi Wang Wang A Suren Zhang Lu Xia Zongsong Wang Tsechoe Dorji ailing Su Caiyun luo Zhenhua Zhang Shiping Wang Key Laboratory of Alpine Ecology Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of the Chinese Academy of Sciences Beijing 100049China College of Science Tibet UniversityLhasa 850000China CAS Center for Excellence in Tibetan Plateau Earth Science of the Chinese Academy of Sciences Beijing 10010lChina Key Laboratory of Adaptationand Evolution of Plateau Biota Northwestern Institute of Plateau BiologyChinese Academy of SciencesXining 810008China

Warming and grazing,and ltter quality jointly determine liter decomposition and nutrient releases in grazing ***,their effects have previously been studied in *** conducted a two factorial experiment with asymmetric warming using infrared heaters and moderate grazing in an alpine *** samples were collected from all plots in each treatment,among which some subsamples were placed in their original plots and other samples were translocated to other treatment plots to test the relative effects of each treatment on litter decomposition and nutrient *** found that warming rather than grazing alone significantly increased total losses of litter mass,total organic carbon,total nitrogen(TN)and total phosphorus(TP)per unit area due to increases in both mass loss rates and ltter ***,grazing with warming did not affect their total mass losses because increased mass loss was offset by decreased litter biomass compared with the *** mean soil temperature better predicted litter decomposition than litter lignin content or carbon to nitrogen *** were interactions between warming and grazing,but there were no interactions between them and litter quality on litter *** temperature sensitivity of TN loss was higher than that of TP loss per unit *** results suggest that increased temperature has a greater effect on litter decomposition and nutrient release than change in litter quality,and that more N release from litter could result in greater P deficiency in the alpine meadow.

关键词： asymmetric warming alpine meadow decomposition rate litter biomass and quality moderate grazing nutrient release

LMS自适应滤波器在雁淮特高压直流工程交流滤波器保护系统中的应用研究

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电力系统保护与控制 2018年第24期46卷 111-117页

作者：刘威鹏曾丽丽张爱玲张健罗磊许继电气股份有限公司河南许昌461000

以雁淮直流输电工程交流滤波器保护系统的不平衡电流校正为研究对象,介绍了C1高压电容器组的结构和不平衡保护的原理。阐明了不平衡电流校正的重要性和意义,指出传统方法所使用的初始不平衡电流不充分考虑其相位和幅值的波动,将其作为... 详细信息

以雁淮直流输电工程交流滤波器保护系统的不平衡电流校正为研究对象,介绍了C1高压电容器组的结构和不平衡保护的原理。阐明了不平衡电流校正的重要性和意义,指出传统方法所使用的初始不平衡电流不充分考虑其相位和幅值的波动,将其作为恒定值是不合理的。针对初始不平衡电流的随机性,介绍了LMS自适应滤波器的原理和特性,并将其在HCM3000平台中进行了实现。研究并给出了滤波器关键参数,阐述了在具体工程应用中的使用方法。工程数据验证了设计的合理性和性能的优越性。

关键词： C1电容器不平衡保护初始不平衡电流 LMS自适应滤波器 HCM3000

类型教育理念下高职院校教师科研评价改革探索--基于S院校的个案研究

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职业技术教育 2023年第21期44卷 55-59页

作者：杨爱玲罗尧成肖纲领上海出版印刷高等专科学校上海200093 上海出版印刷高等专科学校科研处上海出版印刷高等专科学校科研处/复旦大学高等教育研究所

基于类型教育理念推进高职院校教师科研评价改革实践,是职业教育高质量发展的时代诉求。针对学校科研评价存在的不足,S高职院校以类型教育为理念,建立了应用导向的成果评价制度,形成了科技成果的分级分类体系,建立了多元主体参与的评价... 详细信息

基于类型教育理念推进高职院校教师科研评价改革实践,是职业教育高质量发展的时代诉求。针对学校科研评价存在的不足,S高职院校以类型教育为理念,建立了应用导向的成果评价制度,形成了科技成果的分级分类体系,建立了多元主体参与的评价机制,以诊断性评价功能激发了教师科研的内驱力,在应用型科研评价体系构建、科研成果的数量规模、科研学术氛围的营建,以及科研评价示范效应等方面均取得了良好成绩。S院校的改革实践启示高职院校教师科研评价应找准定位,突出高职科研类型与学校特色;分类实施,确保评价体系和考核标准的科学性;质量导向,推进科研成果评价的分级与分类;协同发力,强化评价结果的应用与有效激励;数字赋能,实现教师科研评价的智能便捷。

关键词：科研评价高职院校教师类型教育高质量发展个案研究

融合多特征和IGWO-SVM的肺部肿瘤诊断研究

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微型电脑应用 2023年第8期39卷 142-145页

作者：胡艾苓罗勇泸州市人民医院四川泸州646000

为了实现高精度的肺部肿瘤诊断,提出一种融合多特征和改进的灰狼算法(IGWO)优化支持向量机(SVM)的肺部肿瘤诊断模型。为了提高标准GWO算法的收敛速度、避免局部最优,将非线性收敛因子引入GWO,提出一种改进的灰狼优化算法(IGWO)。针对SV... 详细信息

为了实现高精度的肺部肿瘤诊断,提出一种融合多特征和改进的灰狼算法(IGWO)优化支持向量机(SVM)的肺部肿瘤诊断模型。为了提高标准GWO算法的收敛速度、避免局部最优,将非线性收敛因子引入GWO,提出一种改进的灰狼优化算法(IGWO)。针对SVM模型性能受到惩罚因子和核函数的核宽等参数选择的影响,运用IGWO算法优化选择SVM模型参数并应用于肺部肿瘤诊断。与GWO-SVM、PSO-SVM和GA-SVM相比较,在分类准确率(ACC)、特异性(Specificity)、灵敏度(Sensitivity)和马修斯相关系数(MCC)4个性能评价指标上,IGWO-SVM模型的肺部肿瘤诊断具有更高的准确率、更快的收敛速度,且具有更高的稳定性,为肺部肿瘤诊断提供了新的方法。

关键词：肺部肿瘤肿瘤诊断支持向量机灰狼优化算法

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浅谈手机靓号评估

中国资产评估 2023年第12期 65-71页

作者：罗正魁芦爱玲新兰特房地产资产评估有限公司陕西西安710016 正衡房地产资产评估有限公司陕西西安710001

2015年9月1日开始手机卡实名制,随着智能手机的普及化,越来越多的应用场景需要绑定个人手机号,对追求手机靓号的人来说,手机靓号更加重要。通常说的靓号多数指由阿拉伯数字组成的连续相同的号码及较为顺口的顺子号,或者含有特殊意义的... 详细信息

2015年9月1日开始手机卡实名制,随着智能手机的普及化,越来越多的应用场景需要绑定个人手机号,对追求手机靓号的人来说,手机靓号更加重要。通常说的靓号多数指由阿拉伯数字组成的连续相同的号码及较为顺口的顺子号,或者含有特殊意义的吉祥号码。手机靓号由于自身的稀缺性和唯一性,对不同的人有着不同的特殊意义。手机靓号的估值受到多重因素影响。连号是大家所共同认知的靓号,本文仅探讨连号的手机靓号评估。

关键词：电信网码号资源约定使用权稀缺性和唯一性地域性参照体系

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现代道地中药材生产工程模式构建及评价

农业工程学报 2015年第17期31卷 308-314页

作者：孙君社郑志安王民敬张秀清罗江清郭爱玲农业部规划设计研究院北京100125 中国农业大学工学院北京100083 中国农业大学食品科学与营养工程学院北京100083 天方健(中国)药业有限公司广州510623

中国中药材生产标准缺乏、管理不完善、质量安全问题突出,通过构建科学、系统的中药材生产工程模式来指导中药材产业发展、确保产品质量安全意义重大。该研究涉及中药材生产环节,包括育种、种植、采收加工、储藏等环节,从传统道地中药材... 详细信息

中国中药材生产标准缺乏、管理不完善、质量安全问题突出,通过构建科学、系统的中药材生产工程模式来指导中药材产业发展、确保产品质量安全意义重大。该研究涉及中药材生产环节,包括育种、种植、采收加工、储藏等环节,从传统道地中药材"三因子"(生物因子、环境因子、人为因子),提出现代道地中药材六属性假说(即生物自然属性、生态环境属性、加工储藏属性、品性商品属性、质量安全属性、种植管理属性)。在此基础上,利用系统学的理论、工具和方法,获得在构建生产标准、种植管理、质量安全3个体系的基础上耦合形成现代道地中药材生产工程模式的构建打下方法论的基础。按照科学性、简明性等原则,结合专家咨询法构建了3个层次、19个指标的评价指标体系,利用层次分析法确定了指标权重,利用模糊综合评价方法对段木赤灵芝生产进行实证,结果为0.71,良好,与生产实际一致。该研究不仅对中药材生产具有较高借鉴价值,也为现代农业生产工程模式研究提供理论支撑。

关键词：生产工程标准化农业中药材模式评价