检索结果-南通市图书馆

Attenuation ofβ-Amyloid Toxicity In Vitro and In Vivo by Accelerated Aggregation

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2017年第4期33卷 405-412页

作者： aihua yang Chenxuan Wang Baomin Song Wendi Zhang Yuanyuan Guo Rong yang Guangjun Nie Yanlian yang Chen Wang National Center for Nanoscience and Technology Beijing 100190China

Accumulation and aggregation of β-amyloid（Aβ） peptides result in neuronal death, leading to cognitive dysfunction in Alzheimer＇s disease. The self-assembled Aβ molecules form various intermediate aggregates including oligomers that are more toxic to neurons than the mature aggregates, including fibrils. Thus, one strategy to alleviate Aβ toxicity is to facilitate the conversion of Aβ intermediates to larger aggregates such as fibrils. In this study, we designed a peptide named A3 that significantly enhanced the formation of amorphous aggregates of Aβ by accelerating the aggregation kinetics. Thioflavin T fluorescence experiments revealed an accelerated aggregation of Aβ monomers, accompanying reduced Aβ cytotoxicity. Transgenic Caenorhabditis elegans over-expressing amyloid precursor protein exhibited paralysis due to the accumulation of Aβ oligomers, and this phenotype was attenuated by feeding the animals with A3 peptide. These findings suggest that the Aβ aggregation-promotion effect can potentially be useful for developing strategies to reduce Aβ toxicity.

关键词： Aβ Alzheimer's disease Aggregation Aβ oligomer Amorphous aggregate Cell death C elegans b-sheet

Cambrian integrative stratigraphy and timescale of China

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2019年第1期62卷 25-60页

作者： Maoyan ZHU aihua yang Jinliang YUAN Guoxiang LI Junming ZHANG Fangchen ZHAO Soo-Yeun AHN Lanyun MIAO State Key Laboratory of Palaeobiology and Stratigraphy & Center for Excellence in Life and Paleoenvironment Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences College of Earth Sciences University of Chinese Academy of Sciences Centre for Research and Education on Bilogical Evolution and Environment Nanjing University

The Cambrian Period is the first period of the Phanerozoic Eon and witnessed the explosive appearance of the metazoans, representing the beginning of the modern earth-life system characterized by animals in contrary to the Precambrian earth-life system dominated by microbial life. However, understanding Cambrian earth-life system evolution is hampered by regional and global stratigraphic correlations due to an incomplete chronostratigraphy and consequent absence of a highresolution timescale. Here we briefly review the historical narrative of the present international chronostratigraphic framework of the Cambrian System and summarize recent advances and problems of the undefined Cambrian stage GSSPs, in particular we challenge the global correlation of the GSSP for the Cambrian base, in addition to Cambrian chemostratigraphy and geochronology. Based on the recent advances of the international Cambrian chronostratigraphy, revisions to the Cambrian chronostratigraphy of China, which are largely based on the stratigraphic record of South China, are suggested, and the Xiaotanian Stage is newly proposed for the Cambrian Stage 2 of China. We further summarize the integrative stratigraphy of South China, North China and Tarim platforms respectively with an emphasis on the facies variations of the Precambrian-Cambrian boundary successions and problems for identification of the Cambrian base in the different facies and areas of China. Moreover, we discuss stratigraphic complications that are introduced by poorly fossiliferous dolomite successions in the upper Cambrian System which are widespread in South China, North China and Tarim platforms.

关键词： Cambrian Stratigraphy Golden Spike GSSP Geochronology South China North China Tarim

Direct prejudgement of hot images with detected diffraction rings in high power laser system

在线全文

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2018年第3期6卷 138-144页

作者： aihua yang Zhan Li Dean Liu Jie Miao Jianqiang Zhu Joint Laboratory on High Power Laser and Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049 China

A direct prejudgement strategy that takes the diffraction ring as the analysis target is put forward to predict hot images induced by defects of tens of microns in the main amplifier section of high power laser systems. Analysis of hot-image formation process shows that the hot image can be precisely calculated with the extracted intensity oscillation of the diffraction ring on the front surface of the nonlinear plate. The gradient direction matching （GDM） method is adopted to detect diffraction tings. Recognition of simulated diffraction rings shows that it is feasible to directly prejudge hot images induced by those closely spaced defects and the defects that are far apart from each other. Image compression and cluster analysis are utilized to optimize the performance of the GDM method in recognizing actually collected diffraction images. Results show that hot images induced by defects of tens of microns can be directly prejudged without redundant information.

关键词： diffraction tings gradient direction matching method hot images intensity oscillation

Digital Restoration of Historical Buildings by Integrating 3D PC Reconstruction and GAN Algorithm

在线全文

学校读者我要写书评

暂无评论

Journal of Artificial Intelligence and Technology 2024年第2期4卷 179-187页

作者： Tianke Fang Zhenxing Hui William P.Rey aihua yang Bin Liu Zhiying Xie School of Information Technology Mapua UniversityManilaPhilippines School of Computing and Information Engineering Xiamen University of TechnologyXiamenChina School of Information Media Zhangzhou Vocational College of Science and TechnologyZhangzhouChina College of Software Engineering Xiamen University of TechnologyXiamenChina

Historical architecture is an important carrier of cultural and historical heritage in a country and region,and its protection and restoration work plays a crucial role in the inheritance of cultural ***,the damage and destruction of buildings urgently need to be repaired due to the ancient age of historical buildings and the influence of natural environment and human ***,an artificial intelligence repair technology based on three-dimensional(3D)point cloud(PC)reconstruction and generative adversarial networks(GANs)was proposed to improve the precision and efficiency of repair ***,in-depth research on the principles and algorithms of 3D PC data processing and GANs should be ***,a digital restoration frameworkwas constructed by combining these two artificial intelligence technologies to achieve precise and efficient restoration of historical buildings through continuous adversarial learning *** experimental results showed that the errors in the restoration of palace buildings,defense walls,pagodas,altars,temples,and mausoleums were 0.17,0.12,0.13,0.11,and 0.09,*** technique can significantly reduce the error while maintaining the high-precision repair *** technology with artificial intelligence as the core has excellent accuracy and stability in the digital *** provides a new technical means for the digital restoration of historical buildings and has important practical significance for the protection of cultural heritage.

关键词： 3D PC reconstruction artificial intelligence repair GAN algorithm stereoscopic vision historical buildings

Optimization of compensation for high spatial frequency in distorted wavefront using optical phase conjugation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Optics Letters 2019年第7期17卷 34-37页

作者： Pan Zhang Dean Liu aihua yang Jianqiang Zhu Key Laboratory of High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

A method is proposed to optimize the recording structure of the photorefractive volume grating to compensate high spatial frequency in the distorted wavefront by optical phase *** on the coupled-wave equation, the diffraction efficiency of the recorded grating formed by the scattered beams in different recording structures is *** theoretical results show that the recorded modulations with high spatial frequency can be significantly improved in the small recording *** the experiment, three recording structures with the recording angles of 7.5°, 30°, and 45° are chosen to verify the compensation *** with the reconstructed image in the large recording angle of 45°, the signal to noise ratio of the image recorded at 7.5° increases to 3.2 times of that at 45°.

关键词： Optimization of compensation high spatial frequency optical phase conjugation

智慧图书馆视域下大型馆开架书库管理研究与策划

在线全文

学校读者我要写书评

暂无评论

图书馆学研究 2021年第1期 36-42页

作者：杨爱华湖北省图书馆

智慧图书馆体系介入大型馆已有时日,开架书库的管理尚存在诸多困境,需要查找问题、分析原因并提出解决方案。通过考察实践现状,并且不完全地回顾了近十五年国内智慧图书馆技术更新背景下大型馆开架书库管理的现状,指出由于缺乏联合研究... 详细信息

智慧图书馆体系介入大型馆已有时日,开架书库的管理尚存在诸多困境,需要查找问题、分析原因并提出解决方案。通过考察实践现状,并且不完全地回顾了近十五年国内智慧图书馆技术更新背景下大型馆开架书库管理的现状,指出由于缺乏联合研究和无规范化实施标准,导致多数大型馆技术升级后,开架书库管理仍停留在自助借还和安全防护等初级阶段。在对开架书库管理现状进行分析的基础上,设计构建以"列"为阈值单位的标准化、多方兼容的智慧图书馆开架书库管理体系。

关键词：智慧图书馆大型馆开架书库管理

在线全文

学校读者我要写书评

暂无评论

高校基础研究投入的诊断及对策分析

科技管理研究 2009年第3期29卷 131-133页

作者：杨爱华国防科学技术大学人文与社会科学学院湖南长沙410074 中国科学院研究生院人文学院北京100049

目前我国高校整体科研实力不断提高,并且承担越来越多的基础研究任务,但是基础研究投入问题是制约高校未来承担更多基础研究任务的瓶颈。着重分析了高校基础研究投入存在的问题:R&D经费来源结构单一、分配结构不合理,针对这些问题提出... 详细信息

目前我国高校整体科研实力不断提高,并且承担越来越多的基础研究任务,但是基础研究投入问题是制约高校未来承担更多基础研究任务的瓶颈。着重分析了高校基础研究投入存在的问题:R&D经费来源结构单一、分配结构不合理,针对这些问题提出了相应的对策建议:多样化R&D经费的来源渠道、合理化R&D经费的分配结构、科学化R&D经费的内部配置。

关键词：高校基础研究投入诊断对策

智慧图书馆视野下的开架书库排架方式研究——基于第六次全国公共图书馆省级馆开架书库排架方式评估标准

在线全文

学校读者我要写书评

暂无评论

农业图书情报学报 2020年第12期32卷 87-96页

作者：杨爱华湖北省图书馆武汉430071

[目的/意义]基于技术革新的智慧图书馆对原有开架书库排架方式与评估标准产生冲击,需要研究新环境下最优化的开架书库管理与评价方法。[方法/过程]以第六次全国公共图书馆评估《省级公共图书馆评估标准》的开架书库评估标准为例,提出开... 详细信息

[目的/意义]基于技术革新的智慧图书馆对原有开架书库排架方式与评估标准产生冲击,需要研究新环境下最优化的开架书库管理与评价方法。[方法/过程]以第六次全国公共图书馆评估《省级公共图书馆评估标准》的开架书库评估标准为例,提出开架书库分类到三级,正确率80%。笔者分析其存在理论与实践层面的弊端:分类级数与排架正确率之间逻辑不合理,单个三级类目容量过大,破坏三级以下类目的分类标准;不便读者快速查找同类文献,不利于工作人员工作,导致编目和排架工作脱节。分析产生弊端的原因:对开架书库排架方式研究不足,智慧图书馆技术革新带来的冲击以及开架书库评估标准不成熟、不稳定。[结果/结论]多方协同研究,寻求智慧图书馆以“阈值”为单位的多方兼容线性排架体系;智慧图书馆时代,明确原有开架书库排架方式人机兼容的特性并微调应用;完善开架书库评估标准,改进智慧图书馆内部管理与外部评价。

关键词：智慧图书馆技术革新开架书库排架方式

对我国科技奖励问题的分析与思考——从2004年度国家最高科学技术奖空缺谈起

在线全文

学校读者我要写书评

暂无评论

科技管理研究 2006年第5期26卷 4-6页

作者：杨爱华国防科学技术大学人文社会科学学院人文系湖南长沙410074

2004年度国家最高科学技术奖的空缺使我们对目前我国科技奖励工作有了进一步的思考。本文在对我国科技奖励工作存在的问题进行分析之后,针对这些具体问题提出了几点对策性的建议:提高民间奖的待遇;注重成果奖与人物奖的平衡度;坚持延迟... 详细信息

2004年度国家最高科学技术奖的空缺使我们对目前我国科技奖励工作有了进一步的思考。本文在对我国科技奖励工作存在的问题进行分析之后,针对这些具体问题提出了几点对策性的建议:提高民间奖的待遇;注重成果奖与人物奖的平衡度;坚持延迟评审和调控好评审程序与透明度。

关键词：科技奖励对策性建议 2004年度国家最高科学技术奖评审程序中国