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Preface to the Special Issue on Causes, Impacts, and Predictability of Droughts for the Past, Present, and Future

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Advances in Atmospheric Sciences 2024年第2期41卷 191-192页

作者： Tianbao ZHAO aiguo dai Jianping HUANG Lixia ZHANG Key Laboratory of Regional Climate-Environment Research for Temperate East Asia Institute of Atmospheric Physics(IAP)Chinese Academy of Sciences(CAS)Beijing 100029China Department of Atmospheric and Environmental Sciences University at AlbanySUNYAlbanyNew York 80307USA Key Laboratory for Semi-Arid Climate Change of the Ministry of Education Lanzhou UniversityLanzhou 730000China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Drought is a recurring dry condition with below-normal precipitation and is often associated with warm temperatures or heatwaves. A drought event can develop slowly over several weeks or suddenly within days, commonly under abnormal atmospheric conditions(e.g., quasi-stationary high-pressure systems), and can persist for weeks, months, or even years.

关键词： drought within suddenly

Quercetin,the key constituent of Astragali Radix,modulates ferroptosis in PASMCs and attenuates hypoxia pulmonary hypertension via the MAPK signaling pathway

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Journal of Chinese Pharmaceutical Sciences 2024年第8期33卷 714-729页

作者： Xia Li Beibei Cheng Junlan Tan Jiajing Wan Yuhong Wang aiguo dai Hunan Academy of Chinese Medicine Changsha 410208HunanChina Department of Respiratory Diseases Medical SchoolHunan University of Chinese MedicineChangsha 410208HunanChina Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine Changsha 410208HunanChina Science and Technology Innovation Center Hunan University of Chinese MedicineChangsha 410208HunanChina

This study delved into the mechanism by which the principal component of Astragali Radix regulated ferroptosis in the context of hypoxia-induced pulmonary hypertension,employing a combination of network pharmacology and experimental validation *** constituents of Astragali Radix and their corresponding targets were identified using the TCMSP database,while therapeutic targets associated with hypoxia-induced pulmonary hypertension were sourced from the GeneCards *** Venn online tool facilitated the identification of overlapping targets between the active constituents of Astragali Radix and hypoxia-induced pulmonary *** network diagrams depicting the relationship between Astragali Radix’s active constituents and their targets were constructed using Cytoscape software,with core targets and sub-networks identified using the CytoHubba *** ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were conducted using the DAVID ***,the FerrDb database was consulted to analyze genes implicated in regulating *** investigation revealed 18 active constituents selected from Astragali Radix,with quercetin emerging as the key component.A total of 35 potential targets associated with Astragali Radix in regulating ferroptosis and addressing hypoxia-induced pulmonary hypertension were *** validation demonstrated that quercetin could inhibit the MAPK signaling pathway,resulting in reduced Fe2+and lipid peroxide levels,increased GPX4 expression,and the reversal of *** summary,this study elucidated the fundamental constituents and pivotal signaling pathways through which Astragali Radix modulated ferroptosis and mitigated hypoxia-induced pulmonary ***,quercetin,a core constituent of Astragali Radix,was observed to inhibit ferroptosis in pulmonary arterial smooth muscle cells via the MAPK pathway and alleviate hypoxia-induc

关键词： Network pharmacology Astragali Radix Quercetin PASMCs Ferroptosis Hypoxia pulmonary hypertension

Establishment of the South Asian High over the Indo-China Peninsula During Late Spring to Summer

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Advances in Atmospheric Sciences 2017年第2期34卷 169-180页

作者： Lijuan WANG aiguo dai Shuaihong GUO Jing GE Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Science and Technology Innovation Team on Climate Simulation and Forecast Nanjing University of Information Science and Technology Department of Atmospheric and Environmental Sciences University at AlbanySUNY National Center for Atmospheric Research Meteorological Observatory of No.95147 Unit of PLA

The establishment of the upper-level South Asian high(SAH) over the Indo-China Peninsula(ICP) during late boreal spring and its possible causes are investigated using long-term NCEP–NCAR and ERA-40 reanalysis and satellite-observed OLR data. Results show that, from early March to mid-April, deep convection stays south of ～6?N over the northern Sumatran islands. As the maximum solar radiation moves over the latitudes of the ICP(10?–20?N) in late April, the air over the ICP becomes unstable. It ascends over the ICP and descends over the adjacent waters to the east and west. This triggers deep convection over the ICP that induces large latent heating and strong updrafts and upper-level divergence, leading to the formation of an upper-level anticyclonic circulation and the SAH over the ICP. During early to mid-May, deep convection over the ICP intensifies and extends northwards to the adjacent waters. Strong latent heating from deep convection enhances and maintains the strong updrafts and upper-level divergence, and the SAH is fully established by mid-May. Thus, the seasonal maximum solar heating and the land–sea contrast around the ICP provide the basic conditions for deep convection to occur preferentially over the ICP, which leads to the formation of the SAH over the ICP from late April to mid-May. Simulations using Reg CM4 also indicate that the diabatic heating over the ICP is conducive to the generation and development of upperlevel anticyclonic circulation, which leads to an earlier establishment of the SAH.

关键词： South Asian high Indo-China Peninsula diabatic heating deep convection

超声心动图评估低氧性肺动脉高压小鼠模型右心室收缩压

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中国医学影像技术 2024年第6期40卷 825-831页

作者：周灵灵王飞英易健曹闲雅谭骏岚谢思琳张超宋岚戴爱国湖南中医药大学医学院呼吸疾病研究室湖南长沙410208 血管生物学与转化医学湖南省重点实验室湖南长沙410208 湖南中医药大学第一附属医院医学创新实验中心湖南长沙410021 湖南中医药大学医学院湖南长沙410208 湖南中医药大学第一附属医院呼吸内科湖南长沙410021

目的以超声心动图监测单纯低氧及低氧联合血管内皮生长因子受体抑制剂SU5416诱导低氧性肺动脉高压(PH)小鼠模型心脏相关参数,据此建立预测右心室收缩压(RVSP)方程。方法将24只C57BL/6J雄性小鼠随机分为单纯低氧组(A组)、低氧联合SU5416... 详细信息

目的以超声心动图监测单纯低氧及低氧联合血管内皮生长因子受体抑制剂SU5416诱导低氧性肺动脉高压(PH)小鼠模型心脏相关参数,据此建立预测右心室收缩压(RVSP)方程。方法将24只C57BL/6J雄性小鼠随机分为单纯低氧组(A组)、低氧联合SU5416组(B组)及对照组(C组),每组8只。对A、B组分别以单纯低氧法及低氧联合SU5416构建低氧性PH模型。于造模前及后(开始干预后2、3、4周)行超声心动图检查,获得相关参数;于末次超声检查后以心导管法测量RVSP。观察各组超声参数变化,以及造模后4周超声参数与RVSP的相关性,建立直线方程预测RVSP。结果开始干预后,随时间延长,A、B组肺动脉内径(PAD)、PAD/主动脉内径(AOD)及右心室前壁厚度(RVAWT)均增大,心率、肺动脉射血加速时间(PAAT)、PAAT/肺动脉射血时间(PAET)及三尖瓣环收缩期位移(TAPSE)均下降(P均<0.05)。开始干预后3、4周,B组PAET、PAAT/PAET、TAPSE均低于A组(P<0.05)。开始干预后4周,A、B组RVSP均与PAD/AOD、RVAWT、PAAT、PAAT/PAET及TAPSE呈高度相关(P均<0.05)。以PAAT/PAET、TAPSE预测单纯低氧PH小鼠模型RVSP的直线回归方程为RVSP=-161.7×(PAAT/PAET)+63.85、RVSP=-36.53×TAPSE+71.55,预测低氧联合SU5416 PH小鼠模型RVSP的直线回归方程为RVSP=-266.4×(PAAT/PAET)+91.59、RVSP=-69.14×TAPSE+116.5。结论开始干预后4周,以单纯低氧及低氧联合SU5416构建的PH小鼠表型更为明显;根据超声心动图所获PAAT/PAET及TAPSE构建的预测PH模型小鼠RVSP方程可为相关研究提供参考。

关键词：高血压,肺性超声心动描记术小鼠

Hypoxia Induces Transforming Growth Factor-β1 Gene Expression in the Pulmonary Artery of Rats via Hypoxia-inducible Factor-1α

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Acta Biochimica et Biophysica Sinica 2007年第1期39卷 73-80页

作者： Yongliang JIANG aiguo dai Qifang LI and Ruicheng HU Depoptment of Respiratory Medicine,Hunan Institute of Gerontology,Hunan Province Geriatric Hospital,Changsha 410001,China Department of Respiratory Medicine Hunan Institute of Gerontology Hunan Province Geriatric HospitalChangsha 410001 China

The present study was undertaken to investigate the dynamic expression of hypoxia induciblefactor-1 α (HIF-1α) and transforming growth factor-β1 (TGF-β1) in hypoxia-induced pulmonary hypertensionof *** was found that mean pulmonary arterial pressure (mPAP) increased significantly after 7 d *** artery remodeling index and right ventricular hypertrophy became evident after 14 d ***-1α mRNA staining was less positive in the control,hypoxia for 3 d and hypoxia for 7 d,butbegan to enhance significantly after 14 d of hypoxia,then remained *** of HIF-1 α protein inthe control was less positive,but was up-regulated in pulmonary arterial tunica intima of all hypoxic ***-β1 mRNA expression in pulmonary arterial walls was increased significantly after 14 d of hypoxia, butshowed no obvious changes after 3 or 7 d of *** pulmonary tunica adventitia and tunica media,TGF-β1 protein staining was less positive in control rats,but was markedly enhanced after 3 d of hypoxia,reaching its peak after 7 d of hypoxia,and then weakening after 14 and 21 d of *** blottingshowed that HIF- 1α protein levels increased significantly after 7 d of hypoxia and then remained at a highlevel. TGF-β1 protein level was markedly enhanced after 3 d of hypoxia,reaching its peak after 7 d ofhypoxia,and then decreasing after 14 and 21 d of *** correlation analysis showed that HIF-1αmRNA, TGF-β1 mRNA, TGF-β1 protein were positively correlated with mPAP,vessel morphometry andright ventricular hypertrophy ***-β1 protein (tunica adventitia) was negatively correlated withHIF-lα *** together,our results suggest that changes in HIF-lα and TGF-β1 expression afterhypoxia play an important role in hypoxia-induced pulmonary hypertension of rats.

关键词： hypoxia inducible factor-1α transforming growth factor-β1 hypertension lung hypoxia

基于"多元协同式"的诊断学课程思政体系的构建与实践

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中华诊断学电子杂志 2024年第2期12卷 125-127页

作者：刘艳丽戴爱国胡兆勇邹芳刘惠娜逯晶湖南中医药大学医学院诊断学教研室长沙410208 湖南中医药大学党政办公室长沙410208 湖南中医药大学医学院解剖实验室中心长沙410208

课程思政是我国高等教育的理论创新与实践创新,是落实立德树人根本任务的重要途径。诊断学作为联系基础与临床的桥梁课程,必须推进课程思政在课程中的改革与实践。本研究在传统的诊断学课程思政基础上,充分利用线上教学平台、多种线下... 详细信息

课程思政是我国高等教育的理论创新与实践创新,是落实立德树人根本任务的重要途径。诊断学作为联系基础与临床的桥梁课程,必须推进课程思政在课程中的改革与实践。本研究在传统的诊断学课程思政基础上,充分利用线上教学平台、多种线下教学手段、诊断学实验课、临床技能竞赛、医院见习等,构建"线上线下相结合""理论实践相结合""课内课外相结合""学校医院相结合"的"多元协同式"诊断学课程思政体系,以期全方位、多角度、多样化地促进育人与育才相统一。

关键词：课程思政诊断学多元协同式

中性粒细胞胞外诱捕网在呼吸系统疾病研究热点的可视化分析

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中国医药科学 2024年第10期14卷 162-165,198页

作者：谢思琳谭骏岚周灵灵程贝贝王飞英易健宋岚戴爱国湖南中医药大学医学院呼吸疾病研究室湖南长沙410208 血管生物学与转化医学湖南省重点实验室湖南省高校重点实验室湖南长沙410208

目的对2003—2022年中性粒细胞胞外诱捕网在呼吸系统疾病领域相关研究进行可视化分析,探究中性粒细胞胞外诱捕网在该领域的研究热点及趋势。方法选用Web of Science核心数据库,检索2003—2022年中性粒细胞胞外诱捕网在呼吸系统疾病领... 详细信息

目的对2003—2022年中性粒细胞胞外诱捕网在呼吸系统疾病领域相关研究进行可视化分析,探究中性粒细胞胞外诱捕网在该领域的研究热点及趋势。方法选用Web of Science核心数据库,检索2003—2022年中性粒细胞胞外诱捕网在呼吸系统疾病领域的文献,运用VOSviewer软件对国家、机构、作者、关键词等进行可视化分析。结果本研究共纳入研究性文章和综述1601篇。近20年中性粒细胞胞外诱捕网在呼吸系统疾病领域发文量不断上升,美国、中国和德国是出版文献数最多的国家,中性粒细胞胞外诱捕网在肺癌、细菌性肺炎是该领域的研究热点。结论 2003—2022年中性粒细胞胞外诱捕网在呼吸系统疾病领域的研究热点不断更新,中性粒细胞胞外诱捕网相关靶向药物是未来的重点研究方向。

关键词：可视化分析中性粒细胞胞外诱捕网呼吸系统疾病肺癌细菌性肺炎

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基于络病理论探讨靶向肺血管重塑治疗肺动脉高压

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中国中医药信息杂志 2024年第9期31卷 18-23页

作者：曹闲雅谭骏岚郑润锈易健彭果然丁蓉珍李霞王飞英戴爱国湖南中医药大学中西医结合学院湖南长沙410208 血管生物学与转化医学湖南省重点实验室湖南长沙410208 湖南中医药大学医学院呼吸疾病研究室湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410021

肺动脉高压(PH)是一种进行性的肺血管疾病,可导致右心衰竭及死亡。近年来,PH发病率逐年上升且缺乏有效治疗手段。中医辨治PH疗效显著,可发挥重要的协同作用。肺血管重塑是PH的核心病理特征,其与络脉的生理结构及病理变化关系密切。本文... 详细信息

肺动脉高压(PH)是一种进行性的肺血管疾病,可导致右心衰竭及死亡。近年来,PH发病率逐年上升且缺乏有效治疗手段。中医辨治PH疗效显著,可发挥重要的协同作用。肺血管重塑是PH的核心病理特征,其与络脉的生理结构及病理变化关系密切。本文基于络病理论阐述PH中西医关键病机肺心脉络病变、肺血管重塑,分析PH中“脉络-血管”的生理,梳理其病理相关性,探讨中医靶向肺血管重塑辨治PH,从而为PH的临床治疗提供新思路。

关键词：肺动脉高压络病理论肺血管重塑理论探讨

肺心汤通过调控AMPK/mTOR信号通路抑制自噬对低氧性肺动脉高压大鼠的保护作用

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湖南中医药大学学报 2024年第5期44卷 744-753页

作者：张超易健丁蓉珍万佳婧谭骏岚王飞英周灵灵宋岚戴爱国湖南中医药大学医学院呼吸疾病研究室湖南长沙410208 血管生物学与转化医学湖南省重点实验室/湖南省高校重点实验室湖南长沙410208 湖南中医药大学第一附属医院医学创新实验中心湖南长沙410007 湖南中医药大学第一附属医院呼吸内科湖南长沙410007 湖南中医药大学医学院湖南长沙410208

目的探究肺心汤通过调控腺苷酸活化蛋白激酶(adenosine monophosphate-activated protein kinase,AMPK)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路对低氧性肺动脉高压(hypoxic pulmonary hypertension,HPH)大鼠的治疗作用及机制。方法36只SD雄性大鼠随机分为正常组、模型组、西地那非组以及肺心汤低、中、高剂量组。除正常组外,将其余5组置于氧气浓度为10.0%±0.5%的低氧舱内造模28 d,每天8 h,造模同时灌胃给药。4周后检测大鼠心肺血流动力学指标[右心室收缩压(right ventricular systolic pressure,RVSP),右心室肥厚指数(right ventricular hypertrophy index,RVHI),肺动脉加速时间/肺动脉射血时间(pulmonary acceleration time/pulmonary ejection time,PAT/PET)、三尖瓣环收缩期位移(tricuspid annulus plane systolic excursion,TAPSE)、右心室前壁厚度(right ventricular anterior wall thickness,RVAWT)];HE染色法检测肺动脉重塑;免疫荧光法检测α平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)和增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)蛋白共定位表达;透射电镜观察自噬溶酶体的数量;免疫组织化学法检测肺组织中p-AMPK、p-mTOR、微管相关蛋白1轻链3B(microtubule-associated protein light chain 3B,LC3B)、Beclin1和p62蛋白阳性表达。结果与正常组相比,模型组大鼠RVSP、RVHI及RVAWT显著升高(P<0.01),PAT/PET和TAPSE显著降低(P<0.01);肺小动脉壁明显增厚,管腔狭窄,肺小动脉管壁厚度占血管直径的百分比(the percentage of wall thickness of pulmonary arterioles to vascular diameter,WT%)显著升高(P<0.01);α-SMA和PCNA共定位表达显著增加;自噬溶酶体数量增加;肺组织中p-AMPK、LC3B和Beclin1蛋白阳性表达上调(P<0.01),p-mTOR及p62蛋白阳性表达下调(P<0.01)。与模型组相比,各给药组大鼠RVSP、RVHI及RVAWT显著下降(P<0.01),PAT/PET、TAPSE显著升高(P<0.05,P<0.01);肺小动脉壁增厚程度减轻,WT%显著降低(P<0.01);α-SMA和PCNA共定位表达减少;自噬溶酶体数量减少;肺组织中p-AMPK、LC3B和Beclin1蛋白阳性表达显著下降(P<0.05,P<0.01),p-mTOR及p62蛋白阳性表达显著上调(P<0.01)。与西地那非组相比,肺心汤低、中剂量组TAPSE降低(P<0.01);肺心汤低、中剂量组肺动脉中膜增厚程度增加,WT%增加(P<0.01);肺心汤低、中剂量组p-AMPK蛋白阳性表达升高(P<0.01),肺心汤高剂量组p-AMPK蛋白阳性表达降低(P<0.05);肺心汤低剂量组p-mTOR蛋白阳性表达降低(P<0.01)。结论肺心汤可能通过下调AMPK/mTOR信号通路抑制自噬,发挥改善HPH的作用。

关键词：肺心汤低氧性肺动脉高压腺苷酸活化蛋白激酶哺乳动物雷帕霉素靶蛋白自噬

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