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基于疾病中医证候分类的中药药效评价研究思路和方法(英文)

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中西医结合学报 2009年第6期7卷 501-504页

作者：吕爱平刘学文丁晓蓉中国中医科学院中医临床基础医学研究所北京100700

中药的临床应用建立在辨证的基础上,因此其药效评价也应该建立在中医证候分类的基础之上。通过药效学实验阐明中药治疗疾病的药效作用特点及其机制,揭示中药作用机制的科学内涵,是中药现代化和国际化的必然要求,也是探索药物作用靶点,... 详细信息

中药的临床应用建立在辨证的基础上,因此其药效评价也应该建立在中医证候分类的基础之上。通过药效学实验阐明中药治疗疾病的药效作用特点及其机制,揭示中药作用机制的科学内涵,是中药现代化和国际化的必然要求,也是探索药物作用靶点,指导临床合理用药的关键所在。如何利用成熟疾病动物模型,并明确其证候特征,是中药药效评价载体研究的关键问题。随着生物医学的发展,通过研究疾病动物模型的生物学指标有可能分析得出该疾病动物模型的证候特性。利用以方测证方法,建立针对该疾病常见证候类型且临床验证有效的中药干预疾病动物模型,并将治疗有效的动物作为体现相应证候特征的动物模型,通过探寻其现代生物学基础,确立相应的中医证候特征相关指标,从而明确疾病动物模型的证候特征,是建立适合辨证论治中药药效评价动物模型的重要途径。建立基于中医证候分类的中药药效评价研究方法,将有助于从中医理论出发提高我国中药研发水平。

关键词：中药治疗效果证候模型动物

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甘草多糖对H22荷瘤小鼠的免疫调节作用

中西医结合学报 2010年第4期8卷 363-367页

作者：李晓冰何小鹃刘彪徐荔鞠大宏姜淼吕爱平上海中医药大学上海201203 中国中医科学院中医临床基础医学研究所北京100700 湖北大学生命科学学院湖北武汉430062 北京化工大学生命科学与技术学院北京100029 中国中医科学院中医基础理论研究所北京100700

目的:建立H22荷瘤小鼠模型,观察甘草多糖对模型小鼠脾脏调节性T细胞(regulatory T cell,Treg)及脾淋巴细胞转化率的影响,探讨甘草多糖的免疫调节机制。方法:50只Balb/c小鼠随机分为正常组、模型组、环磷酰胺组、甘草多糖组和甘草多糖加... 详细信息

目的:建立H22荷瘤小鼠模型,观察甘草多糖对模型小鼠脾脏调节性T细胞(regulatory T cell,Treg)及脾淋巴细胞转化率的影响,探讨甘草多糖的免疫调节机制。方法:50只Balb/c小鼠随机分为正常组、模型组、环磷酰胺组、甘草多糖组和甘草多糖加环磷酰胺组。除正常组外,其余各组建立H22荷瘤小鼠模型。造模第2天各组开始给药,正常组和模型组腹腔注射生理盐水,环磷酰胺组腹腔注射环磷酰胺1周,甘草多糖组颈后皮下注射甘草多糖,连续14 d。取脾制备脾单细胞悬液,用流式细胞仪检测脾调节性T细胞,四甲基偶氮唑盐比色法检测脾淋巴细胞转化率。结果:模型组小鼠Treg细胞比例明显高于正常组,甘草多糖组Treg细胞比例低于模型组(P<0.01),甘草多糖组脾淋巴细胞转化率明显高于环磷酰胺组。甘草多糖与环磷酰胺无交互作用。结论:甘草多糖可能通过降低荷瘤小鼠Treg细胞的比例及提高脾淋巴细胞转化率而发挥抗肿瘤免疫调节作用。

关键词：甘草多糖 T细胞,调节性肝肿瘤,实验性小鼠

Development of Chinese Medicine Research in Hong Kong,China in Last Decade

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Chinese Journal of Integrative Medicine 2017年第7期23卷 483-485页

作者： lu ai-ping CHENG Shi-ping LIU Biao School of Chinese Medicine Hong Kong Baptist UniversityHong Kong SAR China School of Nursing Jiangxi University of Traditional Chinese Medicine Nanchang (330004) China

Chinese medicine（CM）has attracted wide attention from the public after the return of Hong Kong（HK）to China in July *** 1999,the HK Chinese Medicine Ordinance was enacted to confirm the legal position of CM and sin... 详细信息

关键词： legal entirely return funding institutions funded official encourage Figure Number

亚临床型甲状腺功能减退症对妊娠及其结局的影响

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中国妇幼保健 2017年第5期32卷 900-902页

作者：蔡秀丽刘爱萍卢菊昌宜都市妇幼保健院妇产科湖北襄阳443300

目的探讨亚临床型甲状腺功能减退症对妊娠过程及结局的影响。方法将212例亚临床型甲状腺功能减退孕妇随机平均分为治疗组与对照组,并选取同期正常妊娠孕妇100例作为正常组,治疗组给予左甲状腺素钠片口服治疗,对照组不给予左甲状腺素治疗... 详细信息

目的探讨亚临床型甲状腺功能减退症对妊娠过程及结局的影响。方法将212例亚临床型甲状腺功能减退孕妇随机平均分为治疗组与对照组,并选取同期正常妊娠孕妇100例作为正常组,治疗组给予左甲状腺素钠片口服治疗,对照组不给予左甲状腺素治疗,对比3组孕妇妊娠期并发症及妊娠结局。结果对照组妊娠期高血压、子痫前期、妊娠期糖尿病、胎儿生长受限、妊娠期贫血发生率、早产、流产、剖宫产率均显著高于治疗组与正常组(P<0.05),而顺产率显著低于治疗组与正常组(P<0.05);对照组新生儿出生体重、Apgar评分均显著低于治疗组与正常组(P<0.05)。结论亚临床型甲状腺功能减退明显增加不良妊娠结局发生,对SCH孕妇应早期诊断、早期治疗,以降低不良妊娠结局发生率,建议妇女在妊娠前、妊娠早期常规进行TSH检查以保证孕产妇与后代的健康。

关键词：亚临床型甲状腺功能减退妊娠结局

Progress in ion detection and clinical diagnosis based on G-quadruplex combined with fluorescence properties

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Advanced Sensor and Energy Materials

Advanced Sensor and Energy Materials 2024年第3期3卷 61-70页

作者： ping lu Gerile Aodeng Jun ai College of Chemistry and Environmental Science Inner Mongolia Key Laboratory of Environmental ChemistryInner Mongolia Normal UniversityHohhot 010022China

G-quadruplex is a high-level structure composed of folded DNA or RNA rich in tandem repeats of guanine(G).In recent years,G-quadruplex is widely used in various fields due to its unique structural *** article briefly introduces the structural properties of G-quadruplex,and provides a brief introduction to the research on DNA and RNA G-quadruplex in various detection and medical *** is hoped that this can provide some help to readers who want to understand G-quadruplex.

关键词： G-quadruplex DNA G-quadruplex RNA G-quadruplex Detection Medical

Microstructural refinement and performance improvement of Cu-36 wt%Zn alloy by Al_(2)O_(3)nanoparticles coupling electromagnetic stirring

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Rare Metals 2022年第10期41卷 3560-3565页

作者： Ya-Bo Fu Yi-ping lu Zhi-Jun Wang Zhi-Qiang Cao ai-Jiao Xu School of Physics and Electronic Engineering Taizhou UniversityTaizhou318000China School of Materials Science and Engineering Dalian University of TechnologyDalian116024China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an710048China

Cu-36 wt%Zn alloy is widely used in valves of water and heating and auto parts,***,the structure is still coarse,and performances are much *** structure and performances of Cu-36 wt%Zn alloy were investigated by adding Al_(2)O_(3)nanoparticles and *** indicate that by Al_(2)O_(3)nanoparticles coupling electromagnetic stirring,the Cu-36 wt%Zn alloy with refined microstructure was successfully *** average grain size is refined by 99%compared with that without nanoparticles and *** tensile strength(R_m)and percentage elongation after fracture(A11.3)increase by 20.58%and 19.40%,respectively,compared with that without nanoparticles and *** increase heterogeneous nucleation rate by 50%compared with that without *** depth of dezincification layer decreases by 78.71%compared with that without nanoparticles and stirring,as protective layer(Cu-Al_(2)O_(3)-Zn)is completely formed around the grain boundaries.

关键词： Microstructural refinement Rotating electromagnetic field Mechanical performance Al_(2)O_(3)nanoparticles

Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis

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Chinese Journal of Integrative Medicine 2021年第6期27卷 465-469页

作者： ZHANG Chi LI Li ZHANG Ge CHEN Ke-ji lu ai-ping Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing(100700)China Institute for Advancing Translational Medicine in Bone and Joint Diseases Hong Kong Baptist UniversityHong Kong SARChina Cardiovascular Disease Centre Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China

Biological complexity and the need for personalized medicine means that biomarker development has become increasingly ***,new paradigms for research need to be created that bring together a different classifier of *** potential solution is collaboration between biomarker development and Chinese medicine pattern *** this article,two examples of rheumatoid arthritis are discussed,including a new biomarker candidate casein kinase 2 interacting protein 1(CKIP-1)and a micro RNA *** authors obtained a"snapshot"of pattern classification with disease in biomarker *** analyses revealed underlying biological functions of two biomarker candidates,in varying degrees,are correlated with Chinese medicine pattern of rheumatoid *** authors'initial attempt can provide a new window for studying the win-win potential correlation between the biomarkers and pattern classification in Chinese medicine.

关键词： Chinese medicine pattern classification biomarker rheumatoid arthritis

Preparation of Polyurea Elastomer with Flame Retardant, Insulation and Thermal Conductivity Properties

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 781-789页

作者：方今 DONG Yang lu Shangkai LIU Junbang ai Lianghui 刘平 State Key Laboratory of luminescent Materials and Devices Research Institute of Materials ScienceSouth China University of TechnologyGuangzhou 510640China

By using 6,6-((sulfonylbis(4,1-phenylene)bis(azanediyl))bis(thiophen-2-ylm-ethylene))bis6H-di-benzo[c,e][1,2]oxaphosphinine 6-oxide(DOPO-N)as phosphorus-nitrogen flame retardant,the polyurea(PUA)with flame retardant properties(PUA/DOPO-N)was *** addition,organically modified montmorillonite(OMMT)and magnesium hydroxide(MH)were used as co-effectors respectively,and the flame retardant PUA(PUA/DOPO-N/OMMT and PUA/DOPO-N/MH)were also *** properties,flame retardant properties,flame retardant mechanism and mechanical properties of PUA/DOPO-N,PUA/DOPO-N/OMMT and PUA/DOPO-N/MH were investigated by thermogravimetric(TG)analysis,limiting oxygen index(LOI),UL 94,cone calorimeter test,scanning electron microscopy(SEM),and tensile *** results show that the LOI value of PUA/20%DOPO-N,PUA/18%DOPO-N/2%OMMT and PUA/15%DOPO-N/5%MH are 27.1%,27.7%,and 28.3%,respectively,and UL 94 V-0 rating is *** with PUA,the peak heat release rate(pk-HRR),total heat release(THR)and average effective heat combustion(av-EHC)of PUA/20%DOPO-N,PUA/18%DOPO-N/2%OMMT and PUA/15%DOPO-N/5%MH decrease *** results indicate that the residual chars of PUA/20%DOPO-N,PUA/18%DOPO-N/2%OMMT and PUA/15%DOPO-N/5%MH are completer and more *** complex of DOPO-N/OMMT and DOPO-N/MH have synergistic flame *** mechanical properties of PUA can be improved by the addition of DOPO-N,DOPO-N/OMMT and DOPO-N/MH,*** insulation performance test shows that the volume resistivity of PUA/20%DOPO-N is 6.25×10^(16)Ω.***,by using modified boron nitride(MBN)as heat dissipating material,the complex of PUA/MBN was prepared,and the thermal conductivity of PUA/MBN was *** thermal conductivity of PUA/8%MBN complex coating at room temperature is 0.166 W/(M·K),which is a 163%improvement over pure PUA.

关键词： polyurea organic flame retardant inorganic flame retardant synergistic flame retardancy insulation thermal conductivity

Foliar application of sodium hydrosulfide(NaHS),a hydrogen sulfide(H2S) donor,can protect seedlings against heat stress in wheat(Triticum aestivum L.)

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Journal of Integrative Agriculture 2016年第12期15卷 2745-2758页

作者： YANG Min QIN Bao-ping MA Xue-li WANG ping LI Mei-ling CHEN lu-lu CHEN Lei-tai SUN ai-qing WANG Zhen-lin YIN Yan-ping State Key Laboratory of Crop Biology/Agronomy College Shandong Agricultural University Tai'an 271018 P.R.China Tai'an Academy of Agricultural Sciences Tai'an 271018 P.R.China

Temperature extremes represent an important limiting factor to plant growth and productivity. Low concentration of hydrogen sulfide （H2S） has been proven to function in physiological responses to various stresses. The present study evaluated the effect of foliar application of wheat seedlings with a H2S donor, sodium hydrosulfide （NariS）, on the response to acute heat stress. The results showed that pretreatment with NariS could promote heat tolerance of wheat seedlings in a dose-depen- dent manner. Again, it was verified that H2S, rather than other sulfur-containing components or sodion derived from NariS solution, should contribute to the positive role in promoting wheat seedlings against heat stress. To further study antioxidant mechanisms of NariS-induced heat tolerance, superoxide dismutase （SOD, EC 1.***.1.1 ）, catalase （CAT, EC 1.***.1.6） and ascorbate peroxidase （APX, EC 1.***.1.11 ） activities, and HzS, hydrogen peroxide （H2O2）, malonaldehyde （MDA）, and soluble sugar contents in wheat seedlings were determined. The results showed that, under heat stress, the activities of SOD, CAT, and APX, H2S, H2O2, MDA, and soluble sugar contents in NaHS-pretreated seedlings and its control all increased. Meanwhile, NaHS-pretreated seedlings showed higher antioxidant enzymes activities and gene expression levels as well as the H2S and soluble sugar levels, and lower H2O2, MDA contents induced by heat stress. While little effect was detected in antioxidant enzymes activities and soluble substances contents in pretreated wheat seedlings compared with its control under normal culture conditions （data not shown）. All of our results suggested that exogenous NariS could alleviate oxidative damage and improve heat tolerance by regulating the antioxidant system in wheat seedlings under heat stress.

关键词： wheat seedlings sodium hydrosulfide heat stress antioxidant system mitigative effect