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Artificial intelligence for the detection of glaucoma with SD-OCT images:a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 408-419页

作者： Nan-Nan Shi Jing Li Guang-Hui Liu ming-Fang Cao Department of Ophthalmology Affiliated People’s Hospital(Fujian Provincial People’s Hospital)Fujian University of Traditional Chinese MedicineFuzhou 350004Fujian ProvinceChina Eye Institute of Integrated Chinese and Western Medicine Fujian University of Traditional Chinese MedicineFuzhou 350004Fujian ProvinceChina

●aiM:To quantify the performance of artificial intelligence(ai)in detecting glaucoma with spectral-domain optical coherence tomography(SD-OCT)images.●METHODS:Electronic databases including PubMed,Embase,Scopus,ScienceDirect,ProQuest and Cochrane Library were searched before May 31,2023 which adopted ai for glaucoma detection with SD-OCT *** pieces of the literature were screened and extracted by two ***-analysis,Meta-regression,subgroup,and publication of bias were conducted by *** risk of bias assessment was performed in Revman5.4 using the QUADAS-2 tool.●RESULTS:Twenty studies and 51 models were selected for systematic review and *** pooled sensitivity and specificity were 0.91(95%CI:0.86–0.94,I2=94.67%),0.90(95%CI:0.87–0.92,I2=89.24%).The pooled positive likelihood ratio(PLR)and negative likelihood ratio(NLR)were 8.79(95%CI:6.93–11.15,I2=89.31%)and 0.11(95%CI:0.07–0.16,I2=95.25%).The pooled diagnostic odds ratio(DOR)and area under curve(AUC)were 83.58(95%CI:47.15–148.15,I2=100%)and 0.95(95%CI:0.93–0.97).There was no threshold effect(Spearman correlation coefficient=0.22,P>0.05).●CONCLUSION:There is a high accuracy for the detection of glaucoma with ai with SD-OCT *** application of ai-based algorithms allows together with“doctor+artificial intelligence”to improve the diagnosis of glaucoma.

关键词： artificial intelligence spectral-domain optical coherence tomography glaucoma Meta-analysis

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无针注射技术的研究进展

药学学报 2024年第3期59卷 591-599页

作者：张郃李硕程艺王增明刘楠李蒙张慧郑爱萍军事科学院军事医学研究院毒物药物研究所北京100850 联勤保障部队第九〇九医院/厦门大学附属东南医院药剂科福建漳州363000 解放军总医院京南医疗区北京100850

无针注射技术(needle-free injection technology,NFIT)是指药物在压力源作用下形成高速喷射流,透过皮肤到达合适深度的药物递送技术。NFIT可以递送液体、粉末和储库型制剂,具有防止意外针刺伤、提高药物生物利用度、消除针头恐惧、增... 详细信息

无针注射技术(needle-free injection technology,NFIT)是指药物在压力源作用下形成高速喷射流,透过皮肤到达合适深度的药物递送技术。NFIT可以递送液体、粉末和储库型制剂,具有防止意外针刺伤、提高药物生物利用度、消除针头恐惧、增加疫苗免疫效果、简化操作及易于患者自用等优势,是一种非常有潜力的递送药物方式。本文系统介绍了NFIT的研究背景、无针注射器的结构组成及可递送药物、影响注射效果的因素,并且总结了目前该技术的局限性和发展方向,为NFIT的应用和发展提供理论基础。

关键词：无针注射技术无针注射器药物递送压力源疫苗

Metabolomic Analysis of the Anthocyanins Associated with Different Colors of Cymbidium goeringii in Guizhou, China

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1455-1466页

作者： Dongbo Wu Shuang Qu Lianwen Shen Shengqun Chen Xia Jiang ai Rao Yuxue Zhao Yueyun Wang College of Pharmacy Guizhou University of Traditional Chines MedicineGuiyang550025China Research Institute of Juglans Regia Guizhou Academy of ForestryGuiyang550005China Guizhou Liping Rocky Desertification Ecosystem National Observation and Research Station Qiandongnan Prefecture556200China

Cymbidium goeringii is an economically important ornamental plant,and flower color is one of the main features of *** that contributes to its high economic *** clarify the molecular mechanisms underlying the role of anthocyanins in mediating differences in color among varieties,liquid chromatography–tandem mass spectrometry was used to perform anthocyanin-targeted metabolomics of seven *** varieties,including‘Jin Qian Yuan’(JQY),‘Jin Xiu Qian Yuan’(JXQY),‘Miao Jiang Su Die’(MJSD),‘Qian ming Su’(QMS),‘Shi Chan’(SC),and‘Yang ming Su’(YMS),as well as the *** detected 64 anthocyanins,including cyanidins,delphinidins,malvidins,pelargonidins,peonidins,petunidins,procyanidins,and *** identified six shared differentially accumulated metabolites(DAMs),including cyanidin-3-O-rutinoside,delphinidin-3-Osophoroside,pelargonidin-3-O-rutinoside,peonidin-3-O-(6-O-malonyl-beta-D-glucoside),peonidin-3-Osophoroside,and *** DAMs were enriched in the anthocyanin biosynthesis *** Encyclopedia of Genes and Genomes pathway analysis revealed that the differentially expressed metabolites were significantly enriched in the anthocyanin biosynthesis *** of the content of differentially expressed metabolites indicated that peonidin-3-O-(6-O-malonyl-beta-D-glucoside)was the key metabolite underlying color differences among *** *** B2,pelargonidin-3-O-galactoside,and naringenin might also affect the color formation of JQY and QMS,SC,and MJSD,*** results of this study shed light on the metabolic mechanism underlying flower color differences in *** at the molecular *** findings will aid future studies of the mechanism of flower color regulation in *** and have implications for the breeding of new varieties.

关键词： Cymbidium goeringii ﬂower color anthocyanins metabolomics

Orifice plate cavitation mechanism and its influencing factors

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Water Science and Engineering 2010年第3期3卷 321-330页

作者： Wan-zheng ai Tian-ming DING Marine College of Zhejiang Ocean University Zhoushan 316000 P. R. China

The orifice plate energy dissipater is an economic and highly efficient dissipater. However, there is a risk of cavitaion around the orifice plate flow： In order to provide references for engineering practice, we examined the cavitation mechanism around the orifice plate and its influencing factors by utilizing mathematical analysis methods to analyze the flow conditions around the orifice plate in view of gas bubble dynamics. Through the research presented in this paper, the following can be observed： The critical radius and the critical pressure of the gas nucleus in orifice plate flow increase with its initial state parameter r0 ; the development speed of bubbles stabilizes at a certain value after experiencing a peak value and a small valley value; and the orifice plate cavitation is closely related to the distribution of the gas nucleus in flow. For computing the orifice plate cavitation number, we ought to take into account the effects of pressure fluctuation. The development time of the gas nucleus from the initial radius to the critical radius is about 107-10-5 s; therefore, the gas nucleus has sufficient time to develop into bubbles in the negative half-cycle of flow fluctuation. The orifice critical cavitation number is closely related to the orifice plate size, and especially closely related with the ratio of the orifice plate radius to the tunnel radius. The approximate formula for the critical cavitation number of the square orifice plate that only considers the main influencing factor was obtained by model experiments.

关键词： orifice plate cavitation gas nucleus critical radius critical pressure pressure fluctuation critical cavitation number

Electromagnetic pulses produced by a picosecond laser interacting with solid targets

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Chinese Physics B 2024年第5期33卷 430-436页

作者：牛爱慧康宁许国潇谢佳节滕建刘会亚孙明营李廷帅 School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Key Laboratory on High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China University of Chinese Academy of Sciences Beijing 100049China Science and Technology on Plasma Physics Laboratory Research Center of Laser FusionChina Academy of Engineering PhysicsMianyang 621900China

A high-power laser ablating solid targets induces giant electromagnetic pulses(EMPs),which are intimately pertinent to laser parameters,such as energy and pulse *** this study,we reveal the features of EMPs generated from a picosecond(ps)laser irradiating solid targets at the SG-Ⅱpicosecond petawatt(PSPW)laser *** laser energy and pulse,as well as target material and thickness,show determinative effects on the EMPs’*** intense EMPs are detected behind targets compared to those at the other three positions,and the EMP amplitude decreases from 90.09 kV/m to 17.8 kV/m with the gold target thickness increasing from 10μm to 20μm,which is suppressed when the laser pulse width is *** results are expected to provide more insight into EMPs produced by ps lasers coupling with targets and lay the foundation for an effective EMP shielding design in high-power laser infrastructures.

关键词： laser electromagnetic pulse target proton

Challenges and recent advances in HfO_(2)-based ferroelectric films for non-volatile memory applications

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Chip 2024年第3期3卷 50-72页

作者： ming-Hao Shao Rui-Ting Zhao Houfang Liu Wen-Jia Xu Yi-Da Guo Da-Peng Huang Yu-Zhe Yang Xin-Ru Li Wancheng Shao Peng-Hui Shen Junwei Liu Kuanmao Wang Jinguo zheng Zhao-Yi Yan Jian-Lan Yan Tian Lu Yi Yang Tian-Ling Ren School of Integrated Circuits and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100084China

The emergence of data-centric applications such as artificial intelligence(ai),machine learning,and the Internet of Things(IoT),has promoted surges in demand for storage memories with high operating speed and nonvolatile ***_(2)-based ferroelectric memory technologies,which emerge as a promising alternative,have attracted considerable attention due to their high performance,energy efficiency,and full compatibility with the standard complementary metal-oxide-semiconductors(CMOS)*** nonvolatile storage elements,such as ferroelectric random access memory(FeRAM),ferroelectric field-effect transistors(FeFETs),and ferroelectric tunnel junctions(FTJs),possess different data access mechanisms,individual merits,and specific application boundaries in next-generation memories or even beyond von Neumann *** paper provides an overview of ferroelectric HfO2 memory technologies,addresses the current challenges,and offers insights into future research directions and prospects.

关键词： Ferroelectric memory Ferroelectric random-access memory Ferroelectricﬁeld effect transistor Ferroelectric tunneling junction Hafnium oxide

1,3-氧硫戊环为受体的Hg^(2+)荧光探针的设计、合成及性能

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光谱学与光谱分析 2024年第7期44卷 1913-1917页

作者：梁庆祥周五吴爱斌舒文明余维初长江大学化学与环境工程学院化学系湖北荆州434023 长江大学非常规油气协同创新中心湖北荆州434023 油气田清洁生产与污染物控制湖北省工程研究中心湖北荆州434023

Hg^(2+)是毒性最强的重金属离子之一,会造成空气、土壤和水的污染,严重损害人体健康,开发有效的分析方法检测环境体系中的Hg^(2+)尤为重要。荧光探针因其灵敏度高、选择性好、响应速度快、可实时在线检测等优点,已广泛应用于Hg^(2+)检... 详细信息

Hg^(2+)是毒性最强的重金属离子之一,会造成空气、土壤和水的污染,严重损害人体健康,开发有效的分析方法检测环境体系中的Hg^(2+)尤为重要。荧光探针因其灵敏度高、选择性好、响应速度快、可实时在线检测等优点,已广泛应用于Hg^(2+)检测。以Hg^(2+)促进硫代缩醛的去保护反应设计合成了一种全新的以1,3-氧硫戊环为受体的开启型Hg^(2+)荧光探针[2-(pyren-1-yl)-1,3-oxathiolane,POX],通过^(1)H NMR、^(13)C NMR和HRMS对POX结构进行表征,考察了POX在CH_(3)CH_(2)OH/H_(2)O中对Hg^(2+)的选择性、竞争性、浓度滴定、pH滴定、时间依赖性、检出限和识别机理等。研究结果表明,POX可在较宽的pH范围内对Hg^(2+)快速识别,并表现出高度的选择性和灵敏度;向POX中加入Hg^(2+)后,在386 nm处出现明显的荧光发射峰,表明POX对Hg^(2+)呈现出显著的荧光“开启”效应,其识别过程几乎不受其他金属离子干扰;荧光滴定实验表明POX在Hg^(2+)浓度为0~6.5μmol·L^(-1)范围内具有良好的线性响应(R^(2)=0.9994),检出限为0.168μmol·L^(-1),在实际水样中检测Hg^(2+)的RSD小于2.92%。由于POX合成简单、原料易得且pH适用范围较广,可作为定性和定量检测环境中Hg^(2+)的潜在工具。

关键词：荧光探针 Hg^(2+) 1,3-氧硫戊环荧光开启

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主轴箱铸件的消失模铸造工艺优化

现代铸铁 2024年第1期44卷 35-37,41页

作者：王爱铭杨争光龚楠共享装备股份有限公司宁夏银川750021

介绍了主轴箱铸件的结构及技术要求,针对主轴箱铸件的碳缺陷问题,从浇注系统设计、冒口、集渣条设计和埋箱造型方式等3个方面入手,对主轴箱铸件的消失模铸造工艺进行优化设计。经实际生产验证,通过优化浇注系统机构,更改造型方式,增加... 详细信息

介绍了主轴箱铸件的结构及技术要求,针对主轴箱铸件的碳缺陷问题,从浇注系统设计、冒口、集渣条设计和埋箱造型方式等3个方面入手,对主轴箱铸件的消失模铸造工艺进行优化设计。经实际生产验证,通过优化浇注系统机构,更改造型方式,增加出气系统,可以有效消除铸件的碳缺陷问题,铸件无夹砂、夹渣等铸造缺陷,铸件尺寸精度高,质量稳定,满足技术要求,铸件的合格率达到95%以上。

关键词：灰铸铁主轴箱消失模工艺

On the Downshift of Wave Frequency for Bragg Resonance

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China Ocean Engineering 2022年第1期36卷 76-85页

作者： PENG Ji TAO ai-feng FAN Jun zheng Jin-hai LIU Yu-ming Key Laboratory of Ministry of Education for Coastal Disaster and Protection Hohai UniversityNanjing 210098China Quality Supervision Department China Renewable Energy Engineering InstituteBeijing 100120China College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridge 02139USA

For surface gravity waves propagating over a horizontal bottom that consists of a patch of sinusoidal ripples,strong wave reflection occurs under the Bragg resonance *** critical wave frequency,at which the peak reflection coefficient is obtained,has been observed in both physical experiments and direct numerical simulations to be downshifted from the well-known theoretical *** has long been speculated that the downshift may be attributed to higher-order rippled bottom and free-surface boundary effects,but the intrinsic mechanism remains *** a regular perturbation analysis,we derive the theoretical solution of frequency downshift due to third-order nonlinear effects of both bottom and free-surface *** is found that the bottom nonlinearity plays the dominant role in frequency downshift while the free-surface nonlinearity actually causes frequency *** frequency downshift/upshift has a quadratic dependence in the bottom/free-surface *** bottom leads to a larger frequency downshift relative to the monochromatic *** addition,direct numerical simulations based on the high-order spectral method are conducted to validate the present *** theoretical solution of frequency downshift compares well with the numerical simulations and available experimental data.

关键词： gravity surface wave Bragg resonance frequency downshift regular perturbation analysis