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Increased immune escape of the new SARS-CoV-2 variant of concern Omicron

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Cellular & Molecular Immunology 2022年第2期19卷 293-295页

作者： Jie Hu Pai Peng Xiaoxia Cao Kang Wu Juan Chen Kai Wang Ni Tang ai-long huang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious Diseasesthe Second Affiliated HospitalChongqing Medical UniversityChongqingChina.

On 24 November,a new detected variant B.1.1.529 of SARS-CoV-2 by South Africa was reported to *** only 2 days,this variant was designated as“variant of concern”(VOC)and named as *** the past few weeks,Omicron had reported from more than 80 *** has been reported as the dominant SARS-CoV-2 in *** to the rapid spread of Omicron.A new wave of infection driven by Omicron is in progress.

关键词： immune infection Omi

Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera

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Genes & Diseases 2022年第5期9卷 1290-1300页

作者： Jie Hu Xiao-yu Wei Jin Xiang Pai Peng Feng-li Xu Kang Wu Fei-yang Luo ai-shun Jin Liang Fang Bei-zhong Liu Kai Wang Ni Tang ai-long huang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqing 400010PR China Yong-Chuan Hospital Chongqing Medical UniversityChongqing 402177PR China Department of Immunology College of Basic MedicineChongqing Medical UniversityChongqing 400016PR China

Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The Spike protein that mediates coronavirus entry into host cells is a major target for COVID-19 vaccines and antibody ***,multiple variants of SARS-CoV-2 have emerged,which may potentially compromise vaccine *** a pseudovirus-based assay,we evaluated SARS-CoV-2 cell entry mediated by the viral Spike B.1.617 and B.1.1.7 *** also compared the neutralization ability of monoclonal antibodies from convalescent sera and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine)and ZF2001(RBD-subunit vaccine)against B.1.617 and B.1.1.7 *** results showed that,compared to D614G and B.1.1.7 variants,B.1.617 shows enhanced viral entry and membrane fusion,as well as more resistant to antibody *** findings have important implications for understanding viral infectivity and for immunization policy against SARS-CoV-2 variants.

关键词： Coronavirus Immune escape Mutation Neutralizing antibodies SARS-CoV-2 Vaccine Viral entry

Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao SU Meng-qing LI Lan YU ai-ling CHEN Ken huang Yun-ke ZHAO Qiu-long huang Wen-ya huang Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,P<0.01)and endothelial function-protective(lower VEGF,ET-1,P<0.01)*** increases in aortic relaxation,endothelial NO levels and phosphorylated PI3K/Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

APOE interacts with ACE2 inhibitingg SARS-CoV-2 cellular entry and inflammation in COVID-19 patients

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3459-3467页

作者： Hongsheng Zhang Lin Shao Zhihao Lin Quan-Xin long Huilong Yuan Lujian Cai Guangtong Jiang Xiaoyi Guo Renzhi Yang Zepeng Zhang Bingchang Zhang Fan Liu Zhiyong Li Qilin Ma Yun-Wu Zhang ai-long huang Zhanxiang Wang Yingjun Zhao Huaxi Xu Center for Brain Sciences the First Aliated Hospital of Xiamen UniversityInstitute of NeuroscienceFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging ResearchXiamen UniversityXiamenChina Institute for Brain Science and Disease Chongqing Medical UniversityChongqingChina school of Medicine Xiamen UniversityXiamenChina Key Laboratory of Molecular Biology for Infectius Diseases(Minstry of Educatio) Chongqing Medical UniversityChongqingChina

Apolipoprotein E(APOE)plays a pivotal role in lipid including cholesterol *** APOE 4(APOE4)allele is a major genetic risk factor for Alzheimer's and cardiovascular *** APOE has recently been associated with increased susceptibility to infections of several viruses,whether and how APOEand its isoforms affect SARS-CoV-2 infection remains ***,we show that serum concentrations of APOE correlate inversely with levels of cytokine/chemokine in 73 COVID-19 *** multiple protein interaction assays,we demonstrate that APOE3 and APOE4 interact with the SARS-CoV-2 receptor ACE2;and APOE/ACE2 interactions require zinc metallopeptidase domain of ACE2,a key docking site for SARS-CoV-2 Spike *** addition,immuno-imaging assays using confocal,super-resolution,and transmission electron microscopies reveal that both APOE3 and APOE4 reduce ACE2/Spikemediated viral entry into ***,while having a comparable binding affinity to ACE2,APOE4 inhibits viral entry to a lesser extent compared to APOE3,which is likely due to APOE4's more compact structure and smaller spatial obstacle to compete against Spike binding to ***,APOE e4 carriers clinically correlate with increased SARS-CoV-2 infection and elevated serum inflammatory factors in 142 COVID-19 patients *** study suggests a regulatory mechanism underlying SARS-CoV-2 infection through APOE interactions with ACE2,which may explain in part increased COVID-19 infection and disease severity in APOE e4 carriers.

关键词： ACE2 patients inflammation

Semi-supervised surface defect detection of wind turbine blades with YOLOv4

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Global Energy Interconnection 2024年第3期7卷 284-292页

作者： Chao huang Minghui Chen long Wang Department of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083P.R.China Shunde Innovation School University of Science and Technology BeijingFoshan 528399P.R.China

Timely inspection of defects on the surfaces of wind turbine blades can effectively prevent unpredictable *** this end,this study proposes a semi-supervised object-detection network based on You Only Looking Once version 4(YOLOv4).A semi-supervised structure comprising a generative adversarial network(GAN)was designed to overcome the difficulty in obtaining sufficient samples and sample *** a GAN,the generator is realized by an encoder-decoder network,where the backbone of the encoder is YOLOv4 and the decoder comprises inverse convolutional *** features from the generator are passed to the defect detection *** several unlabeled images can significantly improve the generalization and recognition capabilities of defect-detection *** small-scale object detection capacity of the network can be improved by enhancing essential features in the feature map by adding the concurrent spatial and channel squeeze and excitation(scSE)attention module to the three parts of the YOLOv4 network.A balancing improvement was made to the loss function of YOLOv4 to overcome the imbalance problem of the defective *** results for both the single-and multi-category defect datasets show that the improved model can make good use of the features of the unlabeled *** accuracy of wind turbine blade defect detection also has a significant advantage over classical object detection algorithms,including faster R-CNN and DETR.

关键词： Defect detection Generative adversarial network scSE attention Semi-supervision Wind turbine

Small temporal variation in abundance of virioplankton compared to bacterioplankton and phytoplankton in two bays in the northern South China Sea

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Journal of Oceanology and Limnology 2024年第4期42卷 1130-1142页

作者： Jiandong ZHANG Yineng LI Lijuan long Sijun huang CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Marine Environmental Engineering Center South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Guangdong Provincial Observation and Research Station for Coastal Upwelling Ecosystem South China Sea Institute of OceanologyChinese Academy of SciencesShantou 515041China

Variations of picoplankton groups were investigated over a one-month period in Daya Bay and Sanya Bay,in the northern South China *** two coastal regions exhibited different variation patterns in physicochemical ***,the diel variations of picoplankton groups were different between the two *** abundance of the picoplankton in Sanya Bay displayed a pronounced diel variation,while it was not significant in Daya *** addition,some similar patterns of picoplankton abundance were *** the two bays,virioplankton exhibited the smallest fluctuation range,whereas picocyanobacteria fluctuated most *** fluctuation range of picoplankton groups was larger in spring tide than in neap tide,especially in Sanya *** forest model analysis demonstrated that the variation of picoplankton groups was attributed to physical and chemical factors in Sanya Bay and Daya Bay,***,our findings suggest that virioplankton abundance can persist more stably in response to changing environmental conditions compared to bacterioplankton and picophytoplankton.

关键词： diel variation abundance picoplankton group virioplankton picocyanobacteria

A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 295-299页

作者： Qi Fu Zhongming Lian Mengya Niu Yaru huang Yanqiu ai long He Dandan Zhang Cuixia Zheng Jian-Jun Yang Lei Wang Dandan Tian Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Translational Medical Center of Huaihe Hospital Henan UniversityKaifeng 475004China Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and *** concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are *** this study,we construct a near-infrared light-activated nano-therapeutic system to meet this *** detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs *** designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone ***,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone ***,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.

关键词： Breast cancer bone metastasis Cancer-induced bone pain Cystine/glutamate antiporter Sorafenib Photodynamic therapy

Constitutive Behavior of the Interface between UHPC and Steel Plate without Shear Connector:From Experimental to Numerical Study

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1863-1888页

作者： Zihan Wang Boshan Zhang Hui Wang Qing ai Xingchun huang School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Department of Bridge Engineering Tongji UniversityShanghai200092China

The application of ultra-high performance concrete(UHPC)as a covering layer for steel bridge decks has gained widespread *** employing a connection without a shear connector between the steel plate and UHPC,namely,the sandblasted interface and the epoxy adhesive with sprinkled basalt aggregate interface,the installation cannot only be simplified but also the stress concentration resulting from the welded shear connectors can be *** study develops constitutive models for these two interfaces without shear connectors,based on the interfacial pull-off and push-out *** validation,three-point bending tests on the steel-UHPC composite plates are *** results indicated that the proposed bilinear traction-separation model for the sandblasted interface and the trapezoidal traction-separation model for the epoxy adhesive with sprinkled basalt aggregate interface can generally calibrate the interfacial ***,the utilization of the experimentally determined pure shear strength underestimates the load-carrying capacity of the composite plates in the case of three-point bending *** recalling the Mohr-Coulomb criterion,this underestimation is attributed to the enhancement of the interface shear strength by the presence of normal stress.

关键词： Cohesive zone model interfacial behavior finite element simulation UHPC steel plate

Novel intelligent reasoning system for tool wear prediction and parameter optimization in intelligent milling

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Advances in Manufacturing 2024年第1期12卷 76-93页

作者： long-Hua Xu Chuan-Zhen huang Zhen Wang Han-Lian Liu Shui-Quan huang Jun Wang School of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiPeople’s Republic of China Center for Advanced Jet Engineering Technologies(CaJET) Key Laboratory of High-efficiency and Clean Mechanical Manufacture(Ministry of Education)National Experimental Teaching Demonstration Center for Mechanical Engineering(Shandong University)School of Mechanical EngineeringShandong UniversityJinan250061People’s Republic of China Institute of Manufacturing Technology Guangdong University of TechnologyGuangzhou510006People’s Republic of China

Accurate intelligent reasoning systems are vital for intelligent *** this study,a new intelligent reasoning system was developed for milling processes to accurately predict tool wear and dynamically optimize machining *** developed system consists of a self-learning algorithm with an improved particle swarm optimization(IPSO)learning algorithm,prediction model determined by an improved case-based reasoning(ICBR)method,and optimization model containing an improved adaptive neural fuzzy inference system(IANFIS)and *** results showed that the IPSO algorithm exhibited the best global convergence *** ICBR method was observed to have a better performance in predicting tool wear than standard CBR *** IANFIS model,in combination with IPSO,enabled the optimization of multiple objectives,thus generating optimal milling *** paper offers a practical approach to developing accurate intelligent reasoning systems for sustainable and intelligent manufacturing.

关键词： Improved particle swarm optimization(IPSO)algorithm Improved case-based reasoning(ICBR)method Adaptive neural fuzzy inference system(ANFIS)model Tool wear prediction Intelligent manufacturing