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Observation of Low-Level Jets in the Eastern Tropical Indian Ocean Based on shipborne Coherent Doppler Lidar

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Journal of Ocean University of China 2024年第5期23卷 1163-1172页

作者： WANG Haiyuan LIU Lin FAN Mengqi YANG Yang YANG Guang DUAN Yongliang LIU Baochao SU Qinglei ZHANG Binbin WANG Fengjun shi Xuliang LI Qiuchi ZENG ai First Institute of Oceanography Ministry of Natural Resources and Laboratory for Regional Oceanography and Numerical Modeling Qingdao Marine Science and Technology Center Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) Key Laboratory of Marine Science and Numerical Modeling Ministry of Natural Resources Qingdao Leice Transient Technology Co. Ltd. Qingdao Innovation and Development Base of Harbin Engineering University

In contrast to the Pacific and Atlantic Oceans, the Indian Ocean has lacked in-situ observations of wind profiles over open sea areas for decades. In 2021, a shipborne coherent Doppler lidar（CDL） was used to observe in-situ wind profiles in the eastern tropical Indian Ocean. This equipment successfully captured low-level jets（LLJs） in the region, and their characteristics were thoroughly analyzed. Results reveal that the observed wind speed of LLJs in the eastern Indian Ocean ranges from 6-1m s-1to 10 m s during the boreal winter and spring seasons, showing a height range of 0.6 to 1 km and two peak times at 0800 and 2000 UTC. This wind shear is weaker than that in land or offshore areas, ranging from 01 s-1to 0.006 s-1. Moreover, the accuracy of the CDL data is compared to that of ERA5 data in the study area. The results indicate that the zonal wind from ERA5 data significantly deviated from the CDL measurement data, and the overall ERA5 data are substantially weaker than the in-situ observations. Notably, ERA5 underestimates northwestward LLJs.

关键词： coherent Doppler lidar eastern Indian Ocean ERA5 low-level jets radiosonde

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重视子宫内膜异位症患者生育力保护

中国实用妇科与产科杂志 2024年第5期40卷 481-484页

作者：冷金花史精华中国医学科学院北京协和医学院、北京协和医院妇产科、国家妇产疾病临床研究中心北京100730

子宫内膜异位症(简称内异症,EM)是指子宫内膜组织(腺体和间质)在子宫腔被覆内膜及子宫以外的部位出现、生长、浸润,反复出血。内异症是生育年龄女性的常见疾病,全世界预计约1亿7600万女性患有内异症[1],其中以25~45岁育龄期女性为主体,... 详细信息

子宫内膜异位症(简称内异症,EM)是指子宫内膜组织(腺体和间质)在子宫腔被覆内膜及子宫以外的部位出现、生长、浸润,反复出血。内异症是生育年龄女性的常见疾病,全世界预计约1亿7600万女性患有内异症[1],其中以25~45岁育龄期女性为主体,约占72.27%[2]。内异症可通过多种机制对生育能力产生负面影响,包括生殖道解剖扭曲、卵巢储备功能降低、卵母细胞和胚胎质量下降以及手术相关医源性损伤等。内异症发病机制不明,非根治性手术难以治愈,对生育的影响持久。在临床工作中要重视内异症患者生育力的保护,并将贯穿整个青春期和育龄期。

关键词：子宫内膜异位症生育力经验性药物治疗卵巢储备功能长期管理

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超高沥青混凝土心墙坝砂板岩堆石料试验研究

岩土工程学报 2024年第S01期46卷 191-196页

作者：张石吴世勇吴忠凌华傅华石北啸中国电建集团华东勘测设计研究院有限公司浙江杭州311122 南京水利科学研究院岩土工程研究所江苏南京210024 水利部水库大坝安全重点实验室江苏南京210024

开展了超高沥青混凝土心墙坝砂板岩堆石混合料的试验研究。研究结果表明:随板岩含量的提升和孔隙率的增大,应力应变曲线软化特性趋弱硬化特性增强、剪切峰值降低,剪切过程中的体变增大且剪胀现象减弱,相应的线性强度c,φ和非线性强度指... 详细信息

开展了超高沥青混凝土心墙坝砂板岩堆石混合料的试验研究。研究结果表明:随板岩含量的提升和孔隙率的增大,应力应变曲线软化特性趋弱硬化特性增强、剪切峰值降低,剪切过程中的体变增大且剪胀现象减弱,相应的线性强度c,φ和非线性强度指标φ_(0),Δφ均降低,邓肯模型参数K与Kb减小;建立了同时可反映孔隙率、板岩含量的强度指标及邓肯模型参数经验公式,能较高精度地预测不同板岩含量、不同孔隙率砂板岩堆石混合料的工程力学特性;板岩含量是影响渗透性能的重要因素,随板岩含量的提升渗透系数降低,工程建设中对于含板岩的堆石料应关注排水设计。

关键词：砂板岩堆石料强度指标变形参数

Cell softness reveals tumorigenic potential via ITGB8/AKT/glycolysis signaling in a mice model of orthotopic bladder cancer

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Chinese Medical Journal 2024年第2期137卷 209-221页

作者： shi Qiu Yaqi Qiu Linghui Deng Ling Nie Liming Ge Xiaonan Zheng Di Jin Kun Jin Xianghong Zhou Xingyang Su Boyu Cai Jiakun Li Xiang Tu Lina Gong Liangren Liu Zhenhua Liu Yige Bao Jianzhong ai Tianhai Lin Lu Yang Qiang Wei Department of Urology Institute of UrologyNational Clinical Research Center for Geriatrics and Center of Biomedical Big DataWest China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Molecular Oncology Institute of Oncology Research(IOR)Oncology Institute of Southern Switzerland(IOSI)Bellinzona 6500Switzerland Department of Science and Drug Technology University of TurinTurinItaly National Clinical Research Center of Geriatrics The Center of Gerontology and GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610000China Department of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pharmaceutics and Bioengineering School of Chemical EngineeringSichuan UniversityChengduSichuan 610000China

Background:Bladder cancer,characterized by a high potential of tumor recurrence,has high lifelong monitoring and treatment *** date,tumor cells with intrinsic softness have been identified to function as cancer stem cells in several cancer ***,the existence of soft tumor cells in bladder tumors remains ***,our study aimed to develop a microbarrier microfluidic chip to efficiently isolate deformable tumor cells from distinct types of bladder cancer ***:The stiffness of bladder cancer cells was determined by atomic force microscopy(AFM).The modified microfluidic chip was utilized to separate soft cells,and the 3D Matrigel culture system was to maintain the softness of tumor *** patterns of integrinβ8(ITGB8),protein kinase B(AKT),and mammalian target of rapamycin(mTOR)were determined by Western *** immunostaining was conducted to examine the interaction between F-actin and tripartite motif containing 59(TRIM59).The stem-cell-like characteristics of soft cells were explored by colony formation assay and in vivo studies upon xenografted tumor ***:Using our newly designed microfluidic approach,we identified a small fraction of soft tumor cells in bladder cancer *** importantly,the existence of soft tumor cells was confirmed in clinical human bladder cancer specimens,in which the number of soft tumor cells was associated with tumor ***,we demonstrated that the biomechanical stimuli arising from 3D Matrigel activated the F-actin/ITGB8/TRIM59/AKT/mTOR/glycolysis pathways to enhance the softness and tumorigenic capacity of tumor ***,we detected a remarkable up-regulation in ITGB8,TRIM59,and phospho-AKT in clinical bladder recurrent tumors compared with their non-recurrent ***:The ITGB8/TRIM59/AKT/mTOR/glycolysis axis plays a crucial role in modulating tumor softness and ***,the soft tumor cells become more sensitive to chemother

关键词： Soft tumor cells 3D Matrigel Stemness Non-muscle invasive bladder neoplasms Microfluidic analytical techniques

Ultra-efficient and parameter-free computation of submicron thermal transport with phonon Boltzmann transport equation

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Fundamental Research 2024年第4期4卷 907-915页

作者： Yue Hu Yongxing Shen hua Bao University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China

Understanding thermal transport at the submicron scale is crucial for engineering applications,especially in the thermal management of electronics and tailoring the thermal conductivity of thermoelectric *** the submicron scale,the macroscopic heat diffusion equation is no longer valid and the phonon Boltzmann transport equation(BTE)becomes the governing equation for thermal ***,previous thermal simulations based on the phonon BTE have two main limitations:relying on empirical parameters and prohibitive computational ***,the phonon BTE is commonly used for qualitatively studying the non-Fourier thermal transport phenomena of toy *** this work,we demonstrate an ultra-efficient and parameter-free computational method of the phonon BTE to achieve quantitatively accurate thermal simulation for realistic materials and *** properly integrating the phonon properties from first-principles calculations,our method does not rely on empirical material properties *** can be generally applicable for different materials and the predicted results can match well with experimental ***,by developing a suitable ensemble of advanced numerical algorithms,our method exhibits superior numerical *** full-scale(from ballistic to diffusive)thermal simulation of a 3-dimensional fin field-effect transistor with 13 million degrees of freedom,which is prohibitive for existing phonon BTE solvers even on supercomputers,can now be completed within two hours on a single personal *** method makes it possible to achieve the predictive design of realistic nanostructures for the desired thermal *** also enables accurately resolving the temperature profiles at the transistor level,which helps in better understanding the self-heating effect of electronics.

关键词： Submicron thermal transport Boltzmann transport equation Deterministic numerical method Phonon transport Transistors Nanostructured materials

基于差分进化算法的FMS中机器与多载AGV调度

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控制与决策 2024年第9期39卷 3108-3116页

作者：王子实吴耀华山东大学控制科学与工程学院济南250061

针对柔性制造系统中机器与混合多载自动导引搬运车(automated guided vehicle, AGV)集成调度问题,以最小化最大完工时间为目标,提出一种改进混合离散差分进化算法,通过离散操作进行差分进化算法的变异、交叉,并对每次迭代的最优个体进... 详细信息

针对柔性制造系统中机器与混合多载自动导引搬运车(automated guided vehicle, AGV)集成调度问题,以最小化最大完工时间为目标,提出一种改进混合离散差分进化算法,通过离散操作进行差分进化算法的变异、交叉,并对每次迭代的最优个体进行变邻域搜索.设计基于搬运任务、机器和AGV的3层编码结构,并进行合理化调整;设计基于关键路径的变邻域搜索,有针对性地调整关键路径上任务的次序、对应工序的机器和AGV,提高局部搜索效率;设计基于外部档案的个体更新策略,将种群中较差的个体从外部档案中进行替换,提高全局搜索效率.最后,通过实验验证算法改进策略的有效性以及所提出算法的有效性,分析AGV数量、AGV载位容量以及AGV电池可用时间对算法求解结果和改进效果的影响.

关键词：柔性制造系统多载位AGV 差分进化算法变邻域搜索关键路径最大完工时间

Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval:A randomized controlled trial

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Journal of Integrative Medicine 2024年第1期22卷 32-38页

作者： Li-ying Liu Yang Su Rong-rong Wang Yuan-yuan Lai Lei huang Yi-ting Li Xin-yue Tao Meng-hua Su Xiao-yan Zheng shi-chen huang Yong-na Wu Si-yi Yu Fan-rong Liang Jie Yang Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Traditional Chinese Medicine Department Sichuan Jinxin Xi’nan Women's and Children's HospitalChengdu 610000Sichuan ProvinceChina

Background Transvaginal oocyte retrieval is frequently followed by adverse events related to anesthesia and the *** research showed that transcutaneous electrical acupoint stimulation(TEAS)can relieve intraoperative pain and postoperative *** This study examined whether TEAS can alleviate pain and relieve adverse symptoms after oocyte ***,setting,participants and interventions Altogether 128 patients were randomly divided into the TEAS group and the mock TEAS *** two groups received a 30-minute-long TEAS or mock TEAS treatment that began 30 min after oocyte *** outcome measures The primary outcome was the visual analog scale(VAS)pain *** outcomes were pressure pain threshold,McGill score,pain rating index(PRI),present pain intensity(PPI),VAS stress score,VAS anxiety score,and postoperative adverse *** The baseline characteristics of the two groups were comparable(P>0.05).The VAS pain scores of the TEAS group were lower than those of the mock TEAS group at 60 and 90 min after oocyte retrieval(P0.05).The TEAS group was superior to the mock TEAS group for relieving postoperative adverse symptoms(Pain and postoperative adverse symptoms for patients undergoing oocyte retrieval.

关键词： Transcutaneous electrical acupoint stimulation Fertilization Embryo transfer Oocyte retrieval Pain Randomized controlled trial

Clinical characteristics and treatment of splenic infarction in children with systemic lupus erythematosus

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World Journal of Pediatrics 2024年第5期20卷 525-531页

作者： Yan Li Yu-Rong Piao Tong-Xin Han hua-Wei Mao Department of Immunology Ministry of Education Key Laboratory of Major Diseases in ChildrenBeijing Key Laboratory for Genetics of Birth DefectsNational Center for Children’s HealthBeijing Children’s HospitalCapital Medical UniversityNo.56 Nan Li Shi LuBeijing100045China

Splenic infarction(SI)is a rare clinical phenomenon that occurs when the blood supply to the spleen is interrupted,resulting in tissue ischemia and necrosis[1].There are many causes of SI;in adult patients,cardioembolism,hematological malignancy,and infectious disease are the most common[2].Rheumatic diseases,especially systemic lupus erythematosus(SLE)and granulomatosis with polyangitis,can also lead to SI[3];however,only a few cases have been *** are currently no statistically meaningful data on the etiology of SI in *** most patients with SI can recover after conservative treatment,a small number of patients develop complications,such as splenic abscess,splenic rupture,splenic hemorrhage,and hemoperitoneum,and may even undergo splenectomy in severe cases.

关键词： erythematosus lupus treatment

Predictors of stricture after endoscopic submucosal dissection of the esophagus and steroids application

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World Journal of Gastrointestinal Endoscopy 2024年第9期16卷 509-518页

作者： Qing-Xia Wang Yuan Ding Qi-Liu Qian Yin-Nan Zhu Rui-hua shi Department of Gastroenterology Southeast University Affiliated Zhongda HospitalMedical SchoolNanjing 210009Jiangsu ProvinceChina

BACKGROUND Endoscopic submucosal dissection(ESD)is a reliable method to resect early esophageal *** stricture is one of the major complications after ESD of the *** prophylaxis for esophageal strictures,particularly local injection of triamcinolone acetonide(TA),is a relatively effective method to prevent esophageal ***,even with steroid prophylaxis,stenosis still occurs in up to 45%of *** the risk of stenosis formation after local TA injection would enable additional interventions in risky *** To identify the predictors of esophageal strictures after steroids *** Patients who underwent esophageal ESD and steroid prophylaxis and who were comprehensively assessed for lesion-and ESD-related factors at Southeast University Affiliated Zhongda Hospital between February 2018 and March 2023 were included in the *** univariate and multivariate regression analyses were conducted to identify the predictors of stricture among patients undergoing steroid *** A total of 120 patients were included in the *** the oral prednisone and oral prednisone combined with local tretinoin injection groups,the stenosis rates were 44/53(83.0%)and 56/67(83.6%),*** them,univariate analysis showed that the lesion circumference(P=0.01)and submucosal injection solution(P=0.04)showed significant correlation with the risk of stenosis *** regression analyses were then performed using predictors that were significant in the univariate analyses and combined with known predictors from previous reports,such as additional chemoradiotherapy and tumor *** identified a lesion circumference<5/6(OR=0.19;P=0.02)and submucosal injection of sodium hyaluronate(OR=0.15;P=0.03)as independent predictors of on esophageal stricture *** Steroid prophylaxis effectively prevents ***,the lesion circumference and submucosal injection of sodium h

关键词： Endoscopic submucosal dissection Esophageal stricture Oral steroids Triamcinolone acetonide Predictors