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Chinese Chemical Letters 2015年第6期26卷 768-772页

作者： ai-ling li Yan-Ping Ma Dong Qiu Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of Sciences

Silicon is usually found to be four-coordinated when neighbored with oxygen. Six-coordinated silicon is only seen in samples at very specific composition or made at high temperature/pressure. In this study, we managed to synthesize calcium phosphosilicate xerogels containing six-coordinated silicon with the help of polyols by sol-gel method, without the need of treatment at high temperature or high pressure. Both phosphorus precursors and polyols were found to be essential for the formation of six-coordinated silicon species; in the absence of either species, only normal four-coordinated silicon was observed under otherwise identical conditions. Samples containing six-coordinated silicon sites were found to release silicon species faster than those without six-coordinated silicon sites upon dissolved in water, suggesting that six-coordinated silicon species have higher reactivity toward hydrolysis.

关键词： Phosphosilicate Six-coordinated silicon PolyolsMAS-NMR

Changes in intraocular pressure and central corneal thickness during pregnancy:a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1573-1579页

作者： Chao Wang ai-ling li Yu Pang Ying-Qing Lei ling Yu Department of Ophthalmology the Affiliated Hospital of Southwest Medical University Department of the School of Public Health of Southwest Medical University

aiM：To conduct a Meta-analysis for investigating the variations in intraocular pressure（IOP）and central corneal thickness（CCT）during normal ***：We searched for clinical trials published up to November 2015 without language or region restrictions in Pub Med,EMBASE,Web of Science,the Cochrane Central Register of Controlled Trials,Ovid,EBSCO,Elsevier,the Chinese Biomedicine Database,Wan Fang,CNKI,CQVIP and Google *** of the ocular changes observed in pregnant women were *** main outcomes were assessed by changes in IOP and ***：Fifteen studies were *** subgroup analyses,IOP was significantly decreased during the second MD=-1.53,95%CI（-2.19,-0.87）;P〈0.00001,and third MD=-2.91,95%CI（-3.74,-2.08）;P〈0.00001 trimesters of *** was increased during the second MD=10.12,95%CI（2.01,18.22）;P=0.01,trimester of pregnancy;moreover,during the third trimester of pregnancy,the CCT displayed an increasing trend,but the difference was not significant MD=5.98,95%CI（-1.11,13.07）;P=***：A decrease in IOP is accompanied by an increase in CCT in the second and third trimesters of a normal pregnancy in women.

关键词： intraocular pressure central corneal thickness pregnancy Meta-analysis

A low-temperature sol-gel route for the synthesis of bioactive calcium silicates

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Chinese Chemical Letters 2013年第2期24卷 170-172页

作者： Yong-Sen Sun ai-ling li Fu-Jian Xu Dong Qiu Beijing National Laboratory for Molecular Sciences.State Key Laboratory of Polymer Physics and Chemistry.Institute of Chemistry.Chinese Academy of Sciences Key Laboratory of Chemical Resource Engineering College of Materials Science & EngineeringBeijing University of Chemical Technology Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of Sciences

Received 14 August 2012 Received in revised form 19 November 2012 Accepted 28 November 2012 Available online 7 February 2013

关键词： Sol-gelCalcium 2-methoxyethoxideBioactive calcium silicate

Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models

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Neuroscience Bulletin 2018年第1期34卷 85-97页

作者： ai-ling li Jing-Dong Zhang Wenrui Xie Judith A. Strong Jun-Ming Zhang Department of Anesthesiology University of Cincinnati College of Medicine Cincinnati OH 45267 USA Department of Psychological and Brain Science Indiana University Bloomington 702 N Walnut Grove Ave. Bloomington IN 47405 USA

Injury to peripheral nerves can lead to neuropathic pain, along with well-studied effects on sensory neurons, including hyperexcitability, abnormal spontaneous activity, and neuroinflammation in the sensory ganglia. Neuropathic pain can be enhanced by sympathetic activity. Peripheral nerve injury may also damage sympathetic axons or expose them to an inflammatory environment. In this study, we examined the lumbar sympathetic ganglion responses to two rat pain models： ligation of the L5 spinal nerve, and local inflammation of the L5 dorsal root ganglion （DRG）, which does not involve axotomy. Both models resulted in neuroinflammatory changes in the sympathetic ganglia, as indicated by macrophage responses, satellite glia activation, and increased numbers of T cells, along with very modest increases in sympathetic neuron excitability （but not spontaneous activity） measured in ex vivo recordings. The spinal nerve ligation model generally caused larger responses than DRG inflammation. Plasticity of the sympathetic system should be recognized in studies of sympathetic effects on pain.

关键词： Neuropathic pain Sympathetic Macrophage T cell Satellite glia Inflammation Hyperexcitability

Removal of residual nitrate ion from bioactive calcium silicate through soaking

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Chinese Chemical Letters 2016年第4期27卷 579-582页

作者： Yong-Sen Sun ai-ling li Hui-Hui Ren Xin-Ping Zhang Chao Wang Dong Qiu Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100190 China

Bioactive calcium silicates prepared by sol–gel routes mainly use calcium nitrate as the calcium precursor. However, the toxic nitrate ions are usually removed by calcination（i.e. 550 8C or over）, which poses great challenge for the in situ preparation of inorganic/polymer composites, as polymer moieties could not survive such temperatures. In this study, we prepared 70Si30Ca（70 mol% Si O_2 and 30 mol%Ca O） bioactive glass at low temperatures where polymer could survive（i.e. 200 8C and 350 8C）, and proposed to remove the residual nitrate ions through soaking. Deionized water and simulated body fluid（SBF） were employed as the soaking medium. The results showed that the residual nitrate ions could be removed as quickly as 0.5 h while maintain the bioactivity of the samples. This technique may open the possibility of preparing sol–gel derived bioactive glass/polymer hybrids in situ with reduced potential toxicity.

关键词： Nitrate ion Bioactive Calcium silicate Soaking FTIR

Global trend and future landscape of intestinal microcirculation research from 2000 to 2021:A scientometric study

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World Journal of Gastroenterology 2023年第9期29卷 1523-1535页

作者： Sun-Jing Fu Meng-Ting Xu Bing Wang Bing-Wei li Hao ling Yuan li Qin Wang Xue-Ting liu Xiao-Yan Zhang ai-ling li Ming-Ming liu Institute of Microcirculation Key Laboratory of MicrocirculationMinistry of HealthChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Department of Radiology The Affiliated Changsha Central HospitalHengyang Medical SchoolUniversity of South ChinaChangsha 410004Hunan ProvinceChina Diabetes Research Center Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

BACKGROUND The intestinal microcirculation functions in food absorption and metabolic substance *** evidence indicates that intestinal microcirculatory dysfunction is a significant source of multiple gastrointestinal *** date,there has not been a scientometric analysis of intestinal microcirculatory *** To investigate the current status,development trends,and frontiers of intestinal microcirculatory research based on bibliometric *** VOSviewer and CiteSpace 6.1.R2 were used to identify the overall characteristics and knowledge map of intestinal microcirculatory research based on the core literature published from 2000 to 2021 in the Web of Science *** characteristics of each article,country of origin,institution,journal,cocitations,and other information were analyzed and *** There were 1364 publications enrolled in the bibliometric analysis,exhibiting an upward trend from 2000 to 2021 with increased participation *** United States and Dalhousie University took the lead among countries and institutions,*** was the most prolific journal,and Nature Reviews Microbiology Clinical had the most *** topical hotspots and frontiers in intestinal microcirculatory research were centered on the pathological processes of functional impairment of intestinal microvessels,diverse intestinal illnesses,and clinical *** Our study highlights insights into trends of the published research on the intestinal microcirculation and offers serviceable guidance to researchers by summarizing the prolific areas in intestinal disease research to date.

关键词： Intestinal microcirculation Bibliometric analysis CiteSpace VOSviewer Visualization

Poly(1,8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration

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Chinese Chemical Letters 2017年第11期28卷 2116-2120页

作者： Hui-Hui Ren Hui-Yu Zhao Yang Cui Xiang Ao ai-ling li Zhong-Min Zhang Dong Qiu Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and Chemistry CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100190 China Department of Orthopedics The Third Affiliated Hospital of Southern Medical University Guangzhou 510665 China

Poly（1,8-octanediol-co-citrate）（POC） represents a new promising biocompatible and biodegradable polyester that has been extensively investigated for soft tissue engineering. However, the poor mechanical performance and poor bioactivity limit its application in bone regeneration. In this study, a series of POC/bioactive glasses （BG） composites were developed using 45S5 Bioglass^Θ and a phytic acid- derived bioactive glass （referred as PSC）. The results indicated that calcium in BG could enhance the crosslinking of the POC/BG composites by forming calcium dicarboxylate bridges and thus improve their mechanical performances. When PSC were used, the composites exhibited significantly better mechanical properties compared to composites with 45S5 Bioglass^Θ. For example, by incorporating 70wt% PSC, the compressive strength of POC/PSC composites could be improved to approximately 50 MPa and modulus 1.3-h 0.1 GPa. Furthermore, all these POC/PSC composites showed good in vitro bioactivity and cellular biocompatibility. Histology results in femoral condyle defects of Sprague-Dawley rats indicated that the POC/PSC samples integrated well with surrounding tissues and stimulated bone regeneration. The improved mechanical properties and bioactivity of POC/PSC composites make them promising for potential application in bone regeneration.

关键词： Bioactive glasses Poly(1 8-octanediol-co-citrate) Composites Mechanical properties Bioactivity

Role of insulin in pancreatic microcirculatory oxygen profile and bioenergetics

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World Journal of Diabetes 2022年第9期13卷 765-775页

作者： Bing-Wei li Yuan li Xu Zhang Sun-Jing Fu Bing Wang Xiao-Yan Zhang Xue-Ting liu Qin Wang ai-ling li Ming-Ming liu Institute of Microcirculation Diabetes Research CenterChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Laboratory of Electron Microscopy Ultrastructural Pathology CenterPeking University First HospitalBeijing 100005China

BACKGROUND The pancreatic islet microcirculation adapts its metabolism to cope with limited oxygen availability and nutrient *** diabetes,the balance between oxygen delivery and consumption is *** has been proven to exert complex actions promoting the maintenance of homeostasis of the pancreas under *** To test the hypothesis that insulin administration can improve the integrated pancreatic microcirculatory oxygen profile and *** The pancreatic microcirculatory partial oxygen pressure(PO_(2)),relative hemoglobin(rHb)and hemoglobin oxygen saturation(SO_(2))were evaluated in nondiabetic,type 1 diabetes mellitus(T1DM),and insulin-treated mice.A threedimensional framework was generated to visualize the microcirculatory oxygen *** changes in the microvasculature were examined using transmission electron *** Extracellular Flux Analyzer was used to detect the real-time changes in bioenergetics by measuring the oxygen consumption rate and extracellular acidification rate in islet microvascular endothelial cells(IMECs).RESULTS Significantly lower PO_(2),rHb,and SO_(2) values were observed in T1DM mice than in nondiabetic *** administration ameliorated the streptozotocin-induced decreases in these microcirculatory oxygen parameters and improved the mitochondrial ultrastructural abnormalities in *** profiling revealed that the IMECs did not have spare respiratory ***-treated IMECs exhibited significantly greater basal respiration than glucotoxicity-exposed IMECs(Plism in insulin-treated IMECs,with significantly increased ATP production,non-mitochondrial respiration,and oxidative metabolism(all P<0.05).Significant negative correlations were revealed between microcirculatory SO_(2) and bioenergetic *** Glucotoxicity deteriorates the integrated pancreatic microcirculatory oxygen profil

关键词： Diabetes mellitus Glucotoxicity Endothelial cells Microcirculation Mitochondria Bioenergetics

A Way to Build Software Culture: Distributed Object-Oriented Software Engineering over Internet

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 359-361页

作者： Tian ai jing, Zhang ling, li Zong rong Department of Computer Science, Hubei University, Wuhan 430062, China State Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, China Department of Computer Science Hubei University Wuhan China State Key Laboratory of Software Engineering Wuhan University Wuhan China

This paper focuses on Distributed Object Oriented Software Engineering over Internet, which is a way to build software culture. We believe that our work will contribute to better understanding of how to meet the needs of the big potential software market and to promote the software industry in developing country. The United States and Western Europe have well established software industry and related civilization. Software science, technology, and engineering are needed in China; however, maybe what is needed, first of all, is software civilization, including software ideas, customs, skills, arts, etc. We will draw a framework for the software culture as following: Software is the most important commodity in this age; Brilliance of hardware component era has become past fact; A software component era is ahead; Traditional linear process model is obsolete; Modern software engineering has a new face, object evolution model; Distributed object oriented software engineering over Internet is an approach to software component era; and Complete software civilization will be formed all over the world in next century.

关键词： software software engineering object oriented methodology software component software culture

Associations between the Serum Zinc Levels and Digestive Tract Tumors:A Meta-Analysis

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Journal of Nutritional Oncology 2022年第4期7卷 181-191页

作者： You Wu Min li ai ling li Shan Bin Fu Zhang Ze Yu Chen li Pei Ping Ni Min Wang Department of Clinical Nutrition The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan China Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou Luzhou 646000Sichuan China Department of the School of Public Health of Southwest Medical University Luzhou 646000China Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan China

Background The incidence and mortality rates of digestive tract tumors are among the top ten ***,studies have shown that zinc may be significantly related to digestive tract *** meta analysis was conducted to explore whether the serum zinc level of patients is associated with gastrointestinal *** We systematically searched PUBMED,the Cochrane library,the Web of Science and EMBASE from their start dates up to October 2022 for studies on the association between the serum zinc concentration and digestive tract *** I^(2)statistic was used to assess the heterogeneity.A sensitivity analysis,subgroup analysis and meta-regression analysis were also used to analyze ***,Begg’s and Egger’s tests were adopted to assess potential publication *** In total,we identified 24 eligible studies with 1,499 total participants with digestive tract tumors and 6,039 participants without *** average serum zinc concentration in patients with digestive tract tumors was lower than that in the control group(SMD=-0.98,95%CI:-1.29~-0.66,I^(2):94.1%,P<0.001).Specifically,the serum zinc concentration of patients with esophageal cancer(SMD=-2.08,95%CI:-2.89~-1.26,I^(2):92.9%,P<0.001),gastric cancer(SMD=-0.74,95%CI:-1.16~-0.33,I^(2):92.1%,P<0.001),and colorectal cancer(SMD=-0.85,95%CI:-1.51~-0.19,I^(2):95.9%P<0.05)were significantly different from the *** Our review showed that the serum zinc concentration in patients with digestive tract tumors was lower than that in patients without tumors,and further studies are needed to explore how zinc affects the occurrence and development of digestive tract tumors.

关键词： Digestive tract tumor Zinc Meta-analysis