检索结果-南通市图书馆

Prospects for chargino pair production at the CEPC

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2022年第1期46卷 72-79页

作者： Jia-Rong Yuan Hua-Jie Cheng Xu-ai zhuang Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of the Chinese Academy of Sciences Yuquan Road 19AShijingshan DistrictBeijing 100049China Department of Applied Physics Naval University of EngineeringWuhan 430033China

The proposed Circular Electron Positron Collider(CEPC)with a center-of-mass energy√s=240GeV will primarily serve as a Higgs ***,it will offer good opportunities to search for new physics phenomena at low energies,which can be challenging with hadron colliders;however,these discoveries are highly motivated by theoretical models developed to explain,e.g.,the relic abundance of dark *** paper presents sensitivity studies for chargino pair production by considering scenarios for both a Bino-like and a Higgsino-like neutralino as the lightest supersymmetric particle and using a full Monte Carlo(MC)*** assuming systematic uncertainties at the level of 5%,the CEPC has the ability to discover chargino pair production up to the kinematic limit of for√s/2 both *** results have a minor dependence on the reconstruction model and detector *** results can also be considered as a reference and benchmark for similar searches at other proposed electron-positron colliders,such as the Future Circular Collider ee(FCC-ee)or the International Linear Collider(ILC),given the similar nature of the facilities,detectors,center-of-mass energies,and target luminosities.

关键词： CEPC chargino Bino Higgsino

维普期刊数据库

Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第11期7卷 4069-4089页

作者： Ludi Yang Ruobing Jia Tongxin Ge Shengfang Ge ai zhuang Peiwei Chai Xianqun Fan Department of Ophthalmology Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai20025P.R.China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai20025P.R.China

Extrachromosomal circular DNA(eccDNA),ranging in size from tens to millions of base pairs,is independent of conventional ***,eccDNAs have been considered an unanticipated major source of somatic rearrangements,contributing to genomic remodeling through chimeric circularization and reintegration of circular DNA into the linear *** addition,the origin of eccDNA is considered to be associated with essential chromatin-related events,including the formation of super-enhancers and DNA repair ***,our understanding of the properties and functions of eccDNA has continuously and greatly *** investigations demonstrate that eccDNAs serve as multifunctional molecules in various organisms during diversified biological processes,such as epigenetic remodeling,telomere trimming,and the regulation of canonical signaling ***,its special distribution potentiates eccDNA as a measurable biomarker in many diseases,especially *** loss of eccDNA homeostasis facilitates tumor initiation,malignant progression,and heterogeneous evolution in many *** in-depth understanding of eccDNA provides novel insights for precision cancer *** this review,we summarized the discovery history of eccDNA,discussed the biogenesis,characteristics,and functions of ***,we emphasized the role of eccDNA during tumor pathogenesis and malignant ***,we summarized potential clinical applications that target aberrant eccDNA in multiple diseases.

关键词： chromosomal diseases circular

Crosstalk between metabolic reprogramming and epigenetics in cancer:updates on mechanisms and therapeutic opportunities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2022年第11期42卷 1049-1082页

作者： Tongxin Ge Xiang Gu Renbing Jia Shengfang Ge Peiwei Chai ai zhuang Xianqun Fan Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011P.R.China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011P.R.China

Reversible,spatial,and temporal regulation of metabolic reprogramming and epigenetic homeostasis are prominent hallmarks of *** cells reprogram their metabolism to meet the high bioenergetic and biosynthetic demands for vigorous *** dysregulation is a common fea-ture of human cancers,which contributes to tumorigenesis and maintenance of the malignant phenotypes by regulating gene *** epigenome is sensitive to metabolic *** produces various metabolites that are substrates,cofactors,or inhibitors of epigenetic *** in metabolic pathways and fluctuations in intermediate metabolites convey information regarding the intracellular metabolic status into the nucleus by modulating the activity of epigenetic enzymes and thus remodeling the epige-netic landscape,inducing transcriptional responses to heterogeneous metabolic *** metabolism is regulated by epigenetic machinery at both transcriptional and post-transcriptional *** modifiers,chromatin remodelers and non-coding RNAs are integral contributors to the regulatory networks involved in cancer metabolism,facilitating malignant ***,the significance of the close connection between metabolism and epi-genetics in the context of cancer has not been fully ***,it will be constructive to summarize and update the emerging new evidence support-ing this bidirectional crosstalk and deeply assess how the crosstalk between metabolic reprogramming and epigenetic abnormalities could be exploited to optimize treatment paradigms and establish new therapeutic *** this review,we summarize the central mechanisms by which epigenetics and metabolism reciprocally modulate each other in cancer and elaborate upon and update the major contributions of the interplays between epigenetic aber-rations and metabolic rewiring to cancer initiation and ***,we highlight the potential therapeutic op

关键词： cancer epigenetics metabolic reprogramming RNA epigenetics therapy

Epigenetic drug library screening reveals targeting DOT1L abrogates NAD^(+)synthesis by reprogramming H3K79 methylation in uveal melanoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2023年第1期13卷 24-38页

作者： Xiang Gu Yu Hua Jie Yu Ludi Yang Shengfang Ge Renbing Jia Peiwei Chai ai zhuang Xianqun Fan Department of Ophthalmology Shanghai Key Laboratory of Orbital Diseases and Ocular OncologyShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai200011China

Uveal melanoma(UM)is the most frequent and life-threatening ocular malignancy in *** histone methylation contributes to the abnormal transcriptome during ***,a comprehensive understanding of histone methylation patterns and their therapeutic potential in UM remains ***,using a systematic epi-drug screening and a high-throughput transcriptome profiling of histone methylation modifiers,we observed that disruptor of telomeric silencing-1-like(DOT1L),a methyltransferase of histone H3 lysine 79(H3K79),was activated in UM,especially in the high-risk ***,a systematic epi-drug library screening revealed that DOT1L inhibitors exhibited salient tumor-selective inhibitory effects on UM cells,both in vitro and in *** Cleavage Under Targets and Tagmentation(CUT&Tag),RNA sequencing(RNA-seq),and bioinformatics analysis,we identified that DOT1L facilitated H3K79 methylation of nicotinate phosphoribosyltransferase(NAPRT)and epigenetically activated its ***,NAPRT served as an oncogenic accelerator by enhancing nicotinamide adenine dinucleotide(NAD^(+))***,DOT1L inhibition epigenetically silenced NAPRT expression through the diminishment of dimethylation of H3K79(H3K79me2)in the NAPRT promoter,thereby inhibiting the malignant behaviors of ***,our findings delineated an integrated picture of the histone methylation landscape in UM and unveiled a novel DOT1L/NAPRT oncogenic mechanism that bridges transcriptional addiction and metabolic reprogramming.

关键词： Histone methylation Metabolic reprogramming Uveal melanoma Transcriptional addiction

Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m^(6)A RNA methylation in ocular melanoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2023年第11期43卷 1185-1206页

作者： ai zhuang Xiang Gu Tongxin Ge Shaoyun Wang Shengfang Ge Peiwei Chai Renbing Jia Xianqun Fan Department of Ophthalmology Shanghai Ninth People's HospitalShanghai JiaoTong University School of MedicineShanghaiP. R. China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology ShanghaiP. R. China

Background Diversified histone deacetylation inhibitors(HDACis)have demonstrated encouraging outcomes in multiple malignancies.N6-methyladenine(m6A)is the most prevalent messenger RNA modification that plays an essential role in the regulation of ***,an in-depth understanding of the crosstalk between histone acetylation and m6A RNA modifications remains *** study aimed to explore the role of histone acetylation and m6A modifications in the regulation of tumorigenesis of ocular *** Histone modification inhibitor screening was used to explore the effects of HDACis on ocular melanoma *** blot assay was used to detect the global m6A RNA modification ***-omics assays,including RNA-sequencing,cleavage under targets and tagmentation,single-cell sequencing,methylated RNA immunoprecipitation-sequencing(meRIP-seq),and m6A individual nucleotide resolution cross-linking and immunoprecipitation-sequencing(miCLIP-seq),were performed to reveal the mechanisms of HDACis on methyltransferase-like 14(METTL14)and FAT tumor suppressor homolog 4(FAT4)in ocular *** real-time polymerase chain reaction(qPCR),western blotting,and immunofluorescent staining were applied to detect the expression of METTL14 and FAT4 in ocular melanoma cells and *** models and orthotopic xenograft models were established to determine the roles of METTL14 and FAT4 in the growth of ocular ***-binding protein immunoprecipitation-qPCR,meRIP-seq,miCLIP-seq,and RNA stability assay were adopted to investigate the mechanism by which m6A levels of FAT4 were *** First,we found that ocular melanoma cells presented vulnerability towards *** triggered the elevation of m6A RNA modification in ocular *** studies revealed that METTL14 served as a downstream candidate for ***14 was silenced by the hypo-histone acetylation status,whereas HDACi restored the normal histone acetylation level of MET

关键词： epigenetics histone deacetylation inhibitors melanoma N6-methyladenine histone-RNA crosstalk

A non-invasive smart scaffold for bone repair and monitoring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第1期19卷 499-510页

作者： Yazhuo Huang Lingyu Zhang Yongrong Ji Hongpei Deng Mingce Long Shengfang Ge Yanjie Su Siew Yin Chan Xian Jun Loh ai zhuang Jing Ruan Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiaotong University School of MedicineShanghai200011China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai200011China Key Laboratory of Thin Film and Microfabrication(Ministry of Education) Department of Micro/Nano ElectronicsSchool of ElectronicsInformation and Electrical EngineeringShanghai Jiaotong UniversityShanghai200240China Key Laboratory of Thin Film and Microfabrication Technology(Ministry of Education) School of Environmental Science and EngineeringShanghai Jiaotong UniversityShanghai200240China Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WayInnovis#08-03Singapore138634Singapore

Existing strategies for bone defect repair are difficult to *** scaffold materials that can quantify the efficiency of new bone formation are important for bone regeneration and *** nanotubes(CNT)have promising bioactivity and electrical *** this study,a noninvasive and intelligent monitoring scaffold was prepared for bone regeneration and monitoring by integrating carboxylated CNT into chemically cross-linked carboxymethyl chitosan *** scaffold(0.5%w/v)demonstrated improved mechanical properties with good biocompatibility and electrochemical *** voltammetry and electrochemical impedance spectroscopy of CNT scaffold responded sensitively to seed cell differentiation degree in both cellular and animal ***,the CNT scaffold could make up the easy deactivation shortfall of bone morphogenetic protein 2 by sustainably enhancing stem cell osteogenic differentiation and new bone tissue formation through CNT *** research provides new ideas for the development of noninvasive and electrochemically responsive bioactive scaffolds,marking an important step in the development of intelligent tissue engineering.

关键词： Carbon nanotube Osteogenesis Electrochemical response Noninvasive monitoring Tissue engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高频燃烧红外吸收法测定锡锌铅青铜中硫

冶金分析 2017年第4期37卷 33-37页

作者：庄艾春广东省工业分析检测中心

称取0.3g纯铜助熔剂于坩埚底部,再称取0.4g样品,上面覆盖1.0g钨粒,以钢铁标准样品绘制校准曲线,建立了高频燃烧红外吸收法测定锡锌铅青铜中硫的方法。实验表明,当硫质量分数不大于0.01%时,测定低含量硫时应减去空白值;当硫质量分数大于0... 详细信息

称取0.3g纯铜助熔剂于坩埚底部,再称取0.4g样品,上面覆盖1.0g钨粒,以钢铁标准样品绘制校准曲线,建立了高频燃烧红外吸收法测定锡锌铅青铜中硫的方法。实验表明,当硫质量分数不大于0.01%时,测定低含量硫时应减去空白值;当硫质量分数大于0.01%时,空白值的影响可忽略。方法检出限为0.000 1%,方法测定下限为0.000 3%。用硫酸钾基准试剂配制的硫标准溶液进行方法验证,结果表明,测定值与理论值一致;按照实验方法测定由紫铜光谱标准样品5#、锡粒、纯锌、纯铅混合配制的锡锌铅青铜合成样品,测定值与理论值基本一致。利用实验方法对锡锌铅青铜样品中硫进行测定,测定结果的相对标准偏差（RSD,n=11）为0.71%;.5%。按照实验方法在锡锌铅青铜样品中加入硫标准溶液进行加标回收试验,回收率在95%;03%之间。

关键词：锡锌铅青铜硫高频燃烧红外吸收法纯铜钨粒

Critical dispersion of chirped fiber Bragg grating for eliminating time delay signature of distributed feedback laser chaos

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2023年第9期32卷 237-241页

作者：王大铭雷一航史鹏飞李壮爱 School of Information Shanxi University of Finance and EconomicsShanxi 030006China School of Humanities Communication University of ShanxiJinzhong 030619China

Optical chaos has attracted widespread attention owing to its complex dynamic ***,the time delay signature(TDS)caused by the external cavity mode reduces the complexity of optical *** propose and numerically demonstrate the critical dispersion of chirped fiber Bragg grating(CFBG)for eliminating the TDS of laser chaos in this *** critical dispersion,as a function of relaxation frequency and bandwidth of the optical spectrum,is found through extensive dynamics *** is shown that the TDS can be eliminated when the dispersion of CFBG is above this critical *** addition,the influence of dispersive feedback light and output light from a laser is *** results provide important quantitative guidance for designing chaotic semiconductor lasers without TDS.

关键词： chaos semiconductor laser time delay signature chirped fiber Bragg grating(CFBG)

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

生态文明背景下我国绿色教育立法的建构

西南民族大学学报（人文社会科学版） 2021年第5期42卷 109-115页

作者：曹霞李壮爱山西财经大学法学院山西太原030006

绿色教育是全方位推进环境保护和可持续发展的意识教育。我国目前在绿色教育领域的专门立法仍是空白,绿色教育缺乏必要的法制保障。通过科学、合理的绿色教育立法的顶层设计适应绿色发展的时代背景,实现教育价值、社会价值、经济价值和... 详细信息

绿色教育是全方位推进环境保护和可持续发展的意识教育。我国目前在绿色教育领域的专门立法仍是空白,绿色教育缺乏必要的法制保障。通过科学、合理的绿色教育立法的顶层设计适应绿色发展的时代背景,实现教育价值、社会价值、经济价值和生态价值的多赢,为推进生态文明建设提供坚实的法律保障。针对我国目前绿色教育专项立法缺位,实施效果不尽如人意,绿色教育人才及资金匮乏的现状,我国未来专项绿色教育立法应设立专门机构以形成全社会参与的互动格局,建立健全绿色教育监管与评价制度,构建全民绿色教育体系以及保障绿色教育人才培训和资金制度,从而推进《中华人民共和国绿色教育法》尽早出台,为绿色教育事业的稳定和长远发展创造条件。

关键词：绿色发展绿色教育绿色教育立法环境保护生态文明建设

维普期刊数据库