检索结果-南通市图书馆

Ordering Trees by Their Spectral Radii

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2014年第4期30卷 1107-1112页

作者： ai-mei yu Department of Mathematics Beijing Jiaotong University

Let T be a tree with n vertices and let A（T） be the adjacency matrix of T. Spectral radius of T is the largest eigenvalue of A（T）. Wu et al. [Wu, B.F., yuan, X.Y, and Xiao, E.L. On the spectral radii of trees, Journal of East China Normal University （Natural Science）, 3：22-28 （2004）] determined the first seven trees of order n with the smallest spectral radius. In this paper, we extend this ordering by determining the trees with the eighth to the tenth smallest spectral radius among all trees with n vertices.

关键词： tree spectral radius ordering

Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第12期11卷 3950-3965页

作者： Linglong Deng Hannah Petrek Mei-Juan Tu Neelu Batra ai-Xi yu ai-Ming yu Department of Orthopaedic Trauma and Microsurgery Zhongnan Hospital of Wuhan UniversityWuhan 430072China Department of Biochemistry and Molecular Medicine UC Davis School of MedicineSacramentoCA 95817USA

With the understanding of microRNA(miRNA or miR) functions in tumor initiation,progression,and metastasis,efforts are underway to develop new miRNA-based *** recently,we demonstrated effectiveness of a novel humanized bioengineered miR-124-3 p prodrug in controlling spontaneous lung metastasis in mouse *** study was to investigate the molecular and cellular mechanisms by which miR-124-3 p controls tumor *** study identified a set of proteins selectively and significantly downregulated by bioengineered miR-124-3 p in A549 cells,which were assembled into multiple cellular components critical for metastatic *** them,plectin(PLEC) was verified as a new direct target for miR-124-3 p that links cytoskeleton components and *** miR-124-3 p-treated lung cancer and osteosarcoma cells,protein levels of vimentin,talin 1(TLN1),integrin beta-1(ITGB1),IQ motif containing GTPase activating protein 1(IQGAP1),cadherin2 or N-cadherin(CDH2),and junctional adhesion molecule A(F11 R or JAMA or JAM1) decreased,causing remodeling of cytoskeletons and disruption of cell-cell ***,miR-124-3 p sharply suppressed the formation of focal adhesion plaques,leading to reduced cell adhesion ***,efficacy and safety of biologic miR-124-3 p therapy was established in an aggressive experimental metastasis mouse model in *** results connect miR-124-3 p-PLEC signaling to other elements in the control of cytoskeleton,cell junctions,and adhesion essential for cancer cell invasion and extravasation towards metastasis,and support the promise of miR-124 therapy.

关键词： RNA therapy MiR-124-3p Metastasis Proteomics Junctions Cell adhesion Bioengineer Imaging

Bioengineered miR-328-3p modulates GLUT1-mediated glucose uptake and metabolism to exert synergistic antiproliferative effects with chemotherapeutics

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2020年第1期10卷 159-170页

作者： Wanrong Yi Mei-Juan Tu Zhenzhen Liu Chao Zhang Neelu Batra ai-Xi yu ai-Ming yu Department of Orthopaedic Trauma and Microsurgery Zhongnan Hospital of Wuhan UniversityWuhan 430072China Department of Biochemistry&Molecular Medicine UC Davis School of MedicineSacramento 95817CAUSA

MicroRNAs(miRNAs or miRs)are small noncoding RNAs derived from genome to control target gene *** we have developed a novel platform permitting high-yield production of bioengineered miRNA agents(BERA).This study is to produce and utilize novel fully-humanized BERA/miR-3’28-3p molecule(hBERA/miR-3’28)to delineate the role of miR-328-3p in controlling nutrient uptake essential for cell *** first demonstrated successful high-level expression of hBERA/miR-328 in bacteria and purification to high degree of homogeneity(>98%).Biologic miR-328-3p prodrug was selectively processed to miR-328-3p to suppress the growth of highly-proliferative human osteosarcoma(OS)*** glucose transporter protein type 1,gene symbol solute carrier family 2 member 1(GUJTHSLC2A1),we identified and verified large neutral amino acid transporter 1,gene symbol solute carrier family 7 member 5(LPAT1/SLC7A5)as a direct target for miR-3’*** reduction of LAT1 protein levels by miR-3’28-3p did not alter homeostasis of amino acids within OS cells,suppression of GLUT1 led to a significantly lower glucose uptake and decline in intracellular levels of glucose and glycolytic metabolite ***,combination treatment with hBERA/miR-3’28 and cisplatin or doxorubicin exerted a strong synergism in the inhibition of OS cell *** findings support the utility of novel bioengineered RNA molecules and establish an important role of miR-328-3p in the control of nutrient transport and homeostasis behind cancer metabolism.

关键词： Bioengineered RNA MiR-328 LAT1 GLUT1 Chemosensitivity Cancer

Regenerative peripheral nerve interface prevents neuroma formation after peripheral nerve transection

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第4期18卷 814-818页

作者： Zheng Wang Xin-Zeyu Yi ai-Xi yu Department of Orthopedics Trauma and Microsurgery Zhongnan Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Neuroma formation after peripheral nerve transection often leads to severe neuropathic *** peripheral nerve interface has been shown to reduce painful neuroma in the ***,no reports have investigated the underlying mechanisms,and no comparative animal studies on regenerative peripheral nerve interface and other means of neuroma prevention have been conducted to *** this study,we established a rat model of left sciatic nerve transfection,and subsequently interfered with the model using the regenerative peripheral nerve interface or proximal nerve stump implantation inside a fully innervated *** showed that,compared with rats subjected to nerve stump implantation inside the muscle,rats subjected to regenerative peripheral nerve interface intervention showed greater inhibition of the proliferation of collagenous fibers and irregular regenerated axons,lower expressions of the fibrosis markerα-smooth muscle actin and the inflammatory marker sigma-1 receptor in the proximal nerve stump,lower autophagy behaviors,lower expressions of c-fos and substance P,higher expression of glial cell line-derived neurotrophic factor in the ipsilateral dorsal root *** findings suggested that regenerative peripheral nerve interface inhibits peripheral nerve injury-induced neuroma formation and neuropathic pain possibly via the upregulation of the expression of glial cell line-derived neurotrophic factor in the dorsal root ganglia and reducing neuroinflammation in the nerve stump.

关键词： autotomy dorsal root ganglia glial cell line-derived neurotrophic factor nerve injury neuropathic pain peripheral nerve regeneration regenerative peripheral nerve interface retrograde axonal transport traumatic neuroma

On the Inertia Index of a Mixed Graph in Terms of the Matching Number

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2023年第3期39卷 591-604页

作者： Sheng-jie HE Rong-Xia HAO ai-mei yu School of Mathematics and Statistics Beijing Jiaotong UniversityBeijing 100044China

A mixed graph G^(-) is obtained by orienting some edges of G, where G is the underlying graph of G^(-) . The positive inertia index, denoted by p~+( G), and the negative inertia index, denoted by n~-(G^(-) ), of a mixed graph G^(-) are the integers specifying the numbers of positive and negative eigenvalues of the Hermitian adjacent matrix of G^(-) , respectively. In this paper, the positive and negative inertia indices of the mixed unicyclic graphs are studied. Moreover, the upper and lower bounds of the positive and negative inertia indices of the mixed graphs are investigated, and the mixed graphs which attain the upper and lower bounds are characterized respectively.

关键词： Inertia index Mixed graph Matching number

Advanced knowledge in drug metabolism and pharmacokinetics

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2016年第5期6卷 361-362页

作者： ai-Ming yu Xiao-bo Zhong Department of Biochemistry and Molecular Medicine Cancer CenterSchool of MedicineUniversity of California at Davis Department of Pharmaceutical Sciences School of PharmacyUniversity of Connecticut

Drug metabolism and transport in human organs,such as in the liver,intestine,and kidney,control the concentrations of a drug and its metabolites in the circulating system and target organs in a certain period of time following drug *** pharmacokinetic properties will consequently determine therapeutic efficacy and influence toxicological *** of drug metabolism and pharmacokinetics may result in significant inter-

关键词： metabolism administration intestine organs circulating homeostasis consequently estrogen hepatocyte transporters

Polyporous C@WC_(1-x) composite and its electrocatalytic activity for p-nitrophenol reduction

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2011年第4期22卷 497-500页

作者： Hua Jun Zheng ai Mei yu Chun An Ma College of Application Chemistry Zhejiang University of Technology Hangzhou 310014 China

The polyporous carbon supported tungsten carbide（polyporous C@WC_（1-x）） composite was prepared using hexagonal silica MCM-41 as the hard template by raw material solution impregnation,mechanical milling and simultaneous reduction and carbonization by temperature programming in mixture gas（CH4/H2）.The structure and morphology of polyporous C@WC（1-x） composite were studied via X-ray diffraction,transmission electron microscopy and so *** electrocatalytic property was tested for the electroreduction of p-nitrophenol（PNP） in neutral *** revealed that the composite is consisted of polyporous carbon and nanocrystalline WC（1-x）,possessing good electrocatalytic activity in the reaction of PNP reduction.

关键词： Template method Polyporous carbon WC1-x Electrocatalytic activity

The value and limitation of transcatheter arterial chemoembolization in preventing recurrence of resected hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第23期11卷 3644-3646页

作者： Hong-YanCheng XiangWang DongChen ai-MinXu yu-ChenJia DepartmentofRadiology EasternHepatobiliarySurgeryHospitalSecondMilitaryMedicalUniversityShanghai200438China

aiM: To evaluate the value and limitation of postoperative transcatheter arterial chemoembolization (TACE) in preventing recurrence of hepatocellular carcinoma (HCC). METHODS: In the first group, 987 postoperative patients with HCC, who did not have any evidence of recurrence in the first preventative TACE but were found to have recurrence at different times during the follow-up survey, were analyzed. In the second group, 643 postoperative patients with HCC had no TACE for compared study. To study the relationship between the recurrence time and the number of TACE treatments was analyzed. RESULTS: The 6-, 12-, and 18-mo recurrence rates in the first and second groups were 22.2% (210 cases) vs 61.6% (396 cases), 78.0% (770 cases) vs74.7% (480 cases) and 88.6% (874 cases) vs80.1% (515 cases). There were significant differences between the recurrence rates of the two groups at 6 mo (P＜0.0001).CONCLUSION: The principal role of TACE after HCC operation is to suppress, detect early and treat micrometastasis. It has a good effect of preventing recurrence of HCC in 6 mo, but such an effect is less satisfactory in a longer period. When it is uncertain whether HCC is singlecentral or multi-central and if there is cancer residue or metastasis after operation, TACE is valuable to prevent recurrence.

关键词： Liver neoplasm Prevent recurrence Therapy Resection

Author correction to ‘Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo’ [Acta Pharmaceutica Sinica B 11 (2021) 3950e3965]

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第8期13卷 3577-3578页

The authors regret that there was one incorrect image used within Fig.4A,143B cells treated with LSA at 24 h time point,which was obtained from vehicle group but mislabelled as LSA in the *** our studies,three biological replicates were included in each treatment group and at least three images were taken for different fields of each *** thus selected a correct representative image from the LSA treated 143B cells at 24 h time point to replace that mislabelled image,and the updated Fig.4 is provided *** authors apologize for any inconvenience caused to the journal and readers,while this correction does not affect any results and *** authors have provided the original data of this figure to Editorial Office,and the corresponding authors or the Editorial Office can be contacted for original data access.

关键词： journal correction replace