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Dietary isoflavones,the modulator of breast carcinogenesis:Current landscape and future perspectives

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 186-193页

作者： Javed iqbal Banzeer ahsan Abbasi Ali Talha Khalil Barkat Ali Tariq Mahmood Sobia Kanwal Sayed Afzal Shah Wajid Ali Department of Plant Sciences Quaid-i-Azam University Department of Eastern Medicine and Surgery Qarshi University UNESCO UNISA Africa chair in nanoscience and nanotechnology Nanosciences African Network(NANOAFNET) Department of Zoology University of GujratSub Campus

Breast cancer is a frightful disease and serious concern in women around the world causing significant health care burden in both developed and developing countries. Extensive research work has shown that breast cancer provides strong resistance to chemical agents, U V radiation,and hormonal treatments. It is generally accepted that cell genetics is not the only main reason for breast cancer and genetic risk factors, for example, mutations in RRCAI and BRCA2 genes constitute 5%-10% of all breast cancer rates. Other related factors include age, gender,race, ethnicity, weight, reproductive factors, exo-and endogenous hormonal exposures, oral contraceptives use, ultraviolet radiation, diet, and night work(circadian disruption). Many studies have revealed that dietary isoflavones regulate breast cancer occurrence, recurrence and prognosis. Dietary isoflavones have long been part of Asian population diet and there is a significant increase as compared to dietary isoflavones intake among other populations. Dietary isoflavones are natural phytoestrogens having both estrogenic and anti-estrogenic potentials on breast cancer cells in culture, animal models and in experimental trials. This literature survey provides a comprehensive overview on the tumor preventive and tumor promoting potentials of dietary isoflavones on breast cancer. In addition, this paper provides a literature review of dietary isoflavones and their effects on up-regulation and down-regulation of different signaling pathways, genes and proteins. Finally, future perspectives of dietary isoflavones and breast cancer researchers are also critically discussed, which will provide a deeper insight regarding the inner molecular mechanisms of action.

关键词： Dietary isoflavones Breast cancer Signaling pathways Natural phytoestrogens

Validity,Reliability,and Measurement Invariance of the Thai Smartphone Application-Based Addiction Scale and Bergen Social Media Addiction Scale

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International Journal of Mental Health Promotion 2024年第4期26卷 293-302页

作者： Kamolthip Ruckwongpatr Chirawat Paratthakonkun Usanut Sangtongdee iqbal Pramukti Ira Nurmala Kanokwan Angkasith Weena Thanachaisakul Jatuphum Ketchatturat Mark DGriffiths Yi-Kai Kao Chung-Ying Lin Institute of Allied Health Sciences College of MedicineNational Cheng Kung UniversityTainan701401Taiwan College of Sports Science and Technology Mahidol UniversityNakhon Pathom73170Thailand Department of Forensic Science Royal Police Cadet AcademyNakhon Pathom73110Thailand School of Computing Engineeringand Digital TechnologyTeesside UniversityMiddlesbroughUK Faculty of Nursing Universitas PadjadjaranWest Java45363Indonesia Division of Health Promotion and Behavioral Sciences Faculty of Public HealthUniversitas AirlanggaSurabaya60115Indonesia Faculty of Education Chiang Mai UniversityChiang Mai50200Thailand Faculty of Education Khon Kaen UniversityKhon Kaen40002Thailand International Gaming Research Unit Psychology DepartmentNottingham Trent UniversityNottinghamNG14FQUK Division of Colorectal Surgery E-DA HospitalKaohsiung82445Taiwan College of Medicine National Cheng Kung UniversityTainan701401Taiwan Biostatistics Consulting Center National Cheng Kung University HospitalTainan701401Taiwan

Background:In recent years,there has been increased research interest in both smartphone addiction and social media addiction as well as the development of psychometric instruments to assess these ***,there is a lack of psychometric evaluation for instruments assessing smartphone addiction and social media addiction in *** present study evaluated the psychometric properties and gender measurement invariance of the Thai version of the Smartphone Application-Based Addiction Scale(SABAS)and Bergen Social Media Addiction Scale(BSMAS).Method:A total of 801 Thai university students participated in an online survey from January 2022 to July 2022 which included demographic information,SABAS,BSMAS,and the Internet Gaming Disorder Scale-Short Form(IGDS9-SF).Results:Confirmatory Factor Analyses(CFAs)found that both the SABAS and BSMAS had a one-factor *** demonstrated adequate psychometric properties of both instruments and also supported measurement invariance across ***,scores on the SABAS and BSMAS were correlated with scores on the ***:The results indicated that the SABAS and BSMAS are useful psychometric instruments for assessing the risk of smartphone addiction and social media addiction among Thai young adults.

关键词： Factor analysis smartphone addiction social media addiction smartphone application-based addiction scale bergen social media addiction scale psychometric validation

Role of dietary phytochemicals in modulation of miRNA expression:Natural swords combating breast cancer

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Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 501-509页

作者： Banzeer ahsan Abbasi Javed iqbal Tariq Mahmood Ali Talha Khalil Barkat Ali Sobia Kanwal Sayed Afzal Shah Riaz Ahmad Department of Plant Sciences Quaid-i-Azam University Nanosciences African Network(NANOAFNET) iThemba LABS-National Research Foundation Somerset West Department of Zoology University of GujratSub Campus Department of Eastern Medicine and Surgery Qarshi University UNESCO UNISA Africa Chair in Nanoscience and Nanotechnology College of Graduate StudiesUniversity of South Africa College of Life Sciences Shaanxi Normal University

The National Cancer Institute had projected breast cancer(BC) as one of the topmost prevalent malignancies around the *** many cases,BC becomes resistant to chemotherapy,radiation and hormonal *** BC therapies are associated with adverse side effects,drug resistance and *** research work has shown that these dietary phytochemicals(DPs) may exert therapeutic effects by regulating the miRNA expression.A large number of DPs have been researched as miRNA regulatory agents against BC and some other DPs have not yet been tested against *** have discussed the effects of curcumin,diallyl disulphide,3,3′ diindolylmethane,ellagic acid,genistein,indole-3-carbinol,quercetin,resveratrol,and sulforaphane on regulation of expression of BC miRNAs in a wide range of in vitro and in vivo *** have also shown some of the possible DPs(Oleanolic acid,capsaicin,benzyl isothiocyanate,epigallocatechin gallate,phenethyl isothiocyanate and ursolic acid) that have shown miRNA regulatory activities and have not yet been tested against BC ***,current limitations,challenges,future perspectives of DPs and BC research are also critically discussed.

关键词： Breast cancer miRNAs Dietary phytochemicals In vitro In vivo

Can Strategies to Cope with Hazard Shocks be Explained by At-Risk Households' Socioeconomic Asset Profile? Evidence from Tropical Cyclon-Prone Coastal Bangladesh

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International Journal of Disaster Risk Science 2017年第1期8卷 46-63页

作者： Md.Nasif ahsan Economics Discipline Khulna UniversityKhulna-9208Bangladesh

This article documents the results of an empirical investigation on the complex interplay between diverse coping mechanisms and the socioeconomic asset profiles of coastal households at risk. Focusing on household-level perceptions and responses to cyclone hazards, a case study was carried out in a poor area in Bangladesh that is prone to natural hazards. We developed and tested our own analytical models based on the asset approach. We conducted a face-to-face household survey in southwestern coastal Bangladesh, in the Koyra sub-district, in late *** asked 360 households affected by the May 2009 tropical Cyclone Aila about their hazard perceptions, preparedness, coping practices, and socioeconomic assets. The results suggest that the majority of households at risk perceive an increasing trend of different climate hazards,with a distinct dominance of tropical cyclones, storm surges, and flash floods in the study area, which resulted in a yearly average economic damage of USD 144 for each household in the first year after Aila. However, such damage is significantly and inversely correlated with the number of adopted coping practices. Significant and systematic differences exist between upstream and downstream households in the study area with respect to hazard perception, hazard induced damages, asset accessibility,and adopted diversified coping practices. The empirical findings suggest that the degree of adoption of coping practices depends primarily on elements of socioeconomic asset profile and the duration of the consequences of cyclone hazards. Disaster preparedness training seems to improve at-risk households' degree of information access and eventually leads them to adopt more coping practices to reduce adverse impacts of climate hazards. Area-specific practical modules on coping practices should be incorporated in curricula of disaster preparedness training to make people at risk more resilient to hazard shocks.

关键词： Climatic hazard risk Coastal Bangladesh Coping mechanism Cyclone Aila

Dimeric quinacridone cyclophanes: Synthesis,structures,and photophysical properties

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Science China Chemistry 2011年第2期54卷 314-319页

作者： JAVAD iqbal State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University

Two novel quinacridone (QA) cyclophanes with intrinsic intramolecular dye-dye interactions have been designed and synthesized.X-ray crystal structures as well as detailed photophysical properties have been well *** two dyes have a major advantage that efficient fluorescence quenching can be observed even in their dilute solutions.A comparison of photophysical properties between the dimeric QA cyclophane and its reference monomeric counterpart indicates that the dimerization is predominant for the fluorescence quenching of QA dyes in *** study provided some model QA derivatives with dimeric structures for understanding the fluorescence quenching of QA dyes in solutions.

关键词： quinacridone cyclophanes dye-dye interactions photophysics fluorescence quenching

Heat Transfer Analysis of MHD Power Law Nano Fluid Flow through Annular Sector Duct

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Journal of Thermal Science 2020年第1期29卷 169-181页

作者： AHMED Farhan iqbal Mazhar School of Natural Sciences National University of Science and Technology

Flow and heat transfer analysis of an electrically conducting MHD power law nano fluid is carried out through annular sector duct,under the influence of constant pressure *** types of nano particles(*** and TiO2)are used in power law nano *** implicit procedure,(SIP)is used to simulate the discretized coupled algebraic *** has been observed that volume fraction of nano particles,ϕand magnetic field parameter,Ha are favourable for the heat transfer rate,however,both resist the fluid *** of applied uniform transverse magnetic field exceeds in the case of shear thickening fluids(i.e.n>1)by increasing the value of Ha as compared to that in shear thinning fluids(i.e.n<1).Therefore,enhancement in heat transfer rate is comparably more in shear thickening ***,comparable limiting case study with published result is also carried out in this research paper.

关键词： electrically conducting power law nano fluid Cu nano particles TiO2 nano particles shear thickening fluid shear thinning fluid heat transfer rate friction factor

Deep learning for the internet of things:Potential benefits and use-cases

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Digital Communications and Networks 2021年第4期7卷 526-542页

作者： Tausifa Jan Saleem Mohammad ahsan Chishti Department of Computer Science and Engineering National Institute of TechnologySrinagarJ&KIndia

The massive number of sensors deployed in the Internet of Things(IoT)produce gigantic amounts of data for facilitating a wide range of *** Learning(DL)would undoubtedly play a role in generating valuable inferences from this massive volume of data and hence will assist in creating smarter *** this regard,exploring the potential of DL for IoT data analytics becomes highly *** paper begins with a concise discussion on the Deep Neural Network(DNN)and its different *** potential benefits that DL will bring to the IoT are also ***,a detailed review of DL-driven IoT use-cases is ***,this paper formulates a DL-based model for Human Activity Recognition(HAR).It carries out a performance comparison of the proposed model with other machine learning techniques to delineate the superiority of the DL model over other *** from enlightening the potential of DL in IoT applications,this paper will serve as an impetus to encourage advanced research in the realm of DL-driven IoT applications.

关键词： Internet of things(IoT) Deep learning Convolutional neural network Recurrent neural network Long short term memory

Big Data Analytics in Healthcare——A Systematic Literature Review and Roadmap for Practical Implementation

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IEEE/CAA Journal of Automatica Sinica 2021年第1期8卷 1-22页

作者： Sohail Imran Tariq Mahmood ahsan Morshed Timos Sellis the Faculty of Computer Science Karachi Institute of Economics and TechnologyKarachi 75190Pakistan the Faculty of Computer Science Institute of Business AdministrationKarachi 75270Pakistan the School of Engineering and Technology CQ UniversityMelbourne 3000Australia the Data Science Research Institute Swinburne University of TechnologyHawthorn 3122Australia

The advent of healthcare information management systems(HIMSs)continues to produce large volumes of healthcare data for patient care and compliance and regulatory requirements at a global *** of this big data allows for boundless potential outcomes for discovering *** data analytics(BDA)in healthcare can,for instance,help determine causes of diseases,generate effective diagnoses,enhance Qo S guarantees by increasing efficiency of the healthcare delivery and effectiveness and viability of treatments,generate accurate predictions of readmissions,enhance clinical care,and pinpoint opportunities for cost ***,BDA implementations in any domain are generally complicated and resource-intensive with a high failure rate and no roadmap or success strategies to guide the *** this paper,we present a comprehensive roadmap to derive insights from BDA in the healthcare(patient care)domain,based on the results of a systematic literature *** initially determine big data characteristics for healthcare and then review BDA applications to healthcare in academic research focusing particularly on No SQL *** also identify the limitations and challenges of these applications and justify the potential of No SQL databases to address these challenges and further enhance BDA healthcare *** then propose and describe a state-of-the-art BDA architecture called Med-BDA for healthcare domain which solves all current BDA challenges and is based on the latest zeta big data *** also present success strategies to ensure the working of Med-BDA along with outlining the major benefits of BDA applications to ***,we compare our work with other related literature reviews across twelve hallmark features to justify the novelty and importance of our *** aforementioned contributions of our work are collectively unique and clearly present a roadmap for clinical administrators,practitioners and professionals to successf

关键词： Big data analytics(BDA) big data architecture healthcare NoSQL data stores patient care roadmap systematic literature review

Effect of Minor Alloying on Crystallization Behavior and Thermal Properties of Zr_(64.5)Ni_(15.5)Al_(11.5)Cu_(8.5) Bulk Amorphous Alloy

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Journal of Materials Science & Technology 2011年第6期27卷 534-538页

作者： Muhammad iqbal Javed iqbal Akhter Haifeng Zhang Zhuangqi Hu MicrostructuralStudies Group Physics Division Pakistan Institute of Nuclear Science and Technology (PINSTECH) P.O. Nilore Islamabad Pakistan Shenyang Nationel Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Minor alloying plays an important role in the synthesis and improvement of thermal stability of bulk metallic glasses（BMGs）.The present study was conducted to investigate the effect of minor additions of Y,Ti and Nb on the crystallization behavior and the thermal properties of Zr64.5Ni15.5Al11.5Cu8.5 *** parameters and the activation energies for crystallization were calculated for four（Zr0.645Ni0.155Al0.115-Cu0.085）100-xMx（M=Y,Ti and Nb,while x=0,2 at.） *** present alloys have wide supercooled liquid region of ≥87 *** activation energy was found to be greater than 300 kJ/mol for the base *** crystalline phases were identified in the samples annealed at 823 K for 20 *** glass transition temperature（Trg） and other thermal parameters such as γ,δ and β were improved by Y and Ti *** addition resists crystallization below annealing temperature 713 K,however,its effect on thermal properties is not very promising.

关键词： Activation energy Thermal properties Glass-forming ability Thermal stability Precipitation Microstructure