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A Component Selection Framework of Cohesion and Coupling Metrics

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Computer Systems Science & Engineering 2023年第1期44卷 351-365页

作者： M.Iyyappan Arvind Kumar Sultan Ahmad Sudan Jha Bader Alouffi Abdullah alharbi Department of Computer Science and Engineering SRM UniversityDelhi-NCRSonepat131029India Department of Computer Science College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia School of Sciences Christ(Deemed to be University)Delhi-NCRGhaziabad201003India Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

Component-based software engineering is concerned with the develop-ment of software that can satisfy the customer prerequisites through reuse or inde-pendent *** and cohesion measurements are primarily used to analyse the better software design quality,increase the reliability and reduced system software *** complexity measurement of cohesion and coupling component to analyze the relationship between the component *** this paper,proposed the component selection framework of Hexa-oval optimization algorithm for selecting the suitable components from the *** measures the interface density modules of coupling and cohesion in a modular software *** cohesion measurement has been taken into two parameters for analyz-ing the result of complexity,with the help of low cohesion and high *** coupling measures between the component of inside parameters and outside *** process of coupling and cohesion,the measured values were used for the average calculation of components *** paper measures the complexity of direct and indirect interaction among the component as well as the proposed algorithm selecting the optimal component for the *** better result is observed for high cohesion and low coupling in compo-nent-based software engineering.

关键词： Component-based software system coupling metric cohesion metric complexity component interface module density

Computerized Detection of Limbal Stem Cell Deficiency from Digital Cornea Images

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Computer Systems Science & Engineering 2022年第2期40卷 805-821页

作者： Hanan A.Hosni Mahmoud Doaa S.Khafga Amal H.alharbi Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11047KSA

Limbal Stem Cell Deficiency(LSCD)is an eye disease that can cause corneal opacity and *** its advanced stage it can lead to a degree of visual *** involves the changing in the semispherical shape of the cornea to a drooping shape to downwards *** is hard to be diagnosed at early *** color and texture of the cornea surface can provide significant information about the cornea affected by *** such as shape and texture are very crucial to differentiate normal from LSCD *** several medical approaches exist,most of them requires complicated procedure and medical ***,in this paper,we pursued the development of a LSCD detection technique(LDT)utilizing image processing *** diagnosis of LSCD is very crucial for physicians to arrange for effective *** the proposed technique,we developed a method for LSCD detection utilizing frontal eye images.A dataset of 280 eye images of frontal and lateral LSCD and normal patients were used in this ***,the cornea region of both frontal and lateral images is segmented,and the geometric features are extracted through the automated active contour model and the spline *** the texture features are extracted using the feature selection *** experimental results exhibited that the combined features of the geometric and texture will exhibit accuracy of 95.95%,sensitivity of 97.91% and specificity of 94.05% with the random forest classifier of n=*** a result,this research developed a Limbal stem cell deficiency detection system utilizing features’fusion using image processing techniques for frontal and lateral digital images of the eyes.

关键词： Feature extraction corneal opacity geometric features computerized detection image processing

Quaternion Integers Based Higher Length Cyclic Codes and Their Decoding Algorithm

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Computers, Materials & Continua 2022年第10期73卷 1177-1194页

作者： Muhammad Sajjad Tariq Shah Mohammad Mazyad Hazzazi Adel R.alharbi Iqtadar Hussain Department of Mathematics Quaid-I-Azam UniversityIslamabad45320Pakistan Department of Mathematics College of ScienceKing Khalid UniversityAbha61413Saudi Arabia College of Computing and Information Technology University of TabukTabuk71491Saudi Arabia Department of Mathematics Statistics and PhysicsQatar UniversityDoha2713Qatar

The decoding algorithm for the correction of errors of arbitrary Mannheim weight has discussed for Lattice constellations and codes from quadratic number *** these lines,the decoding algorithms for the correction of errors of n=p−12 length cyclic codes(C)over quaternion integers of Quaternion Mannheim(QM)weight one up to two coordinates have *** continuation,the case of cyclic codes of lengths n=p−12 and 2n−1=p−2 has studied to improve the error correction *** this study,we present the decoding of cyclic codes of length n=ϕ(p)=p−1 and length 2n−1=2ϕ(p)−1=2p−3(where p is prime integer andϕis Euler phi function)over Hamilton Quaternion integers of Quaternion Mannheim weight for the correction of ***,the error correction capability and code rate tradeoff of these codes are also ***,an increase in the length of the cyclic code is achieved along with its better code rate and an adequate error correction capability.

关键词： Mannheim distance monoid ring cyclic codes parity check matrix extension syndromes decoding code rate and error correction capability

Exploring the Current Practices,Costs and Benefits of FAIR Implementation in Pharmaceutical Research and Development:A Qualitative Interview Study

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Data Intelligence 2021年第4期3卷 507-527页

作者： Ebtisam alharbi Rigina Skeva Nick Juty Caroline Jay Carole Goble School of Computer Science University of ManchesterManchesterManchester M139PLUK College of Computer and Information Systems Umm Al-Qura UniversityMeccaMakkah 21421Saudi Arabia

The findable,accessible,interoperable,reusable(FAIR)principles for scientific data management and stewardship aim to facilitate data reuse at scale by both humans and *** and development(R&D)in the pharmaceutical industry is becoming increasingly data driven,but managing its data assets according to FAIR principles remains costly and *** date,little scientific evidence exists about how FAIR is currently implemented in practice,what its associated costs and benefits are,and how decisions are made about the retrospective FAIRification of data sets in pharmaceutical R&*** paper reports the results of semi-structured interviews with 14 pharmaceutical professionals who participate in various stages of drug R&D in seven pharmaceutical *** thematic analysis identified three primary themes of the benefits and costs of FAIRification,and the elements that influence the decision-making process for FAIRifying legacy data *** collectively acknowledged the potential contribution of FAIRification to data reusability in diverse research domains and the subsequent potential for *** costs,however,were still considered a barrier by participants,with the need for considerable expenditure in terms of resources,and cultural *** decisions were made about FAIRification was influenced by legal and ethical considerations,management commitment,and data *** findings have significant implications for those in the pharmaceutical R&D industry who are engaged in driving FAIR implementation,and for external parties who seek to better understand existing practices and challenges.

关键词： FAIR FAIRification Retrospective FAIRification Pharmaceutical R&D Cost-benefit Decision-making process

Statistical Analysis with Dingo Optimizer Enabled Routing for Wireless Sensor Networks

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Computers, Materials & Continua 2022年第11期73卷 2865-2878页

作者： Abdulaziz S.Alghamdi Randa alharbi Suliman A.Alsuhibany Sayed Abdel-Khalek Department of Mathematics College of Science&ArtsKing Abdulaziz UniversityRabigh21911Saudi Arabia Department Statistics College of ScienceUniversity of TabukTabukSaudi Arabia Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Mathematics and Statistics College of ScienceTaif UniversityTaif21944Saudi Arabia Mathematics Department Faculty of ScienceSohag UniversitySohag82524Egypt

Security is a vital parameter to conserve energy in wireless sensor networks(WSN).Trust management in the WSN is a crucial process as trust is utilized when collaboration is important for accomplishing trustworthy data *** the available routing techniques do not involve security in the design of routing *** study develops a novel statistical analysis with dingo optimizer enabled reliable routing scheme(SADO-RRS)for *** proposed SADO-RRS technique aims to detect the existence of attacks and optimal routes in *** addition,the presented SADORRS technique derives a new statistics based linear discriminant analysis(LDA)for attack detection,Moreover,a trust based dingo optimizer(TBDO)algorithm is applied for optimal route selection in the WSN and accomplishes secure data transmission in ***,the TBDO algorithm involves the derivation of the fitness function involving different input variables of *** demonstrating the enhanced outcomes of the SADO-RRS technique,a wide range of simulations was carried out and the outcomes demonstrated the enhanced outcomes of the SADO-RRS technique.

关键词： Statistical analysis reliability routing wireless sensor networks linear discriminant analysis dingo optimizer security

Age-Based Automatic Voice Conversion Using Blood Relation for Voice Impaired

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Computers, Materials & Continua 2022年第2期70卷 4027-4051页

作者： Palli Padmini C.Paramasivam G.Jyothish Lal Sadeen alharbi Kaustav Bhowmick Department of Electronics&Communication Engineering Amrita School of EngineeringBengaluruAmrita Vishwa VidyapeethamIndia Center for Computational Engineering and Networking(CEN) Amrita School of EngineeringCoimbatoreAmrita Vishwa VidyapeethamIndia Department of Software Engineering College of Computer and Information SciencesKing Saud UniversityRiyadhSaudi Arabia Department of Electronics and Communication Engineering PES UniversityBengaluruIndia

The present work presents a statistical method to translate human voices across age groups,based on commonalities in voices of blood *** age-translated voices have been naturalized extracting the blood relation features e.g.,pitch,duration,energy,using Mel Frequency Cepstrum Coefficients(MFCC),for social compatibility of the *** system has been demonstrated using standard English and an Indian *** voice samples for resynthesis were derived from 12 families,with member ages ranging from 8–80 *** voice-age translation,performed using the Pitch synchronous overlap and add(PSOLA)approach,by modulation of extracted voice features,was validated by perception *** translated and resynthesized voices were correlated using Linde,Buzo,Gray(LBG),and Kekre’s Fast Codebook generation(KFCG)*** translated voice targets,a strong(θ>∼93%andθ>∼96%)correlation was found with blood relatives,whereas,a weak(θ<∼78%andθ<∼80%)correlation range was found between different families and different gender from same *** study further subcategorized the sampling and synthesis of the voices into similar or dissimilar gender groups,using a support vector machine(SVM)choosing between available voice ***,∼96%,∼93%,and∼94%accuracies were obtained in the identification of the gender of the voice sample,the age group samples,and the correlation between the original and converted voice samples,*** results obtained were close to the natural voice sample features and are envisaged to facilitate a near-natural voice for speech-impaired easily.

关键词： Blood relations KFCG LBG MFCC vector quantization correlation speech samples same-gender dissimilar gender voice conversion PSOLA SVM

A Real-Time Oral Cavity Gesture Based Words Synthesizer Using Sensors

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Computers, Materials & Continua 2022年第6期71卷 4523-4554页

The present system experimentally demonstrates a synthesis of syllables and words from tongue manoeuvers in multiple languages,captured by four oral sensors *** an experimental demonstration of the system used in the oral cavity,a prototype tooth model was *** on the principle developed in a previous publication by the author(s),the proposed system has been implemented using the oral cavity(tongue,teeth,and lips)features alone,without the glottis and the *** positions of the sensors in the proposed system were optimized based on articulatory(oral cavity)gestures estimated by simulating the mechanism of human *** system has been tested for all English alphabets and several words with sensor-based input along with an experimental demonstration of the developed algorithm,with limit switches,potentiometer,and flex sensors emulating the tongue in an artificial oral *** system produces the sounds of vowels,consonants,and words in English,along with the pronunciation of meanings of their translations in four major Indian languages,all from oral cavity *** experimental setup also caters to gender mapping of *** sound produced from the hardware has been validated by a perceptual test to verify the gender and word of the speech sample by listeners,with∼98%and∼95%accuracy,*** a model may be useful to interpret speech for those who are speech-disabled because of accidents,neuron disorder,spinal cord injury,or larynx disorder.

关键词： English vowels and consonants oral cavity proposed system sensors speech-disabled speech production vocal tract model

Non-target lung embolization during portal vein embolization due to an unrecognized portosystemic venous fistula:A case report

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World Journal of Clinical Cases 2023年第15期11卷 3625-3630页

作者： Sultan R alharbi Mohammed Bin Nasif Haifa Bandar Alwaily Interventional Radiology Unit Department of RadiologyCollege of MedicineKing Saud UniversityKing Khalid University HospitalRiyadh 11362Saudi Arabia Department of Radiology College of MedicineKing Saud UniversityRiyadh 11362Saudi Arabia

BACKGROUND Portal vein embolization(PVE)is an effective and relatively safe procedure performed prior to major hepatic resection to enhance future liver *** embolization during PVE is rare,and if it occurs,it usually affects the future liver *** portosystemic venous fistulas are extremely rare in non-cirrhotic *** report a case of non-targeted lung embolization during PVE due to an unrecognized intrahepatic portosystemic *** SUMMARY A 60-year-old male presented with metastatic colon cancer of the *** patient underwent preoperative right *** the embolization procedure,a small amount of glue and lipiodol emulsion was embolized to the heart and lungs through an unrecognized intrahepatic portosystemic *** patient remained clinically stable and underwent the planned hepatic resection after 4 wk,with an uneventful postoperative *** Conventional portograms and careful evaluation prior to PVE are advisable to avoid such complications.

关键词： Portal vein embolization Non-target embolization Portosystemic venous fistula Case report

Methods of screening,monitoring and management of cardiac toxicity induced by chemotherapeutics

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Chinese Chemical Letters 2022年第6期33卷 2773-2782页

作者： Humayra Afrin Christiancel Joseph Salazar Mohsin Kazi Syed Rizwan Ahamad Majed alharbi Md Nurunnabi Environmental Science&Engineering University of Texas at El PasoEl PasoTX 79965United States Border Biomedical Research Center University of Texas at El PasoEl PasoTX 79965United States Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh 11451Kingdom of Saudi Arabia Central Laboratory Department of Pharmaceutical ChemistryCollege of PharmacyKing Saud UniversityRiyadh 11451Kingdom of Saudi Arabia Department of Biomedical Engineering University of Texas at El PasoEl PasoTX 79965United States Department of Pharmaceutical Sciences School of PharmacyUniversity of Texas at El PasoEl PasoTX 79902United States

Cardiac toxicity is one of the most common side effects of anticancer *** toxicity results dysfunction of heart including hypotension,heart failure,and even cause death in extreme *** potential risk of cardiotoxicity is a huge concern in chemotherapeutics mediated cancer *** individual with any pre-existing cardiac issues are excluded from clinical trials due to the potential risk of *** of the potential cardiotoxicity,there is an emerging need for alternatives of some very potent anticancer drugs(doxorubicin/DOX,5-fluorouracil/5 FU,trastuzumab).While a patient is being treated with anticancer drugs,early blood screening,biomarker detection,and careful monitoring of cardiac functions are necessary to be able to avoid any irreversible cardiac ***,early detection methodology to monitor cardiotoxicity in real-time,and a drug formulation that prevent interaction between drug and cardiac cell,seemingly have potential to mitigate the *** this review,we have summarized the cardiotoxicity of the most used anticancer drugs,their pathophysiology and some of the conventional and newer screening methods available to manage an individual patient in *** have also incorporated our perspective on how a rationale designing of biomolecules can be used to overcome the cardiotoxicity generated chemotherapeutics.

关键词： Cardiotoxicity Anticancer drug Chemotherapy Screening Biomarker