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What is the relationship between frailty and orthostatic hypotension in older adults?

Journal of Geriatric Cardiology 2019年第3期16卷 272-279页

作者： Suleyman Emre Kocyigit Pinar Soysal Esra Ates Bulut Ali Ekrem Aydin Ozge Dokuzlar ahmet turan isik Unit for Aging Brain and Dementia Department of Geriatric MedicineFaculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Geriatric Medicine Bezmialem Vakif UniversityFaculty of MedicineIstanbulTurkey

Background Frailty and orthostatic hypotension (OH),which is common in older adults,is associated with morbidity and *** relationship between them remains *** aim of the study is to determine whether there is a relationship between frailty and *** A total of 496 patients who were admitted to the geriatric clinic and underwent comprehensive geriatric assessment were retrospectively *** a cross-sectional and observational study,OH was measured by the Head-up Tilt Table test at 1,3,and 5 min (respectively,OH1,OH3,and OH5) and the frailty was measured by the Fried’s frailty *** The mean age of all patients was 75.4 ± *** prevalence of females was 69.8%.When the frail people were compared with the pre-frail and the robust ones,the frailty was associated with *** was no relationship between the groups in terms of OH1 when the pre-frail group was compared with the robust ***3 were higher in the frail group than in the pre-frail group (P 0.05).Slowness and weakness were associated with OH1 (P < 0.05),whereas the other components of the Fried’s test were *** Frailty may be a risk factor for *** 1^st min measurements of OH should be routinely evaluated in frail older adults to prevent OH-related poor outcomes.

关键词： Frail Orthostatic hypotension Pre-frail Robust

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Combination of allopurinol and hyperbaric oxygen therapy:A new treatment in experimental acute necrotizing pancreatitis?

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World Journal of Gastroenterology 2007年第46期13卷 6203-6207页

作者： Bilgin Comert ahmet turan isik Sezai Aydin Ergun Bozoglu Bulent Unal Salih Deveci Nuket Mas Esref Cinar Mehmet Refik Mas Division of Intensive Care Departments of Internal MedicineGulhane School of MedicineAnkara 06018Turkey Division of Geriatric Medicine Department of Internal MedicineGulhane School of MedicineAnkara 06018Turkey Department of Surgery Guven HospitalA.AyranciAnkara 06018Turkey Department of Surgery Numune Training HospitalSihhiyeAnkara 06018Turkey Department of Pathology Gulhane School of MedicineAnkara 06018Turkey Department of Anatomy Medical FacultyBaskent UniversityAnkara 06018Turkey Department of Infection Disease Gulhane School of MedicineAnkara 06018Turkey Department of Internal Medicine Gulhane School of MedicineAnkara 06018Turkey

AIM： To investigate the individual and combined effects of allopurinol and hyperbaric oxygen （HBO） therapy on biochemical and histopathological changes, oxidative stress, and bacterial translocation （BT） in the experimental rat acute pancreatitis （AP）. METHODS： Eighty-five Sprague-Dawley rats were included in the study. Fifteen of the eighty-five rats were used as controls （sham, Group I ）. AP was induced via intraductal taurocholate infusion in the remaining seventy rats. Rats that survived to induction of acute necrotizing pancreatitis were randomized into four groups. Group H received saline, Group m allopurinol, Group IV allopurinol plus HBO and Group v HBO alone. Serum amylase levels, oxidative stress parameters, BT and histopathologic scores were determined. RESULTS： Serum amylase levels were lower in Groups Ⅲ, Ⅳ and v compared to Group H （974 ± 110, 384 ± 40, 851 ＋ 56, and 1664 Ⅳ 234 U/L, respectively, P 〈 0.05, for all）. Combining the two treatment optionsrevealed significantly lower median [25-75 percentiles] histopathological scores when compared to individual administrations （13 [12.5-15] in allopurinol group, 9.5 [7-11.75] in HBO group, and 6 [4.5-7.5] in combined group, P 〈 0.01）. Oxidative stress markers were significantly better in all treatment groups compared to the controls. Bacterial translocation into the pancreas and mesenteric lymph nodes was lower in Groups m, iV and v compared to Group H （54%, 23%, 50% vs 100% for translocation to pancreas, and 62%, 46%, 58% vs 100% for translocation to mesenteric lymph nodes, respectively, P 〈 0.05 for all）. CONCLUSION： The present study confirms the benefit of HBO and allopurinol treatment when administered separately in experimental rat AP. Combination of these treatment options appears to prevent progression of pancreatic injury parameters more effectively.

关键词： Experimental pancreatitis AIIopurinol Hyperbaric oxygen

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Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis

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World Journal of Gastroenterology 2007年第23期13卷 3237-3244页

作者： Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu ahmet turan isik Harun M Said Department of Internal Medicine Gulhane School of Medicine Ankara 06018 Turkey Department of Pathology Veterinarian Faculty Ankara University Ankara Turkey Department of Pathology Gulhane School of Medicine Ankara 06018 Turkey Department of Anatomy Baskent University Ankara Turkey Institute for Hepatology Ankara University Ankara Turkey Department of Radiation Oncology Medical Faculty University of Würzburg Wiürzburg Germany 不详

AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine ***: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy.

关键词： Liver fibrosis Liver cirrhosis Pegylated interferons Taurine Oxidative stress Hepatic stelate cells Apoptosis Malondialdehyde Glutathione peroxidase Superoxide dismutase

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