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Modeling Liver Cancer and Leukemia Data Using Arcsine-Gaussian Distribution

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Computers, Materials & Continua 2021年第5期67卷 2185-2202页

作者： Farouq Mohammad A.Alam Sharifah Alrajhi Mazen Nassar ahmed z.afify Department of Statistics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Statistics Faculty of CommerceZagazig UniversityZagazig44511Egypt Department of Statistics Mathematics and InsuranceBenha UniversityBenha13511Egypt

The main objective of this paper is to discuss a general family of distributions generated from the symmetrical arcsine *** considered family includes various asymmetrical and symmetrical probability distributions as special cases.A particular case of a symmetrical probability distribution from this family is the Arcsine–Gaussian *** statistical properties of this distribution including quantile,mean residual life,order statistics and moments are *** Arcsine–Gaussian parameters are estimated using two classical estimation methods called moments and maximum likelihood methods.A simulation study which provides asymptotic distribution of all considered point estimators,90%and 95%asymptotic confidence intervals are performed to examine the estimation efficiency of the considered methods *** simulation results show that both biases and variances of the estimators tend to zero as the sample size increases,i.e.,the estimators are asymptotically ***,when the sample size increases the coverage probabilities of the confidence intervals increase to the nominal levels,while the corresponding length decrease and approach *** real data sets from the medicine filed are used to illustrate the flexibility of the Arcsine–Gaussian distribution as compared with the normal,logistic,and Cauchy *** proposed distribution is very versatile to fit real applications and can be used as a good alternative to the traditional gaussian distribution.

关键词： Liver cancer data leukemia data normal distribution moments estimation maximum likelihood estimation

Modeling COVID-19 Pandemic Dynamics in Two Asian Countries

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Computers, Materials & Continua 2021年第4期67卷 965-977页

作者： Jin zhao zubair Ahmad zahra Almaspoor M.El-Morshedy ahmed z.afify School of Finance Shanghai Lixin University of Accounting and FinanceShanghaiChina Department of Statistics Yazd UniversityYazdIran Department of Mathematics College of Science and Humanities in Al-KharjPrince Sattam bin Abdulaziz UniversityAl-Kharj11942Saudi Arabia Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Statistics Mathematics and InsuranceBenha UniversityBenha13511Egypt

The current epidemic outbreak COVID-19 first took place in the Wuhan city of China and then spread *** deadly disease affected millions of people and compelled the governments and other concerned institutions to take serious *** 0.28 million people have died from the COVID-19 outbreak as of May 11,2020,05:41 GMT,and the number is still increasing *** results of any scientific investigation of this phenomenon are still to ***,now it is urgently needed to evaluate and compare the disease dynamics to improve the quarantine activities and the level of individual protection,to at least speed up the rate of isolation of infected *** the domain of big data science and other related areas,it is always of interest to provide the best description of the data under ***,in this article,we compare the COVID-19 pandemic dynamics between two neighboring Asian countries,Iran and Pakistan,to provide a framework to arrange the appropriate quarantine *** tools for comparing this deadly pandemic dynamic have been presented that can be adopted to produce the bases for *** importantly,a new statistical model is developed to provide the best description of COVID-19 daily deaths data in Iran and Pakistan.

关键词： COVID-19 pandemic dynamics Pakistan mathematical modeling statistical methods Monte Carlo simulation

Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed Mohamed z.Sayed-ahmed Shaimaa ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

Remodeling Tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulmottaleb E.zetrini HoYin Lip Azhar z.Abbasi Ibrahim Alradwan Taksim ahmed Chunsheng He Jeffrey T.Henderson Andrew M.Rauth Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departments of Medical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatment of castration-resistant prostate cancer (CRPC), including radiation therapy and immunotherapy alone or in combination, the response to treatment remains poor due to the hypoxic and immunosuppressive nature of the tumor microenvironment. Herein, we exploited the bioreactivity of novel polymer–lipid manganese dioxide nanoparticles (PLMDs) to remodel the tumor immune microenvironment (TIME) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced immunogenic cell death. This study demonstrated that PLMD treatment sensitized hypoxic human and murine CRPC cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultimately cell death, which enhanced the secretion of damage-associated molecular patterns, attributable to the induction of autophagy and endoplasmic reticulum stress. Reoxygenation via PLMDs also polarized hypoxic murine RAW264.7 macrophages toward the M1 phenotype, enhancing tumor necrosis factor alpha release, and thus reducing the viability of murine CRPC TRAMP-C2 cells. In a syngeneic TRAMP-C2 tumor model, intravenous injection of PLMDs suppressed, while radiation alone enhanced recruitment of regulatory T cells and myeloid-derived suppressor cells. Pretreatment with PLMDs followed by radiation down-regulated programmed death-ligand 1 and promoted the infiltration of antitumor CD8+ T cells and M1 macrophages to tumor sites. Taken together, TIME modulation by PLMDs plus radiation profoundly delayed tumor growth and prolonged median survival compared with radiation alone. These results suggest that PLMDs plus radiation is a promising treatment modality for improving therapeutic efficacy in radioresistant and immunosuppressive solid tumors.

关键词： RAW264.7 alone treatment

Rituximab Induced Vasculitis: Dose the Antigen-Antibody Complex of Rituximab Play a Role in Developing Leukocytoclastic Vasculitis?—A Case Report and Review of the Literature

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Journal of Biosciences and Medicines 2024年第9期12卷 89-94页

作者： ahmed A. AlTaroti zahra z. Alzahir Salah Abohelaika Department of Internal Medicine Qatif Central Hospital Qatif Saudi Arabia Research Centre Qatif Central Hospital Qatif Saudi Arabia

Rituximab is a monoclonal antibody that targets CD20, which is a specific B-cell surface antigen. It was the first monoclonal antibody that was approved for the treatment of non-Hodgkin lymphoma, rheumatoid arthritis, and other cutaneous lymphoid malignancies. There are many off-label uses of rituximab, such as systemic lupus erythematosus, autoimmune hemolytic anemia, multiple sclerosis, graft-versus-host disease, chronic lymphocytic leukemia, and chronic immune-mediated thrombocytopenia. Among the rare side effects associated with rituximab treatment is vasculitis, more specifically, leukocytoclastic vasculitis. Here, we describe a 21-year-old Saudi female with leukocytoclastic vasculitis occurring three months after treatment with rituximab.

关键词： Rheumatoid Arthritis Rituximab Vasculitis Leukocytoclastic Vasculitis

Boosted photocatalytic removal of NO using direct z-scheme UiO-66-NH_(2)/Bi_(2)MoO_(6) nanoflowers heterojunction:mechanism insight and humidity effect

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Rare Metals 2024年第8期43卷 3758-3770页

作者： Jiang-Yu-Shan Liang Hai-Tao Ren Abdelkader Labidi Qiu-Hui zhu Qi-Bing Dong ahmed A.Allam ahmed Rady Chuan-Yi Wang School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi'an 710021China zoology Department Faculty of ScienceBeni-Suef UniversityBeni-Suef 6251lEgypt Department of zoology College of ScienceKing Saud University11451 RiyadhSaudi Arabia

In practical applications,relative humidity in the air is a key factor affecting the photocatalytic removal of NO,which is often overlooked in previous ***,we developed a direct z-scheme UiO-66-NH_(2)/Bi_(2)MoO_(6)heterojunction with a nanoflower-like structure to systematically investigate the effect of relative humidity on photocatalytic removal of *** optimized heterojunction for the removal efficiency of NO was 71.6%at1.07 mg·m^(-3)NO concentration(relative humidity=10%),and the generation of NO_(2) was only 1.1%.Interestingly,with the increase in relative humidity,it showed a higher inhibition effect on NO_(2),while the removal of NO decreased slightly(8%),which might be attributed to the affinity effect of NO_(2) with water molecules and the competitive adsorption of H_(2)O and NO on the surface of the heterojunction ***,the reaction pathways of NO removal at the developed heterojunctions were revealed by in situ DRIFTS *** work provides a novel vision for the development of direct z-scheme heterojunction photocatalysts to effectively remove NO and inhibit the formation of toxic intermediate NO_(2) under different humidities.

关键词： NO removal Relative humidity Direct z-scheme Bismuth molybdate Visible-light photocatalysis

Experimental Study on Heat Storage Properties Comparison of Paraffin/Metal Foams Phase Change Material Composites

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Journal of Thermal Science 2024年第2期33卷 469-478页

作者： Waqar ahmed Abid HUSSAIN Hanzla SHAHID Imran ALI Hafiz Muhammad ALI Department of Mechanical Engineering University of Engineering and TechnologyTaxila47080Pakistan Department of Mechanical Engineering Institute of Space TechnologyIslamabadPakistan Department of Mechanical Mechatronics and Manufacturing EngineeringUniversity of Engineering and Technology LahoreFaisalabad CampusPunjabPakistan Mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Renewable Energy and Power Systems(IRC-REPS) King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia

Heat storage properties of phase change materials(PCMs) are essential characteristics that perform a key role in thermal heat energy storage *** thermal properties of PCMs can be improved by developing metal foam/PCM *** addition of metal foam in PCMs has a significant effect on the thermal characteristics of *** this paper,the heat storage properties of two different metal foam/PCM composites were experimentally *** behavior of paraffin in metal foam(copper and iron-nickel)/paraffin composites concerning pure paraffin at a constant heat flux of 1000 W/m^(2) in three directions simultaneously(x,y,and z) was *** was infiltrated into copper and iron-nickel foams to develop composite materials which resulted in enhancing the thermal conductivity of the paraffin.A comparative analysis is made on the heat storage properties of paraffin in copper and iron-nickel foams/paraffin *** temperature distribution during the phase transition process is experimentally *** comparison indicates that temperature uniformity in copper foam/paraffin composite is better than in iron-nickel foam/paraffin composite and pure paraffin at the same heat *** results show that at heat flux of 1000 W/m^(2),the heat storage time for copper foam/paraffin composite is 20.63% of that of iron-nickel foam/paraffin composite.

关键词： heat storage capacity paraffin/metal foam composite temperature uniformity heat storage rate phase transition process

Effect of a chemical reaction on magnetohydrodynamic boundary layer flow of a Maxwell fluid over a stretching sheet with nanoparticles

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Particuology 2016年第6期14卷 154-161页

作者： ahmed A. afify Nasser S. Elgazery Department of Mathematics Faculty of Science Helwan University Ain Helwan PO Box 11795 Cairo Egypt Department of Mathematics Faculty of Education Ain Shams University Roxy Heliopolis Cairo Egypt

The influences of the convective boundary condition and heat generation/absorption on magnetohydro- dynamic boundary layer flow of a Maxwell fluid over a stretching surface in the presence of nanoparticles have been numerically investigated. In the model, the physical mechanisms responsible for Brownian motion and thermophoresis with a chemical reaction are considered. Similarity equations are derived and then solved using the shooting method with the fourth-order Runge-Kutta integration scheme, The rates of heat and mass transfer are enhanced with a destructive chemical reaction and Blot number. The opposite influence is found with a generative chemical reaction in the presence of Brownian motion and the thermophoretic property.

关键词： Magnetohydrodynamics Nanoparticle Maxwell fluid Boundary layer flow Chemical reaction

Stock appraisal for Atlantic tripletail(Lobotes surinamensis;Bloch,1790)in the Bay of Bengal,Bangladesh

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Journal of Oceanology and Limnology 2024年第5期42卷 1683-1694页

作者： Suman BARUA Qun LIU ahmed Fazley RABBY MdAbdullah AL-MAMUN Xu CHEN Rokeya SULTANA Aidah BALOCH College of Fisheries Ocean University of ChinaQingdao 266003China Department of Fisheries Ministry of Fisheries and LivestockDhaka 1215Bangladesh Bangladesh Fisheries Research Institute Cox’s Bazar 4700Bangladesh Directorate of Secondary and Higher Education Ministry of EducationDhaka 1000Bangladesh Gwadar Development Authority Gwadar 91200Pakistan

The Atlantic tripletail(Lobotes surinamensis)is a high revenue-generating fish species predominantly caught by mechanized artisanal fishers community and the most available member of its family in *** is a ground work of fish stock assessment study in the Bay of Bengal region to explore the life history parameters and associated biomass of this species,using three length-based approaches of TropFishR,the length-based Bayesian biomass estimation(LBB),and Froese’s length based indicators(LBIs).An almost homogenous body growth pattern(b=3.07;R^(2)=0.98)was observed in the length-weight relationship of *** life history parameters for tripletail,as determined by the von Bertalanffy Growth Function(VBGF)model,were L_(∞)=113.36 cm and k=0.51/*** length converted catch curve(LCCC)yielded an estimation of the total mortality(z=1.77/a),with the natural mortality estimated at(M=0.53/a)and the fishing mortality estimated at(F=1.24/a).But,the ratio of mortality(F/M=0.15)by LBB captured the non-fully exploited status of biomass(B/B_(MSY)=2.1).LBI analysis indicated that the tripletail fishery’s spawning stock biomass is greater than the target and limit reference points,indicating a healthy state of biomass.

关键词： Bay of Bengal Lobotes surinamensis TropFishR length based indicator(LBI) length-based Bayesian biomass estimation(LBB) Bangladesh