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Circulating microRNA 9-3p and serum endocan as potential biomarkers for hepatitis C virus-related hepatocellular carcinoma

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World Journal of Hepatology 2021年第11期13卷 1753-1765页

作者： Amany Mohamed Salah Eldin Wahb Mohamed El Kassas ahmed kamal khamis Mostafa Elhelbawy Nesreen Elhelbawy Mona Salah Eldin Habieb Department of Medical Biochemistry and Molecular Biology Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Hepatology and Gastroenterology National Liver InstituteMenoufia UniversityShebin Elkom 32512MenoufiaEgypt Department of Medical Biochemistry and Molecular Biology Faculty of MedicineMenoufia UniversityShebin Elkoum 3511Egypt

BACKGROUND The high mortality rate of hepatocellular carcinoma(HCC)in Egypt is due mainly to the increasing prevalence of hepatitis C virus infection(HCV)and late diagnosis of the ***(miRNA),which regulate tumor proliferation and metastasis in HCC,may serve as a useful diagnostic approach for the early detection of HCC,thus decreasing its ***,endocan is a protein with angiogenic and inflammatory properties that are associated with tumor progression and poor *** To analyze the levels of miRNA 9-3p and endocan in HCV-infected HCC patients and correlate them with clinicopathological *** We compared levels of endocan and circulating miRNA 9-3p from 35 HCVrelated HCC patients to 33 patients with HCV-induced chronic liver disease and 32 age and gender matched healthy controls recruited from inpatient and outpatient clinics of the National Liver Institute,Menoufia University,Egypt in the period from January to March 2021 in a case-control *** samples from all groups were analyzed for *** was measured by enzymelinked immunosorbent assays,and the expression levels of circulating miRNA 9-3p were measured by real-time quantitative reverse transcriptase *** The levels of circulating miRNA 9-3p were significantly lower in the HCC group compared to the chronic liver disease(P<0.001)and control(P<0.001)groups,while levels in the chronic liver disease were significantly lower than those in the control group(P<0.001).The levels of serum endocan were significantly higher in the HCC group compared to the chronic liver disease(P<0.001)and control(P<0.001)*** miRNA 9-3p and endocan performed better thanα-fetoprotein in discriminating HCC patients from cirrhosis and healthy *** levels of miRNA 9-3p were significantly inversely correlated to vascular invasion(P=0.002),stage of advancement of Barcelona Clinical Liver Cancer(P<0.001)and the metastatic site(P<0.001)of the HCC ***

关键词： MicroRNA 9-3p Hepatocellular carcinoma Endocan Diagnostic Biomarker Egypt

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Role of endoscopic ultrasound in evaluation of patients with missed common bile duct stones

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World Journal of Gastrointestinal Endoscopy 2022年第9期14卷 564-574页

作者： Mohamed Eissa Hussein Hassan Okasha Mohamed Abbasy ahmed kamal khamis Abeer Abdellatef Mohamed Akl Rady Department of Hepatology and Gastroenterology National Liver InstituteMenoufia UniversityMenoufia 32951Egypt Department of Internal Medicine Hepatogastroenterology DivisionKasr AL-Ainy School of MedicineCairo UniversityCairo 11451Egypt

BACKGROUND Choledocholithiasis develops in up to 20%of patients with gall bladder *** challenge in diagnosis usually occurs with small stones that may be missed by magnetic resonance cholangiopancreatography(MRCP).Endoscopic ultrasound(EUS)is accurate in detecting common bile duct(CBD)stones missed by MRCP,especially the small ones or those impacted at the distal CBD or the papillary *** To evaluate the accuracy of EUS in detecting CBD stones missed by *** Patients with an intermediate likelihood of choledocholithiasis according to ESGE guidelines and those with acute pancreatitis of undetermined cause were *** presence of choledocholithiasis was evaluated by MRCP and EUS,and then results were confirmed by endoscopic retrograde cholangiopancreatography(ERCP).The sensitivity and specificity of EUS and MRCP were compared regarding the presence of stones,the size,and the number of detected *** Ninety out of 100 involved patients had choledocholithiasis,while ten patients were excluded as they had pancreatic or gall bladder masses during EUS *** choledocholithiasis patients,the mean age was 52.37±14.64 years,and 52.2%were *** patients had biliary obstruction(74.4%),while only 23(25.6%)patients had unexplained *** overall prevalence of choledocholithiasis was 83.3%by EUS,41.1%by MRCP,and 74.4%by ***,the number and size of CBD stones could be detected accurately in 78.2%and 75.6%by EUS and 41.1%and 70.3%by MRCP,*** sensitivity of EUS was higher than that of MRCP(98.51%vs 55.22%),and their predictive value was statistically different(P<0.001).Combination of both tools raised the sensitivity to 97.22%and specificity to 100%.CONCLUSION EUS could be a useful tool in assessing patients with suspected choledocholithiasis especially if combined with ***,its usefulness depends on its availability and the experience of the local centers.

关键词： Magnetic resonance cholangiopancreatography Endoscopic ultrasonography Choledocholithiasis Missed common bile duct stones

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The Role of Electrocardiogram DETERMINE Score in Prediction of Coronary Artery Disease Severity

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World Journal of Cardiovascular Diseases 2024年第9期14卷 567-580页

作者： Ismail N. El-Sokkary Essam ahmed Khalil Mohammed Wael Badawi Ibrahim K. Gamil Shousha Abdalla A. Elsebaey Mohamed kamal Rehan Mahmoud Ibrahim Elshamy Yasser ahmed Sadek Department of Cardiovascular & Thoracic Surgery Faculty of Medicine Al-Azhar University Cairo Egypt Department of Cardiology Al-Azhar University Cairo Egypt Department of Internal Medicine Beni-Sueif University Beni Suef Egypt Department of Radiology Al-Azhar University Cairo Egypt Department of Cardiology Helwan University Cairo Egypt

Background: A major cause of mortality and disability on a global scale is myocardial infarction (MI). These days, the most reliable way to detect and measure MI is via cardiovascular magnetic resonance imaging (CMR). Aims and Objectives: To evaluate the effectiveness of the Electrocardiogram DETERMINE Score in predicting the severity of coronary artery disease (CAD) in patients who have experienced an Acute Myocardial Infarction (AMI) & to assess improvements in left ventricular function at 6 months following coronary artery bypass grafting (CABG). Subjects and Methods: This Observational cohort study was done at the Cardiology and Radiology department and cardiac surgery department, Al-Azhar university hospitals and Helwan University hospital. The study involved 700 cases who patients diagnosed with Acute Myocardial Infarction and fulfilled specific criteria for selection. Result: There was highly statistically significant relation between Myocardial infarction size and ECG Marker Score as mean infarct size elevated When the number of ECG markers increased. There was a highly statistically significant relation between myocardial infarct segments, myocardial infarction size and improvement of cardiac function 6 months post-CABG. Conclusion: The study found that larger myocardial infarctions corresponded with higher DETERMINE Scores. It concluded that an ECG-based score better estimates infarct size than LVEF alone. Additionally, there was a significant statistical correlation between the size and segmentation of myocardial infarction and better cardiac function six months after CABG.

关键词： Electrocardiogram DETERMINE Score Coronary Artery Disease Outcome Acute Myocardial Infarction Coronary Artery Bypass Grafting

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Association between direct-acting antiviral agents in hepatitis C virus treatment and hepatocellular carcinoma occurrence and recurrence:The endless debate

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World Journal of Clinical Cases 2022年第6期10卷 1764-1774页

作者： ahmed kamal ahmed Elsheaita Mahmoud Abdelnabi Internal Medicine Department Faculty of Medicine Alexandria UniversityAlexandria 21131Egypt Clinical and Experimental Internal Medicine Department Medical Research Institute Alexandria UniversityAlexandria 21561Egypt Internal Medicine Department Texas Tech University Health Science CenterLubbockTX 79430United States

Since direct-acting antiviral agents(DAAs)have been introduced into hepatitis C virus treatment,the sustained viral response(SVR)rate has significantly increased to more than 95%.Scientific evidence supports the idea that SVR after interferon therapy has beneficial effects related to cirrhosis progression,resulting in a reduction in the incidence of hepatocellular carcinoma(HCC).However,a significant debate exists related to DAA impact on HCC *** reviewed the current literature highlighting the controversial data related to DAA association with de novo HCC occurrence or recurrence and possible pathophysiology of HCC related to *** a review of the published literature,we believe that the current evidence does not confirm or repudiate a higher rate of de novo HCC occurrence or recurrence related to DAA *** trials are needed to determine if there is an association between HCC occurrence or recurrence and DAA or if it is related to preexisting liver cirrhosis.

关键词： Hepatitis C virus Sustained virologic response Direct-acting antiviral drugs Hepatocellular carcinoma Liver cirrhosis

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Thomson and rotation effects during photothermal excitation process in magnetic semiconductor medium using variable thermal conductivity

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Applied Mathematics and Mechanics(English Edition) 2020年第6期41卷 909-926页

作者： K.LOTFY A.K.khamis A.A.EL-BARY M.H.ahmed Department of Mathematics Faculty of ScienceZagazig UniversityZagazig 44519Egypt Department of Mathematics Faculty of ScienceTaibah UniversityAl-Madinah 30002Saudi Arabia Department of Mathematics Faculty of ScienceNorthern Border UniversityArar 91431Saudi Arabia Arab Academy for Science Technology and Maritime TransportAlexandria 1029Egypt

This study investigates a strong magnetic field acting over an elastic rotator semiconductor *** Thomson effect due to the magnetic field during the photothermal transport process is studied,and the thermoelectricity theory is used to explain the behavior of waves in the homogenous and isotropic medium under the effect of variable thermal *** variable thermal conductivity is considered as a linear function of the *** two-dimensional deformation equations are used to describe the overlaps among plasma,electrical,thermal,and magneto-elastic *** charge density of inertia-particles is considered as a function of time for studying the induced electric *** normal mode analysis is used to obtain the exact solutions of the physical field distributions as part of this *** obtain the complete solutions of the physical field quantities,the certain mechanical loads,electromagnetic effects,thermal effects,and plasma recombination process are applied *** results of the physical distributions are graphically depicted and discussed in consideration of the internal heat source,rotation,and Peltier coefficient.

关键词： photothermal thermal conductivity Thomson effect rotation magnetic field Peltier coefficient

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Anti-wear properties evaluation of frictional sliding interfaces in automobile engines lubricated by copper/graphene nanolubricants

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Friction 2020年第5期8卷 905-916页

作者： Mohamed kamal ahmed ALI Xianjun HOU Mohamed AAABDELKAREEM Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Automotive and Tractors Engineering Department Faculty of EngineeringMinia UniversityEl-Minia 61111Egypt Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan 430070China

Owing to the significance of improving fuel economy, reducing emissions, and extending the durability of engine components, this study focused on the tribological performance of nano-additives. In this study, copper (Cu) and graphene (Gr) nanomaterials were dispersed in a fully formulated engine oil (5W-30) with different concentrations. The tribological trials were investigated under various speeds and loads, utilizing a reciprocating tribometer to mimic the ring/liner interfaces in the engine. The frictional surface morphologies were com-prehensively analyzed using electron probe X-ray microanalysis (EPMA), field emission scanning electron microscopy (FESEM), energy dispersive spectrometer (EDS), and three dimensional (3D) surface profilometry to explore the mechanisms responsible for improving the tribological performance of the frictional sliding parts in the engine. The tribological test results illustrated that lubrication by nano-additives reduced the wear rate (WR) and friction coefficient (COF) by 25%–30% and 26.5%–32.6%, respectively, as compared with 5W-30. The results showed that this is a promising approach for increasing the durability and lifespan of frictional sliding components and fuel economy in automobile engines.

关键词： engine tribology nanomaterial nanolubricant friction wear tribofilm

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Commutativity of Near-rings with Derivations

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Algebra Colloquium 2014年第2期21卷 215-230页

作者： ahmed A.M. kamal Khalid H. AI-Shaalan Department of Mathematics College of Science King Saud University P.O. Box 2455 Riyadh 11451 Kingdom of Saudi Arabia

In this paper we first prove that a near-ring admits a derivation if and only if it is zero-symmetric. Also, we prove some commutativity theorems for a non-necessarily 3-prime near-ring R with a suitably-constrained derivation d satisfying the condition that d（a） is not a left zero-divisor in R for some a ∈ R. As consequences, we generalize several commutativity theorems for 3-prime near-rings admitting derivations.

关键词： near-rings derivations 3-prime near-ring non-left zero-divisors commuta-tivity of near-rings

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Results of intravitreal dexamethasone implant 0.7 mg (Ozurdex^(█)) in non-infectious posterior uveitis

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 835-838页

作者： Yew Chong Yap Thomas Papathomas ahmed kamal Department of Ophthalmology University Hospital Aintree

· AIM: To evaluate the safety and efficacy of dexamethasone implant in patients with non-infectious posterior uveitis with cystoid macular edema(CME).·METHODS: Retrospective analysis of patients reports with CME secondary to non-infectious uveitis treated with dexamethasone implant. Data included type of posterior uveitis, any systemic immunosuppressive therapy, Early Treatment Diabetic Retinopathy Study(ETDRS) best-corrected visual acuity(BCVA), central macular thickness(CMT) on optical coherence tomography(OCT) and signs of intraocular inflammation at baseline and then at 2wk postoperatively and monthly thereafter. Follow-up is up to 10 mo. Any per-operative and post-operative complications were recorded.·RESULTS: Six eyes of 4 patients with CME due to non-infectious posterior uveitis treated with dexamethasone implant. Diagnosis included idiopathic panuveitis, birdshot chorioretinopathy and idiopathic intermediate uveitis. At baseline mean ETDRS BCVA was63 letters and mean CMT 556 μm at 2wk postoperatively mean ETDRS BCVA improved to 70 letters and mean CMT decreased to 329 μm. All eyes showed clinical evidence of decreased inflammation. The duration of effect of the implant was 5 to 6mo and retreatment was required in 2 eyes. Two patients required antiglaucoma therapy for increased intraocular pressures.·CONCLUSION: In patients with non-infectious posterior uveitis dexamethasone implant can be a short-term effective treatment option for controlling intraocular inflammation.

关键词： Ozurdex~? cystoids macular oedema central macular thickness posterior uveitis

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Solar thermochemical reactions Ⅱ:Synthesis of 2-aminothiophenes via Gewald reaction induced by solar thermal energy

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Chinese Chemical Letters 2008年第7期19卷 788-790页

作者： Ramadan ahmed Mekheimer Mohamed Abdallah Ameen kamal Usef Sadek Chemistry Department Faculty of ScienceEl-Minia UniversityEl-Minia 61519Egypt

Green conditions have been developed for the synthesis of substituted 2-aminothiophenes employing multicomponent reactions of a ketone with active methylene nitrile and elemental sulphur induced by free solar thermal ... 详细信息

关键词： 2-Aminothiophenes Gewald reaction Solar thermal energy

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Evaluation of implanted perforated lacrimal punctal plugs using anterior segment optical coherence tomography

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Eye and Vision 2021年第1期8卷 366-373页

作者： Raafat Mohyeldeen Abdelrahman Abdallah ahmed Mohamed kamal Elshafei Heba Radi AttaAllah Ophthalmology Department Minia UniversityEl‑MiniaEgypt Ophthalmology Department Minia University HospitalEl‑MiniaEgypt

Purpose:Evaluation of the patency and position of perforated lacrimal punctal plugs implanted for treating punctal stenosis together with quantitative assessment of the precorneal tear film using anterior segment optical coherence tomography(AS-OCT).Methods:In a prospective study,the lower punctum of 54 eyes of 29 patients implanted with perforated punctal plugs were examined using AS-OCT during the early postoperative *** tear meniscus height(TMH)and tear meniscus area(TMA)were ***,the patency of the plug,its position,TMH and TMA were evaluated,and the results were correlated with postoperative *** scale was used for epiphora ***:Using AS-OCT,48(88.9%)plugs were found in proper position while 6(11.1%)were *** lumen of the plugs was completely patent in 47(87%)plugs,partially obstructed in 2(3.7%)plugs and completely occluded in 5(9.2%)*** was a statistically significant postoperative decrease of TMH and TMA(P<0.001)and postoperative epiphora Munk score(P<0.001).Conclusion:AS-OCT is a valuable,reliable,and noninvasive investigative tool that can detect the proper positioning,patency,and contents of the implanted perforated lacrimal punctal plugs in addition to measurement of TMH and TMA.

关键词： AS-OCT Perforated plugs Plugs

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