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The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL MAGDY MYOUSSEF ahmed el-sebaie SHERIF REFAAT AFAF el-SAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including *** gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,pely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

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Mafic and felsic magmatism in the Wadi Kalalat area, South Eastern Desert, Egypt: mineralogy, geochemistry and geodynamic evolution during the Neoproterozoic in the Nubian Shield

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Acta Geochimica 2024年第1期43卷 150-173页

作者： Adel A.Surour ahmed A.Madani Mohamed A.el-Sobky Faculty of Science Galala UniversityNew Galala CitySuez 43511Egypt Department of Geology Faculty of ScienceCairo UniversityGiza 12613Egypt Egyptian Mineral Resources Authority P.O.Box 11517AbbasiyaCairoEgypt

In the south Eastern Desert of Egypt,two contrasting types of magmatism(mafic and felsic) are recorded in the Wadi Kalalat area,and form the Gabal el Motaghiarat and Gabal Batuga intrusions,*** two intrusions post-dates ophiolitic and arc associations represented by serpentinite and metagabbro-diorite,*** mafic intrusion has a basal ultramafic member represented by fresh peridotite,which is followed upward by olivine gabbro and anorthositic or *** mafic intrusion pertains to the Alaskan-type mafic-ultramafic intrusions in the Arabian-Nubian Shield(ANS)being of tholeiitic nature and emplaced in a typical arc *** the other hand,the Gabal Batuga intrusion comprises three varieties of fresh A-type granites of high K-calc alkaline nature,which is peraluminous and garnetbearing in parts.A narrow thermal aureole in the olivine gabbro of the mafic intrusion was developed due to the intrusion of the Batuga *** results in the development of a hornfelsic melagabbro variety in which the composition changed from tholeiitic to a calc-alkaline composition due to the addition of S_(i)O_(2),Al_(2)O_(3),alkalis,lithosphile elements(LILEs) such as Rb(70 ppm) and Y(28 ppm) from the felsic *** the thermal aureole,Rb amounts 2-8 ppm and Y lies in the range elieved that the Gabal Batuga felsic intrusion started to emplace during the waning stage of an arc system,with transition from the pre-collisional(i.e.,arc setting) to post-collisional and within plate *** from which the Gabal Batuga granites were fractionated is high-K calc-alkaline giving rise to a typical post-collisional A-type granite(A_(2)-subtype) indicating an origin from an underplating crustal ***,it is stressed here that the younger granites in the ANS are not exclusively post-collisional and within-plate but most likely they started to develop before closure of the arc *** possible source(s) of mafic magmas

关键词： Wadi Kalalat Gabal el Motaghairat mafic intrusion Gabal Batuga felsic intrusion Arc setting Post-collision Within-plate

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Classical taxonomy,molecular phylogeny and genetic analysis of the genus Exitianus Ball,1929(Hemiptera:Cicadellidae:Deltocephalinae)from Egypt

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Zoological Systematics 2024年第2期49卷 143-157页

作者： Rabab M.el-Hady ahmed F.el-Sayed Survey&Taxonomy Department Plant Protection Research InstituteAgriculture Research CentreGizaEgypt Microbial Genetics Department Biotechnology Research InstituteNational Research CentreGizaEgypt Egypt Center for Research and Regenerative Medicine(ECRRM) CairoEgypt

Egyptian species of the leafhopper genus Exitianus Ball,1929,***(St?l,1855),***(Distant,1908),and *** Ross,1968 are ***,morphological descriptions,and a key for their identification are *** this study,we used molecular techniques to confirm morphological identification and detect phylogeny among the three Exitianus *** partial nucleotide sequences of the amplified products obtained were determined by Macrogen *** nucleotide sequences of 28S rDNA and COX genes of the EGY-ARC-9,EGY-ARC-4,and EGY-ARC-5 were determined by Macrogen Korea,blasted into BLAST at the National Center for Biotechnology Information website(NCBI)and compared with those deposited in the GenBank DNA *** results represented the homology percentage between the partial sequences of the 28S rRNA and COX genes from each species and related species obtained from GenBank DNA *** morphological identifications of the three Exitianus species were confirmed by molecular characterization and sequencing of 28S rDNA and COX genes and identified as ***,***,and ***,their sequences of 28srDNA and COX genes were deposited in GenBank with an accession number(LC670610,LC670607,and OQ196105)for 28srDNA gene and(LC775357,LC775358,and LC775359)for the COX gene.

关键词： Auchenorrhyncha Chaismini taxonomic 28S rDNA phylogenetic

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Evaluation of urea breath test as a diagnostic tool for Helicobacter pylori infection in adult dyspeptic patients

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World Journal of Gastroenterology 2024年第17期30卷 2302-2307页

作者： Zeinab Nabil ahmed Said Asmaa Mohamed el-Nasser Department of Medical Microbiology&Immunology Faculty of Medicine for Girls Al-Azhar UniversityNasr City 11754CairoEgypt

In this editorial,we discuss the article in the World Journal of *** article conducts a meta-analysis of the diagnostic accuracy of the urea breath test(UBT),a non-invasive method for detecting Helicobacter pylori(***)infection in *** is based on radionuclide-labeled *** methods,both invasive and non-invasive,are available for diagnosing *** infection,inclu-ding endoscopy with biopsy,serology for immunoglobulin titers,stool antigen analysis,and *** guidelines recommend UBTs as the primary choice for diagnosing *** infection and for reexamining after eradication *** is used to be the first choice non-invasive test due to their high accuracy,specificity,rapid results,and ***,its performance remains unaffected by the distribution of *** in the stomach,allowing a high flow of patients to be *** its widespread use,the performance characteristics of UBT have been inconsistently described and remain incompletely *** are two UBTs available with Food and Drug Administration approval:The 13C and 14C *** tests are affordable and can provide real-time *** may prefer the 13C test because it is non-radioactive,compared to 14C which uses a radioactive isotope,especially in young children and pregnant *** there was heterogeneity among the studies regarding the diagnostic accuracy of both UBTs,13C-UBT consistently outperforms the *** makes the 13C-UBT the preferred diagnostic ***,the provided findings of the meta-analysis emphasize the significance of precise considerations when choosing urea dosage,assessment timing,and measurement techniques for both the 13C-UBT and 14C-UBT,to enhance diagnostic precision.

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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Standardization of meibomian gland dysfunction in an Egyptian population sample using a non-contact meibography technique

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 61-65页

作者： ahmed Mohamed Karara Zeinab el-Sanabary Mostafa Ali el-Helw Tamer ahmed Macky Mohamad Amr Salah Eddin Abdelhakim Department of Ophthalmology Kasr Al-Ainy HospitalCairo UniversityCairo 11431Egypt

AIM:To develop normative data for meibomian gland dysfunction(MGD)parameters,using non-contact meibography technique of Sirius Costruzione Strumenti Oftalmici(CSO)machine,in an Egyptian population ***:Observational,cross-sectional,analytic study,in which 104 Egyptian volunteers were *** upper lids were examined,using“Sirius CSO”*** eyelid was given a degree of meibomian gland loss(MGL),which was calculated by the software of the ***:Mean percentage MGL in right upper lid was of 30.9%±12.6%,and that of left upper lid was 32.6%±11.8%.Thirty-four volunteers(32.7%)had first-degree MGL in their right upper lid,and 67.3%had second-degree *** volunteer(1%)had zero-degree MGL in left upper lid,28(26.9%)had first-degree loss,and 75(72.1%)had second-degree *** of MGL in right upper eyelid was not related to age,but degree of MGL in left upper eyelid increased with *** was statistically significant difference between both genders for degree of MGL in right eye(P=0.036)and in left eye(P=0.027).CONCLUSION:Noncontact meibography is a useful non-invasive tool for diagnosing *** is diagnosed in 100%of apparently normal individuals;26.9%-32.7%of which have first-degree MGL,and 67.3%-72.1%have second-degree MGL.

关键词： Egyptian population meibomian gland dysfunction non-contact meibography standardization upper lid

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Impact of demand growth on the capacity of long-duration energy storage under deep decarbonization

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Clean Energy 2024年第4期8卷 237-247页

作者： Sara Ashfaq Ilyass el Myasse Daming Zhang ahmed S.Musleh Carnegie Institution Stanford UniversityStanfordCAUSA electric Power Research Institute(EPRI) Palo AltoCAUSA EEIS Laboratory ENSET MohammediaHassan II UniversityCasablancaMorocco School of electrical Engineering and Telecommunications University of New South WalesSydneyAustralia

The weather-dependent uncertainty of wind and solar power generation presents a challenge to the balancing of power generation and demand in highly renewable electricity *** energy storage can provide flexibility to firm up the variability of renewables and to respond to the increased load demand under decarbonization *** paper explores how the battery energy storage capacity requirement for compressed-air energy storage(CAES)will grow as the load demand *** we used an idealized lowest-cost optimization model to study the response of highly renewable electricity systems to the increasing load demand of California under deep *** show that providing bulk CAES to the zero-emission power system offers substantial benefits,but it cannot fully compensate for the 100%variability of highly renewable power *** capacity requirement of CAES increases by≤33.3%with a 1.5 times increase in the load demand and by≤50%with a two-times increase in the load *** this analysis,a zero-emission electricity system operating at current costs becomes more cost-effective when there is firm power *** least competitive nuclear option plays this role and reduces system costs by 16.4%,curtails the annual main node by 36.8%,and decreases the CAES capacity requirements by≤80.7%in the case of a double-load *** CAES has potential in addressing renewable variability,its widespread deployment is constrained by geographical,societal,and economic fac***,if California is aiming for an energy system that is reliant on wind and solar power,then an additional dispatchable power source other than CAES or similar load flexibility is *** fully harness the benefits of bulk CAES,the development and implementation of cost-effective approaches are crucial in significantly reducing system costs.

关键词： compressed-air energy storage deep decarbonization macro-energy modelling load growth renewable energy

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Intravesical instillation of platelet-rich plasma for treatment of interstitial cystitis/bladder pain syndrome:A pilot study

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Current Urology 2024年第1期18卷 49-54页

作者： ahmed S.el Hefnawy Mohamed Attya ahmed Hasan Esam el Sawy Mohamed Abdel-Razik Nasr el-Tabey Mansoura Urology and Nephrology Center Faculty of MedicineMansoura UniversityMansouraEgypt

Objective:The aim of this study was to evaluate the feasibility of intravesical instillation of platelet-rich plasma(PRP)to treat interstitial cystitis/bladder pain syndrome(IC/BPS).Materials and methods:Twenty PRP samples were tested in vitro for stability after exposure to urine samples with different pH.A pilot study involving 21 female patients with IC/BPS was conducted,and 6 weekly doses of autologous PRP(50 mL)were *** were followed up at the 2nd,4th,8th,and 12th weeks after terminating *** primary endpoint was the visual analog scale(VAS)for pain,and the secondary endpoints included the IC symptom index,IC problem index of the O'Leary-Sant questionnaire and global response assessment,urine culture,and *** was defined as a reduction in VAS by 30%or more compared with basal level,and adverse events were ***:The mean±SD of VAS was significantly reduced compared with basal level(4.4±2.6 vs.8.8±1.1,respectively,p=0.001).Meanwhile,80%of cases were considered successful,with a 50.1%reduction in the mean score compared with the basal *** mean±SD of IC symptom index and IC problem index significantly improved compared with the basal *** response assessment was markedly,moderately,and slightly improved in 2(10%),10(50%),and 5(25%)patients,respectively,and showed no change in 3(15%).Three patients had positive urine cultures at follow-up,but 1 withdrew after 2 sessions because of a lack of ***:Repeated intravesical instillation of PRP could be considered an effective and safe approach for treating IC/BPS.

关键词： Bladder pain syndrome Interstitial cystitis Platelet-rich plasma

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Gastroesophageal reflux after per-oral endoscopic myotomy:Management literature

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World Journal of Gastroenterology 2024年第23期30卷 2947-2953页

作者： ahmed Tawheed Ibrahim Halil Bahcecioglu Mehmet Yalniz Mohamed el-Kassas Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Gastroenterology Faculty of MedicineFirat UniversityElazig 23119Türkiye Liver Disease Research Center College of MedicineKing Saud UniversityRiyadh 7805Saudi Arabia

In this editorial,we respond to a review article by Nabi et al,in which the authors discussed gastroesophageal reflux(GER)following peroral endoscopic myotomy(POEM).POEM is presently the primary therapeutic option for achalasia,which is both safe and effective.A few adverse effects were documented after POEM,including *** diagnostic criteria were not clear enough because approximately 60%of patients have a long acid exposure time,while only 10%experience reflux *** predictors of high disease incidence have been identified,including old age,female sex,obesity,and a baseline lower esophageal sphincter pressure of less than 45 *** technical steps during the procedure,such as a lengthy or full-thickness myotomy,may further enhance the *** pump inhibitors are currently the first line of *** voices are increasingly advocating for the routine combining of POEM with an endoscopic fundoplication method,such as peroral endoscopic fundoplication or transoral incisionless ***,more research is necessary to determine the safety and effectiveness of these procedures in the long term for patients who have undergone them.

关键词： Achalasia Per-oral endoscopic myotomy Gastroesophageal reflux disease Transoral incisionless fundoplication Peroral endoscopic fundoplication

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Arrhythmia Detection by Using Chaos Theory with Machine Learning Algorithms

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Computers, Materials & Continua 2024年第6期79卷 3855-3875页

作者： Maie Aboghazalah Passent el-kafrawy Abdelmoty M.ahmed Rasha elnemr Belgacem Bouallegue Ayman el-sayed Math and Computer Science Department Faculty of ScienceMenoufia UniversityShebin El-komEgypt College of Engineering Computer Science DepartmentEffat UniversityJeddahKingdom of Saudi Arabia Department of Computer Engineering College of Computer ScienceKing Khalid UniversityAbha61421Saudi Arabia Computer Science and Engineering Department Faculty of Electronic EngineeringMenoufia UniversityShebin El-komEgypt Climate Change Information Center and Expert Systems Agriculture Research CenterGizaEgypt

Heart monitoring improves life ***(ECGs or EKGs)detect heart *** learning algorithms can create a few ECG diagnosis processing *** first method uses raw ECG and time-series *** second method classifies the ECG by patient *** third technique translates ECG impulses into Q waves,R waves and S waves(QRS)features using richer *** ECG signals vary naturally between humans and activities,we will combine the three feature selection methods to improve classification accuracy and *** using all three approaches have not been examined till *** researchers found that Machine Learning(ML)techniques can improve ECG *** study will compare popular machine learning techniques to evaluate ECG *** algorithms—Support Vector Machine(SVM),Decision Tree,Naive Bayes,and Neural Network—compare categorization *** plus prior knowledge has the highest accuracy(99%)of the four ML *** characteristics failed to identify signals without chaos *** 99.8%classification accuracy,the Decision Tree technique outperformed all previous experiments.

关键词： ECG extraction ECG leads time series prior knowledge and arrhythmia chaos theory QRS complex analysis machine learning ECG classification

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Performance Evaluation of an Evaporative Cooling Pad for Humidification-Dehumidification Desalination

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Fluid Dynamics & Materials Processing 2024年第10期20卷 2323-2335页

作者： Ibtissam el Aouni Hicham Labrim elhoussaine Ouabida ahmed Ait Errouhi Rachid el Bouayadi Driss Zejli Aouatif Saad Advanced Systems Engineering Laboratory National School of Applied SciencesIbn Tofail UniversityKenitra14000Morocco

The perfect combination of renewable energy and desalination technologies is the key to meeting water demands in a cost-effective,efficient and environmentally friendly *** desalination technique by humidificationdehumidification is non-conventional approach suitable for areas with low infrastructure(such as rural and decentralized regions)since it does not require permanent *** this study,this technology is implemented by using solar energy as a source of thermal power.A seawater desalination unit is considered,which consists of a chamber with two evaporators(humidifiers),a wetted porous material made of a corrugated cellulose cardboard and a condenser(dehumidifier).The evaporation system is tested with dry bulb temperature and relative air humidity *** results of numerical simulations indicate that higher inlet air velocities(from 0.75 to 3 m/s)lead to a decrease in theΔT,ΔRH,and *** the air remaining within the evaporator for 30 cm,the temperature differential increases to 5.7°C,accompanied by a 39%rise in relative humidity *** changes result in a significant enhancement in humidification efficiency,achieving a remarkable efficiency level of 78%.However,a wettability value of 630 m^(2)/m^(3)leads to a smaller reduction of these *** the pad thickness,particularly to 0.3 m,improves performance by boostingΔT,ΔRH,and effectiveness,especially for pads with a wettability of 630 m^(2)/m^(3),for which superior performances are predicted by the numerical tests.

关键词： Desalination humidification dehumidification porous material solar energy evaporator

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