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World Journal of Ophthalmology 2014年第4期4卷 130-139页

作者： Rick N Nordgren ahmed M Elkeeb Bernard f Godley Department of Ophthalmology and Visual sciences University of Texas Medical BranchGalvestonTX 77555United States

Age-related macular degeneration(AMD) is the leading cause of irreversible blindness in the developed world. The quality of life of both patients and families is impacted by this prevalent disease. Previously, macular degeneration had no known effective treatment. Today, vitamins.f.r non-exudative AMD and intravitreal injection of medications.f.r its exudative form are primary forms of current treatment. Modern advances in molecular science give rise to new possibilities of disease management. In the year 2003 the sequencing of the entire human genome was completed. since that time, genes such as complement factor H, high-temperature requirement factor A1, and age-relateed maculopathy susceptibility 2 have been discovered and associated with a higher risk of AMD. A patient's genetic make-up may dictate the effectiveness of current or future therapeutic options. In addition, utilizing genetic data and incorporating it into new treatments(such as viral vectors) may lead to longer-lasting(or permanent) VEGf blockade and specific targeting of complement related genes. There have also been considerable advances in stem cell directed treatment of AMD. Retinal pigment epithelial(RPE) cells can be derived from human embryonic stem cells, induced pluripotent stem cells, or adult human RPE stem cells. Utilizing animal models of RPE and retinal degeneration, stem cell-derived RPE cells have been succes.f.lly implanted into the subretinal space. They have been injected as a cell mass or as a pre-prepared monolayer on a thin membrane. Visual recovery has been demonstrated in a retinal dystrophic rat model. Preliminary data on 2 human subjects also demonstrates possible early visual benefit from transplantation of stem cell-derived RPE. As more data is published, and as differentiation and implantation techniques are optimized, the stabilization and possible improvement of vision in individuals with non-exudative macular becomes a real possibility. We conclude that the technologi

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Computational Analysis of Physicochemical, Pharmacokinetic and Toxicological Properties of Deoxyhypusine synthase Inhibitors with Antimalarial Activity

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Computational Molecular Bioscience 2014年第4期4卷 47-57页

作者： Nayara s.R.silva Luana K.s.Goncalves Jonatas L.Duarte Juliane s.silva César f.santos.f.ancinaldo s.Braga Raí C.silva Josivan s.Costa Lorane I.s.Hage-Melim Cleydson B.Rdos santos Laboratory of Modeling and Computational Chemistry Federal University of AmapáCampus Universitário Marco ZeroMacapáBrazil Postgraduate Program in Pharmaceutical sciences Federal University of AmapáMacapáBrazil

Malaria is a parasitic disease which has as etiological agents protozoa of the genus Plasmodium prevalent in tropical countries. The appearance of Plasmodium strains resistant to artemisinin has become necessary the development of new drugs using computational tools to combat this epidemic. Diverse transporter proteins can act as antimalarials targets, thereby being the enzyme deoxyhypusine synthase a promising antimalarial target. The present study aimed to investigate 15 most active inhibitors of deoxyhypusine synthase target, deposited in databases Binding DB, in order to trace a pattern of physicochemical, pharmacokinetic and toxicological properties of the inhibitors.f.r this enzyme and propose new inhibitors of deoxyhypusine synthase target. The physicochemical properties were obtained according to the Lipinski parameters to evaluate oral absorption. Based on the certain properties were proposed three new inhibitors (A, B and C). The ADME/Tox properties were calculated for new inhibitors compared with results of the selected compounds. The fifteen inhibitors.f.r oral administration showed satisfactory results, because they have adapted to the Lipinski parameters. In relation to the penetration of the blood-brain barrier the inhibitors analyzed showed penetration values less than 1, and ranged from 0.0411815 to 0.481764, being that the compound 1 showed value of CBrain/CBlood = 0.135467. Compound B showed a higher strength in plasma protein binding in relation to the compound 1, having a variation be-tween them of ±1.489344. Therefore, the compound B would present a longer halflife compared with compound 1. The proposed compounds showed positive and satisfactory results, being able to reach less adverse effects related to the central nervous system depending of administered dose.

关键词： Antimalarial Activity Deoxyhypusine synthase Inhibitors Physicochemical Property Pharmacokinetic and Toxicological Properties

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Discrimination of ventricular tachycardia and localization of its exit site using surface electrocardiography

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Journal of Geriatric Cardiology 2019年第4期16卷 362-377页

作者： Heber Ivan Condori Leandro Dmitry s Lebedev Evgeny N Mikhaylov Lang G.f. department of Internal Medicine Pavlov First Saint Petersburg State Medical UniversitySaint-PetersburgRussia Almazov National Medical Research Centre Saint-PetersburgRussia Department of Medical and Biotechnology systems First Electrotechnical UniversitySaint-PetersburgRussia

Differential diagnosis of supraventricular tachycardia (sVT) and ventricular tachycardia (VT) is of paramount importance for appropriate patient management. several diagnostic algorithms.f.r discrimination of VT and sVT based on surface electrocardiogram (ECG) analysis have been proposed. following established diagnosis of VT,a specific origination tachycardia site can be supposed according to QRs complex characteristics. This review aims to cover comprehensive and comparative description of the main VT diagnostic algorithms and to present ECG characteristics which permit to suggest the most common VT origination sites.

关键词： Arrhythmias Electrocardiogram supraventricular Tachycardia Ventricular

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Rollback,scissor-like closure of the Mongol-Okhotsk Ocean and formation of an orocline:magmatic migration based on a large archive of age data

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National science Review 2022年第5期9卷 167-178页

作者： Tao Wang Ying Tong Wenjiao Xiao Lei Guo Brian f.Windley Tatiana Donskaya shan Li Narantsetseg Tserendash Jianjun Zhang Beijing sHRIMP Center Institute of Geology Chinese Academy of Geological Sciences Key Laboratory of Earth Probe and Geodynamics Chinese Academy of Geological Sciences Xinjiang Research Center for Mineral Resources Xinjiang Institute of Ecology and GeographyChinese Academy of Sciences school of Geography Geology and the EnvironmentUniversity of Leicester Institute of the Earth's Crust Siberian Branch Russian Academy of Sciences Institute of Geology Mongolian Academy of Sciences

Tracing the closure of oceans with irregular margins and the formation of an orocline are crucial for understanding plate reconstruction and continental *** eastern Central Asian Orogenic Belt,where the Mongol-Okhotsk orocline is situated,is one of the world’s largest magmatic *** a large data set of U-Pb zircon ages,we updated the timing of many published igneous rocks,which allowed us to recognize tightly ’folded’ linear Carboniferous-Jurassic magmatic belts that wrap around the Mongol-Okhotsk suture and their migrations both sutureward and *** new successive magmatic belts reveal a rollback,scissor-like(or zipper-like) closure of the Mongol-Okhotsk Ocean that was.f.ndamentally controlled by coeval subduction rollback and rotation of the siberian and Mongolian-Erguna *** study also demonstrates the complex mechanisms and processes of the closure of an ocean with irregular margins and the formation of a consequent orocline.

关键词： magmatic migration ocean closure orocline Mongol-Okhotsk Ocean

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Quantizing Euclidean Motions via Double-Coset Decomposition

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Research 2019年第1期2019卷 525-540页

作者： Christian Wülker sipu Ruan Gregory s.Chirikjian Johns Hopkins University BaltimoreMDUSA Department of Mechanical Engineering National University of SingaporeSingapore

Concepts.f.om mathematical crystallography and group theory are used here to quantize the group of rigid-body motions,resulting in a“motion alphabet”with which robot motion primitives are *** these primitives it is possible to develop a dictionary of physical *** with an alphabet of the sort developed here,intelligent actions of robots in the world can be approximated with fnite sequences of characters,thereby forming the foundation of a language in which robot motion is *** particular,we use the discrete handedness-preserving symmetries of macromolecular crystals(known in mathematical crystallography as sohncke space groups)to form a coarse discretization of the space sE(3)of rigid-body *** discretization is made fner by subdividing using the concept of double-coset *** specifcally,a very efcient,equivolumetric quantization of spatial motion can be defned using the group-theoretic concept of a double-coset decomposition of the formΓ\sE(3)/Δ,whereΓis a sohncke space group andΔis a fnite group of rotational symmetries such as those of the *** resulting discrete alphabet is based on a very uniform sampling of sE(3)and is a tool for describing the continuous trajectories of robots and *** efcient coarse-to-fne search algorithm is presented to round of any motion sampled from the continuous group of motions to the nearest element of our *** is shown that our alphabet and this efcient rounding algorithm can be used as a geometric data structure to accelerate the performance of other sampling schemes designed for desirable dispersion or discrepancy ***,the general“signals to symbols”problem in artifcial intelligence is cast in this.f.amework for robots moving continuously in the world.

关键词： robot primitive thereby

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Expanding beyond canonical metabolism:Interfacing alternative elements,synthetic biology,and metabolic engineering

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synthetic and systems Biotechnology 2018年第1期3卷 20-33页

作者： Kevin B.Reed Hal s.Alper McKetta Department of Chemical Engineering The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX 78712USA Institute for Cellular and Molecular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX 78712USA

Metabolic engineering offers an exquisite capacity to produce new molecules in a renewable ***,most industrial applications have focused on only a small subset of elements.f.om the periodic table,centered around carbon *** review aims to illustrate the expanse of chemical elements that can currently(and potentially)be integrated into us.f.l products using cellular ***,we describe recent advances in expanding the cellular scope to include the halogens,selenium and the metalloids,and a variety of metal *** examples range from small molecules,heteroatom-linked uncommon elements,and natural products to biomining and nanotechnology ***,this review covers the promise of an expanded range of elemental incorporations and the future impacts it may have on biotechnology.

关键词： Metabolic engineering synthetic biology Unnatural metabolism Halogenation Cellular factories Non-canonical elements

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An Intelligent Intrusion Detection system in smart Grid Using PRNN Class.f.er

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Intelligent Automation & s.f. Computing 2023年第3期35卷 2979-2996页

作者： P.Ganesan s.Arockia Edwin Xavier Department of Electrical and Electronics Engineering Government College of EngineeringSrirangamTrichy620012India Department of Electrical and Electronics Engineering Thiagarajar College of EngineeringMadurai625015India

Typically,smart grid systems enhance the ability of conventional power system networks as it is vulnerable to several kinds of *** vulnerabil-ities might cause the attackers or intruders to collapse the entire network system thus breaching the conﬁdentiality and integrity of smart grid ***,for this purpose,Intrusion detection system(IDs)plays a pivotal part in offering a reliable and secured range of services in the smart grid *** exist-ing approaches are there to detect the intrusions in smart grid framework,however they are utilizing an old dataset to detect anomaly thus resulting in reduced rate of detection accuracy in real-time and huge data *** as to overcome these limitations,the proposed technique is presented which employs both real-time raw data from the smart grid network and KDD99 dataset thus detecting anoma-lies in the smart grid *** the grid side data acquisition,the power trans-mitted to the grid is checked and enhanced in terms of power quality by eradicating distortion in transmission *** this approach,power quality in the smart grid network is enhanced by rectifying the fault using a fACT device termed UPQC(Uniﬁed Power Quality Controller)and thereby storing the data in cloud *** data from smart grid cloud storage and KDD99 are pre-pro-cessed and are optimized using Improved Aquila swarm Optimization(IAsO)to extract optimal *** probabilistic Recurrent Neural Network(PRNN)classiﬁer is then employed for the prediction and classiﬁcation of *** last,the performance is estimated and the outcomes are projected in terms of grid voltage,grid current,Total Harmonic Distortion(THD),voltage sag/swell,accu-racy,precision,recall,f-score,false acceptance rate(fAR),and detection rate of the classiﬁ*** analysis is compared with existing techniques to validate the proposed model efﬁciency.

关键词： Intrusion detection system anomaly detection smart grid power quality enhancement uniﬁed power quality controller harmonics elimination fault rectiﬁcation improved aquila swarm optimization detection rate

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Modeling 3D Magma Dynamics Using a Discontinuous Galerkin Method

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Communications in Computational Physics 2015年第6期18卷 230-246页

作者： seshu Tirupathi Jan s.Hesthaven Yan Liang Division of Applied Mathematics Brown UniversityProvidenceRI 02912USA IBM Research DublinDamastown Industrial ParkMulhuddartDublin 15Ireland EPfL-sB-MATHICsE-MCss Ecole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland Department of Geological sciences Brown UniversityProvidenceRI 02912USA

Discontinuous Galerkin(DG)and matrix-free finite element methods with a novel projective pressure estimation are combined to enable the numerical modeling of magma dynamics in 2D and 3D using the library *** physical model is an advection-reaction type system consisting of two hyperbolic equations to evolve porosity and soluble mineral abundance at local chemical equilibrium and one elliptic equation to recover global pressure.A combination of a discontinuous Galerkin method for the advection equations and a finite element method for the elliptic equation provide a robust and efficient solution to the channel regime problems of the physical system in 3D.A projective and adaptively applied pressure estimation is employed to significantly reduce the computational wall time without impacting the overall physical reliability in the modeling of important features of melt segregation,such as melt channel bifurcation in 2D and 3D time dependent simulations.

关键词： magma dynamics discontinuous Galerkin method finite element method matrixfree method

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Global photometric analysis of Galactic HII regions

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Research in Astronomy and Astrophysics 2018年第8期18卷 21-28页

作者： Anastasiia Topchieva Dmitri Wiebe Maria s.Kirsanova Institute of Astronomy Russian Academy of SciencesMoscow 119017Russia Ural federal University 19 Mira Str.EkaterinburgRussia

Total infrared fluxes are estimated for 99 HII regions around massive stars. The following wavebands have been used for the analysis： 8 and 24 μm, based on data from the spitzer space Telescope （IRAC and MIPs, respectively）; 70, 160, 250, 350 and 500 μm, based on data from the Herschel space Observatory （PACs and sPIRE）. The estimated fluxes are used to evaluate the polycyclic aromatic hy- drocarbon （PAH） mass.f.action （qPAH） and the intensity of ultraviolet emission in the studied objects. It is shown that the PAH mass.f.action, qPAH, is much lower in these objects than the average Galactic value, implying effective destruction of aromatic particles in HII regions. Estimated radiation field inten- sities （U） are close to those derived for extragalactic HII complexes. Color indices [f24/f8], [f70/f24], [f160/f24] and [f160/f70] are compared to criteria proposed to distinguish between regions of ionized hydrogen and planetary nebulae. Also, we relate our results to analogous color indices.f.r extragalactic complexes of ionized hydrogen.

关键词： IsM bubbles - (IsM) HII regions - IsM lines and bands

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Geographic patterns of plant-herbivore interactions are driven by soil fertility

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Journal of Plant Ecology 2019年第4期12卷 653-661页

作者： Joshua s.Lynn Jason D.fridley Department of Biology Syracuse UniversitySyracuseNY 13244USA Department of Biology University of New MexicoAlbuquerqueNM 87131USA

Aims Geographic patterns of the intensity of plant herbivory in relation to climate factors have garnered little general support and appear to be species ***,plant-herbivore interactions are also driven by resource availability,such as soil nutrient content,and it remains unclear whether broad-scale variation in soil factors is reflected in herbivore consumption rates across species’***,we know little of how intraspecific variation in tissue quality associates with edaphic and climatic factors,and how this variation controls herbivore *** resource availability hypothesis(RAH)predicts that plant individuals growing in low-resource environments will have lower leaf nutritional quality and more constitutive defenses,which will result in lower rates of leaf *** We collected leaves.f.om the old-field dominant species,solidago altissima L.,from 20 sites across 10 degrees of latitude in the Eastern UsA to determine the percentage leaf area consumed by insect *** obtained soil and climate data for each site,as well as plant functional and defensive traits,including specific leaf area(sLA),leaf carbon:nitrogen(C:N),and trichome *** findings Although we found no significant latitudinal trend of leaf consump-tion rate,there was strong evidence that leaf herbivory decreased with leaf C:N and trichome density,which themselves decreased with soil N,supporting our hypothesis that the RAH applies.f.r intraspecific variation across spatial ***,high precipitation seasonality and soil nitrogen predicted decreased *** results suggest that spatial variation in herbivory can be driven by factors other than herbivore communities and climatic gradients,and that bottom-up processes,where plant traits and soil fertility control leaf consumption,must be incorporated into spatial predictions of herbivory.

关键词： biogeography bottom-up controls old fields plant-insect interactions plant functional and defense traits

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