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Dental pulp stem cells stimulate neuronal differentiation of PC12 cells

Neural regeneration research 2021年第9期16卷 1821-1828页

作者： Nessma Sultan Laila E.Amin ahmed r.zaher Mohammed E.Grawish Ben A.Scheven School of Dentistry Oral BiologyCollege of Medical and Dental SciencesUniversity of BirminghamBirminghamUK Department of Oral Biology Faculty of DentistryMansoura UniversityEgypt Faculty of Dentistry Horus UniversityNew DamiettaEgypt Department of Oral Biology Faculty of Oral and Dental MedicineDelta University for Science and TechnologyMansouraEgypt

Dental pulp stem cells(DPSCs) secrete neurotrophic factors which may play an important therapeutic role in neural development, maintenance and repair. To test this hypothesis, DPSCs-conditioned medium(DPSCs-CM) was collected from 72 hours serum-free DPSCs cultures. The impact of DPSCs-derived factors on PC12 survival, growth, migration and differentiation was investigated. PC12 cells were treated with nerve growth factor(NGF), DPSCs-CM or co-cultured with DPSCs using Transwell inserts for 8 days. The number of surviving cells with neurite outgrowths and the length of neurites were measured by image analysis. Immunocytochemical staining was used to evaluate the expression of neuronal markers NeuN, microtubule associated protein 2(MAP-2) and cytoskeletal marker βIII-tubulin. Gene expression levels of axonal growth-associated protein 43 and synaptic protein Synapsin-I, NeuN, MAP-2 and βIII-tubulin were analysed by quantitative polymerase chain reaction(qrT-PCr). DPSCs-CM was analysed for the neurotrophic factors(NGF, brain-derived neurotrophic factor [BDNF], neurotrophin-3, and glial cell-derived neurotrophic factor [GDNF]) by specific ELISAs. Specific neutralizing antibodies against the detected neurotrophic factors were used to study their exact role on PC12 neuronal survival and neurite outgrowth extension. DPSCs-CM significantly promoted cell survival and induced the neurite outgrowth confirmed by NeuN, MAP-2 and βIII-tubulin immunostaining. Furthermore, DPSCsCM was significantly more effective in stimulating PC12 neurite outgrowths than live DPSCs/PC12 co-cultures over the time studied. The morphology of induced PC12 cells in DPSCs-CM was similar to NGF positive controls;however, DPSCs-CM stimulation of cell survival was significantly higher than what was seen in NGF-treated cultures. The number of surviving PC12 cells treated with DPSCs-CM was markedly reduced by the addition of anti-GDNF, whilst PC12 neurite outgrowth was significantly attenuated by anti-NGF, an

关键词： brain-derived neurotrophic factor conditioned medium dental pulp stem cell glial cell line-derived nerve growth factor neurite outgrowth neurotrophic factor neurotrophin-3 phaeochromocytoma PC12 cell

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Finite element modeling assumptions impact on seismic response demands of MrF-buildings

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Earthquake Engineering and Engineering Vibration 2018年第4期17卷 821-834页

作者： Shehata E Abdel raheem ahmed K Abdel zaher ahmed MA Taha Civil Engineering Department Engineering College Taibah University Civil Engineering Department Faculty of Engineering Assiut University

recent seismic events have raised concerns over the safety and vulnerability of reinforced concrete moment resisting frame ＂rC-MrF＂ buildings. The seismic response of such buildings is greatly dependent on the computational tools used and the inherent assumptions in the modelling process. Thus, it is essential to investigate the sensitivity of the response demands to the corresponding modelling assumption. Many parameters and assumptions are justified to generate effective structural finite element（FE） models of buildings to simulate lateral behaviour and evaluate seismic design demands. As such, the present study focuses on the development of reliable FE models with various levels of refinement. The effects of the FE modelling assumptions on the seismic response demands on the design of buildings are investigated. the predictive ability of a FE model is tied to the accuracy of numerical analysis; a numerical analysis is performed for a series of symmetric buildings in active seismic zones. The results of the seismic response demands are presented in a comparative format to confirm drift and strength limits requirements. A proposed model is formulated based on a simplified modeling approach, where the most refined model is used to calibrate the simplified model.

关键词： rC-MrF buildings design codes provisions seismic design finite element modeling modeling assumptions response demands

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Sonographic gallbladder wall thickness measurement and the prediction of esophageal varices among cirrhotics

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World Journal of Hepatology 2023年第2期15卷 216-224页

作者： Mohamed H Emara Mariam Zaghloul Ibrahim F Amer Aya M Mahros Mohammed Hussien ahmed Mahmoud A Elkerdawy Eslam Elshenawy Abdelrahman M ahmed rasheda Tarik I zaher Mona Talaat Haseeb Emad Hassan Emara Hassan Elbatae Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Internal Medicine Gastroenterology UnitSecurity Forces HospitalRiyadh 11481Saudi Arabia Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Diagnostic and Interventional radiology Kafrelsheikh UniversityKafr-Elshikh 33516Egypt

Acute variceal bleeding in patients with liver cirrhosis and portal hypertension(PHT) is the most serious emergency complication among those patients and could have catastrophic outcomes if not timely managed. Early screening by esophago-gastro-duodenoscopy(EGD) for the presence of esophageal varices(EVs) is currently recommended by the practice guidelines for all cirrhotic patients. Meanwhile, EGD is not readily accepted or preferred by many patients. The literature is rich in studies to investigate and validate non-invasive markers of EVs prediction aiming at reducing the unneeded endoscopic procedures. Gallbladder(GB) wall thickness(GBWT) measurement has been found promising in many published research articles. We aim to highlight the validity of sonographic GBWT measurement in the prediction of EVs based on the available evidence. We searched databases including Cochrane library, Pub Med, Web of Science and many others for relevant articles. GBWT is associated with the presence of EVs in cirrhotic patients with PHT of different etiologies. The cut-off of GBWT that can predict the presence of EVs varied in the literature and ranges from 3.1 mm to 4.35 mm with variable sensitivities of 46%-90.9% and lower cutoffs in viral cirrhosis compared to non-viral, however GBWT > 4 mm in many studies is associated with acceptable sensitivity up to 90%. Furthermore, a relation was also noticed with the degree of varices and portal hypertensive *** cirrhotics, GBWT > 3.5 mm predicts the presence of advanced(grade Ⅲ-Ⅳ) EVs with a sensitivity of 45%, the sensitivity increased to 92% when a cut-off ≥ 3.95 mm was used in another cohort. Analysis of these results should carefully be revised in the context of ascites, hypoalbuminemia and other intrinsic GB diseases among cirrhotic patients. The sensitivity for prediction of EVs improved upon combining GBWT measurement with other non-invasive predictors, e.g., platelets/GBWT.

关键词： Sonographic Gallbladder wall thickness Prediction Esophageal varices Portal hypertension Esophago-gastro-duodenoscopy

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Influence of butylated hydroxytoluene addition to cryodiluents on freezability and DNA integrity of Boer and Zaraibi buck spermatozoa

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Asian pacific Journal of reproduction 2020年第2期9卷 96-103页

作者： ahmed rMEl-Khawagah zaher Mrawash Diya AEl-Badry Mohamed MMKandiel Theriogenology Department Faculty of Veterinary MedicineBenha UniversityEgypt Artificial Insemination and Embryo Transfer Department Animal Reproduction Research InstituteAgriculture Research CenterGizaEgypt

Objective:To evaluate the cryoprotective effect of butylated hydroxytoluene on buck frozen ***:Semen was collected from Boer(n=6)and Zaraibi(n=6)bucks by electroejaculator for 5 *** aliquots were diluted at 38℃in Tris-buffer with egg yolk 15.0%(vol/vol)(Tris-egg yolk extender)or soya lecithin 2.5%(weight/vol)(Tris-soya lecithin extender)supplemented with butylated hydroxytoluene at 0.0(as the control),0.5,1.0,2.0 and 4.0 ***-thawing motility(at 400×magnification),plasma(hypo-osmotic swelling test),acrosome(Trypan blue/Giemsa dual staining)membranes,DNA(comet assay),and lipid peroxidation(by malondialdehyde concentration)were ***:Spermatozoa motility was enhanced by butylated hydroxytoluene in Tris-soya lecithin extender at 0.5 mM in the two breeds,and in Tris-egg yolk extender at 1.0 mM in Boer and at 2.0 mM in Zaraibi bucks for up to 3 h *** and acrosome membranes and DNA integrity of the two breeds were maximally high with butylated hydroxytoluene at 1.0-2.0 mM in Tris-egg yolk extender and at 0.5-1.0 mM in Tris-soya lecithin *** peroxidation was minimal with butylated hydroxytoluene at 1.0-2.0 mM in Tris-egg yolk and soya lecithin extenders in the two *** hydroxytoluene at 4.0 mM deteriorated spermatozoa motility,and plasma and acrosome ***:The consequence of butylated hydroxytoluene on buck frozen-thawed spermatozoa varies with the levels of supplementation,buck breed,and phospholipid source in the *** parameters of Boer buck are better in their response to butylated hydroxytoluene than Zaraibi *** hydroxytoluene at 1.0 and 2.0 mM in Tris-egg yolk extender,and at 0.5 mM in Tris-soya lecithin extender represents the best concentrations and profitably improves the semen quality of buck semen.

关键词： Butylated hydroxytoluene Buck DNA Frozen semen Lipid peroxidation

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Endoscopic resection of superficial bowel neoplasia:The unmet needs in the Egyptian practice

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World Journal of Gastrointestinal Endoscopy 2022年第4期14卷 235-249页

作者： Mohamed H Emara Mariam Zaghloul Haidi Karam-Allah ramadan Salem Youssef Mohamed Mohammed Tag-Adeen ahmed Alzamzamy Mohamed Alboraie Ahmad Madkour ahmed Youssef Altonbary Tarik I zaher ahmed Abo Elhassan Nermeen Abdeen Mohammed Hussien ahmed Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr Elshiekh 33516Egypt Department of Tropical Medicine and Gastroenterology Assiut UniversityAssiut 71515Egypt Department of Internal Medicine Faculty of MedicineGastroenterology and Hepatology UnitZagazig UniversityZagazig 44519Egypt Division of Gastroenterology and Hepatology Department of Internal MedicineSouth Valley UniversityQena Faculty of MedicineQena 83523Egypt Department of Gastroenterology and Hepatology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11841Egypt Department of Internal Medicine Al-Azhar UniversityCairo11884Egypt Department of Endemic Medicine Helwan UniversityCairo 11795Egypt Department of Gastroenterology and Hepatology Mansoura UniversityMansoura 35516Egypt Department of Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Tropical Medicine Suez Canal UniversityIsmailia 41522Egypt Department of Tropical Medicine Alexandria UniversityAlexandria 21526Egypt

BACKGrOUND Management of superficial bowel neoplasia(SBN)in early stages is associated with better *** last few decades experienced a paradigm shift in the management of SBN with the introduction of advanced endoscopic resection techniques(ErTs).However,there are no clear data about the aspects of ErTs in Egypt despite the growing gastroenterology *** To investigate the knowledge,attitude,and practice of ErTs toward management of SBN among Egyptian practitioners and the suitability of the endoscopy units’infrastructures toward these *** An online 2-pages questionnaire was *** first page comprised demographic data,and questions for all physicians,about the knowledge(11 questions)of and attitude(5 questions)toward ErTs as a therapeutic option for *** second page investigated the practice of ErTs by endoscopists(6 questions)and the infrastructures of their endoscopy units(14 questions).The survey was disseminated through July 2021 and the data were collected in an excel sheet and later analyzed *** The complete responses were 833/2300(36.2%).The majority of the participants were males(n=560,67.2%),middle-aged(n=366,43.9%),consultants(n=464,55.7%),gastroenterologists(n=678,81.4%),spending≥15 years in practice(n=368,44.2%),and were working in university hospitals(n=569,68.3%).The majority correctly identified the definition of SBN(88.4%)and the terms polypectomy,endoscopic mucosal resection(EMr),and endoscopic submucosal dissection(ESD)(92.1%,90.2%,and 89.1%respectively).However,26.9%,43.2%and 49.5%did not recognize the clear indication of polypectomy,EMr,and ESD *** 68.1%of physicians are convinced about the ErTs for management of SBN;only 8.9%referred all candidate cases for *** 76.5%of endoscopists had formal training in the basic polypectomy techniques while formal training for EMr and ESD was encountered only in 31.9%and 7.2%*** 71.6%and 88.4%of endoscopists did not per

关键词： Endoscopic submucosal dissection Endoscopic mucosal resection Polypectomy Superficial bowel neoplasia Egypt

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First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus

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World Journal of Gastroenterology 2020年第43期26卷 6710-6769页

作者： Maryam Alkhatry Ahmad Al-rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar ahmed M Khassouan zaher Koutoubi rahul Nathwani Mazen S Taha Jimmy K Limdi Gastroenterology and Endoscopy Department Ibrahim Bin Hamad Obaid Allah HospitalMinistry of Health and PreventionRas Al KhaimanUnited Arab Emirates Department of Gastroenterology Sheikh Shakbout Medical CityAbu DhabiUnited Arab Emirates Department of Gastroenterology Valiant ClinicDubaiUnited Arab Emirates Department of Gastroenterology and Endoscopy American HospitalDubaiUnited Arab Emirates Gastroenterology and Endoscopy Unit Al Zahra HospitalDubaiUnited Arab Emirates Gastroenterology Division Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Digestive Disease Unit Rashid HospitalDubaiUnited Arab Emirates Digestive Disease Institute Cleveland ClinicAbu DhabiUnited Arab Emirates Department of Gastroenterology Mediclinic City HospitalDubaiUnited Arab Emirates Gastroenterology and Hepatology Tawam HospitalAl AinUnited Arab Emirates Department of Gastroenterology The Pennine Acute Hospitals NHS TrustManchester Academic Health SciencesUniversity of ManchesterManchester M85RBUnited Kingdom

Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal *** incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is *** progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with *** guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based *** up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications.

关键词： Ulcerative colitis Crohn’s disease Infliximab Adalimumab Vedolizumab Ustekinumab Tofacitinib

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Surgery for Pericardial Syndromes in Adults and Children: Clarification of Questionable Aspects

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World Journal of Cardiovascular Surgery 2020年第11期10卷 213-225页

作者： ahmed Abdelrahman Elassal Osman Osama Al-radi Husain Hamza Jabbad zaher Faisal zaher Mohamed Hasan Abdelsalam ahmed Mohamed Dohain Gaser Abdelmohsen Abdelmohsen Khalid Ebrahim Al-Ebrahim Cardiac Surgery Unit King Abdulaziz University Jeddah Saudi Arabia Cardiothoracic Surgery Department Faculty of Medicine Zagazig University Zagazig Egypt Pediatric Cardiology Division King Abdulaziz University Hospital Jeddah Saudi Arabia Department of Cardiology Faculty of Medicine Benha University Benha Egypt Cardiology Division Department of Pediatrics Faculty of Medicine Cairo University Cairo Egypt

Background: The knowledge on pericardial disease has increased but the European Society of Cardiology in the last guidelines 2015 stated a section of perspective and unmet needs referring to the surgical management as... 详细信息

rong>Background:rong> The knowledge on pericardial disease has increased but the European Society of Cardiology in the last guidelines 2015 stated a section of perspective and unmet needs referring to the surgical management as one of these needs. Here, we present an institutional experience to contribute with other studies in explanation of questionable aspects about their surgical management. Methods: Among 127 cases (93 adults and 34 children) that were diagnosed as pericardial syndrome, we retrospectively analyzed 45 cases (40 adults and 5 children) operated for pericardial syndrome from May 2012 to June 2019. Echocardiogram was the main preoperative diagnostic tool. Surgical approach was selected according to each diagnosis. Postoperative clinical assessment, recurrence and mortality rate were the main determinants of outcome. Results: Regarding pericardial effusions, the mean preoperative medical treatment period was 17.7 ± 21.9 days and pericardial window through thoracotomy was the common approach (54.5%). In constrictive pericarditis, infection was the main etiology (40%), mean preoperative medical treatment period was 16 ± 8.8 days and complete pericardiectomy was the surgical procedure for most cases. Trans-sternal drainage was the standard approach for cardiac tamponade. No postoperative same admission recurrences were reported and 11 (24.4%) mortalities were recorded, 7 (15.5%) cases of them rdana;">were

关键词： Surgery Pericardial Syndromes Adults Children

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Adenoma of the Nipple, Mimicking Paget’s Disease of the Breast: report of a Case

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Advances in Breast Cancer research 2014年第3期3卷 96-99页

作者： ahmed Abbas Ali Al-zaher Ali El Arini Ikram Chaudhry Department of Surgery King Fahad Specialist Hospital Dammam KSA

Nipple adenoma is a rare benign condition that simulates malignancy. A 37-year-old woman presented with unilateral bloody nipple discharge for 1-year duration followed by severe nipple erosion. As biopsy revealed nipple adenoma and therefore, complete local excision was done. The final histopathology showed florid papillomatosis which was adequately excised. Nipple adenoma although rare entity this should be included in the differential diagnosis of any nipple erosion such as carcinoma and Paget’s disease of the breast specially when associated with bloody discharge in premenopausal women.

关键词： Nipple Adenoma Benign Breast Lesion Florid Papillomatosis of the Nipple

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Geophysical Evaluation for Evidence of recharging the Pleistocene Aquifer at El-Nubariya Area, West Nile Delta, Egypt

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International Journal of Geosciences 2014年第3期5卷 324-340页

作者： ahmed Khalil Khamis Mansour Taha rabeh Alhussein Basheer Mohamed Abdel zaher Kamal Ali National research Institute of Astronomy and Geophysics Helwan Egypt research Institute for Groundwater National Water Research Center Cairo Egypt

With ever increasing demands on water resources, Egypt is facing increasing water needs, demanded by a rapidly growing population, by higher standards of living and by an agricultural policys. West Nile Delta represents a new agricultural area where the reclaimed lands are irrigated with groundwater in addition to surface water. The evaluation of groundwater aquifers in West Nile Delta area requires information about the extension, depth and distribution and source of recharging these aquifers. In this work, an integrated study using geoelectric, geomagnetic, hydrogeologic and hydrochemistry investigations has been applied to evaluate groundwater aquifers and to delineate subsurface structures predominant in the basement rocks at El-Nubariya area, West Nile Delta, Egypt. Thirty-five Vertical Electrical Soundings (VES) have been applied to identify the subsurface geoelctric layers predominant in the study area. As well as a detailed land magnetic survey has been carried out along the study area using two automatic proton precession magnetometers with an accuracy of 1 nT. These surveys allowed us to establish the subsurface structures and their relation with the detected aquifers. The geoelectric results are illustrated along seven geoelectric profiles and correlated with the lithologic and hydrogeologic data of drilled wells. The third geoelectric layer represents the water saturated zone (aquifer) with thickness varies from 14 m to 58 m, increasing to east and southeast directions. The hydrchemisty anlysis shows that the salinity of the water aquifer ranges from 600 ppm in the southeast to 3900 ppm in the south. The major dominant dissolved salt is Nacl. In the east and southeast, the water type becomes more NaSO4 which refers to dissolution of gypsum in addition to fertilizers. The magnetic data have been analyzed using horizontal gradient and 3D magnetic modeling along the locations of geolectric profiles. The results indicate that the fault structures are trendin

关键词： Geoelectric Geomagnetic Aquifer Groundwater Hydrogeology

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I-131 MIBG Therapy for Advanced Stage III &IV Neuroblastoma

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Journal of Cancer Therapy 2011年第4期2卷 481-489页

作者： raef riad Magdy Kotb Walid Omar ahmed zaher Emad Ebied Alexander Gregory Pitman Hussein Abdel Dayem 不详

radio-labelled MIBG therapy has been tried in the treatment of advanced stage III and IV neuroblastoma in an attempt to improve patients outcome. The use of radiolabelled MIBG to treat neuroblastoma has arisen from the high sensitivity and specificity of in vivo MIBG imaging for detection of primary and metastatic tumours. Although, clinical trials have been performed to determine the role of MIBG therapy, the overall therapeutic strategy of MIBG therapy is not precisely defined. Aim of the work: to determine the impact of MIBG therapy on patients’ outcome especially their quality of life. Patients & methods: 42 paediatri neuroblastoma patients are included in this study, 12 (28.5%) stage III disease and 30 (71.5%) stage IV. I-131 MIBG doses ranged from 100 to 150 mCi with number of courses ranged from 1-8 according to response and toxicity. results: Group I (stage III): 1/12 patients showed complete response, 5/12 patients had partial response and the other 6 patients remained stable. The 5 years event free survival (EFS) of stage III patients was 46.6% and the overall survival was 75%. Group II (stage IV): 2/30 patients achieved Cr, 9/30 patients showed Pr to I-131 MIBG and the other 18 remained stable. The 5 years event free survival (EFS) of stage IV patients was 48.2% and the overall survival was 69%. Conclusion: We conclude that 131I-MIBG therapy has favourable therapeutic effects that are translated into an overall improved outcome with good quality of life.

关键词： I-131 MIBG Neuroblastoma Pediatrics

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