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TrAIL and TrAIL receptors as Prognostic Markers in Breast Cancer Patients

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American Journal of Molecular Biology 2019年第4期9卷 204-217页

作者： Fawziya A. r. Ibrahim Marwa S. Abouelenein Ola S. A. Sakr Sanaa S. ahmed Ebtisam r. zaher Shaymaa E. el Feky Department of Applied Medical Chemistry Medical Research Institute University of Alexandria Alexandria Egypt Department of radiation Sciences Medical Research Institute University of Alexandria Alexandria Egypt Department of Cancer Management and research Medical research Institute University of Alexandria Alexandria Egypt Pathology Department Medical Research Institute University of Alexandria Alexandria Egypt

Background: Tumor necrosis factor-related apoptosis-inducing ligand (TrAIL) is a key player in the extrinsic pathway of apoptosis;it selectively damages cancer cells through binding to its surface receptors, however, cancers can escape this pathway through expression of dysfunctional decoy receptors. Purpose: The present study directed mainly to elucidate the serum TrAIL levels in breast cancer patients and to explore the variation in gene expression of TrAIL death and decoy receptors in breast cancer tissues, and to explore their role as prognostic markers in breast cancer as well as to detect their correlation with Patients’ Clinical Characteristics. Subjects and Methods: TrAIL levels were assayed in the sera of 124 breast cancer patients and 150 healthy females. Moreover, the expression of TrAIL death and decoy receptors was determined in both malignant and adjacent normal breast tissues collected from patients. Er, Pr and Her-2 expression in breast cancer tissue were performed using immunohistochemical method. Apoptotic index (AI) was analyzed using H&E stain under light microscopy. results: Serum levels of TrAIL in breast cancer patients were significantly lower than controls (P Conclusions: The expression of both Dr4 and Dr5 is required for TrAIL-induced apoptosis in breast cancer tissues;in addition, serum TrAIL and profiling of TrAIL receptors expression may serve as prognostic markers in breast cancer patients.

关键词： Breast Cancer Apoptosis TrAIL Prognosis

Endoscopic resection of superficial bowel neoplasia:The unmet needs in the Egyptian practice

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World Journal of Gastrointestinal Endoscopy 2022年第4期14卷 235-249页

作者： Mohamed H Emara Mariam Zaghloul Haidi Karam-Allah ramadan Salem Youssef Mohamed Mohammed Tag-Adeen ahmed Alzamzamy Mohamed Alboraie Ahmad Madkour ahmed Youssef Altonbary Tarik I zaher ahmed Abo Elhassan Nermeen Abdeen Mohammed Hussien ahmed Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr Elshiekh 33516Egypt Department of Tropical Medicine and Gastroenterology Assiut UniversityAssiut 71515Egypt Department of Internal Medicine Faculty of MedicineGastroenterology and Hepatology UnitZagazig UniversityZagazig 44519Egypt Division of Gastroenterology and Hepatology Department of Internal MedicineSouth Valley UniversityQena Faculty of MedicineQena 83523Egypt Department of Gastroenterology and Hepatology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11841Egypt Department of Internal Medicine Al-Azhar UniversityCairo11884Egypt Department of Endemic Medicine Helwan UniversityCairo 11795Egypt Department of Gastroenterology and Hepatology Mansoura UniversityMansoura 35516Egypt Department of Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Tropical Medicine Suez Canal UniversityIsmailia 41522Egypt Department of Tropical Medicine Alexandria UniversityAlexandria 21526Egypt

BACKGrOUND Management of superficial bowel neoplasia(SBN)in early stages is associated with better *** last few decades experienced a paradigm shift in the management of SBN with the introduction of advanced endoscopic resection techniques(ErTs).However,there are no clear data about the aspects of ErTs in Egypt despite the growing gastroenterology *** To investigate the knowledge,attitude,and practice of ErTs toward management of SBN among Egyptian practitioners and the suitability of the endoscopy units’infrastructures toward these *** An online 2-pages questionnaire was *** first page comprised demographic data,and questions for all physicians,about the knowledge(11 questions)of and attitude(5 questions)toward ErTs as a therapeutic option for *** second page investigated the practice of ErTs by endoscopists(6 questions)and the infrastructures of their endoscopy units(14 questions).The survey was disseminated through July 2021 and the data were collected in an excel sheet and later analyzed *** The complete responses were 833/2300(36.2%).The majority of the participants were males(n=560,67.2%),middle-aged(n=366,43.9%),consultants(n=464,55.7%),gastroenterologists(n=678,81.4%),spending≥15 years in practice(n=368,44.2%),and were working in university hospitals(n=569,68.3%).The majority correctly identified the definition of SBN(88.4%)and the terms polypectomy,endoscopic mucosal resection(EMr),and endoscopic submucosal dissection(ESD)(92.1%,90.2%,and 89.1%respectively).However,26.9%,43.2%and 49.5%did not recognize the clear indication of polypectomy,EMr,and ESD *** 68.1%of physicians are convinced about the ErTs for management of SBN;only 8.9%referred all candidate cases for *** 76.5%of endoscopists had formal training in the basic polypectomy techniques while formal training for EMr and ESD was encountered only in 31.9%and 7.2%*** 71.6%and 88.4%of endoscopists did not per

关键词： Endoscopic submucosal dissection Endoscopic mucosal resection Polypectomy Superficial bowel neoplasia Egypt

Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis

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World Journal of Gastroenterology 2013年第8期19卷 1271-1277页

作者： ahmed Abouelkhair Badawy Tarik Ibrahim zaher Samar Mahmoud Sharaf Mohamed Hassan Emara Noha Elsaid Shaheen Talaat Fathy Aly Department of Tropical Medicine Zagazig University Faculty of MedicineZagazig 44519Egypt Department of Clinical Pathology Zagazig University Faculty of MedicineZagazig 44519Egypt

AIM:To evaluate effective alternative antibiotics in treatment of cefotaxime-resistant spontaneous bacterial ***:One hundred cirrhotic patients with spontaneous bacterial peritonitis [ascitic fluid polymorphonuclear cell count(PMNLs) ≥ 250 cells/mm 3 at admission] were empirically treated with cefotaxime sodium 2 g/12 h and volume expansion by intravenous human *** patients were subjected to history taking,complete examination,laboratory tests(including a complete blood cell count,prothrombin time,biochemical tests of liver and kidney function,and fresh urine sediment),chest X-ray,a diagnostic abdominal paracentesis,and the sample subjected to total and differential cell count,chemical examination,aerobic and anaerobic *** were divided after 2 d by a second ascitic PMNL count into group Ⅰ;patients sensitive to cefotaxime(n = 81),group Ⅱ(n = 19);cases resistant to cefotaxime(less than 25% decrease in ascitic PMNL count).Patients of group Ⅱ were randomly assigned into meropenem(n = 11) or levofloxacin(n = 8) *** patients performed an end of treatment ascitic PMNL *** were considered improved when:PMNLs decreased to rowth in previously positive culture cases,and improved clinical manifestations with at least 5 d of antibiotic ***:Age,sex,and Child classes showed no significant difference between group Ⅰ and group Ⅱ.Fever and abdominal pain were the most frequent manifestations and were reported in 82.7% and 80.2% of patients in group Ⅰ and in 94.7% and 84.2% of patients in group Ⅱ,*** in group Ⅱ had a more severe ascitic inflammatory response than group Ⅰ and this was demonstrated by more ascitic lactate dehydrogenase(LDH) [median:540 IU/L(range:150-1200 IU/L) vs median:240 IU/L(range:180-500 IU/L),P = 0.000] and PMNL [median:15 000 cell/mm 3(range:957-23 822 cell/mm 3) vs 3400 cell/mm 3(range:695-26 400 cell/mm 3),P = 0.000] *** fluid culture was po

关键词： Spontaneous bacterial peritonitis Cefotaxime Ascitic polymorphonuclear count Cirrhosis Meropenem Levofloxacin

Surgery for Pericardial Syndromes in Adults and Children: Clarification of Questionable Aspects

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I-131 MIBG Therapy for Advanced Stage III & IV Neuroblastoma

World Journal of Cardiovascular Surgery（心血管外科国际期刊） 2020年第11期

作者： ahmed Abdelrahman Elassal Osman Osama Al-radi Husain Hamza Jabbad zaher Faisal zaher Mohamed Hasan Abdelsalam ahmed Mohamed Dohain Gaser Abdelmohsen Abdelmohsen Khalid Ebrahim Al-Ebrahim

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TrAIL and TrAIL receptors as Prognostic Markers in Breast Cancer Patients

Journal of Cancer Therapy（癌症治疗） 2011年第4期

作者： raef riad Magdy Kotb Walid Omar ahmed zaher Emad Ebied Alexander Gregory Pitman Hussein Abdel Dayem

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