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Validation of a serum microRNA panel as biomarkers for early diagnosis of hepatocellular carcinoma post-hepatitis C infection in Egyptian patients

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World Journal of Gastroenterology 2017年第21期23卷 3864-3875页

作者： Moustafa Nouh Elemeery ahmed noah badr Marwa Anwar Mohamed Doaa ahmed Ghareeb Medical Biotechnology Laboratory Genetic Engineering and Biotechnology Research DivisionNational Research Centre Toxicology and Food Contaminant Laboratory Food Science and Nutrition Research DivisionNational Research Centre Department of Chemical Pathology Medical Research InstituteAlexandria University Molecular Biology Laboratory Faculty of ScienceAlexandria University

AIM To investigate the prospective importance of serum micro(mi)RNAs(mi R-125 b, mi R-138 b, mi R-1269, mi R-214-5p, mi R-494, mi R375 and mi R-145) as early biomarkers for the diagnosis of hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC).METHODS Two-hundred and fifty HCV4 a patients, 224 HCV4 aHCC patients, and 84 healthy controls were enrolled in the study. Expression levels of mi R214-5p, mi R-125 b, mi R-1269 and mi R-375 were quantified using quantitative real-time *** Expression of the selected mi RNAs in serum wassignificantly lower in HCC patients than in the healthy controls, except for mi R-1269 and mi R-494. There was a significant difference between HCC and HCV patients, in particular for HCC and late stage fibrosis, rather than HCV patients and early fibrosis. It is obvious that mi R-1269 was significantly upregulated in HCC cases compared to hepatic fibrosis cases. Each mi RNA can show HCC progression. Multivariate logistic regression analysis indicated that the tested panel of mi RNAs(mi R214-5p, mi R-125 b, mi R-1269 and mi R-375) represent accurate and specific indictors of HCC *** This study presents a panel of mi RNAs with strong power as putative diagnostic and prognostic biomarkers for HCV-induced HCC. Moreover, mi R-214-5p and mi R-1269 could be considered as early biomarkers for tracking the progress of liver fibrosis to HCC.

关键词： Micro RNA Hepatocellular carcinoma Fibrosis progression

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Utilizing lemon peel extract and its nano-emulsion to control aflatoxin toxicity in rats

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Food Bioscience 2022年第6期50卷 1324-1333页

作者： Bassem A.Sabry ahmed noah badr Kawkab A.ahmed Marwa A.Desoukey Dina Mostafa Mohammed Department of Food Toxicology and Contaminants National Research CentreDokkiCairo12622Egypt Pathology Department Faculty of Veterinary MedicineCairo UniversityGiza12211Egypt Department of Nutrition and Food Science National Research CentreDokkiCairo12622Egypt

The lemon peel is a flavonoid-hefty source and also has bioactive constituents,such as *** research was performed to assess the potential of lemon peel essential oil and its nano-emulsion as a fruit waste in protecting against aflatoxin B1-induced toxicity in experimental ***-six male Sprague-Dawley rats were administered a daily dosage of aflatoxin(80μg/kg b.w)treated with lemon peel essential oil and its nano-emulsion(100 mg/kg).All nutritional parameters,biochemical parameters,and histopathological examinations were *** results revealed severe toxicity and carcinogenicity of AFB1 established by elevation of TNF-αand IL-6 and pathogenic elevation in kidney and liver enzymes manifested by significant elevation of creatinine,urea,uric acid,AST,ALT,and ALP to 0.98,79.4,3.2,57.6,38,and 98.14,*** these biochemical changes were confirmed by histopathological *** these harmful changes were amended by the use of lemon peel essential oil and its nano-emulsion,which led to the conclusion that lemon peel essential oil and its nano-emulsion as a fruit waste could be a promising source for the immune-enhancing drug that could protect against aflatoxin ingestion.

关键词： Lemon peel oil Bioactive compounds Nano-emulsion Aflatoxin Biochemical parameters Toxicity

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MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes

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World Journal of Gastroenterology 2019年第42期25卷 6322-6341页

作者： Moustafa Nouh Elemeery Marwa Anwar Mohamed Marwa ahmed Madkour Mohammed Mohammed Shamseya Noha Mahmoud Issa ahmed noah badr Doaa ahmed Ghareeb Cheol-Ho Pan Département de Neurosciences CRCHUMUniversitéde MontréalMontréalQuebec H2X 3E4Canada Medical Biotechnology Laboratory Genetic Engineering and Biotechnology Research DivisionNational Research CentreCairo 12622Egypt Natural Product Informatics Research Center KIST Gangneung Institute of Natural ProductsGangneung 25451South Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792South Korea Department of Chemical Pathology Medical Research InstituteAlexandria UniversityAlexandria 21511Egypt Experimental and Clinical Internal Medicine Department Medical Research InstituteAlexandria UniversityAlexandria 21511Egypt Human Genetics Department Medical Research InstituteAlexandria UniversityAlexandria 21511Egypt Food Toxicology and Contaminates Department National Research CentreDokkiCairo 12622Egypt Bioscreening and preclinical trial lab Biochemistry DepartmentFaculty of ScienceAlexandria UniversityAlexandria 12522Egypt Pharmaceutical and fermentation industries development center the city of scientific research and technological applicationsAlexandria 26411Egypt

BACKGROUND Nonalcoholic steatohepatitis-related cirrhosis is one of the liver complications in type 2 diabetes mellitus(T2DM)and reported to be a risk factor for developing hepatocellular carcinoma(HCC).A reliable screening biomarker of liver cirrhosis(LC)and HCC among T2DM patients is important to reduce the morbidity and mortality of this ***(miRNA)is considered a key player in HCC and T2DM,and it might be a hidden culprit in diabetes-associated HCC,making it a promising reliable prognostic *** To investigate the signature of serum miRNAs as early biomarkers for the screening of HCC among diabetic *** Expression profiles of miRNAs in serum samples of diabetic LC and diabetic HCC patients were assessed using Illumina sequencing;then,RT-qPCR was used to validate significantly altered miRNAs between the two *** miRNAs were tested in serum samples of 200 T2DM patients,270 LC patients,200 HCC patients,and 225 healthy control ***,receiver operating characteristic(ROC)analysis,with area under the curve(AUC),was performed to assess the diagnostic performance of the screened miRNAs for discriminating HCC from LC and nonmalignant patients(LC+T2DM).RESULTS Expression of the sequenced miRNAs in serum was different in HCC vs LCpositive T2DM *** miRNAs(miR-34a,miR-221)were significantly upregulated and five miRNAs(miR-16,miR-23-3p,miR-122-5p,miR-198,miR-199a-3p)were significantly down-regulated in HCC compared to LC *** of ROC curve demonstrated that the combination of these seven miRNAs can be used as a reliable biomarker for detection of HCC in diabetic patients,as it could identify HCC with high diagnostic accuracy in diabetic LC patients(AUC=0.993)and in diabetic nonmalignant patients(AUC=0.961).CONCLUSION This study validates a panel of serum miRNAs that can be used as a reliable noninvasive screening biomarker of HCC among T2DM cirrhotic and noncirrhotic *** study recommends furt

关键词： MicroRNA Hepatocellular carcinoma Type 2 diabetes Nonalcoholic fatty liver disease

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Ecological risk assessment of surficial sediment by heavy metals from a submerged archaeology harbor,South Mediterranean Sea,Egypt

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Acta Geochimica 2020年第2期39卷 226-235页

作者： Maha ahmed Mohamed Abdallah ahmed Mohamed badr-ElDin Marine Pollution Lab National Institute of Oceanography and FisheriesAlexandriaEgypt Oceanography Department Faculty of ScienceAlexandria UniversityAlexandriaEgypt

A protected semi-enclosed embayment,the Eastern Harbor(EH),is situated in the central sector of the Mediterranean coast of Alexandria,*** is a famous fishing dock and water-sport center and its importance arose after the discovery of the Ptolemaic royal quarter of ancient *** protect this national treasure and improve its environmental health,the untreated anthropogenic effluents,which continued for decades into the EH since 1992,must be totally ***,it is an important issue to continually monitor and asses the environmental status of the *** sediment texture,total organic carbon,and the accumulation,distribution,and ecological risks of Cd,Cr,Pb,As,Hg and A1 were determined with a total of 14 surficial sediments samples collected in the EH during *** contents were compared to the literature data to assess the pollution status of *** factors,Degree of contamination(mCd)and potential ecological risk were calculated as a criterion of possible *** mCd calculation produces an overall average value for a range of pollutants,in the present study the contamination factor that provides a measure of the degree of overall contamination in the surface layers in a particular sampling site may provide a better indication of the state of pollution in the EH sediments than other indicators.

关键词： Heavy metals Eastern harbor Enrichment factors Degree of contamination Potential ecological risk

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STRONGLY NONLINEAR VARIATIONAL PARABOLIC EQUATIONS WITH p(x)-GROWTH

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Acta Mathematica Scientia 2016年第5期36卷 1383-1404页

作者： Elhoussine AZROUL badr LAHMI ahmed YOUSSFI Department of Mathematics Faculty of Sciences Dhar El Mahraz University Sidi Mohamed Ben AbdellahLaboratory LAMA University Sidi Mohamed Ben Abdellah National School of Applied Sciences Laboratory of Engineering Systems and Applications

We study the Dirichlet problem associated to strongly nonlinear parabolic equations involving p（x） structure in W;L;（Q）. We prove the existence of weak solutions by applying Galerkin’s approximation method.

关键词： nonlinear parabolic equations existence variable exponents weak solution

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A direct power control of a DFIG based-WECS during symmetrical voltage dips

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Protection and Control of Modern Power Systems 2020年第1期5卷 36-47页

作者： Sara Mensou ahmed Essadki Tamou Nasser badr Bououlid Idrissi Research Center of Engineering and Health Sciences and Technologies from ENSET Mohammed V UniversityRabatMorocco Research Center of Engineering and Health Sciences and Technologies from ENSIAS Mohammed V UniversityRabatMorocco Electromechanical Engineering Department of ENSAM Moulay Ismaïl UniversityMeknèsMorocco.

The Wind Energy Conversion System(WECS)based Doubly Fed Induction Generator(DFIG)has experienced a rapid development in the world,which leads to an increasing insertion of this source of energy in the electrical *** sudden and temporary drop of voltage at the network can affect the operation of the DFIG;the voltage dips produce high peak currents on the stator and rotor circuits,without protection,the rotor side converter(RSC)will suffer also from over-current limit,consequently,the RSC may even be destroyed and the generator be *** this paper a new Direct Power Control(DPC)method was developed,in order to control the stator powers and help the operation of the aero-generator during the faults grid;by injecting the reactive power into the network to contribute to the return of voltage,and set the active power to the optimum value to suppress the high peak *** DPC method was designed using the nonlinear Backstepping(BS)controller associated with the Lyapunov function to ensure the stability and robustness of the system.A comparison study was undertaken to verify the robustness and effectiveness of the DPC-BS to that of the classical vector control(VC)using Proportional-Integral(PI)*** were simulated under the Simulink®software.

关键词： Wind energy Doubly-fed induction aero-generator Voltage dips DPC strategy Backstepping technique Lyapunov function

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Using nanotechnology to prevent fines migration while production

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Petroleum 2021年第2期7卷 168-177页

作者： Mohamed Mansour Mohamed Eleraki ahmed noah El-Abbas Moustafa Faculty of Science Zagazig UniversityEgypt Egyptian Petroleum Research Institute(EPRI) Egypt The British University Egypt

Formation damage due to fines migration is a major reason for well productivity decline for oil and gas *** fines are small enough to pass through pore throats causing pore plugging and permeability *** factors affect fines migration such as flow rate,salinity,pH value,reservoir temperature and oil polarity,as well as changes in chemical environment induced by Enhanced Oil Recovery(EOR)*** paper focuses on the effect of flow rates on fines detachment from the grain surfaces,which causing permeability *** the fluid inside the reservoir moves towards the wellbore,the fluid velocity increases,when the fluid reaches the critical flow rate these fines can be picked up into the *** fines captured by thinner pore throats causing pore plugging and permeability *** concentrations of nanoparticles were used to fix these fines on their sources and prevent their mobilization at high flow *** unique technique used in this study is changing the potential surfaces between fines and grain surfaces to prevent fines movement above the critical flow ***_(2)and MgO NPs used in this study can be adsorbed on the pore surfaces and reduce the repulsion forces between fines and pore ***_(2) and MgO nanoparticles at different concentrations(0.25,0.50 and 0.75 g/L)were used on treating the Abu-Rawash sandstone reservoir using Formation Damage System Cell *** experimental studies showed that using MgO NPs would prevent fines detachment from the pore surfaces and decrease the reduction of permeability at high flow rates more than SiO_(2) *** optimum concentration of MgO NPs was at 0.5 g/L as the permeability remediation at this concentration reaches to 64.83%.

关键词： Formation damage Fines migration Nanoparticles Zeta potential Permeability reduction Fluid flow rate

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Performance of Thermal Insulation of Different Composite Walls and Roofs Materials Used for Energy Efficient Building Construction in Iraq

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Frontiers in Heat and Mass Transfer 2024年第4期22卷 1231-1244页

作者： ahmed Mustaffa Saleem Abdullah A.badr Bahjat Hassan Alyas Omar Rafae Alomar Engineering Technical College of Mosul Cultural GroupNorthern Technical UniversityMosul41002Iraq

This study numerically involves the performance of thermal insulation of different types of composite walls and roofs to demonstrate the best model that can be used for energy-efficient building construction in *** mathematical model is solved by building its code using the Transmission Matrix Method in MATLAB *** weather data of 21st July 2022 in Baghdad City/Iraq is selected as a test *** wall types are selected:the first type consists of cement mortar,brick,and gypsum,the second type consists of cement mortar,brick,gypsum,and plaster and the third type consists of cement mortar,brick,gypsum,air cavity,and sheathing *** roof types are chosen:the first type consists of reinforced concrete,gypsum,and plaster,and the second type consists of the precast concrete flag,river sand,tar,reinforced concrete,gypsum,and *** obtained solutions are compared with previous studies for the same city but with different types of walls and *** findings display that the second and third types of walls reduce the entry heat flux by 4%and 10%as compared to the first type of ***,the results indicate that the second type of roof reduces the entry heat flux by 21%as compared to the first type of *** results confirm that the best models of walls and roofs in Iraq are the third and second types,respectively,as compared to other models and hence,the performance of insulation material strongly depends on the materials used while building them.

关键词： Thermal insulation energy gain composites walls and roofs heat flux transmission matrix method

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The Lambert-G Family:Properties,Inference,and Applications

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 513-536页

作者： Jamal N.Al Abbasi ahmed Z.Afify badr Alnssyan Mustafa S.Shama Accounting Department Ashur UniversityBaghdad10011Iraq Department of Statistics Mathematics and InsuranceBenha UniversityBenha13511Egypt Department of Management Information Systems and Production Management College of Business and EconomicsQassim UniversityBuraydah51452Saudi Arabia Department of Basic Sciences Common First Year(CFY)King Saud UniversityRiyadh11362Saudi Arabia Department of Mathematics and Statistics Osim Higher Institute of Administrative ScienceOsim12961Egypt

This study proposes a new flexible family of distributions called the Lambert-G *** Lambert family is very flexible and exhibits desirable *** three-parameter special sub-models provide all significantmonotonic and non-monotonic failure rates.A special sub-model of the Lambert family called the Lambert-Lomax(LL)distribution is *** expressions for the LL statistical properties are *** of the LL distribution are addressed mathematically based on its hazard *** estimation of the LL parameters is discussed using six estimation *** performance of this estimation method is explored through simulation *** usefulness and flexibility of the LL distribution are demonstrated empirically using two real-life data *** LL model better fits the exponentiated Lomax,inverse power Lomax,Lomax-Rayleigh,power Lomax,and Lomax distributions.

关键词： Lambert function Lomax distribution maximum likelihood hazard function statistical model simulation

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Characterization and Catalytic Activity of New Metal-organic Frameworks Resulted from Self-assembly of Ph3SnCI, K[Cu（CN）2] and Nitrogen Donor Ligands

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Chinese Journal of Chemistry 2011年第7期29卷 1401-1410页

作者： Etaiw, Safaa El-din H. Elsherbiny, Abeer S. badr El-din, ahmed S. Chemistry Department Faculty of Science Tanta University Tanta Egypt

Five new metal-organic frameworks （MOFs） of the general composition [Ph3SnCu（CN）2.L], where L= pyrazine （pyz）（1）, methylpyrazine （mepyz）（2）, 4,4＇-bipyridine （bpy）（3）, trans-l,2-bis（4-pyridyl）ethene （tbpe）（4） or 1,2-bis（4-pyridyl）ethane （bpe）（5）, have been synthesized and characterized to test their potential applications as catalysts. The structures of the MOFs 1--5 mainly consist of Cu（CN）2 building blocks connected by the Ph3Sn cations and the bipodal ligand forming polymeric networks. They exhibit strong fluorescence in the solid state. Also, they are used as heterogeneous catalysts for the degradation of azo-dyes, metanil yellow （MY） by diluted solution of hydrogen peroxide as oxidant. The reaction is first order with respect to MY dye, while the factors affecting the rate constant of the degradation reaction are investigated. The activation parameters of the reaction have been estimated and a possible mechanism has been proposed.

关键词： copper tin heterogeneous catalyst metanil yellow hydrogen peroxide

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