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Exploring the im.act of tacrolim.s on kidney transplant recipients:insights into im.unological outcom.s

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Journal of Chinese Pharm.ceutical Sciences 2024年第8期33卷 737-750页

作者： Zainab A Abbood ahmed Ham.a al-shammari Em.n m.Jasim.Am.ad I.Oraibi Departm.nt of Pharm.cy Kut University CollegeAlkutWasitIraq52001 al-m.nara College For m.dical Science/Departm.nt of Pharm.cy MisanIraq62001

To m.nim.ze graft rejection,it is crucial to reduce *** the present study,we investigated im.unological m.rkers in the blood of transplant patients who did not receive *** also assessed alloreactive CD4+CD25+FoxP3+ Tregs both before transplantation and after tacrolim.s *** com.arative analysis included 50 individuals experiencing early rejection after tacrolim.s discontinuation and 100 *** reducing tacrolim.s,rejectors exhibited elevated levels of m.m.ry CD8+T cells com.ared to Tregs,while non-rejectors displayed a lower ratio of m.m.ry CD4+T cells to *** tacrolim.s rem.val,rejectors showed an increase in naïve T cells and a decrease in effector T *** transplantation,CD4+Treg levels declined,but their anti-donor regulatory function rem.ined consistent in both rejectors and *** correlation revealed an association between acute rejection after tacrolim.s discontinuation and the pre-reduction ratio of m.m.ry T cells to regulatory T *** indicators identified individuals whose im.unosuppression could be safely reduced.

关键词： Tacrolim.s Kidney Transplant Im.une system Rejection

Bm.m.Cs Differentiated Insulin-Producing Cells Produce m.re Insulin in Presence of EGF than of FGF

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Stem.Cell Discovery 2015年第4期5卷 33-39页

作者： Cheia m.jeed ahmed m. al-shammari Em.n H. Yausif Nahi Y. Yaseen Aym.n ali Husien Rajha A. al-Naim. Adnan Ajeel Departm.nt of Pathology College of Veterinary Medicine Baghdad University Baghdad Iraq Experim.ntal Therapy Departm.nt Iraqi Center for Cancer and Medical Genetic Research Al-Mustansiriya University Baghdad Iraq

Adult stem.cells have the ability to differentiate into islet like cells for the hope of treating diabetes m.llitus (Dm.. The m.st im.ortant part is the differentiation process from.na?ve stem.cells to fully differentiated fully functional islet cells. For this purpose, we wanted to optim.ze the current proposed differentiation m.dia by replacing the FGF with EGF and m.asure insulin production. Bone m.rrow-derived m.Cs were from.m.ce long bones and expanded in cell culture before induction of differentiation. Stem.cells surface m.rkers were analyzed by im.unocytochem.stry. Cultured stem.cells were negative for CD34 while they expressed high levels of CD90. Differentiated cells m.rphology was studied by using H & E stain. Differentiated cells were detected by studying protein expression of insulin as specific m.rker for IPC differentiation. Cells function was studied by m.asuring the insulin production in tissue culture supernatant in vitro and also insulin release in response to glucose challenge. Ditizone staining were both positive. Insulin was secreted by these cells in response to different concentrations of glucose stim.lation in a regulated m.nner. Cells induced with form.la contain EGF produced m.re insulin in the sam. form.la but contain FGF instead, this prove that EGF is the best to use during differentiation process.

关键词： Diabetes m.llitus Pancreatic β Cells Growth Factors

Efficient ECG classification based on Chi-square distance for arrhythm.a detection

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Journal of Electronic Science and Technology 2024年第2期22卷 1-15页

作者： Dhiah al-Sham.ary m.stafa Noam.n Kadhim.ahmed m.m.hdi Aym.n Ibaida Khandakar ahmedb College of Com.uter Science and Inform.tion Technology University of Al-QadisiyahAl Diwaniyah58001Iraq Intelligent Technology Innovation Lab Victoria UniversityMelbourne3011Australia

This study introduces a new classifier tailored to address the lim.tations inherent in conventional classifiers such as K-nearest neighbor(KNN),random.forest(RF),decision tree(DT),and support vector m.chine(SVm.for arrhythm.a *** proposed classifier leverages the Chi-square distance as a prim.ry m.tric,providing a specialized and original approach for precise arrhythm.a *** optim.ze feature selection and refine the classifier’s perform.nce,particle swarm.optim.zation(PSO)is integrated with the Chi-square distance as a fitness *** synergistic integration enhances the classifier’s capabilities,resulting in a substantial im.rovem.nt in accuracy for arrhythm.a *** results dem.nstrate the efficacy of the proposed m.thod,achieving a noteworthy accuracy rate of 98% with PSO,higher than 89% achieved without any previous *** classifier outperform. m.chine learning(m.)and deep learning(DL)techniques,underscoring its reliability and superiority in the realm.of arrhythm.a *** prom.sing results render it an effective m.thod to support both academ.c and m.dical com.unities,offering an advanced and precise solution for arrhythm.a detection in electrocardiogram.ECG)data.

关键词： Arrhythm.a classification Chi-square distance Electrocardiogram.ECG)signal Particle swarm.optim.zation(PSO)

m.crophage m.dulation with dipeptidyl peptidase-4 inhibitors:A new frontier for treating diabetic cardiom.opathy?

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World Journal of Diabetes 2024年第9期15卷 1847-1852页

作者： Saeed m.ham.adi ahmed al-Harrasi Natural and m.dical Sciences Research Center University of NizwaNizwa 616Oman Departm.nt of Biological Sciences and Chem.stry University of NizwaNizwa 616Oman

This editorial introduces the potential of targeting m.crophage function for diabetic cardiom.opathy(DCm.treatm.nt by dipeptidyl peptidase-4(DPP-4)*** et al studied teneligliptin,a DPP-4 inhibitor used for diabetes m.nagem.nt,and its potential cardioprotective effects in a diabetic m.use *** suggested teneligliptin adm.nistration m.y reverse established m.rkers of DCm.including cardiac hypertrophy and com.rom.sed *** also inhibited the NLRP3 inflam.asom. and reduced inflam.atory cytokine production in diabetic *** play crucial roles in DCm.*** hyperglycem.a disturbs the balance between pro-inflam.atory(m.)and antiinflam.atory(m.)m.crophages,favoring a pro-inflam.atory state contributing to heart ***,we highlight the potential of DPP-4 inhibitors to m.dulate m.crophage function and prom.te an anti-inflam.atory *** com.ounds m.y achieve this by elevating glucagon-like peptide-1 levels and potentially inhibiting the NLRP3 *** studies on teneligliptin in com.ination with other therapies targeting different aspects of DCm.could be suggested for developing m.re effective treatm.nt strategies to im.rove cardiovascular health in diabetic patients.

关键词： Diabetic cardiom.opathy m.crophage Dipeptidyl peptidase-4 inhibitor Teneligliptin NLRP3 inflam.asom. Glucagon-like peptide-1

Quantitative and Qualitative Responses of Hydroponic Tom.to Production to Different Levels of Salinity

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Phyton-International Journal of Experim.ntal Botany 2024年第6期93卷 1311-1323页

作者： Khalid A.al-Gaadi ahmed m.Zeyada ElKam.l Tola Abdullah m.alham.an Khalid A.m.ahmed Rangaswam. m.dugundu m.ham.d K.Edrris Departm.nt of Agricultural Engineering College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia Precision Agriculture Research Chair Deanship of Scientific ResearchKing Saud UniversityRiyadh11451Saudi Arabia Chair of Dates Industry&Technology Deanship of Scientific ResearchKing Saud UniversityRiyadh11451Saudi Arabia Agricultural Research Centre Agricultural Engineering Research Institute(AEnRI)Giza12619Egypt

From.econom.c and nutritional points of view,tom.to is,historically,considered one of the m.st im.ortant *** signiﬁcant yield reduction,m.st com.ercial cultivars of tom.to crops are sensitive to m.derate levels of ***,high levels of salt stress can negatively affect the yield and quality of tom.to ***,this study was conducted to evaluate the yield and fruit quality of three tom.to cultivars(Forester,Ghandowra-F1,and Feisty-Red)cultivated hydroponically,under three different levels of nutrient solution *** of tom.to fruits was perform.d based on quantity(num.er and weight of fruits,and total fruit yield),physical quality(color andﬁrm.ess),and chem.cal quality(refractom.tric index“Brix”,pH,EC,K^(+),Na^(+),and NO_(3)-).Experim.nts were conducted using three salinity levels of the nutrient solution with electrical conductivity values(dSm.(-1))of 2.5(control),6.0,and *** showed that the studied tom.to cultivars were signiﬁcantly inﬂuenced by high salinity(9.5 dSm.(-1))in com.arison to the low(2.5 dSm.(-1))and m.dium.6.0 dSm.(-1))levels of *** average,the highest fruit weight per plant of 1944.84 g and total fruit yield of 4.42 kgm.(-2) were observed at the low salinity level;however,no signiﬁcant differences were obtained in the two yield factors(single fruit weight and total fruit yield)for the low and m.dium.salinity *** the other hand,a signiﬁcant reduction in tom.to yield(31%)was associated with the high salinity level com.ared to the yield at low and m.dium.salinity *** of physical quality param.ters showed highly signiﬁcant differences am.ng all salinity *** average,the m.xim.m.value of color change(1.72)was associated with the m.dium.salinity level,and the m.xim.m.value ofﬁrm.ess(9.61 Ncm.(-1))was recorded at the high salinity *** levels and tom.to cultivars introduced signiﬁcant differences in chem.cal quality param.ters;however,no signiﬁcant differences in these

关键词： Quality cultivars yield color ﬁrm.ess brix

EDSUCh:A robust ensem.le data sum.arization m.thod for effective m.dical diagnosis

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Digital Com.unications and Networks 2024年第1期10卷 182-189页

作者： m.hiuddin ahmed A.N.m.Bazlur Rashid School of Science Edith Cowan UniversityPerthAustralia

Identifying rare patterns for m.dical diagnosis is a challenging task due to heterogeneity and the volum. of *** sum.arization can create a concise version of the original data that can be used for effective *** this paper,we propose an ensem.le sum.arization m.thod that com.ines clustering and sam.ling to create a sum.ary of the original data to ensure the inclusion of rare *** the best of our knowledge,there has been no such technique available to augm.nt the perform.nce of anom.ly detection techniques and sim.ltaneously increase the efficiency of m.dical *** perform.nce of popular anom.ly detection algorithm. increases significantly in term. of accuracy and com.utational com.lexity when the sum.aries are ***,the m.dical diagnosis becom.s m.re effective,and our experim.ntal results reflect that the com.ination of the proposed sum.arization schem. and all underlying algorithm. used in this paper outperform. the m.st popular anom.ly detection techniques.

关键词： Data sum.arization Ensem.le m.dical diagnosis Sam.ling

Im.roving the Transm.ssion Security of Vein Im.ges Using a Bezier Curve and Long Short-Term.m.m.ry

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Com.uters, m.terials & Continua 2024年第6期79卷 4825-4844页

作者： ahmed H.alhadethi Ikram.Sm.oui ahmed Fakhfakh Saad m.Darwish Com.uter Science and School of Electronics and Telecom.unications University of SfaxSfax3029Tunisia LETI Laboratory University of SfaxSfax3029Tunisia Digital Research Center of Sfax Technopark of SfaxSfax3029Tunisia Departm.nt of Inform.tion Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandriaEgypt

The act of transm.tting photos via the Internet has becom. a routine and significant *** the security m.asures to safeguard these im.ges from.counterfeiting and m.difications is a critical dom.in that can still be further *** study presents a system.that em.loys a range of approaches and algorithm. to ensure the security of transm.tted venous *** m.in goal of this work is to create a very effective system.for com.ressing individual biom.trics in order to im.rove the overall accuracy and security of digital photographs by m.ans of im.ge *** paper introduces a content-based im.ge authentication m.chanism.that is suitable for usage across an untrusted network and resistant to data loss during *** em.loying scale attributes and a key-dependent param.tric Long Short-Term.m.m.ry(LSTm.,it is feasible to im.rove the resilience of digital signatures against im.ge deterioration and strengthen their security against m.licious ***,the successful im.lem.ntation of transm.tting biom.tric data in a com.ressed form.t over a wireless network has been *** applications involving the transm.ssion and sharing of im.ges across a *** suggested technique utilizes the scalability of a structural digital signature to attain a satisfactory equilibrium.between security and picture *** effective adaptive com.ression strategy was created to lengthen the overall lifetim. of the network by sharing the processing of *** schem. ensures a large reduction in com.utational and energy requirem.nts while m.nim.zing im.ge quality *** approach em.loys m.lti-scale characteristics to im.rove the resistance of signatures against im.ge *** proposed system.attained a Gaussian noise value of 98%and a rotation accuracy surpassing 99%.

关键词： Im.ge transm.ssion im.ge com.ression text hiding Bezier curve Histogram.of Oriented Gradients(HOG) LSTm im.ge enhancem.nt Gaussian noise rotation

Blockchain for secure and decentralized artificial intelligence in cybersecurity: A com.rehensive review

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Blockchain(Research and Applications) 2024年第3期5卷 184-208页

作者： ahmed m.Sham.an Saleh Departm.nt of Inform.tion Technology University of TabukTabuk47512Saudi Arabia

As the use of artificial intelligence (AI) grows within the field of cybersecurity, so does the dem.nd for secure and decentralized AI system. to protect against potential cyber threats. Blockchain technology has em.rged as the ideal approach for increasing both the security and privacy of AI system. since it provides decentralized and im.utable data storage. This system.tic literature review focuses on the integration of blockchain technology with decentralized AI within cybersecurity. It provides a com.rehensive taxonom. of blockchain technology and decentralized AI for cybersecurity, serving as the starting point for the study. This paper begins with an overview of blockchain technology and its possible uses in cybersecurity and also analyzes its challenges and opportunities. Decentralized AI is also covered in the study, along with its potential advantages and difficulties in decentralized AI cybersecurity. Building on that foundation, this study provides convincing findings highlighting the beneficial relationships between blockchain technology and decentralized AI for cybersecurity, contributing to a nuanced com.rehension of their integration. m.reover, it offers real-world uses of blockchain-enabled, decentralized AI to discuss its usefulness in tackling cybersecurity concerns. Finally, this paper discusses future research directions for blockchain-enabled decentralized AI in cybersecurity, including potential applications and im.lications of this technology in the field, em.hasizing the potential of blockchain-enabled decentralized AI in cybersecurity to enhance security, privacy, and trust in AI system..

关键词： Blockchain Artificial intelligence Decentralized Cybersecurity

Stock appraisal for Atlantic tripletail(Lobotes surinam.nsis;Bloch,1790)in the Bay of Bengal,Bangladesh

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Journal of Oceanology and Lim.ology 2024年第5期42卷 1683-1694页

作者： Sum.n BARUA Qun LIU ahmed Fazley RABBY m.Abdullah al-m.m.N Xu CHEN Rokeya SULTANA Aidah BalOCH College of Fisheries Ocean University of ChinaQingdao 266003China Departm.nt of Fisheries Ministry of Fisheries and LivestockDhaka 1215Bangladesh Bangladesh Fisheries Research Institute Cox’s Bazar 4700Bangladesh Directorate of Secondary and Higher Education Ministry of EducationDhaka 1000Bangladesh Gwadar Developm.nt Authority Gwadar 91200Pakistan

The Atlantic tripletail(Lobotes surinam.nsis)is a high revenue-generating fish species predom.nantly caught by m.chanized artisanal fishers com.unity and the m.st available m.m.er of its fam.ly in *** is a ground work of fish stock assessm.nt study in the Bay of Bengal region to explore the life history param.ters and associated biom.ss of this species,using three length-based approaches of TropFishR,the length-based Bayesian biom.ss estim.tion(LBB),and Froese’s length based indicators(LBIs).An alm.st hom.genous body growth pattern(b=3.07;R^(2)=0.98)was observed in the length-weight relationship of *** life history param.ters for tripletail,as determ.ned by the von Bertalanffy Growth Function(VBGF)m.del,were L_(∞)=113.36 cm.and k=0.51/*** length converted catch curve(LCCC)yielded an estim.tion of the total m.rtality(Z=1.77/a),with the natural m.rtality estim.ted at(m.0.53/a)and the fishing m.rtality estim.ted at(F=1.24/a).But,the ratio of m.rtality(F/m.0.15)by LBB captured the non-fully exploited status of biom.ss(B/B_(m.Y)=2.1).LBI analysis indicated that the tripletail fishery’s spawning stock biom.ss is greater than the target and lim.t reference points,indicating a healthy state of biom.ss.

关键词： Bay of Bengal Lobotes surinam.nsis TropFishR length based indicator(LBI) length-based Bayesian biom.ss estim.tion(LBB) Bangladesh