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Aspartate transferase-to-platelet ratio index-plus: A new simplified model for predicting the risk of mortality among patients with COVID-19

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World Journal of Gastroenterology 2022年第16期28卷 1671-1680页

作者： Ali Madian ahmed eliwa Hytham Abdalla Haitham A Azeem Aly Department of Internal Medicine Faculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt Department of Internal Medicine Faculty of MedicineAl-Azhar University-CairoCairo 11754Egypt Department of Chest Diseases Faculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt

BACKGROUND Coronavirus disease 2019(COVID-19)has a spectrum of clinical syndromes with serious involvement of the lung and frequent effection of the liver and hemostatic *** biomarkers are affordable,rapid,objective,and useful in the evaluation and prognostication of COVID-19 *** To investigate the association between aspartate transferase-to-platelet ratio index(APRI)and in-hospital mortality to develop a COVID-19 mortality prediction *** A multicenter cohort study with a retrospective design was *** records of all consecutive adult patients admitted to Al-Azhar University Hospital(Assiut,Egypt)and Chest Hospital(Assiut,Egypt)with confirmed COVID-19 from July 1,2020 to October 1,2020,were retrieved and *** patient cohort was classified into the following two categories based on the APRI:(1)COVID-19 presenting with APRI≤0.5;and(2)COVID-19 presenting with APRI(>0.5 and≤1.5).The association between APRI and all-cause in-hospital mortality was analyzed,and the new model was developed through logistic regression *** Of the 353 patients who satisfied the inclusion criteria,10%were admitted to the intensive care unit(n=36)and 7%died during the hospital stay(n=25).The median age was 40 years and 50.7%were *** admission,49%had aspartate transferase-dominant liver *** admission,APRI(>0.5 and≤1.5)was independently associated with all-cause in-hospital mortality in unadjusted regression analysis and after adjustment for age and sex;after stepwise adjustment for several clinically relevant confounders,APRI was still significantly associated with all-cause inhospital *** admission,APRI(>0.5 and≤1.5)increased the odds of mortality by fivetimes(P<0.006).From these results,we developed a new predictive model,the APRI-plus,which includes the four predictors of age,aspartate transferase,platelets,and serum *** for mortality was very good,with an area under the receiver operating curve

关键词： COVID-19 Aspartate transferase-to-platelet ratio index Aspartate transferase All-cause inhospital mortality Serum ferritin SARS-CoV-2

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利用柠檬酸浸泡技术最大化利用磷石膏废弃物回收稀土和残留磷酸盐

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Journal of Central South University 2022年第12期29卷 3896-3911页

作者： ahmed Atef eliwa Amal Essam MUBARK Nasr Abelaziz ABDELFATTAH Ebrahim Abd El GAWAD Production Sector Nuclear Materials AuthorityP.O.Box 530 El-MaadiCairoEgypt

磷石膏(PG)是磷酸生产工业的主要副产物,被认为是稀土元素(REEs)最重要的二次来源之一。本研究重点是回收PG中存在的REEs和残留的磷酸盐的同时,保留CaSO_(4),以用于其他各种应用。这些成果是采用柠檬酸浸出工艺实现的。研究了几个参数... 详细信息

磷石膏(PG)是磷酸生产工业的主要副产物,被认为是稀土元素(REEs)最重要的二次来源之一。本研究重点是回收PG中存在的REEs和残留的磷酸盐的同时,保留CaSO_(4),以用于其他各种应用。这些成果是采用柠檬酸浸出工艺实现的。研究了几个参数对柠檬酸浸出回收稀土的影响,包括浸泡时间、浸泡温度、柠檬酸浓度、固液比以及柠檬酸浸出溶液在进一步的稀土溶解实验中的循环利用。最佳操作条件为室温浸泡时间14 d,柠檬酸浓度为7.5%,固液比为1/5。优化条件下稀土的溶解效率为79.57%。将不同的新鲜PG样品与相同的柠檬酸溶液依次混合浸泡4个阶段,在最佳浸泡条件下,稀土的累积溶解效率为64.7%。采用Dowex 50X8树脂从柠檬酸溶液中回收稀土,萃取效率为96%。溶解动力学证明了稀土的伪一级性质、溶解过程为可逆反应,存在两个活化能。

关键词：磷石膏稀土柠檬酸溶解浸泡 Dowex 50X8 预浓缩

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Hepatocellular injury and the mortality risk among patients with COVID-19: A retrospective cohort study

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World Journal of Hepatology 2021年第8期13卷 939-948页

作者： Ali Madian ahmed eliwa Hytham Abdalla Haitham A Azeem Aly Division of Gastroenterology and Hepatology Department of Internal MedicineFaculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt Division of Gastroenterology and Hepatology Department of Internal MedicineFaculty of MedicineAl-Azhar University-CairoCairo 11754Egypt Department of Chest Diseases Faculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt Department of Internal Medicine Faculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt

BACKGROUND Clearly,infection with severe acute respiratory syndrome coronavirus 2 is not limited to the lung but also affects other *** need predictive models to determine patients’prognoses and to improve health care resource allocation during the coronavirus disease 2019(COVID-19)*** treating COVID-19,we observed differential outcome prediction weights for markers of hepatocellular injury among hospitalized *** To investigate the association between hepatocellular injury and all-cause inhospital mortality among patients with *** This multicentre study employed a retrospective cohort *** adult patients admitted to Al-Azhar University Hospital,Assiut,Egypt and Abo Teeg General Hospital,Assiut,Egypt with confirmed COVID-19 from June 1,2020,to July 30,2020 were *** categorized our cohort into three groups of(1)patients with COVID-19 presenting normal aminotransferase levels;(2)patients with COVID-19 presenting one-fold higher aminotransferase levels;and(3)patients with COVID-19 presenting two-fold higher aminotransferase *** analysed the association between elevated aminotransferase levels and all-cause in-hospital *** survival analysis was performed using the Kaplan–Meier method and tested by log-rank *** In total,376 of 419 patients met the inclusion criteria,while 29(8%)patients in our cohort died during the hospital *** median age was 40 years(range:28-56 years),and 51%were males(n=194).At admission,54%of the study cohort had liver *** pattern of liver injury was hepatocellular injury with an aspartate aminotransferase(AST)*** AST levels were independently associated with all-cause in-hospital mortality in the logistic regression analysis.A one-fold increase in serum AST levels among patients with COVID-19 led to an eleven-fold increase in in-hospital mortality(P<0.001).Admission AST levels correlated with C-reactive protein(r=0.2;P<0.003)and serum fer

关键词： COVID-19 Liver injury Aspartate amino transferase All-cause in-hospital mortality Serum ferritin SARS-CoV-2

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Colorectal cancer in Arab world:A systematic review

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1791-1798页

作者： Nahed A Makhlouf Muhammad Abdel-Gawad Aya M Mahros Sameh A Lashen Mariam Zaghloul ahmed eliwa Eman E Elshemy Zainab Ali-Eldin Doaa Abdeltawab Fathiya El-Raey Dalia Omran Marwa Khalaf Nancy Fanous ahmed Shawkat Abdelmohsen ahmed Abu-Elfatth Mohamed Abdelghani Mahmoud Farouk Mohamed Abdelaziz Mohamed Alboraie Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Department of Hepatology Gastroenterologyand Infectious DiseasesAl-Azhar UniversityAssiut 71631Egypt Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafrelsheikh 33656Egypt Department of Internal Medicine Alexandria UniversityAlexandria 21521Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11884Egypt Department of Hepatogastroenterology and Infectious Diseases Al-Azhar UniversityCairo 11651Egypt Department of Internal Medicine Ain Shams UniversityCairo 11646Egypt Department of Hepatogastroenterology and Infectious diseases Faculty of MedicineAl-Azhar UniversityDamietta 34511CairoEgypt Department of Endemic Medicine Cairo UniversityCairo 12613Egypt Department of Tropical Medicine and Gastroenterology Assiut Liver CenterAssiut 71511Egypt Department of Gastroenterology Hepatology and EndoscopyPolice Authority HospitalCairo 12654Egypt Department of Clinical Oncology and Nuclear Medicine Al-Azhar UniversityCairo 11824Egypt

BACKGROUND The incidence of colorectal cancer(CRC)is increasing among young individuals in the Arab world as well as in other regions of the *** To explore the incidence and prevalence of CRC in the Arab *** The PubMed,Scopus,Web of Science,EBSCO and Wiley databases were searched to retrieve relevant articles irrespective of the language or the publication *** search terms were("colon OR rectum OR sigmoid OR rectal OR colonic OR colorectal")AND("cancer OR malignancy OR malignant OR neoplasm")AND("Jordan"OR"United Arab Emirates"OR"Bahrain"OR"Tunisia"OR"Algeria"OR"Djibouti"OR"Saudi Arabia"OR"Sudan"OR"Syria"OR"Somalia"OR"Iraq"OR"Oman"OR"Palestine"OR"Qatar"OR"Comoros"OR"Kuwait"OR"Lebanon"OR"Libya"OR"Egypt"OR"Morocco"OR"Mauritania"OR"Yemen").Reviews,metaanalyses,and articles containing nonoriginal data were *** articles were screened,and relevant data were *** statistics were used for data *** Nine studies were *** of the studies provided information regarding the prevalence of *** prevalence of CRC was 0.72% in Saudi Arabia and 0.78% in the United Arab Emirate,while in Egypt,it ranged from 0.4% to 14%.Four studies showed information regarding the *** annual incidence rate of CRC in Qatar was 7.5/100000/*** Egypt,the crude incidence rate(CIR)in males was 3.1 for colon cancer and 1 for rectal cancer,while in females,it was 2.3 for colon cancer and 0.8 for rectal *** age-standardized rate for CRC incidence in 2003 was 36.90 for males,26.50 for females,and 30.49 for both sexes in Saudi *** 2016,the CIRs in Saudi Arabia were 3.6 and 2.1 in females for colon cancer and rectal cancer,respectively,while in males,it was 3.3 and 2.8 for colon cancer and rectal cancer,*** study in Egypt revealed that 25% of CRC cases occurred among individuals younger than 40 years *** There is a considerable prevalence of CRC in some Arab *** studies are n

关键词： Colorectal cancer Incidence Prevalence Arab world

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