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Food allergy in children-the current status and the way forward

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World Journal of Clinical Pediatrics 2022年第3期11卷 253-269页

作者： ahmed elghoudi Hassib Narchi Paediatric Department Sheikh Khalifa Medical CityAbu Dhabi NAAbu DhabiUnited Arab Emirates College of Medicine and Health Sciences United Arab Emirates UniversityAlainAbu DhabiUnited Arab Emirates

Food allergy in children is a major health concern,and its prevalence is *** is often over-diagnosed by parents,resulting occasionally in unnecessary exclusion of some important *** also causes stress,anxiety,and even depression in parents and affects the family’s quality of *** diagnostic tests are useful when interpreted in the context of the clinical history,although cross-sensitivity and inability to predict the severity of the allergic reactions remain major *** the oral food challenge is the current gold standard for making the diagnosis,it is only available to a small number of patients because of its requirement in time and medical *** diagnostic methods have recently emerged,such as the Component Resolved Diagnostics and the Basophil Activation Test,but their use is still limited,and the latter lacks ***,there is no definite treatment available to induce life-long natural tolerance and cure for food *** available treatments only aim to decrease the occurrence of anaphylaxis by enabling the child to tolerate small amounts of the offending food,usually taken by *** evidence supports the early introduction of the allergenic food to infants to decrease the incidence of food *** standardised and widely implemented,this may result in decreasing the prevalence of food allergy.

关键词： Oral food challenge Oral immunotherapy Allergens Anaphylaxis Desensitisation Immunoglobulin E Eosinophilic gastrointestinal diseases Histamine Mast cells Basophil activation test

Barriers and challenges affecting parents’use of adrenaline autoinjector in children with anaphylaxis

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World Journal of Clinical Pediatrics 2022年第2期11卷 151-159页

作者： Hassib Narchi ahmed elghoudi Klithem Al Dhaheri College of Medicine and Health Sciences United Arab Emirates UniversityAl Ain 17666United Arab Emirates Department of Pediatrics Sheikh Khalifa Medical CityAbu Dhabi 51900United Arab Emirates Child Health Institute Al Ain HospitalAl Ain 1006United Arab Emirates Department of Pediatric Tawam HospitalAl Ain 15258United Arab Emirates

BACKGROUND Anaphylaxis is a life-threatening condition that develops as a reaction to exposure to an allergen which can be found in common foods such as cow's milk,egg,fish,and nuts in *** use of an intramuscular adrenaline auto-injector(AAI)is considered the most essential treatment in these situations and parents and caregivers are always encouraged to carry this device for use in an emergency which commonly takes place in public places such as restaurants,schools,and parks,where medical staff are not guaranteed to be ***,previous studies,in different settings,have reported underuse of the AAI by *** To explore the reasons for underutilisation of the AAI in our *** A cohort of parents attending the paediatric allergy clinic at Al Ain Hospital in the United Arab Emirates completed a questionnaire survey aimed at assessing their understanding and knowledge of their child's allergy management,including their aptitude with the use of the AAI,as well as their competence and comfort in providing this treatment in an *** Of 47 parents participating in the study,39 were Emirati parents(83%and most parents who completed the survey were mothers(66%).As expected,food was the main cause of allergic reactions requiring prescription of the auto-injector *** nuts and peanuts were noted to be the most common offending food in these children(62%and 38%,respectively).A doctor provided demonstrations and training on using the auto-injector device to 94%of the *** than two-thirds of the parents and caregivers(79%)were deemed knowledgeable on the indication for use of the *** to administer the device was expressed by many of the parents,despite their satisfaction with the coaching they received on using the device in the *** Ongoing coaching and teaching of parents on use of the AAI is ***,this should be carried out together with psychological support to aid the parents

关键词： Anaphylaxis Adrenaline Food allergy Barriers Education Management

A Cross-Sectional Study on Current Practice of the Management of Pregnancy Induced Hypertension and Its Maternal and Foetal Complications and Outcome in the Western Part of the State of Libya

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Open Journal of Obstetrics and Gynecology 2022年第3期12卷 222-241页

作者： ahmed elghoudi Abdulrahman Alsharef Asma elghoudi College of Medicine and Health Sciences United Arab Emirates University Al Ain The United Arab Emirates Faculty of Medicine University of Tripoli Tripoli Libya

Background: Maternal and perinatal mortality and morbidity are mainly affected by hypertension during pregnancy (pre-eclampsia). Haemorrhage and cerebral bleeding are the primary and significant complications of pre-eclampsia. Abruption of the placenta and renal failure are among the major complications caused by this disease. The perinatal complications include Intrauterine Growth Restriction (IUGR), Intrauterine Foetal Death (IUFD), neonatal death, and prematurity. Objective: The purpose of the present study was to examine the incidence of Pregnancy-Induced Hypertension (PIH), pre-eclampsia, the management of PIH, including the early diagnosis, the pharmacological drug management used, and the prevalence of maternal and perinatal complications. Methods and Patients: This cross-sectional study took place in Aljalaa maternity hospital, which represented the west of the state of Libya in the period from 1st January 2012 to 31st December 2012, with patients who were diagnosed, managed, and terminated according to protocol management of the hospital. Results: In the present study, from the total deliveries in Aljalaa Maternity hospital, the incidence of PIH is 8.4% and pre-eclampsia is 5.1%. No maternal mortality, CNS haemorrhaged, hepatic failure, or renal failure. The reported maternal complications included: Eclampsia, HELLP syndrome (Haemolysis, Elevated Liver enzymes and Low platelets), abruption placenta, and pulmonary oedema see in eighteen percent, six percent, nine percent, four percent and less than one percent, respectively. The foetal complications were preterm babies and Intrauterine Growth Restriction (IUGR) in nineteen percent, Low Birth Weight (LBW) in twenty-five percent, Intrauterine Foetal Death (IUFD) in five percent, neonatal death in two percent and, perinatal death in six percent. In the PIH patients, the presence of associated symptoms such as headache, blurred vision, irritability, and the presence of signs such as severe hypertension, generali

关键词： Preeclampsia Proteinuric Pregnancy Induced Hypertension

COVID-19-induced liver injury in infants,children,and adolescents

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World Journal of Clinical Pediatrics 2023年第3期12卷 57-67页

作者： Rana Bitar ahmed A elghoudi David Rawat Amer Azaz Mohamad Miqdady Hassib Narchi Division of Pediatric Gastroenterology Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUnited Arab Emirates Department of Pediatric Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Department of Pediatric College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates

Coronavirus disease 2019(COVID-19)typically presents with fever and respiratory symptoms in *** children develop an asymptomatic and mild illness,with a minority requiring specialist medical *** manifestations and liver injury can also occur in children following *** mechanisms of liver injury may include infection following direct viral hepatic tissue invasion,immune response,or medication *** children might develop mild liver dysfunction which has a benign course in most children with no pre-existing liver ***,the presence of non-alcoholic fatty liver disease or other pre-existing chronic liver disorders is associated with a higher risk of developing severe COVID-19 illness with poor *** the other hand,the presence of liver manifestations is associated with the severity of COVID-19 disease and is considered an independent prognostic ***,hemodynamic,and nutritional supportive therapies are the mainstay of *** of children at increased risk of developing severe COVID-19 disease is *** review describes the liver manifestations in children with COVID-19,detailing its epidemiology,basic mechanisms,clinical expression,management,and prognosis in those with and without pre-existing liver disease and also children who have had earlier liver transplantation.

关键词： Child COVID-19 Gastroenterology Hepatic dysfunction Infection Liver diseases SARS-CoV-2 Liver injury Liver transplant