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Antibody Pattern: Correlation of Age and Gender in ANA and Anti-ds-DNA Prevalence

Journal of Clinical and Nursing Research 2024年第6期8卷 373-381页

作者： Usama ahmed Hijazi Mallick Amber Khan Muhammad Zubair Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Dow International Medical College Karachi Pakistan Department of Biosciences Shaheed Zulfikar Ali Bhutto Institute of Science and Technology(SZABIST)KarachiPakistan Institute of Biological Sciences Khwaja Fareed University of Engineering and Information TechnologyRahim Yar KhanPakistan

The study was designed to find the prevalence of ANA antibodies and anti-dsDNA antibodies in samples tested at AFIP Rawalpindi and their correlation with age and gender and to find positive and negative predictive values of ANA *** this purpose,twelve thousand nine hundred sixty-seven(12,967)patients were analyzed for ANA with four hundred sixty-eight(468)healthy samples tested as control and four thousand seven hundred three(4,703)patients tested for ds-DNA *** data of all samples tested by indirect immunofluorescence(IF)for ANA antibodies and dsDNA antibodies was *** address positive and negative predictive values another control group(autoimmunity not suspected)of serum samples was taken from the healthy *** the first group,age,gender,ANA antibodies and ds-DNA antibodies results(both tests performed by IIF)data was collected from a computer record cell;for the second control group,ANA antibodies were performed by IIF.12,967 and 4,703 samples(Group 1)were tested for ANA antibodies and dsDNA antibodies,respectively,during this period.1,119(9%)and 99(2%)were found positive for ANA antibodies and ds DNA *** these positive samples,850(76%)and 73(74%)were females *** predisposition towards autoimmunity(ANA)was found significant with a P value of(P=0.001).Relation of age was also found significant with anti-ANA antibodies with a P value of(P=0.001).This study shows a negative correlation between age(P=0.025)and gender(P=0.001)with anti-dsDNA which is also *** prevalence was found below the mean age of 38 years(SD±16.635)for ANA antibodies and the mean age of 35 years(SD±15.066)for ds-DNA *** age of ANA antibodies and dsDNA antibodies positive patients ranged from 1 year old to 98 years old and 2 years old to 95 years old *** the second(autoimmunity-free)control group,a total of 468 samples were tested for ANA antibodies and 9(2%)were found ***

关键词： ANA Anti ds-DNA Autoimmunity SLE Immune fluorescence

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Incidence and predictors of hypocalcemia in end-stage renal disease patients on denosumab therapy: A systematic review and metaanalysis

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World Journal of Meta-Analysis 2024年第3期12卷 68-78页

作者： Abdul Hannan Siddiqui Misbah Shaikh Afia Salman Muhammad ahmed ali Fahim Fizzah Batool Tahreem Mari Sarah Musani Muneeb Fareed Rooma Rehan Amna Hassni Urooj Nizami Ayesha Amir Abdul Moeed Salim R Surani Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Denosumab inhibits the receptor activator of nuclear factor *** markedly increases bone mineral density and has been proven to reduce the risk of ***,numerous adverse effects,notably hypocalcemia,are prevalent in patients with end-stage renal disease(ESRD).AIM To analyze the incidence and predictors of hypocalcemia caused by denosumab compared to control in patients with *** We conducted this study in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses ***,Scopus,Cochrane Central,and EMBASE were systematically searched from inception through March *** original studies investigating the effects of denosumab on patients with ESRD compared to control were *** primary outcomes of our study were the incidence of mild,severe,and very severe *** outcomes included serum levels of intact parathyroid hormone,calcium,and *** results were pooled and analyzed using a random-effects *** Seven articles comprising 3240 patients were included in our *** treated with denosumab had a significantly increased incidence of mild hypocalcemia[risk ratio(RR):2.79;95%confidence interval(CI):0.99-7.91;P=0.05;I^(2)=37%]and of very severe hypocalcemia(RR:9.58;95%CI:1.58-57.98;P=0.01;I^(2)=49%).However,an increase in the occurrence of severe hypocalcemia was non-significant(RR:4.23;95%CI:0.47-38.34;P=0.20;I^(2)=96%).Alternatively,denosumab showed a significant decrease in serum intact parathyroid hormone[mean difference(MD):-433.20,95%CI:-775.12 to-91.28,I2=98%,P=0.01],while there was a non-significant decrease in phosphate(MD:-0.47,95%CI:-1.35 to 0.41,I^(2)=88%,P=0.30)and calcium levels(MD:-0.33,95%CI:-0.95 to 0.29,I^(2)=94%,P=0.29).CONCLUSION Our study demonstrated that denosumab is significantly associated with mild and very severe hypocalcemia in patients with ESRD making it necessary to detect and prevent this side effect of treatmen

关键词： Denosumab End-stage renal disease Hypocalcemia Parathyroid hormone Dialysis

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Modeling the rate of corrosion of carbon steel using activated diethanolamine solutions for CO2 absorption

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Chinese Journal of Chemical Engineering 2020年第8期28卷 2099-2110页

作者： Lubna Ghalib ahmed Abdulkareem Brahim Si ali Shaukat ali Mazari Materials Engineering Department Mustansiriyah UniversityBaghdad 14022Iraq Mathematics Science Directorate General of Education Rusafa 1BaghdadIraq Department of Chemical Engineering University of Malaya50603 Kuala LumpurMalaysia Department of Chemical Engineering Dawood University of Engineering and TechnologyKarachi 74800Pakistan

A mechanistic model is developed to investigate the influence of an activator on the corrosion rate of carbon steel in the absorption processes of carbon dioxide(CO2).Piperazine(PZ)is used as the activator in diethanolamine(DEA)aqueous *** developed model for corrosion takes into consideration the effect of fluid flow,transfer of charge and diffusion of oxidizing agents and operating parameters like temperature,activator concentration,CO2 loading and *** study consists of two major models:Vapor–liquid Equilibrium(VLE)model and electrochemical corrosion *** electrolyte-NRTL equilibrium model was used for determination of concentration of chemical species in the bulk *** results of speciation were subsequently used for producing polarization curves and predicting the rate of corrosion occurring at the surface of *** increase in concentration of activator,increases the rate of corrosion of carbon steel in mixtures of activated DEA.

关键词： CO2 capture CO2 corrosion Carbon steel Diethanolamine Piperazine Electrochemical model

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Advancements in prokaryotic systematics and the role of Bergey's International Society for Microbial Systematics in addressing challenges in the meta-data era

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National Science Review 2024年第7期11卷 292-304页

作者： Jian-Yu Jiao Rashidin Abdugheni Dao-Feng Zhang Iftikhar ahmed Mukhtiar ali Maria Chuvochina Svetlana N.Dedysh Xiuzhu Dong Markus G?ker Brian P.Hedlund Philip Hugenholtz Kamlesh Jangid Shuang-Jiang Liu Edward R.B.Moore Manik Prabhu Narsing Rao Aharon Oren Ramon Rossello-Mora Bhagwan Narayan Rekadwad Nimaichand Salam Wensheng Shu Iain C.Sutcliffe Wee Fei Aaron Teo Martha E.Trujillo Stephanus N.Venter William B.Whitman Guoping Zhao Wen-Jun Li State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant Resources and Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) School of Life Sciences Sun Yat-Sen University State Key Laboratory of Desert and Oasis Ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsXinjiang Institute of Ecology and Geography Chinese Academy of Sciences Jiangsu Province Engineering Research Center for Marine Bio-resources Sustainable Utilization&College of Oceanography Hohai University National Culture Collection of Pakistan(NCCP) Land Resources Research Institute(LRRI) National Agricultural Research Centre(NARC) The University of Queensland School of Chemistry and Molecular Biosciences Australian Centre for Ecogenomics Winogradsky Institute of Microbiology Research Center of BiotechnologyRussian Academy of Sciences State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Leibniz Institute DSMZ–German Collection of Microorganisms and Cell Cultures School of Life Sciences University of Nevada Nevada Institute of Personalized Medicine University of Nevada Bioenergy Group MACS Collection of Microorganisms Agharkar Research Institute State Key Laboratory of Microbial Technology Shandong University Department of Infectious Disease Institute for Biomedicine and Culture Collection University of Gothenburg(CCUG) Institute for BiomedicineSahlgrenska AcademyUniversity of Gothenburg Instituto de Ciencias Aplicadas Facultad de Ingeniería Universidad Autónoma de Chile The Alexander Silberman Institute of Life Sciences The Edmond J.Safra Campus The Hebrew University of Jerusalem Marine Microbiology Group Department of Animal and Microbial Biodiversity Mediterranean Institute for Advanced Studies(IMEDEA CSIC-UIB) MicrobeAI Lab Division of Microbiology and Biotechnology Yenepoya Research Centre Yenepoya(Deemed to be University) National Agri-Food Biotechnology Institute Institute of Ecological Science Sch

Prokaryotes are ubiquitous in the biosphere, important for human health and drive diverse biological and environmental processes. Systematics of prokaryotes, whose origins can be traced to the discovery of microorganisms in the 17th century, has transitioned from a phenotype-based classification to a more comprehensive polyphasic taxonomy and eventually to the current genome-based taxonomic *** transition aligns with a foundational shift from studies focused on phenotypic traits that have limited comparative value to those using genome sequences. In this context, Bergey's Manual of Systematics of Archaea and Bacteria(BMSAB) and Bergey's International Society for Microbial Systematics(BISMiS) play a pivotal role in guiding prokaryotic systematics. This review focuses on the historical development of prokaryotic systematics with a focus on the roles of BMSAB and BISMiS. We also explore significant contributions and achievements by microbiologists, highlight the latest progress in the field and anticipate challenges and opportunities within prokaryotic systematics. Additionally, we outline five focal points of BISMiS that are aimed at addressing these challenges. In conclusion, our collaborative effort seeks to enhance ongoing advancements in prokaryotic systematics, ensuring its continued relevance and innovative characters in the contemporary landscape of genomics and bioinformatics.

关键词： prokaryotic systematics Bergey's Manual of Systematics of Archaea and Bacteria (BMSAB) Bergey's International Society for Microbial Systematics (BISMiS) meta-data era

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Overall Assessment of Heat Transfer for a Rarefied Flow in a Microchannel with Obstacles Using Lattice Boltzmann Method

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工程与科学中的计算机建模(英文) 2024年第1期138卷 273-299页

作者： Siham Hammid Khatir Naima Omolayo M.Ikumapayi Cheikh Kezrane Abdelkrim Liazid Jihad Asad Mokdad Hayawi Rahman Farhan Lafta Rashid Naseer ali Hussien Younes Menni Laboratory of Development in Mechanics and Materials(LDMM) Zian Achour UniversityDjelfaPB 3117Algeria Department of Technology University Center Salhi Ahmed Naama(Ctr.Univ.Naama)P.O.Box 66Naama45000Algeria Department of Mechanical and Mechatronics Engineering Afe Babalola University Ado Ekiti360101Nigeria Departement of Physics Faculty of ScienceAbou Bekr Belkaid UniversityTlemcen13000Algeria Department of Physics Faculty of Applied SciencesPalestine Technical University-KadoorieTulkarmPalestine Aeronautical Technical Engineering Al-Farahidi UniversityBaghdad10011Iraq Mechanical Engineering Department University of KerbalaKarbala56001Iraq Information and Communication Technology Research Group Scientific Research CenterAl-Ayen UniversityThi-QarIraq National University of Science and Technology Dhi QarIraq

The objective of this investigation is to assess the effect of obstacles on numerical heat transfer and fluid flow momentum in a rectangular microchannel(MC).Two distinct configurations were studied:one without obstacles and the other with alternating obstacles placed on the upper and lower *** research utilized the thermal lattice Boltzmann method(LBM),which solves the energy and momentum equations of fluids with the BGK approximation,implemented in a Python coding *** jump and slip velocity conditions were utilized in the simulation for the MC and extended to all obstacle *** study aims to analyze the rarefaction effect,with Knudsen numbers(Kn)of 0.012,0.02,and *** outcomes indicate that rarefaction has a significant impact on the velocity and temperature *** presence of nine obstacles led to slower fluid movement inside the microchannel MC,resulting in faster cooling at the *** MCs with obstacles,the rarefaction effect plays a crucial role in decreasing the Nusselt number(Nu)and skin friction coefficient(Cf).Furthermore,the study demonstrated that the obstacles played a crucial role in boosting fluid flow and heat transfer in the *** findings suggest that the examined configurations could have potential applications as cooling technologies in micro-electro-mechanical systems and microdevice applications.

关键词： Microfluid rarefied flow LBM microchannel Knudsen number numerical simulation

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Analysis of Factors that Affect Government Digitization:A Pilot Case Study of Pakistan

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Computers, Materials & Continua 2021年第1期66卷 291-301页

作者： Salman ahmed Muhammad ali Khan Department of Computer Systems Engineering University of Engineering&TechnologyPeshawarPakistan

One of the greatest factors that affects the economic condition of a country is its *** the model of good governance,the primary elements for stronger institution include efficiency,transparency,and accountability;and technology plays a major role in improving these ***,there are myriad of challenges when it comes to practical integration of technology in these institutions for *** is more challenging when a country is developing and one that is already weak *** is also important to mention that the challenges of digitization in public sector is not limited to developing countries *** is equally challenging,even today,in already developed countries to digitally transform their public institutions for improved policymaking and for responsive service *** factors contribute to the failure of such digitization initiatives,more so within developing *** the purpose of this paper is to identify those factors,to measure the significance of each of those factors,and to realize and overcome *** research considered the case study of Pakistan;however,the results are very likely to match the conditions of other developing regions around the *** questionnaires and interviews,valuable feedback was gathered from up to 25 senior government officers that are closely associated with digitization initiatives in public *** feedback to the questions were overall *** results indicate the most significant of factors that affect government digitization in this developing region,including some factors that were not expected.

关键词： E-governance government digitization information management sustainability

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Control of Wave Propagation and Effect of Kerr Nonlinearity on Group Index

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Communications in Theoretical Physics 2013年第7期60卷 87-92页

作者： Hazrat ali Ziauddin Iftikhar ahmed Department of Physics University of Malakand Department of Physics COMSATS Institute of Information Technology

We use four-level atomic system and control the wave propagation via forbidden decay rate. The Raman gain process becomes dominant on electromagnetically induced transparency (EIT) medium by increasing the forbidden decay rate via increasing the number of atoms [G.S. Agarwal and T.N. Dey, Phys. Rev. A 74 (2005) 043805 and K. Harada, T. Kanbashi, and M. Mitsunaga, Phys. Rev. A 73 (2006) 013803]. The behavior of wave propagation is dramatically changed from normal (subluminal) to anomalous (superluminal) dispersion by increasing the forbidden decay rate. The system can also give a control over the group velocity of the light propagating through the medium via Kerr field.

关键词： normal and anomalous dispersion Kerr field group index

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Comprehensive evaluation and sensitivity analysis of regeneration energy for acid gas removal plant using single and activated-methyl diethanolamine solvents

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Chinese Journal of Chemical Engineering 2020年第6期28卷 1684-1693页

作者： Ammar ali Abd Samah Zaki Naji ahmed Barifcani Water Resources Engineering College Al-Qasim Green UniversityBabylonIraq Petroleum Engineering Department Kerbala UniversityKerbalaIraq Chemical Engineering Department Curtin University of TechnologyPerthAustralia.

The absorption of acid gas using reactive amines is among the most widely used types of capturing ***,the absorption process requires intensive energy expenditure majorly in the solvent regeneration *** study simultaneously evaluated the regeneration energy of MDEA and PZ/MDEA solvents in terms of heat of absorption,sensible heat,and vaporization *** Hysys version 8.8 simulation tool is applied to model the full acid gas removal plant for the chemical absorption *** new energy balance technique presents around the absorption and desorption columns to bring a new perspective of energy distribution in the capturing of acid gas *** analysis of regeneration energy and its three contributors is performed at several operation parameters such as absorber and stripper pressures,lean amine circulation rate,solvent concentration,reflux ratio,and CO2 and H2 S *** results show that the heat of absorption of PZ/MDEA system is higher than that for MDEA system for the same operating *** sensible heat is the main contributor in the required regeneration energy of MDEA solvent *** simulation results have been validated against data taken from real plant and *** product specifications of our simulation corroborate with real plant data in an excellent approach;additionally,the profile temperature of the absorber and the stripper columns are in good agreement with *** overall results highlight the direction of the effects of each parameter on the heat of absorption,sensible heat,and vaporization heat.

关键词： Heat of absorption Sensible heat Vaporization heat Regeneration energy Acid gases capturing Piperazine Activated-Methyl diethanolamine

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Contralateral eye study of refractive,topographic and aberrometric outcomes after femtosecond assisted Myo Ring implantation and DALK for management of keratoconus

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1621-1630页

作者： Mohamed omar Yousif Azza Mohamed ahmed Said Department of Ophthalmology Faculty of Medicine Ain Shams University

AIM：To evaluate the efficacy of femtosecond laser assisted MyoRing intrastromal corneal implant and deep anterior lamellar keratoplasty （DALK） for management of moderate to advanced keratoconus regarding the degree of changes in visual acuity, refraction, corneal asphericity and ***：A prospective non comparative interventional case study was conducted in Ophthalmology Department,Ain Shams University Hospital in the period from January 2015 to February 2017. The study included 30 eyes of moderate to advanced keratoconus. MyoRing was implanted in one eye （Group Ⅰ） and DALK operation was performed in the contralateral eye of the same patient （Group Ⅱ）.Preoperative and 6mo post-operative uncorrected visual acuity（UCVA）, corrected distance visual acuity （CDVA）, spherical equivalent （SE）, corneal and refractive astigmatisms,keratometry and Q-value using topography images were acquired. Quality of vision was assessed in all eyes including total corneal, anterior corneal high order aberrations analysis at 5 mm pupil size and the Strehl ratio of point spread function （PSF） as an objective measure of ***：Mean postoperative UCVA, CDVA, SE, refractive astigmatism,keratometryreadingsandasphericity were statistically improved compared to preoperative parameters in both groups （P〈0.05）. Significant reduction of all corneal aberrations following both techniques（P〈0.05） was achieved except mean trefoil and mean PSF in Group Ⅰ （P〉0.05）. Postoperative corneal aberrations were significantly lower in Group Ⅱ compared to Group Ⅰ.A statistically significant negative correlation was found in Group Ⅰ between the mean change in CDVA （logMAR）and the mean preoperative and mean postoperative total corneal aberrations root mean square （RMS; r=-0.78,P=0.04）. Also a statistically significant negative correlation was found between mean preoperative coma RMS and mean post PSF （r=-0.86, P=0.01）. In Group Ⅱ, there was a statistically significant positive correlation between m

关键词： aberrations deep anterior lamellar keratoplasty femtosecond laser keratoconus MyoRing

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Design and Development of Low-cost Wearable Electroencephalograms (EEG) Headset

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Intelligent Automation & Soft Computing 2023年第3期35卷 2821-2835页

作者： Riaz Muhammad ahmed ali M.Abid Anwar Toufique ahmed Soomro omar AlShorman Adel Alshahrani Mahmoud Masadeh Ghulam Md Ashraf Naif H.ali Muhammad Irfan Athanasios Alexiou Department of Electrical Engineering Sukkur IBA University65200SukkurPakistan Department of Electronic Engineering Quaid-e-Awam University of EngineeringScience and TechnologyLarkana77150Pakistan Faculty of Engineering and AlShrouk Trading Company Najran UniversityNajran61441Saudi Arabia Department of Medical Rehabilitation Sciences-Physiotherapy Program College of Applied Medical SciencesNajran UniversityNajran61441Saudi Arabia Computer Engineering Department Yarmouk UniversityIrbid21163Jordan Pre-Clinical Research Unit King Fahd Medical Research CenterKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Medical Laboratory Technology Faculty of Applied Medical SciencesKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Internal Medicine Medical CollegeNajran UniversityNajran61441Saudi Arabia Electrical Engineering Department College of EngineeringNajran University Saudi ArabiaNajran61441Saudi Arabia Novel Global Community Educational Foundation HebershamNSW 2770AustraliaAFNP Med AustriaWien2770Austria

Electroencephalogram(EEG)is a method of capturing the electrophy-siological signal of the *** EEG headset is a wearable device that records electrophysiological data from the *** paper presents the design and fab-rication of a customized low-cost Electroencephalogram(EEG)headset based on the open-source OpenBCI Ultracortex Mark IV *** electrode placement locations are modiﬁed under a 10–20 standard *** fabricated headset is then compared to commercially available headsets based on the following para-meters:affordability,accessibility,noise,signal quality,and ***,the data is recorded from 20 subjects who used the EEG Headset,and signals were ***,the participants marked the accuracy,set up time,participant comfort,and participant perceived ease of set-up on a scale of 1 to 7(7 being excellent).Thirdly,the self-designed EEG headband is used by 5 participants for slide *** raw EEG signal is decomposed into a series of band sig-nals using discrete wavelet transform(DWT).Lastly,theseﬁndings have been compared to previously reported *** concluded that when used for slide-changing control,our self-designed EEG headband had an accuracy of 82.0 *** also concluded from the results that our headset performed well on the cost-effectiveness scale,had a reduced setup time of 2±0.5 min(the short-est among all being compared),and demonstrated greater ease of use.

关键词： Brain-computer interface EEG consumer-grade accessibility headset

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