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Genes & Diseases 2023年第6期10卷 2263-2266页

作者： Ikram Ullah Muhammad Waqas Muhammad Ilyas Sobia Ahsan Halim Akmal Ahmad Natalia Dominik Wahid Ullah Muhammad Abbas Muhammad Aamir Henry Houlden Stephanie Efthymiou Ajmal Khan ahmed al-harrasi Centre for Omic Sciences Islamia College University PeshawarPeshawarKhyber Pakhtunkhwa 25120Pakistan Department of Biotechnology and Genetic Engineering Hazara UniversityMansehraDhodial 21120Pakistan Natural and Medical Sciences Research Center University of NizwaNizwa 616Sultanate of Oman Department of Bioengineering University of Engineering and Applied SciencesSwatKhyber Pakhtunkhwa 19060Pakistan Department of Neuromuscular Disorders UCL Queen Square Institute of NeurologyLondon WC1N 3BGUnited Kingdom

Krabbe disease or globoid cell leukodystrophy(GLD;MIM#245200)is a rare and fatal lysosomal storage disease with an autosomal recessive mode of inheritance that results from the deficiency of galactocerebrosidase(GalC;E.C.3.***.1.46),a lysosomal enzyme encoded by the GalC gene.1 GalC breaks down galactosylceramide,a cerebroside located mainly in the myelin *** in GalC cause the accumulation of a cytotoxic metabolite,galactosylsphingosine or psychosine,which can be toxic to oligodendrocytes and Schwann cells.2 The failure to digest galactosylceramide triggers the formation of multi-nucleated globoid cells,causing severe demyelination,axonopathy,and neuronal death.3 The reported frequency of Krabbe disease is 1 in 100,000 live births with symptoms including irritability,loss of motor ability,spasticity,ataxia,visual dysfunction,seizures,andcognitive impairment.

关键词： dynamics birth Gal

Antituberculosis and cytotoxic activities of triorganotin(Ⅳ) complexes

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Chinese Chemical Letters 2012年第6期23卷 731-735页

作者： Hidayat Hussain NaziaBibi ahmed al-harrasi Salman Siddiqi Shahana U. Kazmi Ying Zhang Amin Badshah Department of Chemisty University of Paderborn 33098 Paderborn Germany Department of Biological Siences and Chemistry College of Arts and Sciences University of Nizwa Oman Immnology and Infectious Disease Research Laboratory Department of Microbiology University of＂ Karachi Pakistan Department of Molecular Muclvbiology and Immunology Bloomberg School of Public Health Johns Hopkins University Baltimore MD 21205 USA Becton Dickinson Diagnostic Systems Sparks MD 21152 USA Department of Chemistry Quaid-e-Azam University lslamabad 45320 Pakistan

Five triorganotin（IV）（1-5） complexes of cinnamic acid, （Z）-2-acetamido-3-phenylacrylic acid, 3-methylbut-2-enoic acid, and 2,2-diphenylacetic acid have been synthesized and characterized by IH-13C-119Sn NMR, UV, and IR. The spectroscopic investigation demonstrated that the carboxylate group acts as a monodentate ligand in triorganotin（IV） compounds. Five triorganotin（IV） complexes were screened against the log phase culture of Mycobacterium tuberculosis H37Rv by colorimetric method using XTT dye as growth indicator. The MICs were found to he 0.08 and 1.25μg/mL.

关键词： Triorganotin(IV) complexes Antituberculosis activity MICs Cytotoxicity

Appropriate Combination of Crossover Operator and Mutation Operator in Genetic algorithms for the Travelling Salesman Problem

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Computers, Materials & Continua 2024年第5期79卷 2399-2425页

作者： Zakir Hussain ahmed Habibollah Haron Abdullah al-Tameem Department of Mathematics and Statistics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Kingdom of Saudi Arabia Faculty of Computing Universiti Teknologi MalaysiaJohor Bahru81310Malaysia College of Computer and Information Sciences Imam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Kingdom of Saudi Arabia

Genetic algorithms(GAs)are very good metaheuristic algorithms that are suitable for solving NP-hard combinatorial optimization *** a set of solutions represented by a population of chromosomes and then uses the idea of survival of the fittest in the selection process to select some fitter *** uses a crossover operator to create better offspring chromosomes and thus,converges the ***,it uses a mutation operator to explore the unexplored areas by the crossover operator,and thus,diversifies the GA search space.A combination of crossover and mutation operators makes the GA search strong enough to reach the optimal ***,appropriate selection and combination of crossover operator and mutation operator can lead to a very good GA for solving an optimization *** this present paper,we aim to study the benchmark traveling salesman problem(TSP).We developed several genetic algorithms using seven crossover operators and six mutation operators for the TSP and then compared them to some benchmark TSPLIB *** experimental studies show the effectiveness of the combination of a comprehensive sequential constructive crossover operator and insertion mutation operator for the *** GA using the comprehensive sequential constructive crossover with insertion mutation could find average solutions whose average percentage of excesses from the best-known solutions are between 0.22 and 14.94 for our experimented problem instances.

关键词： Travelling salesman problem genetic algorithms crossover operator mutation operator comprehensive sequential constructive crossover insertion mutation

Antimicrobial chemical constituents from endophytic fungus Phoma sp.

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Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 699-702页

作者： Hidayat Hussain Ines Kock ahmed al-harrasi ahmed al-Rawahi Ghulam Abbas Ivan R.Green Afzal Shah Amin Badshah Muhammad Saleem Siegfried Draeger Barbara Schulz Karsten Krohn Department of Chemistry University of PaderbornWarburger Strasse 10033098 PaderbornGermany UoN Chair of Oman's Medicinal Plants and Marine Natural Products University of NizwaP.O Box 33Postal Code 616Birkat Al MauzNizwaSultanate of Oman Department of Chemistry CUTAbbottabad CampusAbbottabad-22060Pakistan Department of Chemistry and Polymer Science University of StellenboschP/Bag X1 Matieland 7602South Africa Department of Chemistry Quaid-i-Azam University45320 IslamabadPakistan Department of Chemistry The Islamia University of BahawalpurBaghdad Campus-ul-JadidBahawalpurPakistan Institute of Microbiology University of BraunschweigSpielmannstraβe 738106 BraunschweigGermany

Objective:To evaluate the antiniicrobial polenlial of different extracts of the endophytic fungus Phoma *** the tentative identification of their active ***:The extract and compounds were screened for antimicrobial activity using the Agar Well Diffusion *** compounds were purified using column chromatography and tlieir structures were assigned using～1H and～(13)C NMR spectra,DEPT,2D COSY,HMQC and HMBC ***:The ethyl acetate fraction of Phoma *** good antifungal,antibacterial,and algicidal *** new dihydrofuran derivative,named phomafuranol(1),together with tliree known compounds,phomalacton(2),(3R)-5-hydroxymellein(3)and emodin(4)were isolated from the ethyl acetate fraction of Phoma *** studies indicated that phomalacton(2)displayed strong antibacterial,good antifungal and antialgal ***(3R)-5-hydroxymellein(3)and emodin(4)showed good antifungal,antibacterial and algicidal ***:Antimicrobial activities of the ethyl acetate fraction of the endophytic fungus Phoma *** isolated compounds clearly demonstrate that Phoma *** its active compounds represent a great potential for the food,cosmetic and pharmaceutical industries.

关键词： Natural product Endrophytic fungi Phoma sp

A Novel Layered Double Hydroxide and Dodecyl alcohol Assisted PCM Composite with High Latent Heat Storage Capacity and Thermal Conductivity

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Journal of Thermal Science 2024年第2期33卷 537-547页

作者： al-ahmed Amir SARI Ahmet KHAN Firoz al-RASHEIDI Masoud Hekimoğlu Gökhan AFZAal Mohammad A.alSULAMI ahmed DAFalLA Hatim SalHI Billel A.alSULAIMAN Fahad Interdisciplinary Research Center for Renewable Energy and Power Systems(IRC-REPS) King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Department of Metallurgical and Material Engineering Karadeniz Technical UniversityTrabzon61080Turkey Maths and Natural Sciences Division Higher Colleges of TechnologyP.O.Box 7947SharjahUnited Arab Emirates Department of Mechanical Engineering King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Core Research Facilities King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Membranes and Water Security King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia

Dodecyl alcohol(DDA) is a promising solid-liquid phase change material(PCM) due to its favorable latent heat storage(LHS) ***,the leakage issue of PCM in a melted state during the heating period and low thermal conductivity restricts its utilization potential in thermal energy storage(TES) *** the same context,the present work aims to overcome the leakage issue and improve the thermal conductivity of the *** this in mind,a novel leak-proof layered double hydroxide(LDH)/DDA composite PCM is proposed through a solution-based impregnation *** leak-proof impregnation ratio of the DDA impregnated within the cavities of the synthesized al/Fe-LDH was determined to be 60%.Detailed morphological,physicochemical,and thermal properties of the fabricated composite were studied by scanning electron microscopy(SEM),Fourier transforms infrared(FTIR) spectroscopy,X-ray diffraction(XRD)spectroscopy,differential scanning calorimetry(DSC),thermalgravimetric analysis(TGA),and thermal cycling *** results show that the LDH/DDA composite has a suitable phase change temperature(about 20℃) for passive solar thermal management of building *** composite PCM showed high LHS enthalpy(about136 J/g),good thermal stability,and cycling LHS *** also showed nearly 152% higher thermal conductivity compared to that of pure DDA,ultimately reducing the melting and solidification time of the pure DDA by 44.9% and 45.5%,respectively.

关键词： dodecyl alcohol layered double hydroxide composite PCM thermal conductivity thermal energy storage(TES)

Interplay of serum biomarkers bilirubin andγ-glutamyltranspeptidase in predicting cardiovascular complications in type-2 diabetes mellitus

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World Journal of Diabetes 2024年第6期15卷 1074-1078页

作者： Ebtesam Abdullah al-Suhaimi Abdullah ahmed al-Rubaish Scientific Research and Innovation Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia King Abdulaziz and his Companions Foundation for Giftedness and Creativity“Mawhiba” Riyadh 11372Saudi Arabia College of Medicine Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

This editorial synthesizes insights from a series of studies examining the interplay between metabolic and oxidative stress biomarkers in cardiovascular disease(CVD),focusing particularly on type-2 diabetes mellitus(T2DM)and acute coronary syndrome(ACS).The central piece of this synthesis is a study that investigates the balance between oxidative stress and antioxidant systems in the body through the analysis of serum bilirubin andγ-glutamyltranspeptidase(γ-GGT)levels in T2DM patients with *** study highlights serum bilirubin as a protective antioxidant factor,while elevatedγ-GGT levels indicate increased oxidative stress and correlate with major adverse cardiovascular *** to this,other research contributions revealγ-GGT’s role as a risk factor in ACS,its association with cardiovascular mortality in broader populations,and its link to metabolic syndrome,further elucidating the metabolic dysregulation in *** collective findings from these studies underscore the critical roles ofγ-GGT and serum bilirubin in cardiovascular health,especially in the context of T2DM and *** providing a balanced view of the body’s oxidative and antioxidative mechanisms,these insights suggest potential pathways for targeted interventions and improved prognostic assessments in patients with T2DM and *** synthesis not only corroborates the pivotal role ofγ-GGT in cardiovascular pathology but also introduces the protective potential of antioxidants like bilirubin,illuminating the complex interplay between T2DM and heart *** studies collectively underscore the critical roles of serum bilirubin andγ-GGT as biomarkers in cardiovascular health,particularly in T2DM and ACS contexts,offering insights into the body’s oxidative and antioxidative *** synthesis of research supports the potential of these biomarkers in guiding therapeutic strategies and improving prognostic assessments for patients with T2DM and some CVD.

关键词： Type-2 diabetes mellitus Acute coronary syndrome Serum biomarkers γ-glutamyltranspeptidase Bilirubin Cardiovascular disease

A Hybrid Classification and Identification of Pneumonia Using African Buffalo Optimization and CNN from Chest X-Ray Images

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2497-2517页

作者： Nasser alalwan ahmed I.Taloba Amr Abozeid ahmed Ibrahim alzahrani ali H.al-Bayatti Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Information System Department Faculty of Computers and InformationAssiut UniversityAssiutEgypt Mathematics Department Faculty of ScienceAl-Azhar UniversityCairoEgypt Cyber Technology Institute(CTI) De Montfort UniversityLeicesterUK

An illness known as pneumonia causes inflammation in the *** there is so much information available fromvarious X-ray images,diagnosing pneumonia has typically proven *** improve image quality and speed up the diagnosis of pneumonia,numerous approaches have been *** date,several methods have been employed to identify *** Convolutional Neural Network(CNN)has achieved outstanding success in identifying and diagnosing diseases in the fields of medicine and ***,these methods are complex,inefficient,and imprecise to analyze a big number of *** this paper,a new hybrid method for the automatic classification and identification of Pneumonia from chest X-ray images is *** proposed method(ABOCNN)utilized theAfrican BuffaloOptimization(ABO)algorithmto enhanceCNNperformance and *** Weinmed filter is employed for pre-processing to eliminate unwanted noises from chest X-ray images,followed by feature extraction using the Grey Level Co-Occurrence Matrix(GLCM)*** features are then selected from the dataset using the ABO algorithm,and ultimately,high-performance deep learning using the CNN approach is introduced for the classification and identification of *** results on various datasets showed that,when contrasted to other approaches,the ABO-CNN outperforms them all for the classification *** proposed method exhibits superior values like 96.95%,88%,86%,and 86%for accuracy,precision,recall,and F1-score,respectively.

关键词： African buffalo optimization convolutional neural network pneumonia X-ray

Seimatoric acid and colletonoic acid:Two new compounds from the endophytic fungi,Seimatosporium *** Colletotrichum sp.

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Chinese Chemical Letters 2014年第12期25卷 1577-1579页

作者： Hidayat Hussain Natalia Root Farah Jabeen ahmed al-harrasi ahmed al-Rawahi Manzoor Ahmad Zahid Hassan Ghulam Abbas Fazal Mabood Afzal Shah Amin Badshah Amjad Khan Riaz Ahmad Ivan R.Green Siegfried Draeger Barbara Schulz Karsten Krohn Department of Chemistry University of PaderbornWarburger Strasse 100Paderborn 33098Germany UoN Chair of Oman's Medicinal Plants and Marine Natural Products University of NizwaP.O.Box 33Postal Code 616Birkat Al MauzNizwaOman Department of Chemistry University of MalakandChakdaraDir(L)Pakistan Department of Chemistry CIITAbbottabad CampusAbbottabad 22060Pakistan Department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Chemistry and Polymer Science University of StellenboschP/Bag X1Matieland 7602South Africa Institute of Microbiology University of BraunschweigSpielmannstraβe 7Braunschweig 38106Germany

A new metabolite,named seimatoric acid（1）,representing a new oxobutanoic acid derivative has been isolated from Seimatosporium sp., in addition to four known compounds viz.,2-hydroxymethyl-4β,5α,6β-trihydroxycyclohex-2-enone（2）,（-）-phyllostine（3）,（＋）-epiepoxydon（4） and（＋）-epoxydon monoacetate（5）.Similarly one new benzoic acid derivative,named colletonoic acid（6） was isolated from the ethyl acetate fraction of Colletotrichum *** structures of the new compounds were elucidated by detailed ^1 H NMR,^13C NMR,COSY,*** spectroscopic analysis,and *** acid（1）was also isolated from another taxonomical unidentified fungal strain 4295 in *** structures of the known compounds were elucidated by their spectral data comparison to literature *** studies showed that colletonoic acid（6） showed good antibacterial,antifungal,and antialgal activities.

关键词： Seimatosporium sp. Colletotrichum sp. Activity Natural product

Numerical Treatments for Crossover Cancer Model of Hybrid Variable-Order Fractional Derivatives

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1619-1645页

作者： Nasser Sweilam Seham al-Mekhlafi Aya ahmed Ahoud alsheri Emad Abo-Eldahab Mathematics Department Faculty of ScienceCairo UniversityGiza12613Egypt Mathematics Department Faculty of EducationSana’a UniversitySana’a1247Yemen Mathematics Department Faculty of ScienceHelwan UniversityCairo11795Egypt Department of Mathematics College of ScienceUniversity of BishaAl Namas67398-5644Saudi Arabia

In this paper,two crossover hybrid variable-order derivatives of the cancer model are ***ünwald-Letnikov approximation is used to approximate the hybrid fractional and variable-order fractional *** existence,uniqueness,and stability of the proposed model are *** Bashfourth’s fifth-step method with a hybrid variable-order fractional operator is developed to study the proposed *** studies with generalized fifth-order Runge-Kutta method are *** examples and comparative studies to verify the applicability of the used methods and to demonstrate the simplicity of these approximations are *** have showcased the efficiency of the proposed method and garnered robust empirical support for our theoretical findings.

关键词： Cancer diseases hybrid variable-order fractional derivatives adams bashfourth fifth step generalized fifth order Runge-Kutta method

Efficient ECG classification based on Chi-square distance for arrhythmia detection

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Journal of Electronic Science and Technology 2024年第2期22卷 1-15页

作者： Dhiah al-Shammary Mustafa Noaman Kadhim ahmed M.Mahdi Ayman Ibaida Khandakar ahmedb College of Computer Science and Information Technology University of Al-QadisiyahAl Diwaniyah58001Iraq Intelligent Technology Innovation Lab Victoria UniversityMelbourne3011Australia

This study introduces a new classifier tailored to address the limitations inherent in conventional classifiers such as K-nearest neighbor(KNN),random forest(RF),decision tree(DT),and support vector machine(SVM)for arrhythmia *** proposed classifier leverages the Chi-square distance as a primary metric,providing a specialized and original approach for precise arrhythmia *** optimize feature selection and refine the classifier’s performance,particle swarm optimization(PSO)is integrated with the Chi-square distance as a fitness *** synergistic integration enhances the classifier’s capabilities,resulting in a substantial improvement in accuracy for arrhythmia *** results demonstrate the efficacy of the proposed method,achieving a noteworthy accuracy rate of 98% with PSO,higher than 89% achieved without any previous *** classifier outperforms machine learning(ML)and deep learning(DL)techniques,underscoring its reliability and superiority in the realm of arrhythmia *** promising results render it an effective method to support both academic and medical communities,offering an advanced and precise solution for arrhythmia detection in electrocardiogram(ECG)data.

关键词： Arrhythmia classification Chi-square distance Electrocardiogram(ECG)signal Particle swarm optimization(PSO)