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Clinical and experimental studies on polyherbal formulations for diabetes: current status and future prospective

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Journal of Integrative Medicine 2014年第4期12卷 336-345页

作者： ahmad ghorbani Pharmacological Research Center of Medicinal Plants School of Medicine Mashhad University of Medical Sciences

Diabetes is a leading cause of morbidity an active search for antidiabetic drugs with greater and mortality in the world. There is currently effectiveness with fewer and less adverse side effects. Although numerous individual herbs have been experimentally or clinically reported to possess antidiabetic effects, considerably less research has been conducted on polyherbal compounds. It is believed that herbal compounds containing multiple plant products have synergistic antidiabetic effects and could enhance the desired actions. Several polyherbal formulations have been studied as therapeutic agents in diabetes management. To describe the current state of research on polyherbal compounds in the treatment of diabetes, an extensive review of literature was undertaken on several major databases. This paper presents what is known about the efficacy of these polyherbal formulations and compare their antidiabetic effects with those of current oral hypoglycemic drugs as reference. The percent decrease in blood glucose, lipids and other biochemical parameters achieved by each product in diabetic animals and patients is reported. Also, the possible mechanisms responsible for hypoglycemic action of polyherbal formulations are discussed.

关键词： diabetes mellitus hypoglycemic agents plants, medicinal review

Erratum to: Coefficient of consolidation by end of arc method

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Journal of Central South University 2015年第3期22卷 1166-1166页

作者： Mohsen Abbaspour Reza Porhoseini Kazem Barkhordari ahmad ghorbani School of Technical & Engineering Department of Civil Engineering Yazd UniversityUniversity Blvd School of Mining and Metallurgy Department of Mine Exploration Yazd UniversityUniversity Blvd

Erratum to:*** Univ.(2015)22:332-337DOI:10.1007/s11771-015-2526-6The original version of this article unfortunately contained two *** mistakes are corrected as follows:1)The spelling of the first author is *** correct... 详细信息

关键词： Coefficient of consolidation by end of arc method Erratum to

Pathological consequences of C-peptide deficiency in insulin-dependent diabetes mellitus

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World Journal of Diabetes 2015年第1期6卷 145-150页

作者： ahmad ghorbani Reza Shafiee-Nick Pharmacological Research Center of Medicinal Plants School of Medicine Mashhad University of Medical Sciences Department of Pharmacology School of Medicine Mashhad University of Medical Sciences

Diabetes is associated with several complications such as retinopathy, nephropathy, neuropathy and cardiovascular diseases. Currently, insulin is the main used medication for management of insulin-dependentdiabetes mellitus(type-1 diabetes). In this metabolic syndrome, in addition to decrease of endogenous insulin, the plasma level of connecting peptide(C-peptide) is also reduced due to beta cell destruction. Studies in the past decade have shown that C-peptide is much more than a byproduct of insulin biosynthesis and possess different biological activities. Therefore, it may be possible that C-peptide deficiency be involved, at least in part, in the development of different complications of diabetes. It has been shown that a small level of remaining C-peptide is associated with significant metabolic benefit. The purpose of this review is to describe beneficial effects of C-peptide replacement on pathological features associated with insulin-dependent diabetes. Also, experimental and clinical findings on the effects of C-peptide on wholebody glucose utilization, adipose tissue metabolism and tissues blood flow are summarized and discussed. The hypoglycemic, antilipolytic and vasodilator effects of C-peptide suggest that it may contribute to fine-tuning of the tissues metabolism under different physiologic or pathologic conditions. Therefore, C-peptide replacement together with the classic insulin therapy may prevent, retard, or ameliorate diabetic complications in patients with type-1 diabetes.

关键词： C-peptide Diabetes Insulin Nephropathy Neuropathy

不同丁香提取物对戊四唑诱导的小鼠癫癎发作的影响(英文)

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中西医结合学报 2012年第12期10卷 1476-1481页

作者： Mahmoud Hosseini Taha Jafarianheris Navid Seddighi Mohammad Parvaneh ahmad ghorbani Hamid Reza Sadeghnia Hassan Rakhshandeh Neuroscience Research Center and Department of Physiology School of Medicine Mashhad University of Medical Sciences Neuroscience Research Center and Department of Pharmacology School of Medicine Mashhad University of Medical Sciences Pharmacological Research Center of Medicinal Plants School of Medicine Mashhad University of Medical Sciences

目的:研究不同丁香提取物对戊四唑引发小鼠癫癎的作用。方法:实验小鼠被随机分为生理盐水对照组、不同剂量(50、100、250及500mg/kg)丁香水提取物组、不同剂量(50、100、250及500mg/kg)丁香乙醇提取物组、不同剂量(50、100、250及500mg/... 详细信息

目的:研究不同丁香提取物对戊四唑引发小鼠癫癎的作用。方法:实验小鼠被随机分为生理盐水对照组、不同剂量(50、100、250及500mg/kg)丁香水提取物组、不同剂量(50、100、250及500mg/kg)丁香乙醇提取物组、不同剂量(50、100、250及500mg/kg)丁香三氯甲烷提取物组。给予戊四唑前60min为各组小鼠注射药物。记录并比较各组小鼠阵发性强直性抽搐潜伏期(generalized tonic-clonic seizure,GTCS)、最小阵发性痉挛潜伏期(minimal clonic seizure,MCS)及死亡率。结果:低、中、高三种剂量的丁香水提取物能有效延长MSC和GTCS的潜伏期(P<0.05)。50、100和250mg/kg的丁香乙醇提取物显著增加了小鼠MCS潜伏时间(P<0.05)。与盐水治疗组相比,惊厥小鼠模型经50、100、250和500mg/kg丁香的乙醇提取物治疗后,其GTCS的潜伏期显著高于盐水治疗组,但丁香的三氯甲烷提取物对惊厥小鼠的GTCS和MCS潜伏期没有显著的影响。结论:丁香乙醇和水提取物能抑制由戊四唑诱发的小鼠惊厥,但其确切的作用机制和有效的抗惊厥活性物质还有待进一步的研究。

关键词：丁香戊四唑癫癎发作小鼠

A locality-based replication manager for data cloud

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Frontiers of Information Technology & Electronic Engineering 2016年第12期17卷 1275-1286页

作者： Reza SOOKHTSARAEI Javad ARTIN Ali ghorbani ahmad FARAAHI Hadi ADINEH Department of Computer Engineering and Information Technology Payame Noor University Tehran Iran Department of Industrial Engineering Faculty of Engineering Maziar University Noor Iran

Efficient data management is a key issue for environments distributed on a large scale such as the data cloud. This can be taken into account by replicating the data. The replication of data reduces the time of service and the delay in availability, increases the availability, and optimizes the distribution of load in the system. It is worth mentioning, however, that with the replication of data, the use of resources and energy increases due to the storing of copies of the data. We suggest a replication manager that decreases the cost of using resources, energy, and the delay in the system, and also increases the availability of the system. To reach this aim, the suggested replication manager, called the locality replication manager （LRM）, works by using two important algorithms that use the physical adjacency feature of blocks. In addition, a set of simulations are reported to show that LRM can be a suitable option for distributed systems as it uses less energy and resources, optimizes the distribution of load, and has more availability and less delay.

关键词： Data cloud Replication Graph Locality replication manager (LRM)

A Novel High CMRR, Low Power and Low Voltage COS with QFG

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Circuits and Systems 2012年第3期3卷 263-268页

作者： Alireza ghorbani ahmad Ghanaatian Electronics Research Iran University of Science and Technology Tehran Iran

A novel high CMRR current output stage (COS) with QFG is presented in this paper. A novel common mode feedback (CMFB) is used to reject the common mode signal in order to achieve high CMRR. The common mode signal is omitted by the technique of adding the main signal and its opposite polarity one. 112 dB of CMRR is obtained in 0.35 μm CMOS technology with ±0.75 v supply voltage and only 182μw power dissipation which shows good improvement compared to the other work in the literature.

关键词： CMRR QFG Current Mode Current Oprational Amplifier COA COS

GIS-based landslide susceptibility modeling:A comparison between fuzzy multi-criteria and machine learning algorithms

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Geoscience Frontiers 2021年第2期12卷 857-876页

作者： Sk Ajim Ali Farhana Parvin Jana Vojteková Romulus Costache Nguyen Thi Thuy Linh Quoc Bao Pham Matej Vojtek Ljubomir Gigović Ateeque ahmad Mohammad Ali ghorbani Department of Geography Faculty of ScienceAligarh Muslim University(AMU)AligarhUP 202002India Department of Geography and Regional Development Faculty of Natural SciencesConstantine the Philosopher University in NitraTrieda A.Hlinku 194901 NitraSlovakia Research Institute of the University of Bucharest 90-92 Sos.Panduri5th DistrictBucharest 050663Romania National Institute of Hydrology and Water Management București-Ploiești Road97E1st DistrictBucharest 013686Romania Thuyloi University 175 Tay SonDong DaHanoiViet Nam Institute of Research and Development Duy Tan UniversityDanang 550000Viet Nam Faculty of Environmental and Chemical Engineering Duy Tan UniversityDanang 550000Viet Nam Department of Geography University of Defence11000 BelgradeSerbia Sustainable Management of Natural Resources and Environment Research Group Faculty of Environment and Labour SafetyTon Duc Thang UniversityHo Chi Minh CityViet Nam

Hazards and disasters have always negative impacts on the way of *** is an overwhelming natural as well as man-made disaster that causes loss of natural resources and human properties throughout *** present study aimed to assess and compare the prediction efficiency of different models in landslide susceptibility in the Kysuca river basin,*** this regard,the fuzzy decision-making trial and evaluation laboratory combining with the analytic network process(FDEMATEL-ANP),Naïve Bayes(NB)classifier,and random forest(RF)classifier were ***,a landslide inventory map was produced with 2000 landslide and nonlandslide points by randomly dividedwith a ratio of 70%:30%for training and testing,*** geospatial database for assessing the landslide susceptibility was generated with the help of 16 landslide conditioning factors by allowing for topographical,hydrological,lithological,and land cover *** ReliefF methodwas considered for determining the significance of selected conditioning factors and inclusion in the model ***,the landslide susceptibility maps(LSMs)were generated using the FDEMATEL-ANP,Naïve Bayes(NB)classifier,and random forest(RF)classifier ***,the area under curve(AUC)and different arithmetic evaluation were used for validating and comparing the results and *** results revealed that random forest(RF)classifier is a promising and optimum model for landslide susceptibility in the study area with a very high value of area under curve(AUC=0.954),lower value of mean absolute error(MAE=0.1238)and root mean square error(RMSE=0.2555),and higher value of Kappa index(K=0.8435)and overall accuracy(OAC=92.2%).

关键词： Landslide susceptibility modeling Geographic information system Fuzzy DEMATEL Analytic network process Naïve Bayes classifier Random forest classifier

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基于位置的数据云复制管理器（英文）

Frontiers of Information Technology & Electronic Engineering 2016年第12期 1275-1287页

作者： Reza SOOKHTSARAEI Javad ARTIN Ali ghorbani ahmad FARAAHI Hadi ADINEH Department of Computer Engineering and Information Technology Payame Noor University

有效的数据处理是大规模分布式环境(如云数据)中的一个关键性问题,其中需要考虑到数据的复制。数据复制可以减少服务时间和获取数据所需的时间,增加可用性并优化系统负载分布。然而值得一提的是,数据的同样会增加储存数据所需的资源和... 详细信息

有效的数据处理是大规模分布式环境(如云数据)中的一个关键性问题,其中需要考虑到数据的复制。数据复制可以减少服务时间和获取数据所需的时间,增加可用性并优化系统负载分布。然而值得一提的是,数据的同样会增加储存数据所需的资源和能源。我们提出了一种可减少资源、能源消耗,减少系统延迟,并增加系统可用性的复制管理器,称为位置复制管理器(Locality replication manager,LRM)。这一管理器采用的两种重要算法利用了数据块之间的物理邻接特性。对LRM进行的一系列模拟结果显示,LRM消耗了较少的资源和能源,优化了系统负载分布,并增加了系统可用性,减少了系统延迟,因此适用对于分布式系统。

关键词：数据云复制图形位置复制管理器

The Impact of Season, Parity, and Volume of Colostrum on Holstein Dairy Cows Colostrum Composition

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Agricultural Sciences 2017年第7期8卷 572-581页

作者： Soheila Zarei Gholam Reza ghorbani Mohammad Khorvash O'Brien Martin Amir Hossein Mahdavi ahmad Riasi Department of Animal Sciences College of Agriculture Isfahan University of Technology Isfahan Iran Department of Animal Science Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan

The objectives of the study were to assess colostrum quality and nutrients in dairy cows in Isfahan, Iran, and to determine the effects of calving season, parity, and volume of first colostrum on colostrum quality. Colostrum samples were collected over the period January-December, from 365 Holstein dairy cows from 12 dairy farms and analyzed for their IgG, IgM, total solids, fat, protein, lactose, Ca, and P concentrations. The IgG and IgM contents were measured to be 35.8 ± 17.6 and 5.8 ± 3.8 mg/mL, respectively. Mean percentages of total solids, fat, protein, and lactose in the samples were 27.2 ± 5.8, 4.6 ± 3.4, 18.5 ± 4.9, and 2.0 ± 0.9, respectively while calcium and P concentrations were 2.69 ± 0.9 and 2.02 ± 0.88 g/kg. Colostral IgG and IgM concentrations were found to be higher during the winter months. Calving season affected lactose, Ca, and P concentrations as evidenced by the higher colostral lactose percentages in cows calved in the fall but higher calcium and P concentrations in those calved in the summer. Parity had no significant effects on IgG and IgM concentrations. However, a decreasing trend was observed in Ca and P concentrations with increasing parity. Volume of first milking colostrum did not have any effect on colostral composition. The findings of this study indicate that colostrum quality may be affected by calving season.

关键词： Immunoglobulin Colostrum Parity Season Volume of Colostrum