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Exploitation of the antibacterial,antibiofilm and antioxidant activities of salvadora Persica(Miswak)extract

Journal of Bioresources and Bioproducts 2023年第1期8卷 59-65页

作者： Gamal M.el-sherbiny Ahmed Mohamed Gazelly Mohammed H.sharaf saad A.Moghannemm shehata M.E Mahmoud K.A.Ismail ahmad s.el-hawary Botany and Microbiology Department Faculty of Science(Boys)Al-Azhar UniversityCairo 11884Egypt

The salvadora persica(***)*** stick,usually known as miswak,is still being em-ployed as an oral hygiene agent for plaque and gingivitis *** study aims to assess the antibacterial,antibiofilm,antioxidant,and phytochemical profile of *** *** ***-sica was purchased from a local market,grinded and extracted with petroleum *** disk dif-fusion,microdilution,and micro-plate assays were performed to evaluate the antibacterial and an-tibiofilm activities of the prepared extract at different concentrations against𝛽-lactam resistance streptococcus *** radical scavenging 2,2-diphenyl-1-picrylhydrazyl(DPPH)and stable radical cationic chromophore,2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate)(ABTs)methods were used to determine their antioxidant *** and spectrometric analyses were performed using gas chromatography-mass(GC-Ms)*** minimum inhibitory concentration(MIC)of *** extract against𝛽-lactam resistance streptococcus species ranged from 6.25 to 12.5 mg/*** maximum suppression of biofilm formation by *** extract was observed at MIC with a percentage of 68.66%,against streptococcus *** *** ex-tract exhibited antioxidant activity with IC 50 of 20μg/mL and 35μg/mL from DPPH and ABTs,*** phytochemical characterization showed the presence of 22 compounds with ma-jor compounds;benzyl isothiocyanate(36.21%)and n-hexadecanoic acid(27.62%).The *** extract exhibited antibacterial activity against𝛽-lactam resistant streptococcus species,showing a promising natural alternative that could be a treatment option.

关键词： β-lactam resistance streptococcus species s.persica extract Antibacterial Antibiofilm Antioxidant GC-Ms analysis

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Machine learning-enhanced Monte Carlo and subset simulations for advanced risk assessment in transportation infrastructure

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Journal of Mountain science 2024年第2期21卷 690-717页

作者： Furquan ahmad Pijush sAMUI s.s.MIsHRA Department of Civil Engineering National Institute of TechnologyPatna 800006India

The maintenance of safety and dependability in rail and road embankments is of utmost importance in order to facilitate the smooth operation of transportation *** study introduces a comprehensive methodology for soil slope stability evaluation,employing Monte Carlo simulation(MCs)and subset simulation(ss)with the"UPss 3.0 Add-in"in *** on an 11.693-meter embankment with a soil slope(inclination ratio of 2H:1V),the investigation considers earthquake coefficients(kh)and pore water pressure ratios(ru)following Indian zoning *** chance of slope failure showed a considerable increase as the Coefficient of Variation(COV),seismic coefficients(kh),and pore water pressure ratios(ru)experienced an *** ss approach showed exceptional efficacy in calculating odds of failure that are notably *** computational modeling,the study optimized the worst-case scenario using ANFIs-GA,ANFIs-GWO,ANFIs-PsO,and ANFIs-BBO *** ANFIs-PsO model exhibits exceptional accuracy(training R2=0.9011,RMsE=0.0549;testing R2=0.8968,RMsE=0.0615),emerging as the most *** study highlights the significance of conducting thorough risk assessments and offers practical insights into evaluating and improving the stability of soil slopes in transportation *** findings contribute to the enhancement of safety and reliability in real-world situations.

关键词： Monte Carlo simulation subset simulation Machine Learning seismic coefficient

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Agmatine ameliorates diabetes type 2-induced nephropathy in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 8-16页

作者： Fatemah O.Kamel Ohoud shagroud Mai AAlim A.sattar ahmad Gamal s Abd el-Aziz Abdulhadi s.Burzangi Duaa Bakhshwin Maha Jamal shahid Karim Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Objective:To assess the nephroprotective potential of agmatine in a rat model of streptozotocin-induced diabetic ***:A single dose of streptozotocin(40 mg/kg)coupled with a fructose diet induced diabetes in Wistar ***(40 and 80 mg/kg)was administered to rats for 12 *** body weight and fasting blood glucose were measured *** level,urine output,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C were also determined at the end of the ***,superoxide dismutase,glutathione,interleukin-1β,interleukin-6,and tumor necrosis factor-alpha were evaluated in kidney *** study was also performed using hematoxylin and eosin ***:Agmatine at both doses significantly increased final body weight,and lowered fasting blood glucose,urine output,insulin,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C levels compared with the diabetic group(Ps and antioxidant effect were significantly improved in agmatine-treated ***,the histopathological changes in renal structure were ameliorated by agmatine ***:Agmatine alleviates diabetic nephropathy by improving renal functions and reducing inflammation and oxidative *** molecular mechanisms of its nephroprotective actions need to be investigated in future study.

关键词： Agmatine Type 2 diabetes Nephropathy Oxidative stress Nephroprotection

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Optoelectronic and thermoelectric properties of spinel chalcogenides HgLa2X4（X=s and se）:A first-principles study

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Journal of Rare Earths 2024年第10期42卷 1927-1936页

作者： Aparna Dixit Inas A.Ahmed Jisha Annie Abraham Zeinhom M.el-Bahy Mumtaz Manzoor sajad ahmad Dar Ramesh sharma Department of Basic science and Humanities Pranveer Singh Institute of Technology Department of Chemistry Faculty of ScienceKing Khalid University Department of Physics National Defence Academy Department of Chemistry Faculty of ScienceAl-Azhar University Institute of Physics Slovak Academy of Sciences Department of Physics Motilal Vigyan Mahavidyalya College Department of Applied science Feroze Gandhi Institute of Engineering and Technology

We investigated spinel chalcogenides HgLa2（s/se）4by using density function theory,and scrutinized the structural,optical,electrical,mechanical and thermoelectric transport characteristics of HgLa2（s/se）4spinel *** enthalpy of formation,energy of cohesion,and energy volume optimum plots were used to obtain the stability as well as the perfect ground state of these *** ductility of these materials was the best illustrated with the help of Poisson's and Pugh's *** band gap results were obtained using Trans and Blaha modified Becke-Johanson potential（TB-mBJ）.Both the materials present semi-conducting nature with direct band gap equal to 1.449 and 0.892 eV respectively for HgLa2s4and *** were also made for optical characteristics with the values of dielectric function,absorption coefficient,optical conductivity,reflectivity,and refractive *** to the findings,both of these materials are suitable for infrared optoelectronic *** materials were found to have promising optoelectronic and thermoelectric applications after their optical properties and transport aspects were *** tiny levels of temperature conductivities,substantial am ounts of power conductivities,the figure of merit（more than unity）,as well as seebecs coefficients all point to the potential use of both the materials in thermoelectric power generators.

关键词： Density functional theory Direct band gap Optoelectronic Power factor semiconductors Thermoelectric

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Activation of cerebral Ras-related C3 botulinum toxin substrate(Rac) 1 promotes post-ischemic stroke functional recovery in aged mice

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Neural Regeneration Research 2024年第4期19卷 881-886页

作者： Fan Bu Jia-Wei Min Md Abdur Razzaque ahmad el Hamamy Anthony Patrizz Li Qi Akihiko Urayama Jun Li Department of Neurology University of Texas Health Science Center Department of Neurology&Psychology The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine

Brain functional impairment after stroke is common;however,the molecular mechanisms of post-stroke recovery remain *** is well-recognized that age is the most important independent predictor of poor outcomes after stroke as older patients show poorer functional outcomes following *** evidence suggests that axonal regeneration and angiogenesis,the major forms of brain plasticity responsible for post-stroke recovery,diminished with advanced *** studies suggest that Ras-related C3 botulinum toxin substrate(Rac)1 enhances stroke recovery as activation of Rac1 improved behavior recovery in a young mice stroke ***,we investigated the role of Rac1 signaling in long-term functional recovery and brain plasticity in an aged(male,18 to 22 months old C57BL/6J)brain after ischemic *** found that as mice aged,Rac1 expression declined in the *** overexpression of Rac1,using lentivirus encoding Rac1 injected day 1 after ischemic stroke,promoted cognitive(assessed using novel object recognition test)and sensorimotor(assessed using adhesive removal tests)recovery on days 14–*** was accompanied by the increase of neurite and proliferative endothelial cells in the periinfarct zone assessed by *** a reverse approach,pharmacological inhibition of Rac1 by intraperitoneal injection of Rac1 inhibitor NsC23766 for 14 successive days after ischemic stroke worsened the outcome with the reduction of neurite and proliferative endothelial ***,Rac1 inhibition reduced the activation of p21-activated kinase 1,the protein level of brain-derived neurotrophic factor,and increased the protein level of glial fibrillary acidic protein in the ischemic brain on day 28 after *** work provided insight into the mechanisms behind the diminished plasticity after cerebral ischemia in aged brains and identified Rac1 as a potential therapeutic target for improving functional recovery in the older adults after stroke.

关键词： aging angiogenesis brain-derived neurotrophic factor(BDNF) cerebral ischemia cognitive recovery neurite Pak1 Rac1 sensorimotor recovery

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Rotating effects on the thermophysical properties of a two-dimensional GaAs quantum ring

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Communications in Theoretical Physics 2024年第6期76卷 165-173页

作者： ahmad Ghanbari Department of Physics College of ScienceYasouj UniversityYasoujIran

In this work,we have investigated the rotating effect on the thermodynamic properties of a 2D quantum ***,we have considered the radial potential of a 2D quantum ring and solved the schrödinger equation in the presence of the Aharonov-Bohm effect and a uniform magnetic field for the considered *** to the solution of the equation,we calculated the eigenvalues and eigenfunctions of the considered *** the calculated energy spectrum,we obtained the partition function and thermodynamic properties of the system,such as the mean energy,specific heat,entropy and free *** results show that the rotating effect has a significant influence on the thermophysical properties of a 2D quantum *** also study other effects of the rotating term:(1)the effect of different values of rotating parameters,and(2)the effect of negative rotation on the thermodynamic properties of the *** results are discussed in detail.

关键词： schrodinger equation quantum ring rotation effect thermophysical properties

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Finite element model updating for structural damage detection using transmissibility data

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 87-101页

作者： ahmad Izadi Akbar Esfandiari Department of Maritime Engineering Amirkabir University of TechnologyTehran 15875-4413Iran

This paper presents a new finite element model updating method for estimating structural parameters and detecting structural damage location and severity based on the structural responses(output-only data).The method uses the sensitivity relation of transmissibility data through a least-squares algorithm and appropriate normalization of the extracted *** proposed transmissibility-based sensitivity equation produces a more significant number of equations than the sensitivity equations based on the frequency response function(FRF),which can estimate the structural parameters with higher *** abilities of the proposed method are assessed by using numerical data of a two-story two-bay frame model and a plate structure *** evaluating different damage cases,the number,location,and stiffness reduction of the damaged elements and the severity of the simulated damage have been accurately *** reliability and stability of the presented method against measurement and modeling errors are examined using error-contaminated *** parameter estimation results prove the method’s capabilities as an accurate model updating algorithm.

关键词： damage detection model updating output-only transmissibility sensitivity equation

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Correlation between structural phase transition and physical properties of Co^(2+)/Gd^(3+)co-substituted copper ferrite

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Journal of Rare Earths 2024年第7期42卷 1344-1353,I0006页

作者： Mohsen Choupani ahmad Gholizadeh school of Physics Damghan UniversityDamghan36716-45667Iran

The doping of the spinel ferrites with selective cations usually improves the properties of the parent *** effect of Co^(2+)/Gd^(3+)co-substitution on the microstructure,optical,and magnetic properties of Cu1-xCoxFe2-xGdxO4 prepared by the citrate-nitrate auto-combustion synthesis was *** of the samples was performed with powder X-ray diffraction(XRD),Raman and Fouriertransform infrared(FTIR)spectroscopy,field-emission scanning electron microscopy,X-ray energydispersive spectroscopy,UV-Vis spectroscopy,and a vibrating sample *** results of XRD,Raman,and FTIR analysis show a gradual structural phase transition from a tetragonal(I41/amd)structure to a cubic(Fd3m)*** bandgap energy of the studied samples is in a range of 1.57-1.75 eV with a minimum in sample x=0.06 and then *** investigations show that the presence of Co^(2+)/Gd^(3+)cations in an octahedral site of the copper ferrite structure could increase saturation magnetization and coercive field from 567.9 Oe and 23.62 emu/g to 929.4 Oe and 28.27 emu/g,respectively.

关键词： spinel copper ferrite Citrate-nitrate method structure phase transition Microstructure properties Magnetic properties Rare earths

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Evaluation of soil loss severity and ecological restoration approach for sustainable agriculture in the Hindu Kush, Karakoram and Himalaya region

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Journal of Mountain science 2024年第5期21卷 1509-1521页

作者： Arshad AsHRAF Imran ahmad Climate Energy and Water Research InstituteNational Agricultural Research Centre(NARC)Islamabad 44000Pakistan

soil erosion has resulted in removal of the topsoils containing fine soil particles and plant nutrients, causing decrease in soil fertility in the Hindu Kush, Karakoram and Himalaya(HKH) region. The existing production of cereal crop grains has been reduced to one third of the potential crop grains production owing to land degradation and poor farming practices. It is necessary to assess risk of soil loss and identify appropriate controlling measures to address issues of low agriculture productivity and water insecurity in the region. In the present study, severity of soil loss was predicted using Revised Universal Loss Equation(RUsLE) and ecological measures were identified for sustainable mountain agriculture in the HKH region of Upper Indus Basin, Pakistan. Overall 62.6% area was found to have very low risk of soil loss, i.e., sk, i.e., 5-25 t/(ha·yr) and 7.5% area moderate risk, i.e., 25-50 t/(ha·yr) in the region. The risk was high, i.e., 50-100 t/(ha·yr) and very high, i.e., >100 t/(ha·yr) in about 6.8% and 7.4% areas respectively. The mean rate of soil loss was about 41.9 t/(ha·yr) in the Hindu Kush, 31.1 t/(ha·yr) in the Himalayas, 18.8 t/(ha·yr) in the Karakoram and overall 29.7 t/(ha·yr) in the three HKH ranges. As such no considerable measures have been adopted by the communities for restoration of the degraded areas except raising fruit/farm trees and supporting limited social forestry for their livelihoods. The slopes cleared for cultivation and susceptible to erosion may be stabilized through sowing/planting of multi-purpose plant species and formation of proper bench terraces. The conservation of forest ecosystem and pastures at higher elevations would help in reducing overland water flow, risk of flash flood hazard and minimizing sediment loads in the downstream. It is essential to adopt site-specific resource conservation techniques and restore possible ecosystem health for sustainable agriculture and economic developm

关键词： Climate change Erodibility Indus basin Land degradation slope stabilization

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Federated Learning security and Privacy-Preserving Algorithm and Experiments Research Under Internet of Things Critical Infrastructure

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Tsinghua science and Technology 2024年第2期29卷 400-414页

作者： Nasir ahmad Jalali Hongsong Chen Department of Computer science University of Science and Technology Beijing(USTB)Beijing 100083China

The widespread use of the Internet of Things(IoTs)and the rapid development of artificial intelligence technologies have enabled applications to cross commercial and industrial band *** such systems,all participants related to commercial and industrial systems must communicate and generate ***,due to the small storage capacities of IoT devices,they are required to store and transfer the generated data to third-party entity called“cloud”,which creates one single point to store their ***,as the number of participants increases,the size of generated data also ***,such a centralized mechanism for data collection and exchange between participants is likely to face numerous challenges in terms of security,privacy,and *** address these challenges,Federated Learning(FL)has been proposed as a reasonable decentralizing approach,in which clients no longer need to transfer and store real data in the central ***,they only share updated training models that are trained over their private *** the same time,FL enables clients in distributed systems to share their machine learning models collaboratively without their training data,thus reducing data privacy and security ***,slow model training and the execution of additional unnecessary communication rounds may hinder FL applications from operating properly in a distributed ***,these unnecessary communication rounds make the system vulnerable to security and privacy issues,because irrelevant model updates are sent between clients and ***,in this work,we propose an algorithm for fully homomorphic encryption called Cheon-Kim-Kim-song(CKKs)to encrypt model parameters for their local information privacy-preserving *** proposed solution uses the impetus term to speed up model convergence during the model training ***,it establishes a secure communication channel between IoT devices and the *** a

关键词： Federated Learning(FL) Internet of Things(IoTs) lightweight Transport Layer security(iTLs) Cheon-Kim-Kim-song(CKKs)

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