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Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrahim H.Maleki ahmad reza bahrami Maryam M.Matin Department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral School of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotechnology Research Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative Medicine Research Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are highly diverse at genetic,epigenetic,and phenotypic levels,intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects,and recurrence of the *** on the role of heterogeneous subpopulations of cancer cells with varying cell-cycle dynamics and behavior during cancer progression and treatment;herein,we aim to establish a comprehensive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells that play pivotal roles in reducing the effects of chemotherapy:"resistant"and"tolerant"***,this review also highlights the impact of the quiescent phase of the cell cycle as a survival mechanism for cancer *** understanding the mechanisms under-lying the quiescence,it provides an insightful perspective on cancer stem cells(CsCs)and their dual and intertwined functions based on their cell cycle state in response to ***-over,CSCs,epithelial-mesenchymal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),which are mostly in a quiescent state of the cell cycle are proved to have multiple biological links and can be implicated in our viewpoint of cell cycle heterogeneity in ***,increasing our knowledge of cell cycle heterogeneity is a key to identifying new therapeutic solutions,and this emerging concept may provide us with new opportunities to prevent the dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle heterogeneity Quiescence Therapy resistance Therapy tolerance Tumor dormancy

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Isolation and molecular identification of cellulolytic bacteria from Dig Rostam hot spring and study of their cellulase activity

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BIOCELL 2020年第1期44卷 63-71页

作者： Sareh HAJIABADI Mansour MASHREGHI ahmad reza bahrami Kiarash GHAZVINI Maryam M.MATIN Department of Biology Faculty of ScienceFerdowsi University of MashhadMashhadIran Novel Diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of MashhadMashhadIran Microbiology Research Center&Department of Microbiology and Virology Ghaem Medical CenterMashhad University of Medical SciencesMashhadIran

Cellulose is the main structural component of lignocellulosic wastes that can be converted to sugars and biofuels by *** to wide applications of this enzyme in various industries around the world,cellulase is considered as the third industrial *** ability of thermophilic bacteria in the production of heat-stable cellulases has made them valuable tools in *** aim of this study was isolation and molecular identification of cellulolytic thermophile bacteria from Dig Rostam hot spring and investigating their cellulase *** were taken from water and sediments of this hot spring,and cellulolytic bacteria were enriched in media containing cellulose as the only carbon *** bacteria were incubated at 60℃,and single colonies were then isolated on solid *** red assay was used as a quick test for the qualitative screening of cellulase *** to these qualitative results,four colonies named CDB1,CDB2,CDB3,and CDB4 were isolated,and their growth curve and some other characteristics were determined by biochemical ***,endoglucanase,exoglucanase,and FPase activities of the isolates were investigated *** indicated that CDB1 exhibited the highest endoglucanase(0.096 U/mL)and exoglucanase(0.156 U/mL)activities among other isolates.16S rDNA partial sequencing indicated that CDB1 had 99%similarity to the genus Anoxybacillus,and the other isolates showed the highest similarity to the genus *** cellulase gene of CDB1 isolate with the highest cellulase activity was also cloned,and its sequence is reported for the first *** studies on this thermophilic enzyme might be useful for industrial applications.

关键词： Anoxybacillus Cellulase Enzyme activity assay Thermophilic bacteria 16S rDNA

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Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury

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Neural Regeneration Research 2014年第9期9卷 919-923页

作者： Fatemeh Anbari Mohammad Ali Khalili ahmad reza bahrami Arezoo Khoradmehr Fatemeh Sadeghian Farzaneh Fesahat Ali Nabi Research and Clinical Center for Infertility Shahid Sadoughi University of Medical Sciences Institute of Biotechnology Ferdowsi University of Mashhad

To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells.

关键词： nerve regeneration bone marrow mesenchymal stem cells traumatic brain injury intravenous administration cell differentiation neurologic function,cerebral cortex rats neural regeneration

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Rotating effects on the thermophysical properties of a two-dimensional GaAs quantum ring

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Communications in Theoretical Physics 2024年第6期76卷 165-173页

作者： ahmad Ghanbari Department of Physics College of ScienceYasouj UniversityYasoujIran

In this work,we have investigated the rotating effect on the thermodynamic properties of a 2D quantum ***,we have considered the radial potential of a 2D quantum ring and solved the Schrödinger equation in the presence of the Aharonov-Bohm effect and a uniform magnetic field for the considered *** to the solution of the equation,we calculated the eigenvalues and eigenfunctions of the considered *** the calculated energy spectrum,we obtained the partition function and thermodynamic properties of the system,such as the mean energy,specific heat,entropy and free *** results show that the rotating effect has a significant influence on the thermophysical properties of a 2D quantum *** also study other effects of the rotating term:(1)the effect of different values of rotating parameters,and(2)the effect of negative rotation on the thermodynamic properties of the *** results are discussed in detail.

关键词： Schrodinger equation quantum ring rotation effect thermophysical properties

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Finite element model updating for structural damage detection using transmissibility data

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 87-101页

作者： ahmad Izadi Akbar Esfandiari Department of Maritime Engineering Amirkabir University of TechnologyTehran 15875-4413Iran

This paper presents a new finite element model updating method for estimating structural parameters and detecting structural damage location and severity based on the structural responses(output-only data).The method uses the sensitivity relation of transmissibility data through a least-squares algorithm and appropriate normalization of the extracted *** proposed transmissibility-based sensitivity equation produces a more significant number of equations than the sensitivity equations based on the frequency response function(FRF),which can estimate the structural parameters with higher *** abilities of the proposed method are assessed by using numerical data of a two-story two-bay frame model and a plate structure *** evaluating different damage cases,the number,location,and stiffness reduction of the damaged elements and the severity of the simulated damage have been accurately *** reliability and stability of the presented method against measurement and modeling errors are examined using error-contaminated *** parameter estimation results prove the method’s capabilities as an accurate model updating algorithm.

关键词： damage detection model updating output-only transmissibility sensitivity equation

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Correlation between structural phase transition and physical properties of Co^(2+)/Gd^(3+)co-substituted copper ferrite

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Journal of Rare Earths 2024年第7期42卷 1344-1353,I0006页

作者： Mohsen Choupani ahmad Gholizadeh School of Physics Damghan UniversityDamghan36716-45667Iran

The doping of the spinel ferrites with selective cations usually improves the properties of the parent *** effect of Co^(2+)/Gd^(3+)co-substitution on the microstructure,optical,and magnetic properties of Cu1-xCoxFe2-xGdxO4 prepared by the citrate-nitrate auto-combustion synthesis was *** of the samples was performed with powder X-ray diffraction(XRD),Raman and Fouriertransform infrared(FTIR)spectroscopy,field-emission scanning electron microscopy,X-ray energydispersive spectroscopy,UV-Vis spectroscopy,and a vibrating sample *** results of XRD,Raman,and FTIR analysis show a gradual structural phase transition from a tetragonal(I41/amd)structure to a cubic(Fd3m)*** bandgap energy of the studied samples is in a range of 1.57-1.75 eV with a minimum in sample x=0.06 and then *** investigations show that the presence of Co^(2+)/Gd^(3+)cations in an octahedral site of the copper ferrite structure could increase saturation magnetization and coercive field from 567.9 Oe and 23.62 emu/g to 929.4 Oe and 28.27 emu/g,respectively.

关键词： Spinel copper ferrite Citrate-nitrate method Structure phase transition Microstructure properties Magnetic properties Rare earths

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Manakov model of coupled NLS equation and its optical soliton solutions

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Journal of Ocean Engineering and Science 2024年第4期9卷 364-372页

作者： Esra Unal Yilmaz Farid Samsami Khodad Yesim Saglam Ozkan reza Abazari A.E.Abouelregal Mayssam Tarighi Shaayesteh Hadi rezazadeh Hijaz ahmad Department of Mathematics Bolu Abant Izzet Baysal UniversityBoluTurkey Faculty of Engineering Technology Amol University of Special Modern TechnologiesAmolIran Department of Mathematics Bursa Uludag UniversityBursaTurkey Department of Mathematics and Applications University of Mohaghegh ArdabiliArdabilIran Department of Mathematics College of Science and ArtsAl-QurayatJouf UniversitySaudi Arabia Basic Sciences Research Unit Jouf UniversitySaudi Arabia Amir Kabir University TehranIran Mathematics in Applied Sciences and Engineering Research Group Scientific Research CenterAl-Ayen UniversityNasiriyah 64001Iraq Section of Mathematics International Telematic University UninettunoCorso Vittorio Emanuele II39Roma 00186Italy

In the field of maritime transport,motion and energy,the dynamics of deep-sea waves is one of the major problems in ocean science.A mathematical modeling of dynamics of solitary waves in deep sea under the two-layer stratification leads to NLS equation,and consequently,the interaction two of them can be formulated by coupled NLS *** this work,extended auxiliary equation and the exp(−ω(χ))-expansion methods are employed to make the optical solutions of the Manakov model of coupled NLS *** methods used in this paper,in addition to providing the analysis of individual wave solutions,also provide general optical *** previously known solutions can be obtained by some special selections of parameters obtained by solving systems of algebraic *** this stage,it is more practical and convenient to apply methods with a symbolic calculation system.

关键词： Manakov model Extended auxiliary equation method Optical solutions Solitons

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Evaluation of soil loss severity and ecological restoration approach for sustainable agriculture in the Hindu Kush, Karakoram and Himalaya region

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Journal of Mountain Science 2024年第5期21卷 1509-1521页

作者： Arshad ASHRAF Imran ahmad Climate Energy and Water Research InstituteNational Agricultural Research Centre(NARC)Islamabad 44000Pakistan

Soil erosion has resulted in removal of the topsoils containing fine soil particles and plant nutrients, causing decrease in soil fertility in the Hindu Kush, Karakoram and Himalaya(HKH) region. The existing production of cereal crop grains has been reduced to one third of the potential crop grains production owing to land degradation and poor farming practices. It is necessary to assess risk of soil loss and identify appropriate controlling measures to address issues of low agriculture productivity and water insecurity in the region. In the present study, severity of soil loss was predicted using Revised Universal Loss Equation(RUSLE) and ecological measures were identified for sustainable mountain agriculture in the HKH region of Upper Indus Basin, Pakistan. Overall 62.6% area was found to have very low risk of soil loss, i.e., 100 t/(ha·yr) in about 6.8% and 7.4% areas respectively. The mean rate of soil loss was about 41.9 t/(ha·yr) in the Hindu Kush, 31.1 t/(ha·yr) in the Himalayas, 18.8 t/(ha·yr) in the Karakoram and overall 29.7 t/(ha·yr) in the three HKH ranges. As such no considerable measures have been adopted by the communities for restoration of the degraded areas except raising fruit/farm trees and supporting limited social forestry for their livelihoods. The slopes cleared for cultivation and susceptible to erosion may be stabilized through sowing/planting of multi-purpose plant species and formation of proper bench terraces. The conservation of forest ecosystem and pastures at higher elevations would help in reducing overland water flow, risk of flash flood hazard and minimizing sediment loads in the downstream. It is essential to adopt site-specific resource conservation techniques and restore possible ecosystem health for sustainable agriculture and economic developm

关键词： Climate change Erodibility Indus basin Land degradation Slope stabilization

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Molecular investigation of exoU and exoY virulence genes in Pseudomonas aeruginosa collected from hospitalized patients in North of Iran:A descriptive-analytical study

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Journal of Acute Disease 2024年第2期13卷 74-80页

作者： ahmad reza Moradi Mehrdad Gholami Lotfollah Davoodi Negar Hajilou Hamid reza Goli Sana Institute of Higher Education SariIran Department of Medical Microbiology and Virology Faculty of MedicineMazandaran University of Medical SciencesSariIran Antimicrobial Resistance Research Center Faculty of MedicineMazandaran University of Medical SciencesSariIran Molecular and Cell Biology Research Center Faculty of MedicineMazandaran University of Medical SciencesSariIran

Objective:To investigate the frequency of exoU and exoY genes in patients with Pseudomonas aeruginosa ***:In this study,100 clinical isolates of Pseudomonas aeruginosa were collected from patients hospitalized in educational-therapeutic hospitals and were identified using standard microbiological ***,the antibiotic resistance pattern of the isolates was determined by the disk agar diffusion *** bacterial DNAs were extracted by the alkaline lysis ***,the presence of exoU and exoY genes was evaluated by the PCR ***:In this study,47%,72%,29%,39%,40%,and 44%of the isolates were non-susceptible to piperacillin,aztreonam,ceftazidime,imipenem,tobramycin,and ciprofloxacin,*** addition,95%and 93%of the clinical isolates carried the exoU and exoY *** and fecal isolates had both virulence genes,while only one wound isolate had neither ***,all urinary isolates contained the exoY gene and only one isolate lacked the exoU ***,88 isolates simultaneously had both exoU and exoY ***:High prevalence of exoU and exoY genes in this region indicates a significant role of typeⅢsecretion system in pathogenesis of Pseudomonas *** typeⅢsecretion system may be a suitable target to reduce the pathogenicity of this bacterium.

关键词： Pseudomonas aeruginosa exoU exoY Virulence gene TypeⅢsecretion system PCR

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Federated Learning Security and Privacy-Preserving Algorithm and Experiments Research Under Internet of Things Critical Infrastructure

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Tsinghua Science and Technology 2024年第2期29卷 400-414页

作者： Nasir ahmad Jalali Hongsong Chen Department of Computer Science University of Science and Technology Beijing(USTB)Beijing 100083China

The widespread use of the Internet of Things(IoTs)and the rapid development of artificial intelligence technologies have enabled applications to cross commercial and industrial band *** such systems,all participants related to commercial and industrial systems must communicate and generate ***,due to the small storage capacities of IoT devices,they are required to store and transfer the generated data to third-party entity called“cloud”,which creates one single point to store their ***,as the number of participants increases,the size of generated data also ***,such a centralized mechanism for data collection and exchange between participants is likely to face numerous challenges in terms of security,privacy,and *** address these challenges,Federated Learning(FL)has been proposed as a reasonable decentralizing approach,in which clients no longer need to transfer and store real data in the central ***,they only share updated training models that are trained over their private *** the same time,FL enables clients in distributed systems to share their machine learning models collaboratively without their training data,thus reducing data privacy and security ***,slow model training and the execution of additional unnecessary communication rounds may hinder FL applications from operating properly in a distributed ***,these unnecessary communication rounds make the system vulnerable to security and privacy issues,because irrelevant model updates are sent between clients and ***,in this work,we propose an algorithm for fully homomorphic encryption called Cheon-Kim-Kim-Song(CKKS)to encrypt model parameters for their local information privacy-preserving *** proposed solution uses the impetus term to speed up model convergence during the model training ***,it establishes a secure communication channel between IoT devices and the *** a

关键词： Federated Learning(FL) Internet of Things(IoTs) lightweight Transport Layer Security(iTLS) Cheon-Kim-Kim-Song(CKKS)

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