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Genotypic Analysis Revealed Association of HLA Alleles with Clinical Parameters in Bangladeshi Patients with Rheumatoid Arthritis

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American Journal of Molecular Biology 2019年第4期9卷 173-190页

作者： Fauzun Shaona Rubyyat Hassan Sajib Chakraborty Shahanaz Sultana Jobaida Akther ahm nurun nabi Laboratory of Population Genetics Department of Biochemistry and Molecular Biology University of Dhaka Dhaka Bangladesh Popular Diagnostic Center Dhanmondi Branch Dhaka Bangladesh

This study investigated distribution of HLA alleles (HLADRB1*01, *03, *04, *07, HLA-DQB1*0201, *0301/4) in 34 healthy controls and 57 rheumatoid arthritis (RA) patients in a Bangladeshi population and correlated the genotypic frequencies with clinical parameters. Frequency distribution of HLA-DRB1*04 (34%) and HLA-DRB1*01 (32%) were the highest followed by HLA-DQB1*0301/4 (29%) and HLA-DQB1*0201 (26%) in RA patients while HLA-DRB1*03 (12%) had lowest frequency. Plasma level of anti-CCP and rheumatoid factor antibodies confirmed diagnosis of RA patients that varied significantly between patients and healthy controls. Likewise, plasma levels of C-reactive protein, triglycerides, cholesterol, HDL-cholesterol and activities of AST and ALT exhibited significant variation between the two groups. In contrast, the levels of glucose, total protein, uric acid, LDL-cholesterol and plasma activity of ALP in RA patients had no significant deviations from healthy controls. Relationship between HLA genotype frequency and clinical parameters revealed that the mean levels of anti-CCP and rheumatoid factor antibodies were highest in the patients harboring HLA-DRB1*04 allele. These findings underpin the correlation between HLA genotype with clinical markers of RA which are indicative of disease severity. The positive correlation of these markers with certain HLA genes may be used to identify susceptible individuals who are likely to have RA in Bangladeshi population.

关键词： Rheumatoid Arthritis HLA Allele Bangladeshi Population Gene Polymorphisms Genotypes

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Impacts of SARS-CoV-2 on diabetes mellitus:A pre and post pandemic evaluation

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World Journal of Virology 2023年第3期12卷 151-171页

作者： A H M nurun nabi Akio Ebihara Hossain Uddin Shekhar Shekhar Department of Biochemistry and Molecular BiologyUniversity of DhakaDhaka 1000Bangladesh Faculty of Applied Biological Sciences Gifu UniversityGifu 501-1193Japan

The coronavirus disease 2019(COVID-19)pandemic caused by the novel beta coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)crippled the whole world and has resulted in large number of morbidity and *** origin of the SARS-CoV-2 is still *** risk of infection with SARS-CoV-2 is dependent on several risk factors as observed in many *** severity of the disease depends on many factors including the viral strain,host immunogenetics,environmental factors,host genetics,host nutritional status and presence of comorbidities like hypertension,diabetes,Chronic Obstructive Pulmonary Disease,cardiovascular disease,renal *** is a metabolic disorder mainly characterized by *** individuals are intrinsically prone to ***-CoV-2 infection in patients with diabetes result inβ-cell damage and cytokine *** to the cells impairs the equilibrium of glucose,leading to *** ensuing cytokine storm causes insulin resistance,especially in the muscles and liver,which also causes a hyperglycemic *** of these increase the severity of *** also play pivotal role in disease *** review article focuses from the probable sources of coronaviruses and SARS-CoV-2 to its impacts on individuals with diabetes and host genetics in pre-and post-pandemic era.

关键词： Coronavirus SARS-CoV-2 Diabetes MERS SARS Single nucleotide polymorphism

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