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Relationships between emissions of toxic airborne molecules and type 1 diabetes incidence in children:An ecologic study

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World Journal of Diabetes 2021年第5期12卷 673-684页

作者： agostino Di Ciaula Piero Portincasa Clinica Medica"A.Murri" Department of Biomedical Sciences and Human OncologyUniversity of Bari Medical SchoolBari 70124Italy International Society of Doctors for Environment(ISDE) Via XXV Aprile n.34–52100 ArezzoItaly

BACKGROUND Type 1 diabetes originates from gene-environment interactions,with increasing incidence over *** To identify correlates of childhood type 1 diabetes in European countries using an ecological *** environmental variables potentially influencing the onset of type 1 diabetes have been previously ***,the relationships between epidemiologic data and exposure to toxic airborne molecules are scarcely *** We employed an ecological model to explore,in a wide time period(1990-2018),associations between type 1 diabetes incidence in 19 European countries(systematic literature review)and the nationwide production of five widely diffused air pollutants:particulate matter<10μm(PM10),nitrogen oxides(NO),non-methane volatile organic compounds(VOCs),sulphur oxide(SO2),and *** Data confirm a raising incidence of type 1 diabetes in 18 out of 19 explored *** average difference(last vs first report,all countries)was+6.9×100000/year,with values ranging from-1.4(Germany)to+16.6(Sweden)per 100000/*** the overall production of pollutants decreased progressively from 1990 to 2018,type 1 diabetes incidence was positively associated with the nationwide emissions of PM10,VOCs,and NO but not with those of SO2 and *** 1 diabetes incidence was significantly higher in countries with high emissions than in those with low emissions of PM10(27.5±2.4 vs 14.6±2.4×100000 residents,respectively),VOCs(24.5±4.4 vs 13.2±1.7×100000 residents,respectively),and NO(26.6±3 vs 13.4±2.4×100000 residents,respectively),but not of SO2 or *** Evidence justify further studies to explore better links between long-term air quality and type 1 diabetes onset at the individual level,which should include exposures during *** this respect,type 1 diabetes could be,at least in part,a preventable ***,primary prevention policies acting through a marked abatement of pollutant emissions might attenuate fut

关键词： Type 1 diabetes Epidemiology Air pollution Particulate matter Nitrogen oxide Non-methane volatile organic compounds

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“Pseudotumoral” hepatic pattern in acute alcoholic hepatitis:A case report

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World Journal of Gastroenterology 2009年第32期15卷 4070-4074页

作者： Andrea Tenca Sara Massironi agostino Colli Guido Basilisco Dario Conte Policlinico MangiagalliRegina Elena FoundationGastrointestinal Unit 2 and Postgraduate School of Gastro-enterologyUniversità degli Studi di MilanoF.Sforza st.3520122 MilanItaly Department of Internal Medicine Ospedale "A.Manzoni"Lecco 23900Italy

In acute alcoholic hepatitis (AAH), a "pseudotumoral" appearance of the liver parenchyma on computed tomography (CT) scan has been reported. The main findings are hypervascularized areas closely similar to those observed in large hepatocellular carcinomas. We report a case of a patient affected by AAH with an unusual appearance of these "pseudotumoral" areas on CT scan, close resembling a metastatic cancer rather than a primary hepatocellular carcinoma. In fact, in contrast with previous reports, the picture was characterized by the presence of many inhomogeneous, hypoattenuated areas highlighted during both pre- and post-contrast phases. Moreover, we report the first description of "pseudotumoral" lesions on ultrasound scan. This patient was successfully treated with corticosteroids, even if many controversies still exist regarding their efficacy in this setting.

关键词： Acute alcoholic hepatitis Pseudotumoralhepatic lesions Alcoholic liver disease Computed tomography Ultrasound

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Remote sensing ***-based monitoring of agricultural terrace degradation

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International Soil and Water Conservation Research 2021年第1期9卷 1-10页

作者： Anton Pijl Edoardo Quarella Teun A.Vogel Vincenzo D'agostino Paolo Tarolli Dept.of Land EnvironmentAgriculture and ForestryUniversity of PadovaVialedell'Università1635020LegnaroPDItaly Soil Physics and Land Management Group Wageningen UniversityDroevendaalsesteeg 46708PBWageningenthe Netherlands

The degradation of agricultural terraces is considered a major challenge to soil and water conservation in steep-slope *** terracing is a widespread conservation practice,its sustainability is threatened by adverse climatic and man-made *** studies have shown the impact of terrace designs on the formation of runoff pathways,causing degradation processes on terrace platforms(*** erosion)and walls(***,landslides,collapse).This study evaluates a remote sensing versus a field-based approach to monitor hydrological processes responsible for terrace degradation,as tested in a north-Italian *** field-based approach was based on spatially measured Soil Moisture Content(SMC)using a Time Domain Reflectometry(TDR)instrument,which clearly revealed saturation hotspots around two damaged terraces in the study ***,these zones showed a particular cross-sectional SMC profile,with the highest saturation close to the terrace platform *** remote sensing approach was based on aerial imagery acquired by an Unmanned Aerial Vehicle(UAV)and photogrammetric reconstruction of the vineyard geomorphology,allowing terrain-based analysis and physical erosion *** this approach,simulations indicated that terrace damages could be partly explained by the formation of preferential runoff pathways caused by the terrace *** parallel methodology allowed a comparison of the merits and limitations of either approach,as done in light of published *** occurrence of two SMC hotspots at terrace edges(and their non-typical cross-sectional profiles)could be better understood from simulated surface flow *** the causal relationship between heterogeneous soil saturation and terrace instability has been previously reported in literature,the novelty of the presented study is the use of topsoil SMC as an indicator of potential damages,favouring the scalability compared to fixed,local and often intrusive terrace sub-sur

关键词： Agricultural terraces Remote sensing UAV Soil moisture Land degradation

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SIMULATION, ANALYSIS AND OPTIMIZATION OF CONTAINER TERMINALS PROCESSES

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第3期3卷 1-20页

作者： agostino BRUZZONE FRANCESCO LONGO LETIZIA NICOLETTI ELEONORA BOTTANI ROBERTO MONTANARI Simulation Team University of Genoa Via Magliotto 217100 SavonaItaly MSC-LES Mechanical Department University of CalabriaVia P.Bucci 44C 87036 Rende(CS)Italy Department of Industrial Engineering University of Parma Viale G.P.Usberti 181/A43124 ParmaItaly

The freight logistics includes all the processes needed to supply industry,retailers and wholesalers and final customers with *** processes generate a flow of goods that,in the global supply chain,mainly relies on the activities carried out within worldwide container *** this paper,the authors present a simulation model of a real container *** some preliminary analyses,the simulation model is first used with Design of Experiments and Analysis of Variance to investigate the effects of different resources allocations(i.e.,number of forklifts and tractors)and some parameters(i.e.,inter-arrival times,container unloading time)on the container terminal performances in terms of total number of handled containers per ***,based on the results achieved through the Design of Experiments and Analysis of Variance,the simulation model is used with genetic algorithms to carry out a range allocation optimization on berth assignment to incoming ships and number of tractors serving each quay *** aim of the optimization is the minimization of the average time spent by each ship in the port area(decreasing,as consequence,costs and increasing service level provided to final customers).

关键词： Container terminals supply chain node simulation optimization genetic algorithms analysis of variance.

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Ultrasonographic study of postcibal gastro-esophageal reflux and gastric emptying in infants with recurrent respiratory disease

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World Journal of Gastroenterology 2005年第46期11卷 7296-7301页

作者： agostino Di Ciaula Piero Portincasa Leonardo Di Terlizzi Domenico Paternostro Giuseppe Palasciano Division of Internal MedicineHospital of Bisceglie Italy Section of Internal MedicineDepartment of Internal Medicine and Public Medicine(DIMIMP) University Medical SchoolBariItaly Division of PediatricsHospital of Bisceglie Italy

AIM: To check the utility of postcibal ultrasonography for the evaluation of reflux in relation to gastric emptying in infants with recurrent respiratory symptoms and to link imaging with clinical ***: Esophageal reflux (hyperechoic retrograde filling) and gastric emptying (antral areas) were quantified before and after ingestion of a standard formula in 35 untreated infants (13 with chronic cough,22 with recurrent bronchitis) and in 31 ***: The prevalence of abnormal (≥8 episodes)postcibal refluxes was 74% in patients and 3% in controls. Number, duration of the longest episode and extent of refluxes were significantly higher in patients compared to controls. Number of refluxes was higher in patients with symptomatic refluxes than in those *** with recurrent bronchitis had more refluxes than those with chronic cough and controls. Extent and timing of gastric emptying were similar in patients and ***: Esophageal ultrasonography is a useful and physiological test in infants with recurrent respiratory diseases, which have a high prevalence of abnormal postcibal esophageal reflux and a gastric emptying similar to that of normal controls. Esophageal reflux is more severe in subjects with recurrent bronchitis than in those with chronic cough.

关键词： Ultrasonography Gastm-esophageal reflux Gastric emptying Recurrent respiratory disease

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Improved Peptidyl Linkers for Self-Assembly of Semiconductor Quantum Dot Bioconjugates

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Nano Research 2009年第2期2卷 121-129页

作者： Lorenzo Berti Paola Serena D'agostino Kelly Boeneman Igor L.Medintz CNR-INFM National Research Center on nanoStructures and bioSystems at Surfaces(S3)Via Campi213/A 41100 ModenaItaly University of California Davis Medical Center SacramentoCA 95817USA Center for Bio/Molecular Science and Engineering Code 6900 U.S.Naval Research LaboratoryWashingtonDC 20375USA

We demonstrate improved peptide linkers which allow both conjugation to biomolecules such as DNA and self-assembly with luminescent semiconductor quantum dots.A hexahistidine peptidyl sequence was generated by standard solid phase peptide synthesis and modified with the succinimidyl ester of iodoacetamide to yield a thiol-reactive iodoacetyl polyhistidine *** reactive peptide was conjugated to dye-labeled thiolated DNA which was utilized as a model target *** gel electrophoresis and fluorescence resonance energy transfer analysis confirmed that the linker allowed the DNA to self-assemble with quantum dots via metal-affinity driven *** contrast to previous peptidyl linkers that were based on disulfide exchange and were thus labile to reduction,the reactive haloacetyl chemistry demonstrated here results in a more stable thioether bond linking the DNA to the peptide which can withstand strongly reducing environments such as the intracellular *** thiol groups occur naturally in proteins,can be engineered into cloned proteins,inserted into nascent peptides or added to DNA during synthesis,the chemistry demonstrated here can provide a simple method for self-assembling a variety of stable quantum dot bioconjugates.

关键词： Semiconductor quantum dot peptide DNA nanocrystal bioconjugation iodoacetyl sulfhydryl polyhistidine metal-affinity fluorescence fluorescence resonance energy transfer(FRET)

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Over-the-scope clip closure of two chronic fistulas after gastric band penetration

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World Journal of Gastroenterology 2010年第13期16卷 1665-1669页

作者： Federico Iacopini Nicola Di Lorenzo Fabrizio Altorio Marc-Oliver Schurr agostino Scozzarro Gastroenterology and Endoscopy Unit Ospedale San Giuseppe Albano Laziale Department of Surgical Science Policlinico Università di Tor Vergata Steinbeis University Berlin IHCI-Institute

Gastrointestinal perforations are conservatively managed at endoscopy by through-the-scope endoclips and covered self expandable stents, according to the size and tissue features of the perforation. This is believed to be the first report of successful closure of two gastrocutaneous fistulas with over-the-scope clips (OTSCs). After laparoscopic gastric banding, a 45-year old woman presented with band erosion and penetration. Despite surgical band removal and gastric wall suturing, external drainage of enteric material persisted for 2 wk, and esophagogastroduodenoscopy demonstrated two adjacent 10-mm and 15-mm fistulous orifices at the esophagogastric junction. After cauterization of the margins, the 10-mm fistulous tract was grasped by the OTSC anchor, invaginated into the applicator cap, and closed by a traumatic OTSC. The other 15-mm fistula was too large to be firmly grasped, and a fully-covered metal stent was temporarily placed. No leak occurred during the following 6 wk. At stent removal: the OTSC was completely embedded in hyperplastic overgrowth; the 15-mm fistula significantly reduced in diameter, and it was closed by another traumatic OTSC. After the procedure, no external fistula recurred and both OTSCs were lost spontaneously after 4 wk. The use of the anchor and the OTSC seem highly effective for successful closure of small chronic perforations.

关键词： Gastrointestinal endoscopy Fistula Stent Esophagogastric junction

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Investigating the influence of segmentation in estimating safety performance functions for roadway sections

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第2期5卷 129-136页

作者： Salvatore Cafiso Carmelo D'agostino Bhagwant Persaud Department of Civil Engineering & Architecture University of Catania Department of Civil Engineering Ryerson University

Safety performance functions（SPFs） are crucial to science-based road safety *** in developing and applying SPFs, apart data quality and availability, depends fundamentally on two key factors： the validity of the statistical inferences for the available data and on how well the data can be organized into distinct homogeneous entities. The latter aspect plays a key role in the identification and treatment of road sections or corridors with problems related to safety. Indeed, the segmentation of a road network could be especially critical in the development of SPFs that could be used in safety management for roadway types, such as motorways（freeways in North America）, which have a large number of variables that could result in very short segments if these are desired to be homogeneous. This consequence, from an analytical point of view, can be a problem when the location of crashes is not precise and when there is an overabundance of segments with zero crashes. Lengthening the segments for developing and applying SPFs can mitigate this problem, but at a sacrifice of homogeneity. This paper seeks to address this dilemma by investigating four approaches for segmentation for motorways, using sample data from Italy. The best results were obtained for the segmentation based on two curves and two tangents within a segment and with fixed length segments. The segmentation characterized by a constant value of all original variables inside each segment was the poorest approach by all measures.

关键词： Road safety management Rural motorways Safety performance functions Segmentation Crash prediction General estimating equation

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Deep brain stimulation for autism spectrum disorder

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World Journal of Psychiatry 2023年第5期13卷 174-181页

作者： Stefano Marini Lucia D'agostino Carla Ciamarra Alessandro Gentile Department of Mental Health National Health ServiceTermoli 86039Italy

Deep brain stimulation(DBS)is a medical treatment that aims to obtain therapeutic effects by applying chronic electrical impulses in specific brain structures and neurological *** the years,DBS has been studied for the treatment of many psychiatric *** research on the use of DBS in people with autism has focused this interest mainly on treatment-resistant obsessive-compulsive disorder,drug-resistant epilepsy,self-injurious behaviors(SIB),and aggressive behaviors toward the *** spectrum disorder(ASD)includes a group of developmental disabilities characterized by patterns of delay and deviance in the development of social,communicative,and cognitive skills and the presence of repetitive and stereotyped behaviors as well as restricted *** with autism often have numerous medical and psychiatric comorbidities that worsen the quality of life of patients and their ***-compulsive symptoms can be found in up to 81.3%of people with *** are often severe,refractory to treatment,and particularly difficult to *** has a high prevalence in severely retarded individuals and is often associated with *** treatment of both autism and SIB presents a therapeutic *** describe the current state of the art regarding the efficacy of DBS in people with ASD,a literature search was conducted for relevant studies using the PubMed *** studies have been considered in this *** to date,DBS has been used for the stimulation of the nucleus accumbens,globus pallidus internus,anterior limb of the internal capsule,ventral anterior limb of the internal capsule,basolateral amygdala,ventral capsule and ventral striatum,medial forebrain bundle,and posterior *** the total sample of 16 patients,4 were adolescents,and 12 were *** patients had symptoms resistant to multiple drug *** patients taken into consideration by the studies showed clinical improvements as evidenced

关键词： stimulation capsule epilepsy

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Modelling of adsorption of textile dyes over multi-walled carbon nanotubes:Equilibrium and kinetic

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Chinese Journal of Chemical Engineering 2017年第4期25卷 523-532页

作者： Danilo Vuono Enrico Catizzone Alfredo Aloise Alfonso Policicchio Raffaele G.agostino Massimo Migliori Girolamo Giordano University of Calabria Department of Environmental and Chemical Engineeringvia P.Bucci1-87036 RendeCSItaly University of Calabria Department of Physicsvia P.Bacd1-87036 RendeCSItaly

The paper deals with the application of multiwall carbon nanotubes(CNTs) to the adsorption of dyes from wastewater. Textile dyes are dangerous and diffused pollutant in wastewater, and the paper results confirmed the good adsorption ability of CNTs, with respect to classic active carbon, even for different dye types. The effect of surface treatments of CNTs was primarily investigated, revealing that neither the presence of residual catalyst nor common surface treatment(oxidation) affects the CNT's performances. Therefore less expensive nonpurified CNTs were assessed as good and economically convenient alternative for the process. In order to gain in generality in adsorption kinetic modelling, the parameters of the "best fitting" pseudo-second order model have been correlated to the main process variables(the dye initial concentration and the specific mass of CNTs.) setting-up a predictive kinetic model useful design new application of these materials in currently operating industrial operations for adsorption. In addition, isothermal data were used to screen all the relevant adsorption isotherms models and the Temkin model was confirmed as the more effective to accurately fit equilibrium data for any of the considered different dye types.

关键词： wastewater walled classic isotherms dangerous pollutant economically expensive currently adsorbent

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