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Intestinal parameters of oxidative imbalance in celiac adults with extraintestinal manifestations

World Journal of Gastroenterology 2017年第44期23卷 7849-7862页

作者： agnieszka piatek-guziewicz Agata Ptak-Belowska Magdalena Przybylska-Felus Pawel Pasko Pawel Zagrodzki Tomasz Brzozowski Tomasz Mach Malgorzata Zwolinska-Wcislo Department of Gastroenterology and Hepatology University HospitalCracow Department of Physiology Jagiellonian University Medical College Department of Gastroenterology Hepatology and Infectious DiseasesJagiellonian University Medical College Department of Food Chemistry and Nutrition Jagiellonian University Medical College Henryk Niewodniczanski Institute of Nuclear Physics

AIM To evaluate selected intestinal parameters of oxidative stress, and antioxidant capacity in adult celiac disease patients with extraintestinal *** The study involved 85 adult patients divided into the following subgroups:(1) patients with newly diagnosed celiac disease(CD)(n = 7);(2) celiac patients not adhering to a gluten-free diet(GFD)(n = 22);(3) patients with CD on the GFD(n = 31); and(4) patients with functional disorders of the gastrointestinal tract, serving as controls(n = 25). Celiac patients presented with non-classic symptoms or extraintestinal manifestations. Standard blood tests including serum antioxidant levels(uric acid, bilirubin, and vitamin D), celiac antibody levels, and histopathological status of duodenal biopsy specimens have been determined. The expression of m RNA for tumor necrosis factor α(TNF-α), interleukin 1β(IL-1β), interleukin 10(IL-10), superoxide dismutase(SOD), heat-shock protein 70(HSP-70), hypoxia-inducible factor 1(HIF-1α), and BAX in the duodenal mucosa of patients was analyzed by reverse transcriptase-polymerase chain reaction. RESULTS The mean plasma uric acid level in patients with active CD(newly diagnosed and nonadherent patients) and treated celiac patients was significantly higher than in controls(260.17 ± 53.65 vs 190.8 ± 22.98, P < 0.001, and 261.7 ± 51.79 vs 190.8 ± 22.98, P < 0.001, respectively). The mean bilirubin concentration in active and treated celiac patients was significantly lower than in controls(8.23 ± 5.04 vs 10.48 ± 4.08, P < 0.05 and 8.06 ± 3.31 vs 10.48 ± 4.08, P < 0.05, respectively). The mean plasma vitamin D level was significantly lower in active celiac patients than in treated celiac patients and controls(19.37 ± 9.03 vs 25.15 ± 11.2, P < 0.05 and 19.37 ± 9.03 vs 29.67 ± 5.12, P < 0.001, respectively). The expression of TNF-α, IL-10, and HSP-70 m RNAs was significantly elevated in the celiac groups regardless of the diet when compared with controls. Patients on the GFD pre

关键词： Celiac disease Oxidative stress Superoxide dismutase Heat-shock protein 70 Apoptosis Hypoxiainducible factor Uric acid Vitamin D Tumor necrosis factor alpha

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