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Physico-chemical and biological evaluation of doxycycline loaded into hybrid oxide-polymer layer on Ti-Mo alloy

Bioactive Materials 2020年第3期5卷 553-563页

作者： Alicja Kazek-Kęsik agnieszka nosol Joanna Płonka MonikaŚmiga-Matuszowicz Sebastian Student Monika Brzychczy-Włoch Małgorzata Krok-Borkowicz Elżbieta Pamuła Wojciech Simka Faculty of Chemistry Silesian University of TechnologyB.Krzywoustego Street 644-100GliwicePoland Biotechnology Centre Silesian University of TechnologyKrzywoustego 8 Street44-100GliwicePoland Faculty of Chemistry Silesian University of TechnologyM.Strzody 9 Street44-100GliwicePoland Department of Systems Biology and Engineering Faculty of Automatic ControlElectronics and Computer ScienceSilesian University of TechnologyAkademicka 16 Street44-100GliwicePoland Department of Microbiology Jagiellonian University Medical CollegeCzysta 18 Street31-121KrakowPoland Faculty of Materials Science and Ceramics AGH University of Science and TechnologyMickiewicza Av.3030-059KrakowPoland

Oxide-polymer coatings were formed on the surface of the vanadium-free Ti–15Mo titanium *** Ti alloy surface was modified by the plasma electrolytic oxidation process,and then,the polymer layer of a poly(D,Llactide-co-glycolide)with doxycycline was *** polymer evenly covered the porous oxide layer and filled some of the ***,the microstructure of the polymer surface was completely different from that of the PEO *** surface morphology,roughness and microstructure of the polymer layer were examined by scanning electron microscopy(SEM)and a confocal *** results confirmed the effectiveness of polymer and doxycycline deposition in their stable chemical *** drug analysis was performed by highperformance liquid *** 1H NMR technique was used to monitor the course of hydrolytic degradation of *** was shown that the PLGA layer is hydrolysed within a few weeks,and the polyglycolidyl part of the copolymer is hydrolysed to glycolic acid as first and much faster than the polylactide one to lactic *** paper presents influence of different microstructures on the biological properties of modified titanium *** and bacterial adhesion tests were evaluated using osteoblast-like MG-63 cells and using the reference *** and *** *** results showed that the optimum concentration of doxycycline was found to inhibit the growth of the bacteria and that the layer is still cytocompatible.

关键词： Biomaterials Titanium alloy Plasma electrolytic oxidation Oxide-polymer hybrid coatings Doxycycline

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