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Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components

生物活性材料(英文) 2023年第1期19卷 642-652页

作者： Michaela B.Cooley Eric C.Abenojar Dana Wegierak Anirban Sen Gupta Michael C.Kolios agata A.Exner Department of Biomedical Engineering Case Western Reserve UniversityClevelandOH44106United States Department of Radiology Case Western Reserve UniversityClevelandOH44106United States Department of Physics Ryerson UniversityTorontoOntarioM5B 2K3Canada Institute for Biomedical Engineering and Science Technology A Partnership Between Ryerson University and St.Michael’s HospitalTorontoOntarioM5B 1T8Canada

Nanoscale ultrasound contrast agents,or nanobubbles,are being explored in preclinical applications ranging from vascular and cardiac imaging to targeted drug delivery in *** sub-micron particles are approximately 10x smaller than clinically available *** allows them to effectively traverse compromised physiological barriers and circulate for extended periods of *** various aspects of nanobubble behavior have been previously examined,their behavior in human whole blood has not yet been ***,herein we examined,for the first time,the short and long-term effects of blood components on nanobubble acoustic *** observed differences in the kinetics of backscatter from nanobubble suspensions in whole blood compared to bubbles in phosphate buffered saline(PBS),plasma,or red blood cell solutions(RBCs).Specifically,after introducing nanobubbles to fresh human whole blood,signal enhancement,or the magnitude of nonlinear ultrasound signal,gradually increased by 22.8±13.1%throughout our experiment,with peak intensity reached within 145 *** contrast,nanobubbles in PBS had a stable signal with negligible change in intensity(􀀀1.7±3.2%)over 8 *** the same conditions,microbubbles made with the same lipid formulation showed a􀀀56.8±6.1%decrease in enhancement in whole *** confocal,fluorescent,and scanning electron microscopy analysis revealed attachment of the nanobubbles to the surface of RBCs,suggesting that direct interactions,or hitchhiking,of nanobubbles on RBCs in the presence of plasma may be a possible mechanism for the observed *** phenomenon could be key to extending nanobubble circulation time and has broad implications in drug delivery,where RBC interaction with nanoparticles could be exploited to improve delivery efficiency.

关键词： Nanobubbles Ultrasound contrast agents Red blood cells Hitchhiking Ultrasound Drug delivery

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Fe-N-C catalysts for oxygen electroreduction under external magnetic fields:Reduction of magnetic O_(2) to nonmagnetic H_(2)O

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Journal of Energy Chemistry 2022年第1期31卷 296-308,I0008页

作者： Wojciech Kicinski Jakub P.Sek agata Kowalczyk Sylwia Turczyniak-Surdacka Anna M.Nowicka Slawomir Dyjak Boguslaw Budner Mikolaj Donten Institute of Chemistry Military University of Technology2 Kaliskiego Str.PL 00-908 WarsawPoland Faculty of Chemistry University of WarsawPasteura 1 StrPL 02-093 WarsawPoland Faculty of Chemistry Biological and Chemical Research CentreUniversity of WarsawZwirki i Wigury 101 StrPL 02-089 WarsawPoland Institute of Optoelectronics Military University of Technology.2 Kaliskiego StrPL 00-908 WarsawPoland

An extensive analysis of iron-nitrogen-carbon(Fe-N-C)electrocatalysts synthesis and activity is presented concerning synthesis conditions such as initial Fe content,pyrolysis temperature and atmosphere(inert N_(2),reducing NH_(3),oxidizing Cl_(2) and their sequential combinations)and the influence of an external magnetic field on their performance in oxygen reduction reaction(ORR).Thermosetting porous polymers doped with FeCl_(3) were utilized as the Fe-N-C catalysts *** pyrolysis temperature was varied within a 700-900℃*** temperature and atmosphere of pyrolysis strongly affect the porosity and compositi on of the resultant Fe-N-C catalysts,while the in itial amount of Fe precursor shows much weaker *** under NH_(3) yields materials similar to those pyrolyzed under an inert atmosphere(N_(2)).In contrast,pyrolysis under Cl_(2) yields carbon of peculiar character with highly disordered structure and extensive *** application of a static external magnetic field strongly enhances the ORR process(herein studied in an alkaline environment)and the enhancement correlates with the Fe content in the Fe-N-C *** Fe-N-C materials containing ferromagnetic iron phase embedded in N-doped microporous carbon constitute attractive catalysts for magnetic field-aided anion exchange membrane fuel cell technology.

关键词： Oxygen reduction reaction Fe-N-C catalyst PGM-free catalyst Magnetic field Chronoamperometry Anion exchange membrane fuel cell (AEMFC)

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Multi-Objective Optimization of External Louvers in Buildings

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Computers, Materials & Continua 2023年第4期75卷 1305-1316页

作者： Tzu-Chia Chen Ngakan Ketut Acwin Dwijendra I.Wayan Parwata agata Iwan Candra Elsayed M.Tag El Din Department of Industrial Engineering and Management Ming Chi University of TechnologyNew Taipei City24301Taiwan Department of Architecture Faculty of EngineeringUdayana UniversityBali80361Indonesia Faculty of Engineering Warmadewa UniversityBaliIndonesia Department of Civil Engineering Faculty of EngineeringKadiri UniversityKediriIndonesia Electrical Engineering Department Faculty of Engineering&TechnologyFuture University in EgyptNew Cairo11835Egypt

Because solar energy is among the renewable energies,it has traditionally been used to provide lighting in *** solar energy is effectively utilized during the day,the environment is not only more comfortable for users,but it also utilizes energy more efficiently for both heating and cooling *** of this,increasing the building’s energy efficiency requires first controlling the amount of light that enters the *** that the only parts of the building that come into direct contact with the sun are the windows,it is essential to make use of louvers in order to regulate the amount of sunlight that enters the *** the use of Ant Colony Optimization(ACO),the purpose of this study is to estimate the proportions and technical specifications of external louvers,as well as to propose a model for designing the southern openings of educational space in order to maximize energy efficiency and intelligent consumption,as well as to ensure that the appropriate amount of light is *** to the findings of this research,the design of external louvers is heavily influenced by a total of five distinct aspects:the number of louvers,the depth of the louvers,the angle of rotation of the louvers,the distance between the louvers and the window,and the reflection coefficient of the *** results of the 2067 simulated case study show that the best reflection rates of the louvers are between 0 and 15 percent,and the most optimal distance between the louvers and the window is in the range of 0 to 18 ***,the results show that the best distance between the louvers and the window is in the range of 0 to 18 centimeters.

关键词： Ant colony optimization energy consumption multi-objective optimization louvre

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Phylogenetic Analysis of Orgyia pseudotsugata Single-nucleocapsid Nucleopolyhedrovirus

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中国病毒学 2007年第4期22卷 257-265页

作者： agata Jakubowska Monique M. van Oers Imre S. Otvos Just M. Vlak Laboratory of Virology Wageningen UniversityBinnenhaven 11Wageningen6709 PDThe Netherlands Department of Biological Control and Quarantine Institute of Plant ProtectionMiczurina 20 Poznan 60-318 Poland Natural Resources Canada Canadian Forest Service Pacific Forestry Centre 506 West Burnside Road BC V8Z 1M5 Victoria Canada

The Douglas-fir tussock moth Orgyia pseudotsugata (Lepidoptera: Lymantriidae) is a frequent defoliator of Douglas-fir and true firs in western USA and Canada. A single nucleopolyhedrovirus (SNPV) isolated from O. pseudotsugata larvae in Canada (OpSNPV) was previously analyzed via its polyhedrin gene, but is phylogenetic status was ambiguous. Sequences of four conserved baculovirus genes, polyhedrin, lef-8, pif-2 and dpol, were amplified from OpSNPV DNA in polymerase chain reactions using degenerate primer sets and their sequences were analyzed phylogenetically. The analysis revealed that OpSNPV belongs to group II NPVs and is most closely related to SNPVs that infect O. ericae and O. anartoides, respectively. These results show the need for multiple, concatenated gene phylogenies to classify baculoviruses.

关键词：基因分析核型多角体病毒单核壳体生物防治花旗松鳞翅目害虫系统演化

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Technological Innovation in Sustainable Building

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Journal of Modern Accounting and Auditing 2013年第12期9卷 1671-1677页

作者： Antonio Zerbo agata Matarazzo University of Catania Catania Italy

Modern energy services are a necessary prerequisite for human well-being and the economic development of a country. Access to modern energy is essential for the supply of clean water, hygiene and health, and for the provision of reliable and efficient lighting, heating, cooking, and mechanical power. It seems clear, therefore, that the energy factor and its availability, the demand for which is growing, must be ensured over time. Moreover, considering that the world population will significantly increase in coming decades and, legitimately, all of these individuals want access to sources of energy for a better quality of life. The patterns of consumption most commonly used nowadays are expensive and highly polluting, but, most importantly, now they are almost completely exhausted. Therefore, research has to find sources of ＂alternative＂ and renewable energy in order to sustain the continuously growing global demand for energy. It is necessary, therefore, to develop and improve policies in order to change current consumption patterns, while strengthening approaches and strategies for sustainable models, applying incentives for good behavior and penalizing waste, and promoting the empowerment of producers. This paper concerns this sector and aims to highlight innovation in bioclimatic and eco-friendly buildings.

关键词： energy factor innovation building sector eco-friendly materials

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High-precision geochronology of Mesozoic magmatism in Macao,Southeast China:Evidence for multistage granite emplacement

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Geoscience Frontiers 2020年第1期11卷 243-263页

作者： Pedro Quelhas agata Alveirinho Dias Joao Mata Donald Wayne Davis Maria Luísa Ribeiro Institute of Science and Environment University of Saint JosephMacaoChina Instituto Dom Luiz Faculdade de CiênciasUniversidade de LisboaLisboaPortugal Jack Satterly Geochronology Laboratory Department of Earth SciencesUniversity of TorontoTorontoOntCanada Laboratório Nacional de Engenharia e Geologia LisboaPortugal

Six new high precision U-Pb zircon ID-TIMS ages plus thirteen in situ high spatial resolution U-Pb zircon LA-MC-ICPMS ages are reported from Jurassic plutonic(metaluminous to weakly peraluminous biotite granites)and Jurassic to Cretaceous hypabyssal(dacites)rocks from *** its relatively small area(~30 km^2),the new ages tightly constrain the Macao granitic magmatism to two periods ranging from 164.5±0.6 Ma to 162.9±0.7 Ma and 156.6±0.2 Ma to 155.5±0.8 Ma,separated by ca.6 *** zircons point to the existence of a basement with ages up to Paleo-Proterozoic and late Archean in the *** addition,younger dacitic rocks were dated at 150.6±0.6 Ma and<120 Ma.U-Pb zircon ages and whole-rock REE data of Macao granites indicate that the first pulse is also represented in Hong Kong and Southeast(SE)China,while magmatism with the chemical characteristics of the second pulse seems to not be represented outside *** two granitic magmatic pulses have distinct mineralogical and geochemical features that support their discrete nature rather than a continuum of comagmatic activity and suggest that the Macao granitic suite was incrementally assembled during a period of ca.9 Ma,a hypothesis also extendable to the neighboring Hong Kong region for a time lapse of ca.24 *** Macao,the transition from granitic magmatism(Middle to Upper Jurassic)to the younger dacite dykes(Upper Jurassic to Lower Cretaceous)most likely corresponds to a change in the regional tectonic setting,from an extensional regime related with foundering of the subducting paleoPacific plate during the Early Yanshanian period to the reestablishment of a normal subduction system in SE China during the Late Yanshanian period.

关键词： Granites U-Pb geochronology Zircon Jurassic Yanshanian orogeny Macao

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Alternative Polyadenylation of the Sense Transcript Controls Antisense Transcription of DELAY OF GERMINATION 1 in Arabidopsis

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Molecular Plant 2017年第10期10卷 1349-1352页

作者： Justyna Kowalczyk Malgorzata Palusinska agata Wroblewska-Swiniarska Zbigniew Pietras Lukasz Szewc Jakub Dolata Artur Jarmolowski Szymon Swiezewski Department of Protein Biosynthesis Institute of Biochemistry of Biophysics Polish Academy of Sciences Warsaw Poland Department of Gone Expression Institute of Molecular Biology and Biotechnology Adam Mickiewicz University Poznan Poland

Dear Editor,Seed dormancy is adopted by plants to optimize their reproductive strategy. The DOG 1 （DELAY OF GERMINATION 1） gene is the main QTL controlling this trait in Arabidopsis （Bentsink et al., 2006） and therefore is extensively regulated. This includes the alternative polyadenylation （APA） of DOG1 mRNA （Cyrek et al., 2016） and an antisense transcript, asDOGl, which in cis suppresses DOG1 expression during seed maturation （Fedak et al., 2016）. As with many antisense transcripts （Mellor et al., 2016; Rosa et al., 2016）, asDOG1 originates from close to the transcription termination site of the sense gene. This raises the question of how this proximity affects antisense promoter activity.

关键词： the Sense Transcript Controls Transcription

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Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis

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World Journal of Gastroenterology 2017年第15期23卷 2673-2684页

作者： agata Bartczak Jianhua Zhang Oyedele Adeyi Achiya Amir David Grant Reginald Gorczynski Nazia Selzner Andrzej Chruscinski Gary A Levy Multi Organ Transplant Program University Health Network Department of Laboratory Medicine and Pathology University Health Network Gastroenterology Hepatology and Nutrition DivisionThe Hospital for Sick Children

AIMTo determine the effect of overexpression of fibrinogen-like protein 2 (FGL2) on regulatory T cell (Treg) and effector T (Teff) cell function on T cell-induced colitis in Rag1-/- *** and Teff cells from fgl2-/-, fgl2+/+, and fgl2Tg mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1-/- *** vitro, fgl2Tg Treg had enhanced immunosuppressive activity, and fgl2Tg Teff had reduced proliferation to alloantigen stimulation. Transfer of Teff from C57Bl/6J mice (fgl2+/+) into Rag1-/- mice produced both clinical and histologic colitis with dense infiltrates of CD3+ T cells, crypt abscesses and loss of goblet cells. Fgl2Tg Treg prevented the development of T cell-induced colitis, whereas fgl2+/+ and fgl2-/- Treg were only partially protective. In mice that received fgl2Tg Treg, the ratio of Foxp3+ to CD3+ cells was increased both in the colon and in mesenteric lymph nodes, and Teff cell proliferation as determined by staining with Ki67 was reduced. Teff cells from fgl2Tg mice did not produce *** we show that fgl2Tg Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2Tg Treg prevent colitis in contrast to fgl2+/+ Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease.

关键词： Fibrinogen-like protein 2 Colitis Regulatory T cells Transgenic mouse Inflammatory bowel disease

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Emotional Costs and Self-efficacy as Predictors of Coping Among the Reemployed and Professional Interns

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Sociology Study 2013年第5期3卷 354-362页

作者： Katarzyna Slebarska agata Chudzicka-Czupala University of Silesia Poland

The main goal of the study was to investigate the emotional costs experienced by the organizational newcomers during the first period of reemployment and its relation to general self-efficacy CGSE} and coping. The study was conducted among 123 previous unemployed, involving 88 reemployed and 35 interns. Questionnaires battery was administered in two waves {T1 and T2~ in the first month of reemployment and after three months. In this article, the data from T2 were analyzed, which allows observing the final results and interactions between research variables. The results showed emotional costs and GSE as significant predictors of coping in the work re-entry phase. Additionally, emotional costs partially mediate the effect of GSE on coping. The differences between both groups, the reemployed and interns were also analyzed.

关键词： Emotional costs self-efficacy coping strategies reemployment

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Brain-gut-microbiota axis in Parkinson's disease

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World Journal of Gastroenterology 2015年第37期21卷 10609-10620页

作者： agata Mulak Bruno Bonaz Department of Gastroenterology and Hepatology Wroclaw Medical University Grenoble Institut des Neurosciences (GIN) INSERM U836 38043 Grenoble France Clinique Universitaire d’Hépato-Gastroentérologie CHU de Grenoble 38043 Grenoble France

Parkinson's disease(PD) is characterized by alphasynucleinopathy that affects all levels of the braingut axis including the central, autonomic, and enteric nervous systems. Recently, it has been recognized that the brain-gut axis interactions are significantly modulated by the gut microbiota via immunological,neuroendocrine, and direct neural mechanisms. Dysregulation of the brain-gut-microbiota axis in PD may be associated with gastrointestinal manifestations frequently preceding motor symptoms, as well as with the pathogenesis of PD itself, supporting the hypothesis that the pathological process is spread from the gut to the brain. Excessive stimulation of the innate immune system resulting from gut dysbiosis and/or small intestinal bacterial overgrowth and increased intestinal permeability may induce systemic inflammation, while activation of enteric neurons and enteric glial cells may contribute to the initiation of alpha-synuclein ***, the adaptive immune system may be disturbed by bacterial proteins cross-reacting with human antigens. A better understanding of the brain-gutmicrobiota axis interactions should bring a new insight in the pathophysiology of PD and permit an earlier diagnosis with a focus on peripheral biomarkers within the enteric nervous system. Novel therapeutic options aimed at modifying the gut microbiota composition and enhancing the intestinal epithelial barrier integrity in PD patients could influence the initial step of the following cascade of neurodegeneration in PD.

关键词： Brain-gut-microbiota axis Enteric nervous system G

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