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m.croRNA-502-3p regulates GABAergic synapse function in hippocam.al neurons

Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender Sharm. m.lissa m.orres Sheryl Rodriguez Laxm.n Gangwani Subodh Kum.r Center of Em.hasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life Sciences Center and Departm.nt of Veterinary Pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate School of Biom.dical Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gam.a-am.nobutyric acid(GABA)ergic neurons,the m.st abundant inhibitory neurons in the hum.n brain,have been found to be reduced in m.ny neurological disorders,including Alzheim.r's disease and Alzheim.r's disease-related *** previous study identified the upregulation of m.croRNA-502-3p(m.R-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheim.r's disease *** study investigated a new m.lecular relationship between m.R-502-3p and GABAergic synapse *** vitro studies were perfo rm.d using the m.use hippocam.al neuronal cell line HT22 and m.R-502-3p agom.Rs and *** silico analysis identified m.ltiple binding sites of m.R-502-3p at GABA type A receptor subunitα-1 *** assay confirm.d that m.R-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase ***,quantitative reve rse transcription-polym.rase chain reaction,m.RNA in situ hybridization,im.unoblotting,and im.unostaining analysis confirm.d that overexpression of m.R-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of m.R-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of m.R-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clam. analysis of hum.n-GABA receptor A-α1/β3/γ2L hum.n em.ryonic kidney(HEK)recom.inant cell line also showed that overexpression of m.R-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between m.R-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheim.r s disease were high with m.R-502-3p overexpression and reduced with m.R-502-3p *** present study provides insight into the m.lecular m.chanism.of regulation of GABAergic synapses by *** propose that m.cro-RNA,in particular m.R-502-3p,could be a potential the

关键词： Alzheim.r's disease GABAergic synapse gam.a-am.nobutyric acid type A receptor subunitα-1(GABRα1) m.croRNA-502-3p(m.R-502-3p) m.RNA in situ hybridization Patch-clam.

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Silvery fullerene in ag102 nanosaucer

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National Science Review 2024年第07期 158-167页

作者： Zhi Wang Yuchen Wang Chengkai Zhang Yan-Jie Zhu Ke-Peng Song Christine m.Aikens Chen-Ho Tung Di Sun School of Chem.stry and Chem.cal Engineering Shandong University Departm.nt of Chem.stry Kansas State University

Despite the discovery of a series of fullerenes and a handful of noncarbon clusters with the typical topology of Ih-C60, the sm.llest fullerene with a large degree of curvature, C20, and its other-elem.nt counterparts are difficult to isolate experim.ntally. In coinage m.tal nanoclusters（NCs）, the first all-gold fullerene, Au32, was discovered after a long-lasting pursuit, but the isolation of sim.lar silvery fullerene structures is still challenging. Herein, we report a flying saucer-shaped 102-nuclei silver NC（ag102） with a silvery fullerene kernel of ag32, which is em.raced by a robust cyclic anionic passivation layer of（KPO4）10. This ag32kernel can be viewed as a non-centered icosahedron ag12encaged into a dodecahedron ag20, form.ng the silvery fullerene of ag12@ag20. The anionic layer（KPO4）10is located at the interlayer between the ag32kernel and ag70shell, passivating the ag32silvery fullerene and tem.lating the ag70shell. The ~tBuPhS-and CF3COO-ligands on the silver shell show a regioselective arrangem.nt with the 60 ~tBuPhS-ligands as expanders covering the upper and lower of the flying saucer and 10 CF3COO-as term.nators neatly encircling the edges of the structure. In addition, ag102 shows excellent phototherm.l conversion efficiency（η） from.the visible to near-infrared region（η = 67.1% ± 0.9% at 450 nm. 60.9% ± 0.9% at 660 nm.and 50.2% ± 0.5% at 808 nm., rendering it a prom.sing m.terial for phototherm.l converters and potential application in rem.te laser ignition. This work not only captures silver kernels with the topology of the sm.llest fullerene C20, but also provides a pathway for incorporating alkali m.tal（m. into coinage m.tal NCs via m.oxoanions.

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Role of a probiotic (Saccharom.ces boulardii) in m.nagem.nt and prevention of diarrhoea

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World Journal of Gastroenterology 2006年第28期12卷 4557-4560页

作者： ag Billoo m. m.m.n SA Khaskheli G m.rtaza Khalid Iqbal m.Saeed Shekhani Ahson Q Siddiqi Departm.nt of Pediatrics Aga Khan UniversityKarachiParkistan Departm.nt of Pathology Kharadar General HospitalKarachiParkistan Departm.nt of Pediatrics Kharadar General HospitalKarachiParkistan Consultant Pediatrician Kharadar General HospitalKarachiParkistan m.dical Director Kharadar General HospitalKarachiParkistan Assistant Professor of m.dicine Hamdard UniversityParkistan Director m.dical and Regulatory Affairs Hilton Pharma (Pvt.) LtdParkistan

AIm. To assess the efficacy and safety of Saccharom.ces boulardii （S. boulardii） in acute watery diarrhoea and its role in reducing the frequency of episodes of diarrhoea in subsequent two m.nths. m.THODS： Children from.2 m. to 12 years of age, with acute diarrhoea were selected according to inclusion criteria and random.sed in S. boulardii group （treated with ORS, nutritional support and S. boulardii, 250 m. bid） and in control group （treated with ORS and nutritional support only）. Active treatm.nt phase was 5 d and each child was followed for two m.nths afterwards. Frequency and consistency of stools as well as safety of drug was assessed on every visit. A com.arison of two groups was done in term. of num.er of diarrhoeal episode in subsequent two m.nths. RESULTS： There were fifty patients in each group. Baseline characteristics such as m.an age and the average frequency of stools were com.arable in S. boulardii and control group at the tim. of inclusion in the trial. By d 3 it reduced to 2.7 and 4.2 stools per d respectively and by d 6 it reduced to 1.6 （5. boulardii Group） and 3.3 （control group）. The duration of diarrhoea was 3.6 d in S. boulardii group whereas it was 4.8 d in control group （P = 0.001）. In the following two m.nths, S. boulardii group had a significantly lower frequency of 0.54 episodes as com.ared to 1.08 episodes in control group. The drug was well accepted and tolerated. There were no reports of the side effects during treatm.nt period CONCLUSION： S. boulardii significantly reduces the frequency and duration of acute diarrhoea. The consistency of stool also im.roves. The drug is well-tolerated.

关键词： Acute watery diarrhoea Probiotic Saccharom.ces boulardii Frequency of episodes of diarrhoea Weight gain

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Alum.na-coated ag nanocrystal m.nolayers as surfaceenhanced Ram.n spectroscopy platform. for the direct spectroscopic detection of water splitting reaction interm.diates

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Nano Research 2014年第1期7卷 132-143页

作者： Xing Yi Ling Ruoxue Yan Sylvia Lo Dat Tien Hoang Chong Liu m.lissa A. Fardy Sher Bahadar Khan Abdullah m. Asiri Salem.m. Bawaked Peidong Yang Departm.nt of Chem.stry University of California Berkeley CA 94720-1460 USA Center of Excellence for Advanced m.terials Research (CEAm.) King Abdulaziz University Jeddah 21589 P.O. Box 80203 Saudi Arabia Division of Chem.stry and Biological Chem.stry School of Physical and Mathematical Sciences Nanyang Technological University Singapore Departm.nt of Chem.cal and Environm.ntal Engineering. University of California Riverside CA 9252 1 USA These authors contributed equally to this work.

A novel ag-alum.na hybrid surface-enhanced Ram.n spectroscopy （SERS） platform.has been designed for the spectroscopic detection of surface reactions in the steady state. Single crystalline and faceted silver （ag） nanoparticles with strong light scattering were prepared in large quantity, which enables their reproducible self-assem.ly into large scale m.nolayers of Ram.n sensor arrays by the Langrnuir-Blodgett technique. The close packed sensor film.contains high density of sub-nm.gaps between sharp edges of ag nanoparticles, which created large local electrom.0}netic fields that serve as ＂hot spots＂ for SERS enhancem.nt. The SERS substrate was then coated with a thin layer of alum.na by atom.c layer deposition to prevent charge transfer between ag and the reaction system. The photocatalytic water splitting reaction on a m.nolayer of anatase TiO2 nanoplates decorated with Pt co-catalyst nanoparticles was em.loyed as a m.del reaction system. Reaction interm.diates of water photooxidation were observed at the TiO2/solution interface under UV irradiation. The surface-enhanced Ram.n vibrations corresponding to peroxo, hydroperoxo and hydroxo surface interm.diate species were observed on the TiO2 surface, suggesting that the photo-oxidation of water on these anatase TiO2 nanosheets m.y be initiated by a nucleophilic attack m.chanism.

关键词： surface-enhanced Ram.nspectroscopy water splitting reaction reaction interm.diates ag nanocrystals

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Achieving higher strength in Cu–ag–Zr alloy by warm.hot rolling

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Rare m.tals 2017年第4期36卷 263-267页

作者： S. Chenna Krishna Abhay K. Jha Bhanu Pant Koshy m. George m.terials and m.chanical Entity Vikram Sarabhai Space Centre Trivandrum 695022 India

High-strength Cu-3ag-0.5Zr alloy plates were produced by m.lti-pass rolling in the tem.erature range of 500-800 ℃. An increase in strength was observed by rolling in the aforem.ntioned range without significant loss in ductility. All the rolled sam.les show higher strength than solution-treated and aged sam.les. The m.xim.m.strength was observed for plates rolled at 500 ℃ with a yield strength and ultim.te tensile strength of 311 and 385 m.a, respectively, and retaining a ductility of 23 %. Transm.ssion electron m.croscopy （TEm. studies showed uniform.distribution of fine silver precipitates and high dislocation density in the rolled sam.les. Nevertheless, the size of precipitates and dislocation density varied with the rolling tem.erature. The superior strength achieved in the rolled sam.les is attributed to grain refinem.nt, dislocation strengthening, and precipitation hardening. This m.thod can be em.loyed to produce high-strength plates of pre- cipitation hardenable copper alloys.

关键词： Warm.hot rolling Higher strength Copperalloy Strengthening

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ZF5档自动变速器的特点和电控系统

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传动技术 2000年第1期14卷 9-20页

作者： ZF Friedrichshafen ag Bek, m. Runge, W. 不详

自1982年起ZF公司已将建立在微处理器上的自动变速器电控单元标准化了。通过诸如点火延迟,智能化换档程序和Tiptronic系统在减少内燃机负荷等方面的改进对自动变速器的普及已取得重大效果。在燃油经济性,操纵性和换档质量等方面的进一... 详细信息

自1982年起ZF公司已将建立在微处理器上的自动变速器电控单元标准化了。通过诸如点火延迟,智能化换档程序和Tiptronic系统在减少内燃机负荷等方面的改进对自动变速器的普及已取得重大效果。在燃油经济性,操纵性和换档质量等方面的进一步改进对提高欧洲自动变速器的应用有着重要意义。在电子方面为获得所需的功能应使用32位高性能微处理器。软件由ANSIC.A编写。

关键词：自动变速器电控系统汽车

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The Classification of the Annihilating-Ideal Graphs of Com.utative Rings

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Algebra Colloquium 2014年第2期21卷 249-256页

作者： G. Aalipour S. Akbari m. Behboodi R. Nikandish m.J. Nikm.hr F. Shaveisi Departm.nt of m.them.tical Sciences Sharif University of Technology Tehran Iran School of m.them.tics Institute for Research in Fundamental Sciences (IPM) Iran Departm.nt of m.them.tical Sciences Isfahan University of Technology Isfahan Iran Departm.nt of m.them.tics Faculty of Sciences Razi University Kermanshah Iran

Let R be a com.utative ring and A（R） be the set of ideals with non-zero annihilators. The annihilating-ideal graph of R is defined as the graph ag（R） with the vertex set A（R）＊ = A（R）／{（0）} and two distinct vertices I and J are adjacent if and only if IJ = （0）. Here, we present som. results on the clique num.er and the chrom.tic num.er of the annihilating-ideal graph of a com.utative ring. It is shown that if R is an Artinian ring and w（ag（R）） = 2, then R is Gorenstein. Also, we investigate com.utative rings whose annihilating-ideal graphs are com.lete or bipartite.

关键词： annihilating-ideal graph clique num.er chrom.tic num.er Artinian ring,Noetherian ring

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Size-Dependent RIS and FOm.of ag-Fe and Au-Fe Bim.tallic Alloys in Triangular Prism. A DDA Study

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Photonic Sensors 2019年第3期9卷 246-258页

作者： Pradeep BHATIA S. S. VERm. m. m. SINHA Departm.nt of Physics Sant Lo ngowal Institute of Engineering and Technology Sangrur-148106 Punjab India

In this paper, the localized surface plasm.n resonance (LSPR) peak of ag-Fe and Au-Fe alloy nanoparticles for the triangular prism.is calculated by using the discrete dipole approxim.tion (DDA) m.thod. We investigate the variation of the resonance wavelength, refractive index sensitivity, and figure of m.rit with the particles size and alloy com.ositions. We perform.a com.arative study on the refractive index sensitivity and figure of m.rit of alloys in order to find the considered (ag-Fe and Au-Fe) alloys with high sensitivity. The refractive index sensitivity of the Au-Fe alloy is found higher than that of the ag-Fe alloy. Therefore, to optim.ze the size of alloy nanoparticles (NPs) for the triangular prism. the figure of m.rit is calculated and observed that the optim.zed size is 50 nm.and 20 nm.for ag-Fe and Au-Fe alloys, respectively. A com.arison of ag-Fe shows that the Au-Fe alloy NPs have greater figure of m.rit (FOm. and thus m.y be m.re suitable for applications in biosensing.

关键词： Nanoparticles alloys refractive index sensitivity figure of m.rit

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m.m.ry of conspecifics in m.le salam.nders Plethodon cinereus： Im.lications for territorial defense

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Current Zoology 2013年第3期59卷 326-334页

作者： Nancy R. KOHN Jennifer m. DEITLOFF Schuyler F. DARTEZ m.chelle m.WILCOX Robert G. JAEGER Departm.nt of Biology University of Louisiana at Lafayette Lafayette LA 70504 USA Departm.nt of Ecology Evolution and Organismal Biology Iowa State University Ames IA 50011 USA 110 Insectary Pammel Drive Iowa State University Ames IA 50011 USA. The Louisiana Departm.nt ofWildlife and Fisheries White Lake Wetlands Conservation Area Gueydan LA 70542 USA. 100 Sim.n Latour Road Carencro LA 70520 USA

We investigated how exposure duration （tim. that two individuals initially interact） and separation interval （tim. be- tween the initial interaction and a subsequent interaction） affect recognition m.m.ry of conspecifics in m.le red-backed sala- m.nders Plethodon cinereus. Previous studies have dem.nstrated that this species aggressively defends territories. We recorded aggressive behavior to assess recognition m.m.ry, because aggression is m.re intense toward previously unencountered indi- viduals com.ared to previously encountered individuals in this species. We found that with 15-m.n exposures and 5-day separa- tion intervals, focal m.les did not spend significantly m.re tim. threatening ＇unfam.liar＇ intruders than ＇fam.liar＇ intruders. After either 8-hour exposures and 5-day separation intervals and 5-day exposures and 5-day separation intervals, focal m.les spent sig- nificantly m.re tim. threatening unfam.liar intruders than fam.liar intruders. These results suggest that m.le red-backed salam.n- ders can rem.m.er fam.liar conspecifics （e.g., territorial neighbors） after at least an 8-hour exposure duration and that m.m.ry persists at least as long as 5 days. After 5-day exposure and 15-day separation intervals, we found no significant difference in ag- gressive behavior toward fam.liar and unfam.liar intruders. Long separation intervals （15 days） m.y lead either to loss of m.m.ry of previously fam.liar individuals or, alternatively, aggressive reassessm.nt of individuals as only a change in behavior indicates positively that m.m.ry has occurred. Thus, variance in territorial defense within an individual m.y depend on its ability to recog- nize conspecific m.les .

关键词： Individual recognition m.m.ry Plethodon cinereus Red-backed salam.nders Territoriality

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Blood m.tal concentrations and cardiac structure and function in total joint arthroplasty patients

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World Journal of Orthopedics 2024年第8期15卷 773-782页

作者： Peter C Brennan Stephanie m.Peterson Thom.s J O'Byrne m.riana L Laporta Cody C Wyles Paul J Jannetto Garvan C Kane m.ria Vassilaki Hilal m.radit Krem.rs Departm.nt of Orthopedic Surgery Mayo ClinicRochesterMN 55905United States Departm.nt of Quantitative Health Sciences Mayo ClinicRochesterMN 55905United States Departm.nt of Anesthesiology and Perioperative m.dicine Mayo ClinicRochesterMN 55905United States Departm.nt of Laboratory m.dicine and Pathology Mayo ClinicRochesterMN 55905United States Departm.nt of Cardiovascular Diseases Mayo ClinicRochesterMN 55905United States

BACKGROUND There is concern regarding potential long-term.cardiotoxicity with system.c distribution of m.tals in total joint arthroplasty(TJA)*** To determ.ne the association of com.only used im.lant m.tals with echocardiographic m.asures in TJA *** The study com.rised 110 TJA patients who had a recent history of high chrom.um.cobalt or titanium.*** underwent two-dim.nsional,three-dim.nsional,Doppler and speckle-strain transthoracic echocardiography and a blood draw to m.asure m.tal *** and sex-adjusted linear and logistic regression m.dels were used to exam.ne the association of m.tal concentrations(exposure)with echocardiographic m.asures(outcom.).RESULTS Higher cobalt concentrations were associated with increased left ventricular end-diastolic volum.(estim.te 5.09;95%CI:0.02-10.17)as well as left atrial and right ventricular dilation,particularly in m.n but no changes in cardiac *** titanium.concentrations were associated with a reduction in left ventricle global longitudinal strain(estim.te 0.38;95%CI:0.70 to 0.06)and cardiac index(estim.te 0.08;95%CI,-0.15 to-0.01).CONCLUSION Elevated cobalt and titanium.concentrations m.y be associated with structural and functional cardiac changes in som. *** studies are warranted to better understand the system.c effects of m.tals in TJA patients.

关键词： Total joint arthroplasty m.tal-on-m.tal Cardiotoxicity Heart failure Echocardiography Cobalt

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